Process Calculi Abstractions for Biology

Several approaches have been proposed to model biological systems by means of the formal techniques and tools available in computer science. To mention just a few of them, some representations are inspired by Petri Nets theory, and some other by stochastic processes. A most recent approach consists in interpreting the living entities as terms of process calculi where the behavior of the represented systems can be inferred by applying syntax-driven rules. A comprehensive picture of the state of the art of the process calculi approach to biological modeling is still missing. This paper goes in the direction of providing such a picture by presenting a comparative survey of the process calculi that have been used and proposed to describe the behavior of living entities. This is the preliminary version of a paper that was published in Algorithmic Bioprocesses. The original publication is available at http://www.springer.com/computer/foundations/book/978-3-540-88868-

From types to type requirements: Genericity for model-driven engineering

The final publication is available at Springer via http://dx.doi.org/10.1007/s10270-011-0221-0Model-driven engineering (MDE) is a software engineering paradigm that proposes an active use of models during the development process. This paradigm is inherently type-centric, in the sense that models and their manipulation are defined over the types of specific meta-models. This fact hinders the reuse of existing MDE artefacts with other meta-models in new contexts, even if all these meta-models share common characteristics. To increase the reuse opportunities of MDE artefacts, we propose a paradigm shift from type-centric to requirement-centric specifications by bringing genericity into models, meta-models and model management operations. For this purpose, we introduce so-called concepts gathering structural and behavioural requirements for models and meta-models. In this way, model management operations are defined over concepts, enabling the application of the operations to any meta-model satisfying the requirements imposed by the concept. Model templates rely on concepts to define suitable interfaces, hence enabling the definition of reusable model components. Finally, similar to mixin layers, templates can be defined at the meta-model level as well, to define languages in a modular way, as well as layers of functionality to be plugged-in into other meta-models. These ideas have been implemented in MetaDepth, a multi-level meta-modelling tool that integrates action languages from the Epsilon family for model management and code generation.This work has been sponsored by the Spanish Ministry of Science and Innovation with projects METEORIC (TIN2008-02081) and Go Lite (TIN2011-24139), and by the R&D program of the Community of Madrid with project “e-Madrid” (S2009/TIC-1650)

Zero-gravity movement studies

The use of computer graphics to simulate the movement of articulated animals and mechanisms has a number of uses ranging over many fields. Human motion simulation systems can be useful in education, medicine, anatomy, physiology, and dance. In biomechanics, computer displays help to understand and analyze performance. Simulations can be used to help understand the effect of external or internal forces. Similarly, zero-gravity simulation systems should provide a means of designing and exploring the capabilities of hypothetical zero-gravity situations before actually carrying out such actions. The advantage of using a simulation of the motion is that one can experiment with variations of a maneuver before attempting to teach it to an individual. The zero-gravity motion simulation problem can be divided into two broad areas: human movement and behavior in zero-gravity, and simulation of articulated mechanisms

Adaptive Process Management in Cyber-Physical Domains

The increasing application of process-oriented approaches in new challenging cyber-physical domains beyond business computing (e.g., personalized healthcare, emergency management, factories of the future, home automation, etc.) has led to reconsider the level of flexibility and support required to manage complex processes in such domains. A cyber-physical domain is characterized by the presence of a cyber-physical system coordinating heterogeneous ICT components (PCs, smartphones, sensors, actuators) and involving real world entities (humans, machines, agents, robots, etc.) that perform complex tasks in the “physical” real world to achieve a common goal. The physical world, however, is not entirely predictable, and processes enacted in cyber-physical domains must be robust to unexpected conditions and adaptable to unanticipated exceptions. This demands a more flexible approach in process design and enactment, recognizing that in real-world environments it is not adequate to assume that all possible recovery activities can be predefined for dealing with the exceptions that can ensue. In this chapter, we tackle the above issue and we propose a general approach, a concrete framework and a process management system implementation, called SmartPM, for automatically adapting processes enacted in cyber-physical domains in case of unanticipated exceptions and exogenous events. The adaptation mechanism provided by SmartPM is based on declarative task specifications, execution monitoring for detecting failures and context changes at run-time, and automated planning techniques to self-repair the running process, without requiring to predefine any specific adaptation policy or exception handler at design-time

Checking and Enforcing Security through Opacity in Healthcare Applications

The Internet of Things (IoT) is a paradigm that can tremendously revolutionize health care thus benefiting both hospitals, doctors and patients. In this context, protecting the IoT in health care against interference, including service attacks and malwares, is challenging. Opacity is a confidentiality property capturing a system's ability to keep a subset of its behavior hidden from passive observers. In this work, we seek to introduce an IoT-based heart attack detection system, that could be life-saving for patients without risking their need for privacy through the verification and enforcement of opacity. Our main contributions are the use of a tool to verify opacity in three of its forms, so as to detect privacy leaks in our system. Furthermore, we develop an efficient, Symbolic Observation Graph (SOG)-based algorithm for enforcing opacity