10,550 research outputs found

    Realization of Analog Wavelet Filter using Hybrid Genetic Algorithm for On-line Epileptic Event Detection

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    © 2020 The Author(s). This open access work is licensed under a Creative Commons Attribution 4.0 License. For more information, see http://creativecommons.org/licenses/by/4.0/.As the evolution of traditional electroencephalogram (EEG) monitoring unit for epilepsy diagnosis, wearable ambulatory EEG (WAEEG) system transmits EEG data wirelessly, and can be made miniaturized, discrete and social acceptable. To prolong the battery lifetime, analog wavelet filter is used for epileptic event detection in WAEEG system to achieve on-line data reduction. For mapping continuous wavelet transform to analog filter implementation with low-power consumption and high approximation accuracy, this paper proposes a novel approximation method to construct the wavelet base in analog domain, in which the approximation process in frequency domain is considered as an optimization problem by building a mathematical model with only one term in the numerator. The hybrid genetic algorithm consisting of genetic algorithm and quasi-Newton method is employed to find the globally optimum solution, taking required stability into account. Experiment results show that the proposed method can give a stable analog wavelet base with simple structure and higher approximation accuracy compared with existing method, leading to a better spike detection accuracy. The fourth-order Marr wavelet filter is designed as an example using Gm-C filter structure based on LC ladder simulation, whose power consumption is only 33.4 pW at 2.1Hz. Simulation results show that the design method can be used to facilitate low power and small volume implementation of on-line epileptic event detector.Peer reviewe

    Design of Gm-C wavelet filter for on-line epileptic EEG detection

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    Copyright © 2019 The Institute of Electronics, Information and Communication EngineersAnalog filter implementation of continuous wavelet transform is considered as a promising technique for on-line spike detection applied in wearable electroencephalogram system. This Letter proposes a novel method to construct analog wavelet base for analog wavelet filter design, in which the mathematical approximation model in frequency domain is built as an optimization problem and the genetic algorithm is used to find the global optimum resolution. Also, the Gm-C filter structure based on LC ladder simulation is employed to synthesize the obtained analog wavelet base. The Marr wavelet filter is designed as an example using SMIC 1V 0.35μm CMOS technology. Simulation results show that the proposed method can give a stable analog wavelet filter with higher approximation accuracy and excellent circuit performance, which is well suited for the design of low-frequency low-power spike detector.Peer reviewe

    Wavelet analysis of epileptic spikes

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    Interictal spikes and sharp waves in human EEG are characteristic signatures of epilepsy. These potentials originate as a result of synchronous, pathological discharge of many neurons. The reliable detection of such potentials has been the long standing problem in EEG analysis, especially after long-term monitoring became common in investigation of epileptic patients. The traditional definition of a spike is based on its amplitude, duration, sharpness, and emergence from its background. However, spike detection systems built solely around this definition are not reliable due to the presence of numerous transients and artifacts. We use wavelet transform to analyze the properties of EEG manifestations of epilepsy. We demonstrate that the behavior of wavelet transform of epileptic spikes across scales can constitute the foundation of a relatively simple yet effective detection algorithm.Comment: 4 pages, 3 figure

    Brain Control of Movement Execution Onset Using Local Field Potentials in Posterior Parietal Cortex

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    The precise control of movement execution onset is essential for safe and autonomous cortical motor prosthetics. A recent study from the parietal reach region (PRR) suggested that the local field potentials (LFPs) in this area might be useful for decoding execution time information because of the striking difference in the LFP spectrum between the plan and execution states (Scherberger et al., 2005). More specifically, the LFP power in the 0–10 Hz band sharply rises while the power in the 20–40 Hz band falls as the state transitions from plan to execution. However, a change of visual stimulus immediately preceded reach onset, raising the possibility that the observed spectral change reflected the visual event instead of the reach onset. Here, we tested this possibility and found that the LFP spectrum change was still time locked to the movement onset in the absence of a visual event in self-paced reaches. Furthermore, we successfully trained the macaque subjects to use the LFP spectrum change as a "go" signal in a closed-loop brain-control task in which the animals only modulated the LFP and did not execute a reach. The execution onset was signaled by the change in the LFP spectrum while the target position of the cursor was controlled by the spike firing rates recorded from the same site. The results corroborate that the LFP spectrum change in PRR is a robust indicator for the movement onset and can be used for control of execution onset in a cortical prosthesis

    Automatic Detection of Seizures with Applications

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    There are an estimated two million people with epilepsy in the United States. Many of these people do not respond to anti-epileptic drug therapy. Two devices can be developed to assist in the treatment of epilepsy. The first is a microcomputer-based system designed to process massive amounts of electroencephalogram (EEG) data collected during long-term monitoring of patients for the purpose of diagnosing seizures, assessing the effectiveness of medical therapy, or selecting patients for epilepsy surgery. Such a device would select and display important EEG events. Currently many such events are missed. A second device could be implanted and would detect seizures and initiate therapy. Both of these devices require a reliable seizure detection algorithm. A new algorithm is described. It is believed to represent an improvement over existing seizure detection algorithms because better signal features were selected and better standardization methods were used

    Multimodal imaging of human brain activity: rational, biophysical aspects and modes of integration

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    Until relatively recently the vast majority of imaging and electrophysiological studies of human brain activity have relied on single-modality measurements usually correlated with readily observable or experimentally modified behavioural or brain state patterns. Multi-modal imaging is the concept of bringing together observations or measurements from different instruments. We discuss the aims of multi-modal imaging and the ways in which it can be accomplished using representative applications. Given the importance of haemodynamic and electrophysiological signals in current multi-modal imaging applications, we also review some of the basic physiology relevant to understanding their relationship

    Influence of metallic artifact filtering on MEG signals for source localization during interictal epileptiform activity

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    Objective. Medical intractable epilepsy is a common condition that affects 40% of epileptic patients that generally have to undergo resective surgery. Magnetoencephalography (MEG) has been increasingly used to identify the epileptogenic foci through equivalent current dipole (ECD) modeling, one of the most accepted methods to obtain an accurate localization of interictal epileptiform discharges (IEDs). Modeling requires that MEG signals are adequately preprocessed to reduce interferences, a task that has been greatly improved by the use of blind source separation (BSS) methods. MEG recordings are highly sensitive to metallic interferences originated inside the head by implanted intracranial electrodes, dental prosthesis, etc and also coming from external sources such as pacemakers or vagal stimulators. To reduce these artifacts, a BSS-based fully automatic procedure was recently developed and validated, showing an effective reduction of metallic artifacts in simulated and real signals (Migliorelli et al 2015 J. Neural Eng. 12 046001). The main objective of this study was to evaluate its effects in the detection of IEDs and ECD modeling of patients with focal epilepsy and metallic interference. Approach. A comparison between the resulting positions of ECDs was performed: without removing metallic interference; rejecting only channels with large metallic artifacts; and after BSS-based reduction. Measures of dispersion and distance of ECDs were defined to analyze the results. Main results. The relationship between the artifact-to-signal ratio and ECD fitting showed that higher values of metallic interference produced highly scattered dipoles. Results revealed a significant reduction on dispersion using the BSS-based reduction procedure, yielding feasible locations of ECDs in contrast to the other two approaches. Significance. The automatic BSS-based method can be applied to MEG datasets affected by metallic artifacts as a processing step to improve the localization of epileptic foci.Postprint (published version
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