Overlay Recommendations for I 64: Rowan, Carter, and Boyd Counties

A method was developed in 1978 for designing asphaltic concrete overlays for flexible pavements. This procedure utilizes Kentucky\u27s theoretical flexible pavement design curves, estimates of pavement fatigue from traffic data, estimates of subgrade strengths, and estimates of the structural capacity of the existing pavement. Overlay designs were recommended for the asphaltic concrete pavement sections of I 64 in Rowan, Carter, and Boyd Counties. Road Rater deflection data were used to estimate the subgrade strength and the effective worth of the pavement structures. Pavement rutting and roughness were also considered in determining the final overlay thicknesses

Fine Grained Component Engineering of Adaptive Overlays: Experiences and Perspectives

Recent years have seen significant research being carried out into peer-to-peer (P2P) systems. This work has focused on the styles and applications of P2P computing, from grid computation to content distribution; however, little investigation has been performed into how these systems are built. Component based engineering is an approach that has seen successful deployment in the field of middleware development; functionality is encapsulated in ‘building blocks’ that can be dynamically plugged together to form complete systems. This allows efficient, flexible and adaptable systems to be built with lower overhead and development complexity. This paper presents an investigation into the potential of using component based engineering in the design and construction of peer-to-peer overlays. It is highlighted that the quality of these properties is dictated by the component architecture used to implement the system. Three reusable decomposition architectures are designed and evaluated using Chord and Pastry case studies. These demonstrate that significant improvements can be made over traditional design approaches resulting in much more reusable, (re)configurable and extensible systems

Organic Design of Massively Distributed Systems: A Complex Networks Perspective

The vision of Organic Computing addresses challenges that arise in the design of future information systems that are comprised of numerous, heterogeneous, resource-constrained and error-prone components or devices. Here, the notion organic particularly highlights the idea that, in order to be manageable, such systems should exhibit self-organization, self-adaptation and self-healing characteristics similar to those of biological systems. In recent years, the principles underlying many of the interesting characteristics of natural systems have been investigated from the perspective of complex systems science, particularly using the conceptual framework of statistical physics and statistical mechanics. In this article, we review some of the interesting relations between statistical physics and networked systems and discuss applications in the engineering of organic networked computing systems with predictable, quantifiable and controllable self-* properties.Comment: 17 pages, 14 figures, preprint of submission to Informatik-Spektrum published by Springe

Dynamic and multi-pharmacophore modeling for designing polo-box domain inhibitors.

The polo-like kinase 1 (Plk1) is a critical regulator of cell division that is overexpressed in many types of tumors. Thus, a strategy in the treatment of cancer has been to target the kinase activity (ATPase domain) or substrate-binding domain (Polo-box Domain, PBD) of Plk1. However, only few synthetic small molecules have been identified that target the Plk1-PBD. Here, we have applied an integrative approach that combines pharmacophore modeling, molecular docking, virtual screening, and in vitro testing to discover novel Plk1-PBD inhibitors. Nine Plk1-PBD crystal structures were used to generate structure-based hypotheses. A common pharmacophore model (Hypo1) composed of five chemical features was selected from the 9 structure-based hypotheses and used for virtual screening of a drug-like database consisting of 159,757 compounds to identify novel Plk1-PBD inhibitors. The virtual screening technique revealed 9,327 compounds with a maximum fit value of 3 or greater, which were selected and subjected to molecular docking analyses. This approach yielded 93 compounds that made good interactions with critical residues within the Plk1-PBD active site. The testing of these 93 compounds in vitro for their ability to inhibit the Plk1-PBD, showed that many of these compounds had Plk1-PBD inhibitory activity and that compound Chemistry_28272 was the most potent Plk1-PBD inhibitor. Thus Chemistry_28272 and the other top compounds are novel Plk1-PBD inhibitors and could be used for the development of cancer therapeutics

The essence of P2P: A reference architecture for overlay networks

The success of the P2P idea has created a huge diversity of approaches, among which overlay networks, for example, Gnutella, Kazaa, Chord, Pastry, Tapestry, P-Grid, or DKS, have received specific attention from both developers and researchers. A wide variety of algorithms, data structures, and architectures have been proposed. The terminologies and abstractions used, however, have become quite inconsistent since the P2P paradigm has attracted people from many different communities, e.g., networking, databases, distributed systems, graph theory, complexity theory, biology, etc. In this paper we propose a reference model for overlay networks which is capable of modeling different approaches in this domain in a generic manner. It is intended to allow researchers and users to assess the properties of concrete systems, to establish a common vocabulary for scientific discussion, to facilitate the qualitative comparison of the systems, and to serve as the basis for defining a standardized API to make overlay networks interoperable

Two- and Three-dimensional High Performance, Patterned Overlay Multi-chip Module Technology

A two- and three-dimensional multi-chip module technology was developed in response to the continuum in demand for increased performance in electronic systems, as well as the desire to reduce the size, weight, and power of space systems. Though developed to satisfy the needs of military programs, such as the Strategic Defense Initiative Organization, the technology, referred to as High Density Interconnect, can also be advantageously exploited for a wide variety of commercial applications, ranging from computer workstations to instrumentation and microwave telecommunications. The robustness of the technology, as well as its high performance, make this generality in application possible. More encouraging is the possibility of this technology for achieving low cost through high volume usage