Infant and toddler precursors of attentional processes in Fragile X syndrome: A neurodevelopmental perspective

With the recent sequencing of the human genome, the following question has attracted much interest: can the function of single genes be linked to specific neural and cognitive processes? Within this context, developmental disorders of known genetic origins have been used as naturally-occurring models to link the function (and dysfunction) of genes with cognition. Fragile X syndrome (FXS) is a genetically inherited disorder associated with the silencing of a single gene involved in experience-dependent changes at glutamatergic synapses. In adulthood, it is associated with core attentional difficulties accompanied by seemingly proficient visuo-perception, but the profile of infants and toddlers has not been investigated. In this thesis, fragile X syndrome is used as a tool to investigate how initial changes in a generalised property of all cortical neurones can nonetheless result, in the adult, in core difficulties in the control of attention. I argue that, even in disorders associated with the silencing of a single gene like FXS, the answer requires a developmental approach. Chapter 1 delineates a theoretical distinction between endogenous and exogenous influences on attentional control, whereas Chapter 2 defines methodological issues in assessing atypical attention, such as tools for the assessment of general developmental level and choices of control groups. Part II focuses on tasks tapping endogenous attention control. In particular, Chapters 3 and 4 examine the control of eye-movements and manual response conflict in infants and toddlers with FXS and in typically developing controls. In contrast, Part III concentrates on the exogenous effects of sudden peripheral onsets on visual orienting (Chapter 5) and of the perceptual salience of targets during visual search (Chapter 6). Finally, Part IV traces longitudinal changes in visual search performance. The findings suggest that, like adults with the syndrome, infant and toddlers with FXS display striking deficits in endogenous attention. However, unlike adults, infants are also characterised by atypical exogenous influences on attention and longitudinal changes in performance point to complex developmental relationships between early and later measures of attention. The findings are discussed in terms of their theoretical implications for fragile X syndrome and other developmental disorders affecting attention. They challenge the notion of direct genotype-phenotype mappings that fail to take development into account

Inhomogeneity of visual space, discontinuity of perceptual time and cultural imprinting as exemplified with experiments on visual attention, aesthetic appreciation and temporal processing

Eines der wichtigsten Argumente für einen kognitivistischen Zugang zur Psychologie ist, dass sich die Psychologie nicht grundlegend von der Physik zu unterscheiden scheint; mentale Phänomene sind offenbar unmittelbar auf physikalische Realität bezogen. Beginnend mit der Psychophysik seit dem neunzehnten Jahrhunderts haben Experimente gezeigt, dass dieser Denkansatz nicht nur mit großen Vorteilen, sondern auch mit einigen Fallstricken verbunden sein kann. Auf der Basis des zugrundeliegenden Konzepts, dass mentale Phänomene physikalischen Ereignissen unmittelbar zugeordnet werden können, wird automatisch angenommen, dass die zeitliche Verarbeitung von sensorischen Informationen kontinuierlich sei, wie es das Zeitkonzept in der klassischen Physik nahelegt. Dieses Konzept widerspricht der Möglichkeit einer diskreten zeitlichen Informationsverarbeitung, wie sie in der Tat gilt. Des weiteren wird davon ausgegangen, dass Informationsverarbeitung in einem homogenen visuellen Wahrnehmungsraum eingebettet ist; dies ist jedoch nicht der Fall. Es wird dargestellt, dass mit einfachen sensorischen Reizen oder komplexen ästhetischen Stimuli und deren experimenteller Manipulation ein brauchbares empirisches Paradigma für ein besseres Verständnis von kognitiven Mechanismen bereitsteht, das auf diskrete zeitliche Verarbeitung und einen inhomogenen visuellen Wahrnehmungsraum hinweist. In mehreren Experimenten wird gezeigt, daß die Modulation der Aufmerksamkeit im Gesichtsfeld nicht homogen ist; Reaktionszeitexperimente mit spezifischen Modifikationen stützen die Hypothese, dass funktionell zwei Aufmerksamkeitssysteme im Gesichtsfeld eingebettet sind. Weitere unterstützende Beobachtungen über die Inhomogenität des Gesichtsfeldes kommen aus Experimenten zur ästhetischen Wahrnehmung westlicher und östlicher Kunstwerke. Diese Forschung bestätigt überdies das allgemeine Konzept von anthropologischen Universalien sowie kulturellen oder individuellen Spezifika bei der ästhetischen Wahrnehmung. Im Hinblick auf die zeitliche Wahrnehmung weisen Histogramme der Reaktionszeit auf diskrete zeitliche Informationsverarbeitung hin, was sich auch aus Beobachtungen der zeitlichen Ordnungsschwelle herleiten läßt. Bei der Untersuchung verzögerter Reaktionen wird gezeigt, dass eine präzise zeitliche Kontrolle erst nach einem längeren Intervall erreicht wird. Zusammenfassend kann man aus den verschiedenen Experimenten herleiten, dass mentale Prozesse im räumlichen und zeitlichen Bereich zwar offenkundig nicht direkt zugänglich sind, doch sollte dies nicht als eine undurchdringliche Barriere angesehen werden, um Mechanismen mentaler Prozesse zu entschlüsseln. Mit den klar definierten physikalischen Stimuli und der genauen Beachtung von Stationaritätsbedingungen bei Messungen kann diskrete zeitliche Verarbeitung und Inhomogenität des visuellen Wahrnehmungsraums gezeigt werden.One of the most compelling arguments for a cognitivist approach to psychology is that psychology does not seem to be fundamentally different from physics; mental phenomena appear to be directly related to physical reality. Experimental evidence beginning in the nineteenth century with psychophysics has shown that this approach can offer great benefits, but can suffer from some pitfalls as well. On the basis of the underlying concept that mental phenomena match directly physical events, it is automatically assumed that temporal processing of sensory information is continuous as it is assumed in classical physics neglecting the possibility of discrete temporal information processing, which in fact is the case. Furthermore, it is assumed that information processing is embedded in a homogeneous perceptual visual space; this is not the case. It is shown that the use of simple sensory stimuli or complex aesthetic stimuli and their experimental manipulation provide a useful empirical paradigm for a better understanding of the cognitive mechanisms, i.e., indicating discrete temporal processing and an inhomogeneous perceptual visual space. A number of experiments show that attentional modulation is not homogeneous in the visual field; observations using the reaction time paradigm with specific modifications support the hypothesis that two attention systems are functionally embedded in the visual field. Further supportive findings about the inhomogeneity of the visual field come from experiments on the aesthetic perception of Western and Eastern artworks. This research also confirms in addition the general concept of anthropological universals and cultural or individual specifics in aesthetic appreciation. With regard to temporal perception, reaction time distributions suggest discrete time sampling which can also be derived from observations on temporal order threshold. When testing delayed reactions after stimulus presentation, it is shown that precise temporal control is reached only after a rather long interval. It can be concluded on the basis of the different experiments that even though mental processes in the space and time domain are obviously not directly accessible, this should not be considered as an impenetrable barrier to unravel the mechanism of mental processes. Employing well-defined physical stimuli and strictly observing stationarity conditions in measurements indicate discreteness in temporal processing and inhomogeneity of visual space

