A biomechanical modeling study of the effects of the orbicularis oris muscle and jaw posture on lip shape

Purpose: The authors' general aim is to use biomechanical models of speech articulators to explore how possible variations in anatomical structure contribute to differences in articulatory strategies and phone systems across human populations. Specifically, they investigated 2 issues: (a) the link between lip muscle anatomy and variability in lip gestures and (b) the constraints of coupled lip/jaw biomechanics on jaw posture in labial sounds. Method: The authors used a model coupling the jaw, tongue, and face. First, the influence of the orbicularis oris (OO) anatomical implementation was analyzed by assessing how changes in depth (from epidermis to the skull) and peripheralness (proximity to the lip horn center) affected lip shaping. Second, the capability of the lip/jaw system to generate protrusion and rounding, or labial closure, was evaluated for different jaw heights. Results: Results showed that a peripheral and moderately deep OO implementation is most appropriate for protrusion and rounding; a superficial implementation facilitates closure; protrusion and rounding require a high jaw position; and closure is achievable for various jaw heights. Conclusions: Models provide objective information regarding possible links between anatomical and speech production variability across humans. Comparisons with experimental data will illustrate how motor control and cultural factors cope with these constraints

The Distributed Lambda Model (DLM): A 3-D, Finite-Element Muscle Model Based on Feldman's Lambda Model; Assessment of Orofacial Gestures

International audiencePurpose: The authors aimed to design a distributed Lambda model (DLM), which is well-adapted to implement three-dimensional (3-D) Finite Element descriptions of muscles. Method: A muscle element model was designed. Its stress-strain relationships included the active force-length characteristics of the Lambda model along the muscle fibers, together with the passive properties of muscle tissues in the 3-D space. The muscle element was first assessed using simple geometrical representations of muscles in form of rectangular bars. Then, it was included in a 3-D face model, and its impact on lip protrusion was compared with the impact of a Hill-type muscle model. Results: The force-length characteristic associated with the muscle elements matched well with the invariant characteristics of the Lambda model. The impact of the passive properties was assessed. Isometric force variation and isotonic displacements were modeled. The comparison with a Hill-type model revealed strong similarities in terms of global stress and strain. Conclusion: The DLM accounted for the characteristics of the Lambda model. Biomechanically no clear differences were found between the DLM and a Hill-type model. Accurate evaluations of the Lambda model, based on the comparison between data and simulations, are now possible with 3-D biomechanical descriptions of the speech articulators because to the DLM

Tongue Movements in Feeding and Speech

The position of the tongue relative to the upper and lower jaws is regulated in part by the position of the hyoid bone, which, with the anterior and posterior suprahyoid muscles, controls the angulation and length of the floor of the mouth on which the tongue body \u27rides\u27. The instantaneous shape of the tongue is controlled by the \u27extrinsic muscles \u27 acting in concert with the \u27intrinsic \u27 muscles. Recent anatomical research in non-human mammals has shown that the intrinsic muscles can best be regarded as a \u27laminated segmental system \u27 with tightly packed layers of the \u27transverse\u27, \u27longitudinal\u27, and \u27vertical\u27 muscle fibers. Each segment receives separate innervation from branches of the hypoglosssal nerve. These new anatomical findings are contributing to the development of functional models of the tongue, many based on increasingly refined finite element modeling techniques. They also begin to explain the observed behavior of the jaw-hyoid-tongue complex, or the hyomandibular \u27kinetic chain\u27, in feeding and consecutive speech. Similarly, major efforts, involving many imaging techniques (cinefluorography, ultrasound, electro-palatography, NMRI, and others), have examined the spatial and temporal relationships of the tongue surface in sound production. The feeding literature shows localized tongue-surface change as the process progresses. The speech literature shows extensive change in tongue shape between classes of vowels and consonants. Although there is a fundamental dichotomy between the referential framework and the methodological approach to studies of the orofacial complex in feeding and speech, it is clear that many of the shapes adopted by the tongue in speaking are seen in feeding. It is suggested that the range of shapes used in feeding is the matrix for both behaviors

Face

The face is probably the part of the body, which most distinguishes us as individuals. It plays a very important role in many functions, such as speech, mastication, and expression of emotion. In the face, there is a tight coupling between different complex structures, such as skin, fat, muscle, and bone. Biomechanically driven models of the face provide an opportunity to gain insight into how these different facial components interact. The benefits of this insight are manifold, including improved maxillofacial surgical planning, better understanding of speech mechanics, and more realistic facial animations. This chapter provides an overview of facial anatomy followed by a review of previous computational models of the face. These models include facial tissue constitutive relationships, facial muscle models, and finite element models. We also detail our efforts to develop novel general and subject-specific models. We present key results from simulations that highlight the realism of the face models

The adaptive nature of the bone-periodontal ligament-cementum complex in a ligature-induced periodontitis rat model.

