Spatial Smoothing for Diffusion Tensor Imaging with low Signal to Noise Ratios

Though low signal to noise ratio (SNR) experiments in DTI give key information about tracking and anisotropy, e.g. by measurements with very small voxel sizes, due to the complicated impact of thermal noise such experiments are up to now seldom analysed. In this paper Monte Carlo simulations are presented which investigate the random fields of noise for different DTI variables in low SNR situations. Based on this study a strategy for spatial smoothing, which demands essentially uniform noise, is derived. To construct a convenient filter the weights of the nonlinear Aurich chain are adapted to DTI. This edge preserving three dimensional filter is then validated in different variants via a quasi realistic model and is applied to very new data with isotropic voxels of the size 1x1x1 mm3 which correspond to a spatial mean SNR of approximately 3

Random noise in Diffusion Tensor Imaging, its Destructive Impact and Some Corrections

The empirical origin of random noise is described, its influence on DTI variables is illustrated by a review of numerical and in vivo studies supplemented by new simulations investigating high noise levels. A stochastic model of noise propagation is presented to structure noise impact in DTI. Finally, basics of voxelwise and spatial denoising procedures are presented. Recent denoising procedures are reviewed and consequences of the stochastic model for convenient denoising strategies are discussed

DTI denoising for data with low signal to noise ratios

Low signal to noise ratio (SNR) experiments in diffusion tensor imaging (DTI) give key information about tracking and anisotropy, e. g., by measurements with small voxel sizes or with high b values. However, due to the complicated and dominating impact of thermal noise such data are still seldom analysed. In this paper Monte Carlo simulations are presented which investigate the distributions of noise for different DTI variables in low SNR situations. Based on this study a strategy for the application of spatial smoothing is derived. Optimal prerequisites for spatial filters are unbiased, bell shaped distributions with uniform variance, but, only few variables have a statistics close to that. To construct a convenient filter a chain of nonlinear Gaussian filters is adapted to peculiarities of DTI and a bias correction is introduced. This edge preserving three dimensional filter is then validated via a quasi realistic model. Further, it is shown that for small sample sizes the filter is as effective as a maximum likelihood estimator and produces reliable results down to a local SNR of approximately 1. The filter is finally applied to very recent data with isotropic voxels of the size 1×1×1mm^3 which corresponds to a spatially mean SNR of 2.5. This application demonstrates the statistical robustness of the filter method. Though the Rician noise model is only approximately realized in the data, the gain of information by spatial smoothing is considerable

Total variation regularization for manifold-valued data

We consider total variation minimization for manifold valued data. We propose a cyclic proximal point algorithm and a parallel proximal point algorithm to minimize TV functionals with $\ell^p$-type data terms in the manifold case. These algorithms are based on iterative geodesic averaging which makes them easily applicable to a large class of data manifolds. As an application, we consider denoising images which take their values in a manifold. We apply our algorithms to diffusion tensor images, interferometric SAR images as well as sphere and cylinder valued images. For the class of Cartan-Hadamard manifolds (which includes the data space in diffusion tensor imaging) we show the convergence of the proposed TV minimizing algorithms to a global minimizer

Improving Fiber Alignment in HARDI by Combining Contextual PDE Flow with Constrained Spherical Deconvolution

We propose two strategies to improve the quality of tractography results computed from diffusion weighted magnetic resonance imaging (DW-MRI) data. Both methods are based on the same PDE framework, defined in the coupled space of positions and orientations, associated with a stochastic process describing the enhancement of elongated structures while preserving crossing structures. In the first method we use the enhancement PDE for contextual regularization of a fiber orientation distribution (FOD) that is obtained on individual voxels from high angular resolution diffusion imaging (HARDI) data via constrained spherical deconvolution (CSD). Thereby we improve the FOD as input for subsequent tractography. Secondly, we introduce the fiber to bundle coherence (FBC), a measure for quantification of fiber alignment. The FBC is computed from a tractography result using the same PDE framework and provides a criterion for removing the spurious fibers. We validate the proposed combination of CSD and enhancement on phantom data and on human data, acquired with different scanning protocols. On the phantom data we find that PDE enhancements improve both local metrics and global metrics of tractography results, compared to CSD without enhancements. On the human data we show that the enhancements allow for a better reconstruction of crossing fiber bundles and they reduce the variability of the tractography output with respect to the acquisition parameters. Finally, we show that both the enhancement of the FODs and the use of the FBC measure on the tractography improve the stability with respect to different stochastic realizations of probabilistic tractography. This is shown in a clinical application: the reconstruction of the optic radiation for epilepsy surgery planning

Seismic Fault Preserving Diffusion

This paper focuses on the denoising and enhancing of 3-D reflection seismic data. We propose a pre-processing step based on a non linear diffusion filtering leading to a better detection of seismic faults. The non linear diffusion approaches are based on the definition of a partial differential equation that allows us to simplify the images without blurring relevant details or discontinuities. Computing the structure tensor which provides information on the local orientation of the geological layers, we propose to drive the diffusion along these layers using a new approach called SFPD (Seismic Fault Preserving Diffusion). In SFPD, the eigenvalues of the tensor are fixed according to a confidence measure that takes into account the regularity of the local seismic structure. Results on both synthesized and real 3-D blocks show the efficiency of the proposed approach.Comment: 10 page

Anisotropic Diffusion Partial Differential Equations in Multi-Channel Image Processing : Framework and Applications

We review recent methods based on diffusion PDE's (Partial Differential Equations) for the purpose of multi-channel image regularization. Such methods have the ability to smooth multi-channel images anisotropically and can preserve then image contours while removing noise or other undesired local artifacts. We point out the pros and cons of the existing equations, providing at each time a local geometric interpretation of the corresponding processes. We focus then on an alternate and generic tensor-driven formulation, able to regularize images while specifically taking the curvatures of local image structures into account. This particular diffusion PDE variant is actually well suited for the preservation of thin structures and gives regularization results where important image features can be particularly well preserved compared to its competitors. A direct link between this curvature-preserving equation and a continuous formulation of the Line Integral Convolution technique (Cabral and Leedom, 1993) is demonstrated. It allows the design of a very fast and stable numerical scheme which implements the multi-valued regularization method by successive integrations of the pixel values along curved integral lines. Besides, the proposed implementation, based on a fourth-order Runge Kutta numerical integration, can be applied with a subpixel accuracy and preserves then thin image structures much better than classical finite-differences discretizations, usually chosen to implement PDE-based diffusions. We finally illustrate the efficiency of this diffusion PDE's for multi-channel image regularization - in terms of speed and visual quality - with various applications and results on color images, including image denoising, inpainting and edge-preserving interpolation