Inhomogeneity of visual space, discontinuity of perceptual time and cultural imprinting as exemplified with experiments on visual attention, aesthetic appreciation and temporal processing

Eines der wichtigsten Argumente für einen kognitivistischen Zugang zur Psychologie ist, dass sich die Psychologie nicht grundlegend von der Physik zu unterscheiden scheint; mentale Phänomene sind offenbar unmittelbar auf physikalische Realität bezogen. Beginnend mit der Psychophysik seit dem neunzehnten Jahrhunderts haben Experimente gezeigt, dass dieser Denkansatz nicht nur mit großen Vorteilen, sondern auch mit einigen Fallstricken verbunden sein kann. Auf der Basis des zugrundeliegenden Konzepts, dass mentale Phänomene physikalischen Ereignissen unmittelbar zugeordnet werden können, wird automatisch angenommen, dass die zeitliche Verarbeitung von sensorischen Informationen kontinuierlich sei, wie es das Zeitkonzept in der klassischen Physik nahelegt. Dieses Konzept widerspricht der Möglichkeit einer diskreten zeitlichen Informationsverarbeitung, wie sie in der Tat gilt. Des weiteren wird davon ausgegangen, dass Informationsverarbeitung in einem homogenen visuellen Wahrnehmungsraum eingebettet ist; dies ist jedoch nicht der Fall. Es wird dargestellt, dass mit einfachen sensorischen Reizen oder komplexen ästhetischen Stimuli und deren experimenteller Manipulation ein brauchbares empirisches Paradigma für ein besseres Verständnis von kognitiven Mechanismen bereitsteht, das auf diskrete zeitliche Verarbeitung und einen inhomogenen visuellen Wahrnehmungsraum hinweist. In mehreren Experimenten wird gezeigt, daß die Modulation der Aufmerksamkeit im Gesichtsfeld nicht homogen ist; Reaktionszeitexperimente mit spezifischen Modifikationen stützen die Hypothese, dass funktionell zwei Aufmerksamkeitssysteme im Gesichtsfeld eingebettet sind. Weitere unterstützende Beobachtungen über die Inhomogenität des Gesichtsfeldes kommen aus Experimenten zur ästhetischen Wahrnehmung westlicher und östlicher Kunstwerke. Diese Forschung bestätigt überdies das allgemeine Konzept von anthropologischen Universalien sowie kulturellen oder individuellen Spezifika bei der ästhetischen Wahrnehmung. Im Hinblick auf die zeitliche Wahrnehmung weisen Histogramme der Reaktionszeit auf diskrete zeitliche Informationsverarbeitung hin, was sich auch aus Beobachtungen der zeitlichen Ordnungsschwelle herleiten läßt. Bei der Untersuchung verzögerter Reaktionen wird gezeigt, dass eine präzise zeitliche Kontrolle erst nach einem längeren Intervall erreicht wird. Zusammenfassend kann man aus den verschiedenen Experimenten herleiten, dass mentale Prozesse im räumlichen und zeitlichen Bereich zwar offenkundig nicht direkt zugänglich sind, doch sollte dies nicht als eine undurchdringliche Barriere angesehen werden, um Mechanismen mentaler Prozesse zu entschlüsseln. Mit den klar definierten physikalischen Stimuli und der genauen Beachtung von Stationaritätsbedingungen bei Messungen kann diskrete zeitliche Verarbeitung und Inhomogenität des visuellen Wahrnehmungsraums gezeigt werden.One of the most compelling arguments for a cognitivist approach to psychology is that psychology does not seem to be fundamentally different from physics; mental phenomena appear to be directly related to physical reality. Experimental evidence beginning in the nineteenth century with psychophysics has shown that this approach can offer great benefits, but can suffer from some pitfalls as well. On the basis of the underlying concept that mental phenomena match directly physical events, it is automatically assumed that temporal processing of sensory information is continuous as it is assumed in classical physics neglecting the possibility of discrete temporal information processing, which in fact is the case. Furthermore, it is assumed that information processing is embedded in a homogeneous perceptual visual space; this is not the case. It is shown that the use of simple sensory stimuli or complex aesthetic stimuli and their experimental manipulation provide a useful empirical paradigm for a better understanding of the cognitive mechanisms, i.e., indicating discrete temporal processing and an inhomogeneous perceptual visual space. A number of experiments