Apodized pupil Lyot coronagraphs for arbitrary apertures. V. Hybrid Shaped Pupil designs for imaging Earth-like planets with future space observatories

We introduce a new class of solutions for Apodized Pupil Lyot Coronagraphs (APLC) with segmented aperture telescopes to remove broadband diffracted light from a star with a contrast level of $10^{10}$. These new coronagraphs provide a key advance to enabling direct imaging and spectroscopy of Earth twins with future large space missions. Building on shaped pupil (SP) apodization optimizations, our approach enables two-dimensional optimizations of the system to address any aperture features such as central obstruction, support structures or segment gaps. We illustrate the technique with a design that could reach $10^{10}$ contrast level at 34\,mas for a 12\,m segmented telescope over a 10\% bandpass centered at a wavelength $\lambda_0=$500\,nm. These designs can be optimized specifically for the presence of a resolved star, and in our example, for stellar angular size up to 1.1\,mas. This would allow probing the vicinity of Sun-like stars located beyond 4.4\,pc, therefore fully retiring this concern. If the fraction of stars with Earth-like planets is \eta_{\Earth}=0.1, with 18\% throughput, assuming a perfect, stable wavefront and considering photon noise only, 12.5 exo-Earth candidates could be detected around nearby stars with this design and a 12\,m space telescope during a five-year mission with two years dedicated to exo-Earth detection (one total year of exposure time and another year of overheads). Our new hybrid APLC/SP solutions represent the first numerical solution of a coronagraph based on existing mask technologies and compatible with segmented apertures, and that can provide contrast compatible with detecting and studying Earth-like planets around nearby stars. They represent an important step forward towards enabling these science goals with future large space missions.Comment: 9 pages, 6 figures, ApJ accepted on 01/04/201

Low Voltage Totally Free Flexible RF MEMS Switch With Anti-Stiction System

This paper concerns a new design of RF MEMS switch combined with an innovative process which enable low actuation voltage (<5V) and avoid stiction. First, the structure described with principal design issues, the corresponding anti-stiction system is presented and FEM simulations are done. Then, a short description of the process flow based on two non polymer sacrificial layers. Finally, RF measurements are presented and preliminary experimental protocol and results of anti-stiction validation is detailed. Resulting RF performances are -30dB of isolation and -0.45dB of insertion loss at 10 GHz.Comment: Submitted on behalf of EDA Publishing Association (http://irevues.inist.fr/handle/2042/16838

Distinct Impacts of Eda and Edar Loss of Function on the Mouse Dentition

The Eda-A1-Edar signaling pathway is involved in the development of organs with an ectodermal origin, including teeth. In mouse, mutants are known for both the ligand, Eda-A1 (Tabby), and the receptor, Edar (Downless). The adult dentitions of these two mutants have classically been considered to be similar. However, previous studies mentioned differences in embryonic dental development between EdaTa and Edardl-J mutants. A detailed study of tooth morphology in mutants bearing losses of functions of these two genes thus appears necessary to test the pattern variability induced by the developmental modifications. 3D-reconstructions of the cheek teeth have been performed at the ESRF (Grenoble, France) by X-ray synchrotron microtomography to assess dental morphology. The morphological variability observed in EdaTa and Edardl-J mutants have then been compared in detail. Despite patchy similarities, our detailed work on cheek teeth in EdaTa and Edardl-J mice show that all dental morphotypes defined in Edardl-J mice resolutely differ from those of EdaTa mice. This study reveals that losses of function of Eda and Edar have distinct impacts on the tooth size and morphology, contrary to what has previously been thought. The results indicate that unknown mechanisms of the Eda pathway are implicated in tooth morphogenesis. Three hypotheses could explain our results; an unexpected role of the Xedar pathway (which is influenced by the Eda gene product but not that of Edar), a more complex connection than has been appreciated between Edar and another protein, or a ligand-independent activity for Edar. Further work is necessary to test these hypotheses and improve our understanding of the mechanisms of development

Downregulation of FGF Signaling by Spry4 Overexpression Leads to Shape Impairment, Enamel Irregularities, and Delayed Signaling Center Formation in the Mouse Molar.

