Drug Repurposing

This book focuses on various aspects and applications of drug repurposing, the understanding of which is important for treating diseases. Due to the high costs and time associated with the new drug discovery process, the inclination toward drug repurposing is increasing for common as well as rare diseases. A major focus of this book is understanding the role of drug repurposing to develop drugs for infectious diseases, including antivirals, antibacterial and anticancer drugs, as well as immunotherapeutics

Biointormatics of Targeted Therapeutics And Applications in Drug Discovery

Ph.DDOCTOR OF PHILOSOPH

Tuberculosis: a demographic analysis and social study of admissions to a children's sanatorium (1936-1954) in Stannington, Northumberland

This study analyses the data from medical records from a former tuberculous sanatorium for children at Stannington, Morpeth, Northumberland. It focuses on the demographic profile of the sanatorium and also examines the changes in therapy that occurred between 1937 and 1953. The objective of the study was to understand the patterning of tuberculosis in the sanatorium by considering the differences between male and female patients, ages affected, and the socio-economic backgrounds of patients from a sample of patient records taken from pre- and post-antibiotic eras, pre- and post-Second World War, and pre- and post-NHS years. 1,897 patient records were utilized in this study, all held at the Northumberland Record Office at Morpeth. This study was followed in accordance to the limitations given by the Medical Ethics Committee which was to ensure that patient confidentiality would be maintained. A limited database is included with this reasearch, but a complete database will be held in the future at the Northumberland Health Authority, in Morpeth. Overall more females than males were admitted to the sanatorium and all patients from various types of tuberculosis. The majority of the children (over 60%) were suffering from pulmonary tuberculosis, but there were a large number also suffering from tuberculosis of the bones and joints (230 cases or 12%). Most of the children came from poor backgrounds and originated from the Newcastle and Gateshead areas. The introduction of chemotherapy, the end of the Second World War and the implementation of the NHS did not have a great effect on who was being treated at the sanatorium. In conclusion these records hold a wealth of information that may help build an epidemiological model of tuberculosis in the North-East of England. Future work on the records is suggested and limitations of the research outlined

Australia\u27s health 2000 : the seventh biennial report of the Australian Institute of Health and Welfare

Australia\u27s Health 2000 is the seventh biennial health report of the Australian Institute of Health and Welfare. It is the nation\u27s authoritative source of information on patterns of health and illness, determinants of health, the supply and use of health services, and health services costs and performance.This 2000 edition serves as a summary of Australia\u27s health record at the end of the twentieth century. In addition, a special chapter is presented on changes in Australia\u27s disease profile over the last 100 years.Australia\u27s Health 2000 is an essential reference and information source for all Australians with an interest in health

The Social History of Medical Self-Help in 20th-Century England: a Microhistory of a Rural Community

This thesis focuses on the health experiences of an Oxfordshire village 1900-1947 and the aim of the study is to obtain a holistic view of the health status and health strategies of one agricultural community. The period under review covers the years of therapeutic nihilism, the start of the therapeutic revolution, the third and fourth stages of germ theory and the start of the epidemiological transition. From a range of archival sources, the thesis examines the effects of climate, environment, housing, diet and the extant medical provision on the health and wellbeing of the residents. These effects in turn informed the residents’ health beliefs and self-help strategies set against the existing medical and nursing provision during periods of depression and war until the establishment of the National Health Service in 1948. Medical and health information from a range of sources, which were available to residents was explored. It shows that the residents were not passive in the face of illness and misfortune but worked together as a community. The importance of this study is its contribution to the historiography of rural health during the interwar years and offers a portrait of rural resilience and stoicism in the face of medical adversity

International Conference on Advances in Biosciences and Biotechnology – ICABB-2019

International Conference on Advances in Biosciences and Biotechnology – ICABB-201

Incorporating standardised drift-tube ion mobility to enhance non-targeted assessment of the wine metabolome (LC×IM-MS)

Liquid chromatography with drift-tube ion mobility spectrometry-mass spectrometry (LCxIM-MS) is emerging as a powerful addition to existing LC-MS workflows for addressing a diverse range of metabolomics-related questions [1,2]. Importantly, excellent precision under repeatability and reproducibility conditions of drift-tube IM separations [3] supports the development of non-targeted approaches for complex metabolome assessment such as wine characterisation [4]. In this work, fundamentals of this new analytical metabolomics approach are introduced and application to the analysis of 90 authentic red and white wine samples originating from Macedonia is presented. Following measurements, intersample alignment of metabolites using non-targeted extraction and three-dimensional alignment of molecular features (retention time, collision cross section, and high-resolution mass spectra) provides confidence for metabolite identity confirmation. Applying a fingerprinting metabolomics workflow allows statistical assessment of the influence of geographic region, variety, and age. This approach is a state-of-the-art tool to assess wine chemodiversity and is particularly beneficial for the discovery of wine biomarkers and establishing product authenticity based on development of fingerprint libraries

Community participation in the provision of basic health services : the case of the Hanunuo Mangyans of oriental Mindoro, Philippines; final report

Madison, Wisconsin, June 25th 1863.Dear [illegible] Boise, Allow me to introduce to you, the [illegible], Mr. John Muir, a most estimable young gentleman, who had been attending the state University here, & expects to commence study in A[illegible] [illegible] next term. You will find in him the greatest modesty [found?] with high moral & religious ex- cellence. He had also marked mechanical genius. I trust his time of study in your University may be pleasant & profitable. My family joins me in regards to you & yours Fr[illegible]matly yours J E. Johnson.06078https://scholarlycommons.pacific.edu/jmcl/43539/thumbnail.jp