The novel aspect of this study involves illustrating significant adaptation of a functionally loaded bone-PDL-cementum complex in a ligature-induced periodontitis rat model. Following 4, 8, and 15 days of ligation, proinflammatory cytokines (TNF- α and RANKL), a mineral resorption indicator (TRAP), and a cell migration and adhesion molecule for tissue regeneration (fibronectin) within the complex were localized and correlated with changes in PDL-space (functional space). At 4 days of ligation, the functional space of the distal complex was widened compared to controls and was positively correlated with an increased expression of TNF- α. At 8 and 15 days, the number of RANKL(+) cells decreased near the mesial alveolar bone crest (ABC) but increased at the distal ABC. TRAP(+) cells on both sides of the complex significantly increased at 8 days. A gradual change in fibronectin expression from the distal PDL-secondary cementum interfaces through precementum layers was observed when compared to increased and abrupt changes at the mesial PDL-cementum and PDL-bone interfaces in ligated and control groups. Based on our results, we hypothesize that compromised strain fields can be created in a diseased periodontium, which in response to prolonged function can significantly alter the original bone and apical cementum formations

A finite element model of the face including an orthotropic skin model under in vivo tension

Computer models of the human face have the potential to be used as powerful tools in surgery simulation and animation development applications. While existing models accurately represent various anatomical features of the face, the representation of the skin and soft tissues is very simplified. A computer model of the face is proposed in which the skin is represented by an orthotropic hyperelastic constitutive model. The in vivo tension inherent in skin is also represented in the model. The model was tested by simulating several facial expressions by activating appropriate orofacial and jaw muscles. Previous experiments calculated the change in orientation of the long axis of elliptical wounds on patients’ faces for wide opening of the mouth and an open-mouth smile (both 30 degrees). These results were compared with the average change of maximum principal stress direction in the skin calculated in the face model for wide opening of the mouth (18o) and an openmouth smile (25 degrees). The displacements of landmarks on the face for four facial expressions were compared with experimental measurements in the literature. The corner of the mouth in the model experienced the largest displacement for each facial expression (11–14 mm). The simulated landmark displacements were within a standard deviation of the measured displacements. Increasing the skin stiffness and skin tension generally resulted in a reduction in landmark displacements upon facial expression

Biomechanics and Remodelling for Design and Optimisation in Oral Prosthesis and Therapeutical Procedure

The purpose of dental prostheses is to restore the oral function for edentulous patients. Introducing any dental prosthesis into mouth will alter biomechanical status of the oral environment, consequently inducing bone remodelling. Despite the advantageous benefits brought by dental prostheses, the attendant clinical complications and challenges, such as pain, discomfort, tooth root resorption, and residual ridge reduction, remain to be addressed. This thesis aims to explore several different dental prostheses by understanding the biomechanics associated with the potential tissue responses and adaptation, and thereby applying the new knowledge gained from these studies to dental prosthetic design and optimisation. Within its biomechanics focus, this thesis is presented in three major clinical areas, namely prosthodontics, orthodontics and dental implantology. In prosthodontics, the oral mucosa plays a critical role in distributing occlusal forces a denture to the underlying bony structure, and its response is found in a complex, dynamic and nonlinear manner. It is discovered that interstitial fluid pressure in mocosa is the most important indicator to the potential resorption induced by prosthetic denture insertion, and based on this finding, patient-specific analysis is performed to investigate the effects caused by various types of dentures and prediction of the bone remodelling activities. In orthodontic treatments, a dynamic algorithm is developed to analyse and predict potential bone remodelling around the target tooth during orthodontic treatment, thereby providing a numerical approach for treatment planning. In dental implantology, a graded surface morphology of an implant is designed to improve osseointegration over that of a smooth uniform surface in both the short and long term. The graded surface can be optimised to achieve the best possible balance between the bone-implant contact and the peak Tresca stress for the specific clinical application need

