Clinical Data Reuse or Secondary Use: Current Status and Potential Future Progress

Objective: To perform a review of recent research in clinical data reuse or secondary use, and envision future advances in this field. Methods: The review is based on a large literature search in MEDLINE (through PubMed), conference proceedings, and the ACM Digital Library, focusing only on research published between 2005 and early 2016. Each selected publication was reviewed by the authors, and a structured analysis and summarization of its content was developed. Results: The initial search produced 359 publications, reduced after a manual examination of abstracts and full publications. The following aspects of clinical data reuse are discussed: motivations and challenges, privacy and ethical concerns, data integration and interoperability, data models and terminologies, unstructured data reuse, structured data mining, clinical practice and research integration, and examples of clinical data reuse (quality measurement and learning healthcare systems). Conclusion: Reuse of clinical data is a fast-growing field recognized as essential to realize the potentials for high quality healthcare, improved healthcare management, reduced healthcare costs, population health management, and effective clinical research

Computational and human-based methods for knowledge discovery over knowledge graphs

The modern world has evolved, accompanied by the huge exploitation of data and information. Daily, increasing volumes of data from various sources and formats are stored, resulting in a challenging strategy to manage and integrate them to discover new knowledge. The appropriate use of data in various sectors of society, such as education, healthcare, e-commerce, and industry, provides advantages for decision support in these areas. However, knowledge discovery becomes challenging since data may come from heterogeneous sources with important information hidden. Thus, new approaches that adapt to the new challenges of knowledge discovery in such heterogeneous data environments are required. The semantic web and knowledge graphs (KGs) are becoming increasingly relevant on the road to knowledge discovery. This thesis tackles the problem of knowledge discovery over KGs built from heterogeneous data sources. We provide a neuro-symbolic artificial intelligence system that integrates symbolic and sub-symbolic frameworks to exploit the semantics encoded in a KG and its structure. The symbolic system relies on existing approaches of deductive databases to make explicit, implicit knowledge encoded in a KG. The proposed deductive database $DS$ can derive new statements to ego networks given an abstract target prediction. Thus, $DS$ minimizes data sparsity in KGs. In addition, a sub-symbolic system relies on knowledge graph embedding (KGE) models. KGE models are commonly applied in the KG completion task to represent entities in a KG in a low-dimensional vector space. However, KGE models are known to suffer from data sparsity, and a symbolic system assists in overcoming this fact. The proposed approach discovers knowledge given a target prediction in a KG and extracts unknown implicit information related to the target prediction. As a proof of concept, we have implemented the neuro-symbolic system on top of a KG for lung cancer to predict polypharmacy treatment effectiveness. The symbolic system implements a deductive system to deduce pharmacokinetic drug-drug interactions encoded in a set of rules through the Datalog program. Additionally, the sub-symbolic system predicts treatment effectiveness using a KGE model, which preserves the KG structure. An ablation study on the components of our approach is conducted, considering state-of-the-art KGE methods. The observed results provide evidence for the benefits of the neuro-symbolic integration of our approach, where the neuro-symbolic system for an abstract target prediction exhibits improved results. The enhancement of the results occurs because the symbolic system increases the prediction capacity of the sub-symbolic system. Moreover, the proposed neuro-symbolic artificial intelligence system in Industry 4.0 (I4.0) is evaluated, demonstrating its effectiveness in determining relatedness among standards and analyzing their properties to detect unknown relations in the I4.0KG. The results achieved allow us to conclude that the proposed neuro-symbolic approach for an abstract target prediction improves the prediction capability of KGE models by minimizing data sparsity in KGs

On Applications of Relational Data

With the advances of technology and the popularity of the Internet, a large amount of data is being generated and collected. Much of these data is relational data, which describe how people and things, or entities, are related to one another. For example, data from sale transactions on e-commerce websites tell us which customers buy or view which products. Analyzing the known relationships from relational data can help us to discover knowledge that can benefit businesses, organizations, and our lives. For instance, learning the products that are commonly bought together allows businesses to recommend products to customers and increase their sales. Hidden or new relationships can also be inferred based on relational data. In addition, based on the connections among the entities, we can approximate the level of relatedness between two entities, even though their relationship may be hard to observe or quantify. This research aims to explore novel applications of relational data that will help to improve our life in various aspects, such as improving business operations, improving experiences in using online services, and improving health care services. In applying relational data in any domain, there are two common challenges. First, the size of the data can be massive, but many applications require that results are obtained within a short time. Second, relational data are often noisy and incomplete. Many relationships are extracted automatically from text resources, and hence they are prone to errors. Our goal is not only to propose novel applications of relational data but also to develop techniques and algorithms that will facilitate and make such applications practical. This work addresses three novel applications of relational data. The first application is to use relational data to improve user experiences in online video sharing services. Second, we propose the use of relational data to find entities that are closely related to one another. Such problems arise in various domains, such as product recommendation and query suggestion. Third, we propose the use of relational data to assist medical practitioners in drug prescription. For these applications, we introduce several techniques and algorithms to address the aforementioned challenges in using relational data. Our approaches are evaluated extensively to demonstrate their effectiveness. The approaches proposed in this work not only can be used in the specific applications we discuss but also can help to facilitate and promote the use of relational data in other application domains