show that attentional modulation is not homogeneous in the visual field; observations using the reaction time paradigm with specific modifications support the hypothesis that two attention systems are functionally embedded in the visual field. Further supportive findings about the inhomogeneity of the visual field come from experiments on the aesthetic perception of Western and Eastern artworks. This research also confirms in addition the general concept of anthropological universals and cultural or individual specifics in aesthetic appreciation. With regard to temporal perception, reaction time distributions suggest discrete time sampling which can also be derived from observations on temporal order threshold. When testing delayed reactions after stimulus presentation, it is shown that precise temporal control is reached only after a rather long interval. It can be concluded on the basis of the different experiments that even though mental processes in the space and time domain are obviously not directly accessible, this should not be considered as an impenetrable barrier to unravel the mechanism of mental processes. Employing well-defined physical stimuli and strictly observing stationarity conditions in measurements indicate discreteness in temporal processing and inhomogeneity of visual space

The development of viewing strategies in patients with macular disease.

Background: This thesis describes the results of the first longitudinal study of visual behaviour in patients with newly developed macular disease (MD). The study is of a natural history, case series design. Methods: Twenty patients with age-related macular disease and five with juvenile forms of MD were recruited. All patients had developed scotomas in their second affected eye within the previous two weeks. Patients were assessed five times over the next twelve months. In addition to clinical tests, fixation behaviour was assessed using a scanning laser ophthalmoscope, eye movements were measured using an infra-red eyetracker and reading speed was recorded. Multivariate statistical techniques were applied to determine which factors limit reading speed and which variables lead to a change in reading speed. Results: All 25 patients developed a preferred retinal locus (PRL) within six months. Sixteen patients made an adaptation whereby they were unaware of using the PRL. By the end of the study, fifteen patients (60%) repeatedly made eye movements which displayed the characteristics of non-foveating saccades. Saccade efficiency reached normal levels in eight patients (32%). Over the course of the study, reading speed improved in four patients (16%), deteriorated in 7 patients (28%) and remained constant in the remaining 14 patients. Changes in reading speed were due to changes in fixation stability, non-awareness of using the PRL and developing a strategy of repeatedly using the same number of PRLs. The likelihood of a change in reading speed could not be predicted by disease type, visual acuity or scotoma size. Conclusions: It was not possible to predict which patients' reading speed will change from the measures used in this study. The conclusions of this thesis have implications for the counselling of patients with macular disease and the development of training programs for patients with this common, debilitating condition

Empirical studies in translation and discourse (Volume 14)

The present volume seeks to contribute some studies to the subfield of Empirical Translation Studies and thus aid in extending its reach within the field of translation studies and thus in making our discipline more rigorous and fostering a reproducible research culture. The Translation in Transition conference series, across its editions in Copenhagen (2013), Germersheim (2015) and Ghent (2017), has been a major meeting point for scholars working with these aims in mind, and the conference in Barcelona (2019) has continued this tradition of expanding the sub-field of empirical translation studies to other paradigms within translation studies. This book is a collection of selected papers presented at that fourth Translation in Transition conference, held at the Universitat Pompeu Fabra in Barcelona on 19–20 September 2019

