Blind MultiChannel Identification and Equalization for Dereverberation and Noise Reduction based on Convolutive Transfer Function

This paper addresses the problems of blind channel identification and multichannel equalization for speech dereverberation and noise reduction. The time-domain cross-relation method is not suitable for blind room impulse response identification, due to the near-common zeros of the long impulse responses. We extend the cross-relation method to the short-time Fourier transform (STFT) domain, in which the time-domain impulse responses are approximately represented by the convolutive transfer functions (CTFs) with much less coefficients. The CTFs suffer from the common zeros caused by the oversampled STFT. We propose to identify CTFs based on the STFT with the oversampled signals and the critical sampled CTFs, which is a good compromise between the frequency aliasing of the signals and the common zeros problem of CTFs. In addition, a normalization of the CTFs is proposed to remove the gain ambiguity across sub-bands. In the STFT domain, the identified CTFs is used for multichannel equalization, in which the sparsity of speech signals is exploited. We propose to perform inverse filtering by minimizing the $\ell_1$-norm of the source signal with the relaxed $\ell_2$-norm fitting error between the micophone signals and the convolution of the estimated source signal and the CTFs used as a constraint. This method is advantageous in that the noise can be reduced by relaxing the $\ell_2$-norm to a tolerance corresponding to the noise power, and the tolerance can be automatically set. The experiments confirm the efficiency of the proposed method even under conditions with high reverberation levels and intense noise.Comment: 13 pages, 5 figures, 5 table

Proceedings of the second "international Traveling Workshop on Interactions between Sparse models and Technology" (iTWIST'14)

The implicit objective of the biennial "international - Traveling Workshop on Interactions between Sparse models and Technology" (iTWIST) is to foster collaboration between international scientific teams by disseminating ideas through both specific oral/poster presentations and free discussions. For its second edition, the iTWIST workshop took place in the medieval and picturesque town of Namur in Belgium, from Wednesday August 27th till Friday August 29th, 2014. The workshop was conveniently located in "The Arsenal" building within walking distance of both hotels and town center. iTWIST'14 has gathered about 70 international participants and has featured 9 invited talks, 10 oral presentations, and 14 posters on the following themes, all related to the theory, application and generalization of the "sparsity paradigm": Sparsity-driven data sensing and processing; Union of low dimensional subspaces; Beyond linear and convex inverse problem; Matrix/manifold/graph sensing/processing; Blind inverse problems and dictionary learning; Sparsity and computational neuroscience; Information theory, geometry and randomness; Complexity/accuracy tradeoffs in numerical methods; Sparsity? What's next?; Sparse machine learning and inference.Comment: 69 pages, 24 extended abstracts, iTWIST'14 website: http://sites.google.com/site/itwist1

Dynamic Thermal Imaging for Intraoperative Monitoring of Neuronal Activity and Cortical Perfusion

Neurosurgery is a demanding medical discipline that requires a complex interplay of several neuroimaging techniques. This allows structural as well as functional information to be recovered and then visualized to the surgeon. In the case of tumor resections this approach allows more fine-grained differentiation of healthy and pathological tissue which positively influences the postoperative outcome as well as the patient's quality of life. In this work, we will discuss several approaches to establish thermal imaging as a novel neuroimaging technique to primarily visualize neural activity and perfusion state in case of ischaemic stroke. Both applications require novel methods for data-preprocessing, visualization, pattern recognition as well as regression analysis of intraoperative thermal imaging. Online multimodal integration of preoperative and intraoperative data is accomplished by a 2D-3D image registration and image fusion framework with an average accuracy of 2.46 mm. In navigated surgeries, the proposed framework generally provides all necessary tools to project intraoperative 2D imaging data onto preoperative 3D volumetric datasets like 3D MR or CT imaging. Additionally, a fast machine learning framework for the recognition of cortical NaCl rinsings will be discussed throughout this thesis. Hereby, the standardized quantification of tissue perfusion by means of an approximated heating model can be achieved. Classifying the parameters of these models yields a map of connected areas, for which we have shown that these areas correlate with the demarcation caused by an ischaemic stroke segmented in postoperative CT datasets. Finally, a semiparametric regression model has been developed for intraoperative neural activity monitoring of the somatosensory cortex by somatosensory evoked potentials. These results were correlated with neural activity of optical imaging. We found that thermal imaging yields comparable results, yet doesn't share the limitations of optical imaging. In this thesis we would like to emphasize that thermal imaging depicts a novel and valid tool for both intraoperative functional and structural neuroimaging

A visual analytics approach to feature discovery and subspace exploration in protein flexibility matrices

The vast amount of information generated by domain scientists makes the transi- tion from data to knowledge difficult and often impedes important discoveries. For example, the knowledge gained from protein flexibility data sets can speed advances in genetic therapies and drug discovery. However, these models generate so much data that large scale analysis by traditional methods is almost impossible. This hinders biomedical advances. Visual analytics is a new field that can help alleviate this problem. Visual analytics attempts to seamlessly integrate human abilities in pattern recognition, domain knowledge, and synthesis with automatic analysis techniques. I propose a novel, visual analytics pipeline and prototype which eases discovery, com- parison, and exploration in the outputs of complex computational biology datasets. The approach utilizes automatic feature extraction by image segmentation to locate regions of interest in the data, visually presents the features to users in an intuitive way, and provides rich interactions for multi-resolution visual exploration. Functional- ity is also provided for subspace exploration based on automatic similarity calculation and comparative visualizations. The effectiveness of feature discovery and subspace exploration is shown through a user study and user scenarios. Feedback from analysts confirms the suitability of the proposed solution to domain tasks

A Model-Based Signal Processing Approach to Nuclear Explosion Monitoring

This report describes research performed under Laboratory Research and Development Project 05-ERD-019, entitled ''A New Capability for Regional High-Frequency Seismic Wave Simulation in Realistic Three-Dimensional Earth Models to Improve Nuclear Explosion Monitoring''. A more appropriate title for this project is ''A Model-Based Signal Processing Approach to Nuclear Explosion Monitoring''. This project supported research for a radically new approach to nuclear explosion monitoring as well as allowed the development new capabilities in computational seismology that can contribute to NNSA/NA-22 Programs