Smart implants for mucoperiosteal tissue expansion in cleft palate defects

Cleft lip and palate are the most common craniofacial malformations, affecting one in every 500 to 700 live births, thus accounting for about 220,000 new cases each year worldwide with tremendous variations across geographic areas, ethnic groups and socioeconomic status. Affected children have a range of both functional and aesthetic problems comprising of feeding difficulties due to incomplete oral seal, swallowing, nasal regurgitation, respiratory problems, hearing difficulties due to abnormalities in the palatal musculature, and speech impairments due to air escape and articulations problems. The surgery can solve the problems, but the two major factors which determine a good surgical outcome and its assessment are the interpretation of the actual size of the cleft and generation of periosteal tissue to close the defect. The surgeons faced a challenge to measure the cleft size due to wide diversity in methodologies employed which resulted in improper estimation of the deficient palatal tissue and thus resulted contradictory results in measuring outcomes such as occlusion or midface skeletal development. We have introduced the vomer edge for establishing a validated 3D measuring method for the width, area and height of the true cleft with reproducible landmarks for easy and accurate measurement of the outcomes in unilateral cleft lip and palate patients. The passive plate therapy provided to UCLP patients gave favourable anatomical conditions for subsequent surgical palatal repair in patients by alleviating the problems of tissue deficiency to some extent. We therefore adopted periosteal tissue distraction osteogenesis as potential treatment strategy to target the tissue deficiency while using the magnetic forces to exert necessary strain. In our study, we have assessed whether the dental magnets have the potential to act as a device to generate mucoperiosteal tissue in UCLP. We have used in-silica approach in the form of 3D FE-model and found that strain levels in the palatal segments of the cleft for the load cases do reach 1500 µstrain limit, a requirement for bone formation, according to the mild overload window of the Mechanostat theory proposed by Harold Frost. We further examined the forces, which reach threshold for regeneration of the hard and soft tissue volumes along the cleft edges in both UCLP and BCLP by means of periosteal distraction. We found that a 5N attraction force could initiate generation of soft and hard tissues along the cleft edges in in-silico model within the optimal biological limits

Age-Related Adaptation of Bone-PDL-Tooth Complex: Rattus-Norvegicus as a Model System

Functional loads on an organ induce tissue adaptations by converting mechanical energy into chemical energy at a cell-level. The transducing capacity of cells alters physico-chemical properties of tissues, developing a positive feedback commonly recognized as the form-function relationship. In this study, organ and tissue adaptations were mapped in the bone-tooth complex by identifying and correlating biomolecular expressions to physico-chemical properties in rats from 1.5 to 15 months. However, future research using hard and soft chow over relevant age groups would decouple the function related effects from aging affects. Progressive curvature in the distal root with increased root resorption was observed using micro X-ray computed tomography. Resorption was correlated to the increased activity of multinucleated osteoclasts on the distal side of the molars until 6 months using tartrate resistant acid phosphatase (TRAP). Interestingly, mononucleated TRAP positive cells within PDL vasculature were observed in older rats. Higher levels of glycosaminoglycans were identified at PDL-bone and PDL-cementum entheses using alcian blue stain. Decreasing biochemical gradients from coronal to apical zones, specifically biomolecules that can induce osteogenic (biglycan) and fibrogenic (fibromodulin, decorin) phenotypes, and PDL-specific negative regulator of mineralization (asporin) were observed using immunohistochemistry. Heterogeneous distribution of Ca and P in alveolar bone, and relatively lower contents at the entheses, were observed using energy dispersive X-ray analysis. No correlation between age and microhardness of alveolar bone (0.7±0.1 to 0.9±0.2 GPa) and cementum (0.6±0.1 to 0.8±0.3 GPa) was observed using a microindenter. However, hardness of cementum and alveolar bone at any given age were significantly different (P<0.05). These observations should be taken into account as baseline parameters, during development (1.5 to 4 months), growth (4 to 10 months), followed by a senescent phase (10 to 15 months), from which deviations due to experimentally induced perturbations can be effectively investigated