FGF signaling plays a critical role in tooth development, and mutations in modulators of this pathway produce a number of striking phenotypes. However, many aspects of the role of the FGF pathway in regulating the morphological features and the mineral quality of the dentition remain unknown. Here, we used transgenic mice overexpressing the FGF negative feedback regulator Sprouty4 under the epithelial keratin 14 promoter (K14-Spry4) to achieve downregulation of signaling in the epithelium. This led to highly penetrant defects affecting both cusp morphology and the enamel layer. We characterized the phenotype of erupted molars, identified a developmental delay in K14-Spry4 transgenic embryos, and linked this with changes in the tooth developmental sequence. These data further delineate the role of FGF signaling in the development of the dentition and implicate the pathway in the regulation of tooth mineralization. © 2019 The Authors. JBMR Plus is published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research

Databases and Information Systems in the AI Era: Contributions from ADBIS, TPDL and EDA 2020 Workshops and Doctoral Consortium

Research on database and information technologies has been rapidly evolving over the last couple of years. This evolution was lead by three major forces: Big Data, AI and Connected World that open the door to innovative research directions and challenges, yet exploiting four main areas: (i) computational and storage resource modeling and organization; (ii) new programming models, (iii) processing power and (iv) new applications that emerge related to health, environment, education, Cultural Heritage, Banking, etc. The 24th East-European Conference on Advances in Databases and Information Systems (ADBIS 2020), the 24th International Conference on Theory and Practice of Digital Libraries (TPDL 2020) and the 16th Workshop on Business Intelligence and Big Data (EDA 2020), held during August 25–27, 2020, at Lyon, France, and associated satellite events aimed at covering some emerging issues related to database and information system research in these areas. The aim of this paper is to present such events, their motivations, and topics of interest, as well as briefly outline the papers selected for presentations. The selected papers will then be included in the remainder of this volume

Proceedings of the second "international Traveling Workshop on Interactions between Sparse models and Technology" (iTWIST'14)

The implicit objective of the biennial "international - Traveling Workshop on Interactions between Sparse models and Technology" (iTWIST) is to foster collaboration between international scientific teams by disseminating ideas through both specific oral/poster presentations and free discussions. For its second edition, the iTWIST workshop took place in the medieval and picturesque town of Namur in Belgium, from Wednesday August 27th till Friday August 29th, 2014. The workshop was conveniently located in "The Arsenal" building within walking distance of both hotels and town center. iTWIST'14 has gathered about 70 international participants and has featured 9 invited talks, 10 oral presentations, and 14 posters on the following themes, all related to the theory, application and generalization of the "sparsity paradigm": Sparsity-driven data sensing and processing; Union of low dimensional subspaces; Beyond linear and convex inverse problem; Matrix/manifold/graph sensing/processing; Blind inverse problems and dictionary learning; Sparsity and computational neuroscience; Information theory, geometry and randomness; Complexity/accuracy tradeoffs in numerical methods; Sparsity? What's next?; Sparse machine learning and inference.Comment: 69 pages, 24 extended abstracts, iTWIST'14 website: http://sites.google.com/site/itwist1

Microarray-Based Sketches of the HERV Transcriptome Landscape

Human endogenous retroviruses (HERVs) are spread throughout the genome and their long terminal repeats (LTRs) constitute a wide collection of putative regulatory sequences. Phylogenetic similarities and the profusion of integration sites, two inherent characteristics of transposable elements, make it difficult to study individual locus expression in a large-scale approach, and historically apart from some placental and testis-regulated elements, it was generally accepted that HERVs are silent due to epigenetic control. Herein, we have introduced a generic method aiming to optimally characterize individual loci associated with 25-mer probes by minimizing cross-hybridization risks. We therefore set up a microarray dedicated to a collection of 5,573 HERVs that can reasonably be assigned to a unique genomic position. We obtained a first view of the HERV transcriptome by using a composite panel of 40 normal and 39 tumor samples. The experiment showed that almost one third of the HERV repertoire is indeed transcribed. The HERV transcriptome follows tropism rules, is sensitive to the state of differentiation and, unexpectedly, seems not to correlate with the age of the HERV families. The probeset definition within the U3 and U5 regions was used to assign a function to some LTRs (i.e. promoter or polyA) and revealed that (i) autonomous active LTRs are broadly subjected to operational determinism (ii) the cellular gene density is substantially higher in the surrounding environment of active LTRs compared to silent LTRs and (iii) the configuration of neighboring cellular genes differs between active and silent LTRs, showing an approximately 8 kb zone upstream of promoter LTRs characterized by a drastic reduction in sense cellular genes. These gathered observations are discussed in terms of virus/host adaptive strategies, and together with the methods and tools developed for this purpose, this work paves the way for further HERV transcriptome projects

On the determination of Poisson's ratio of stressed monolayer and bilayer submicron thick films

In this paper, the bulge test is used to determine the mechanical properties of very thin dielectric membranes. Commonly, this experimental method permits to determine the residual stress (s0) and biaxial Young's modulus (E/(1-u)). Associating square and rectangular membranes with different length to width ratios, the Poisson's ratio (u) can also be determined. LPCVD Si3N4 monolayer and Si3N4/SiO2 bilayer membranes, with thicknesses down to 100 nm, have been characterized giving results in agreement with literature for Si3N4, E = 212 $\pm$ 14 GPa, s0 = 420 $\pm$ 8 and u = 0.29.Comment: Submitted on behalf of EDA Publishing Association (http://irevues.inist.fr/handle/2042/16838