Efficient Decision Support Systems

This series is directed to diverse managerial professionals who are leading the transformation of individual domains by using expert information and domain knowledge to drive decision support systems (DSSs). The series offers a broad range of subjects addressed in specific areas such as health care, business management, banking, agriculture, environmental improvement, natural resource and spatial management, aviation administration, and hybrid applications of information technology aimed to interdisciplinary issues. This book series is composed of three volumes: Volume 1 consists of general concepts and methodology of DSSs; Volume 2 consists of applications of DSSs in the biomedical domain; Volume 3 consists of hybrid applications of DSSs in multidisciplinary domains. The book is shaped decision support strategies in the new infrastructure that assists the readers in full use of the creative technology to manipulate input data and to transform information into useful decisions for decision makers

Information retrieval and text mining technologies for chemistry

Efficient access to chemical information contained in scientific literature, patents, technical reports, or the web is a pressing need shared by researchers and patent attorneys from different chemical disciplines. Retrieval of important chemical information in most cases starts with finding relevant documents for a particular chemical compound or family. Targeted retrieval of chemical documents is closely connected to the automatic recognition of chemical entities in the text, which commonly involves the extraction of the entire list of chemicals mentioned in a document, including any associated information. In this Review, we provide a comprehensive and in-depth description of fundamental concepts, technical implementations, and current technologies for meeting these information demands. A strong focus is placed on community challenges addressing systems performance, more particularly CHEMDNER and CHEMDNER patents tasks of BioCreative IV and V, respectively. Considering the growing interest in the construction of automatically annotated chemical knowledge bases that integrate chemical information and biological data, cheminformatics approaches for mapping the extracted chemical names into chemical structures and their subsequent annotation together with text mining applications for linking chemistry with biological information are also presented. Finally, future trends and current challenges are highlighted as a roadmap proposal for research in this emerging field.A.V. and M.K. acknowledge funding from the European Community’s Horizon 2020 Program (project reference: 654021 - OpenMinted). M.K. additionally acknowledges the Encomienda MINETAD-CNIO as part of the Plan for the Advancement of Language Technology. O.R. and J.O. thank the Foundation for Applied Medical Research (FIMA), University of Navarra (Pamplona, Spain). This work was partially funded by Consellería de Cultura, Educación e Ordenación Universitaria (Xunta de Galicia), and FEDER (European Union), and the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684). We thank Iñigo Garciá -Yoldi for useful feedback and discussions during the preparation of the manuscript.info:eu-repo/semantics/publishedVersio

Data Mining Techniques for Complex User-Generated Data

Nowadays, the amount of collected information is continuously growing in a variety of different domains. Data mining techniques are powerful instruments to effectively analyze these large data collections and extract hidden and useful knowledge. Vast amount of User-Generated Data (UGD) is being created every day, such as user behavior, user-generated content, user exploitation of available services and user mobility in different domains. Some common critical issues arise for the UGD analysis process such as the large dataset cardinality and dimensionality, the variable data distribution and inherent sparseness, and the heterogeneous data to model the different facets of the targeted domain. Consequently, the extraction of useful knowledge from such data collections is a challenging task, and proper data mining solutions should be devised for the problem under analysis. In this thesis work, we focus on the design and development of innovative solutions to support data mining activities over User-Generated Data characterised by different critical issues, via the integration of different data mining techniques in a unified frame- work. Real datasets coming from three example domains characterized by the above critical issues are considered as reference cases, i.e., health care, social network, and ur- ban environment domains. Experimental results show the effectiveness of the proposed approaches to discover useful knowledge from different domains

Lifted relational neural networks: efficient learning of latent relational structures

We propose a method to combine the interpretability and expressive power of firstorder logic with the effectiveness of neural network learning. In particular, we introduce a lifted framework in which first-order rules are used to describe the structure of a given problem setting. These rules are then used as a template for constructing a number of neural networks, one for each training and testing example. As the different networks corresponding to different examples share their weights, these weights can be efficiently learned using stochastic gradient descent. Our framework provides a flexible way for implementing and combining a wide variety of modelling constructs. In particular, the use of first-order logic allows for a declarative specification of latent relational structures, which can then be efficiently discovered in a given data set using neural network learning. Experiments on 78 relational learning benchmarks clearly demonstrate the effectiveness of the framework