Empirical studies in translation and discourse

The present volume seeks to contribute some studies to the subfield of Empirical Translation Studies and thus aid in extending its reach within the field of translation studies and thus in making our discipline more rigorous and fostering a reproducible research culture. The Translation in Transition conference series, across its editions in Copenhagen (2013), Germersheim (2015) and Ghent (2017), has been a major meeting point for scholars working with these aims in mind, and the conference in Barcelona (2019) has continued this tradition of expanding the sub-field of empirical translation studies to other paradigms within translation studies. This book is a collection of selected papers presented at that fourth Translation in Transition conference, held at the Universitat Pompeu Fabra in Barcelona on 19–20 September 2019

Neural foundations of cooperative social interactions

The embodied-embedded-enactive-extended (4E) approach to study cognition suggests that interaction with the world is a crucial component of our cognitive processes. Most of our time, we interact with other people. Therefore, studying cognition without interaction is incomplete. Until recently, social neuroscience has only focused on studying isolated human and animal brains, leaving interaction unexplored. To fill this gap, we studied interacting participants, focusing on both intra- and inter-brain (hyperscanning) neural activity. In the first study, we invited dyads to perform a visual task in both a cooperative and a competitive context while we measured EEG. We found that mid-frontal activity around 200-300 ms after receiving monetary rewards was sensitive to social context and differed between cooperative and competitive situations. In the second study, we asked participants to coordinate their movements with each other and with a robotic partner. We found significantly stronger EEG amplitudes at frontocentral electrodes when people interacted with a robotic partner. Lastly, we performed a comprehensive literature review and the first meta-analysis in the emerging field of hyperscanning that validated it as a method to study social interaction. Taken together, our results showed that adding a second participant (human or AI/robotic) fostered our understanding of human cognition. We learned that the activity at frontocentral electrodes is sensitive to social context and type of partner (human or robotic). In both studies, the participants’ interaction was required to show these novel neural processes involved in action monitoring. Similarly, studying inter-brain neural activity allows for the exploration of new aspects of cognition. Many cognitive functions involved in successful social interactions are accompanied by neural synchrony between brains, suggesting the extended form of our cognition

Gesture and Speech in Interaction - 4th edition (GESPIN 4)

International audienceThe fourth edition of Gesture and Speech in Interaction (GESPIN) was held in Nantes, France. With more than 40 papers, these proceedings show just what a flourishing field of enquiry gesture studies continues to be. The keynote speeches of the conference addressed three different aspects of multimodal interaction:gesture and grammar, gesture acquisition, and gesture and social interaction. In a talk entitled Qualitiesof event construal in speech and gesture: Aspect and tense, Alan Cienki presented an ongoing researchproject on narratives in French, German and Russian, a project that focuses especially on the verbal andgestural expression of grammatical tense and aspect in narratives in the three languages. Jean-MarcColletta's talk, entitled Gesture and Language Development: towards a unified theoretical framework,described the joint acquisition and development of speech and early conventional and representationalgestures. In Grammar, deixis, and multimodality between code-manifestation and code-integration or whyKendon's Continuum should be transformed into a gestural circle, Ellen Fricke proposed a revisitedgrammar of noun phrases that integrates gestures as part of the semiotic and typological codes of individuallanguages. From a pragmatic and cognitive perspective, Judith Holler explored the use ofgaze and hand gestures as means of organizing turns at talk as well as establishing common ground in apresentation entitled On the pragmatics of multi-modal face-to-face communication: Gesture, speech andgaze in the coordination of mental states and social interaction.Among the talks and posters presented at the conference, the vast majority of topics related, quitenaturally, to gesture and speech in interaction - understood both in terms of mapping of units in differentsemiotic modes and of the use of gesture and speech in social interaction. Several presentations explored the effects of impairments(such as diseases or the natural ageing process) on gesture and speech. The communicative relevance ofgesture and speech and audience-design in natural interactions, as well as in more controlled settings liketelevision debates and reports, was another topic addressed during the conference. Some participantsalso presented research on first and second language learning, while others discussed the relationshipbetween gesture and intonation. While most participants presented research on gesture and speech froman observer's perspective, be it in semiotics or pragmatics, some nevertheless focused on another importantaspect: the cognitive processes involved in language production and perception. Last but not least,participants also presented talks and posters on the computational analysis of gestures, whether involvingexternal devices (e.g. mocap, kinect) or concerning the use of specially-designed computer software forthe post-treatment of gestural data. Importantly, new links were made between semiotics and mocap data