Advanced Technologies for Oral Controlled Release: Cyclodextrins for oral controlled release

Cyclodextrins (CDs) are used in oral pharmaceutical formulations, by means of inclusion complexes formation, with the following advantages for the drugs: (1) solubility, dissolution rate, stability and bioavailability enhancement; (2) to modify the drug release site and/or time profile; and (3) to reduce or prevent gastrointestinal side effects and unpleasant smell or taste, to prevent drug-drug or drug-additive interactions, or even to convert oil and liquid drugs into microcrystalline or amorphous powders. A more recent trend focuses on the use of CDs as nanocarriers, a strategy that aims to design versatile delivery systems that can encapsulate drugs with better physicochemical properties for oral delivery. Thus, the aim of this work was to review the applications of the CDs and their hydrophilic derivatives on the solubility enhancement of poorly water soluble drugs in order to increase their dissolution rate and get immediate release, as well as their ability to control (to prolong or to delay) the release of drugs from solid dosage forms, either as complexes with the hydrophilic (e.g. as osmotic pumps) and/ or hydrophobic CDs. New controlled delivery systems based on nanotechonology carriers (nanoparticles and conjugates) have also been reviewed

Controlled Drug Release Asymptotics

The solution of Higushi's model for controlled release of drugs is examined when the solubility of the drug in the polymer matrix is a prescribed function of time. A time-dependent solubility results either from an external control or from a change in pH due to the activation of pH immobilized enzymes. The model is described as a one-phase moving boundary problem which cannot be solved exactly. We consider two limits of our problem. The first limit considers a solubility much smaller than the initial loading of the drug. This limit leads to a pseudo-steady-state approximation of the diffusion equation and has been widely used when the solubility is constant. The second limit considers a solubility close to the initial loading of the drug. It requires a boundary layer analysis and has never been explored before. We obtain simple analytical expressions for the release rate which exhibits the effect of the time-dependent solubility

Controlled release device Patent

Controlled release device for use in launching rockets or missile

Trends and uptake of new formulations of controlled-release oxycodone in Canada

Purpose: This study investigated the impact of changing availability of tamper‐deterrent and non‐tamper‐deterrent oxycodone on prescribing patterns of controlled‐release oxycodone across Canada. Methods: We conducted a population‐based, serial cross‐sectional study of controlled‐release oxycodone dispensing from community pharmacies across Canada between October 2007 and April 2016. We calculated rates of dispensing (tablets per 100 population) and reported the relative market share of generic non‐tamper‐deterrent controlled‐release oxycodone. All analyses were reported nationally and stratified by province. Results: After the introduction of a tamper‐deterrent formulation, the national rate of controlled‐release oxycodone dispensing fell by 44.6% (from 26.4 to 14.6 tablets per 100 population from February 2012 to April 2016). Between December 2012 and July 2013, there was moderate uptake of generic non‐tamper‐deterrent controlled‐release oxycodone (968 452 tablets; 16.0% in July 2013), which appeared to have little impact on the overall rate of controlled‐release oxycodone dispensing in Canada. However, the uptake of generic non‐tamper‐deterrent oxycodone varied considerably by province. By April 2016, 55.0% of all controlled‐release oxycodone tablets dispensed in Quebec were for the generic formulation. […

Controlled-release fertilizers: advances and challenges

Controlled- release fertilizers (CRFs) offer an excellent option to improve nutrients uptake by plants and reduce the environmental hazards due to excess release of chemicals. Polymer-coated fertilizers, compared to the other types of CRF, are by far the most intensively researched topic because of their great characteristics. Polymer-coated fertilizers, which are less sensitive to the soil and environmental factors, offer superior control over nutrients release for plants uptake. In recent years, the art has mainly focused on the design of biodegradable polymer-based coating for fertilizers considering the effective control on nutrient release. This review covers the basic information about CRFs with an emphasis on the development of polymer-coated fertilizers. Topics that are discussed herewith include materials and methods utilized for coated fertilizer, particularly polymer-coated fertilizers, manufacturing and related issues. The large market potential for fertilizer using necessitates more studies for development and commercial production of polymer-coated fertilizers

Controlled release nanoparticulate matter delivery system

A controlled release nanoparticulate matter delivery system includes a plurality of thermoresponsive modules containing a respective nanoparticulate matter. Each thermoresponsive module is selectively operable in at least one of a heating mode that releases the nanoparticulate matter and a cooling mode that inhibits release of the nanoparticulate matter. A control module is in electrical communication with the plurality of thermoresponsive modules. The control module is configured to determine a temperature of each thermoresponsive module and to select the at least one heating mode and cooling mode based on the temperature. The heating and cooling mode may be selected in response to a desired dosing profile and/or a biometric condition.Board of Regents, University of Texas Syste

Melt-extruded polyethylene oxide (PEO) rods as drug delivery vehicles: Formulation, performance as controlled release devices and the influence of co-extruded excipients on drug release profiles

The utility of controlled release medication formulations lies in their ability to keep drugs at steady levels in the blood plasma of recipients and within the termini of the maximum and minimum effective therapeutic levels. This avoids the “ups” and “downs” of medication levels within the body which would have been the result had conventional immediate release tablets been administered instead. In the veterinary field, controlled release medications are essential¹ because of the logistical difficulties of administering drugs on a regular (e.g., daily) basis to animals. The chief advantages of controlled release veterinary medications lie in the ease with which they can be administered; decrease in stress for animals, owing to less need for rounding up and frequent dosing; and, most importantly for farmers, the reduced cost of treatment relative to that for a multiple dosage regime

Controlled-release and stabilized fertilizers are equivalent options to split application of ammonium nitrate in a double maize-oats cropping system

The application of fertilizers as a topdressing in maize raises serious concerns because too much fertilizer is retained in the upper leaves, causing burning to the tissues. In this study, the use of a controlled-release and a stabilized fertilizer (with 3, 4-dimethylpyrazole phosphate) was compared with the application of a conventional fertilizer split into two equivalent applications in a forage maize-oats cropping system. In maize, 100 and 200 kg N ha−1 of different fertilizers were used in addition to an unfertilized control. The oat crop was not fertilized, since it served only as a winter catch crop. Maize dry matter (DM) yield increased significantly with N rate only in 2019, being the second growing season, with the control showing the lowest average value (7.1 t ha−1). The most fertilized treatments (200 kg N ha−1) gave the highest DM yields, ranging between 14.2 and 16.7 t ha−1, but with no significant differences between them. Oats had a relevant role as a catch crop recovering residual N that could have potentially been lost from the soil. Stalk nitrate concentration proved to be very sensitive to N fertilization (varying from 150.4 to 1945.6 mg kg−1 in 2018 and 494.9 to 1574.9 mg kg−1 in 2019), showing great potential as a tool of N management. These three fertilization strategies seem to be valid options that farmers can consider, after incorporating technical-economic information related to equipment suitability and the price of fertilizers.The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and European Regional Development Fund (ERDF) under Programme PT2020 for financial support to CIMO (UIDB/00690/2020).info:eu-repo/semantics/publishedVersio

Controlled-release and stabilized fertilizers are equivalent options to split application of ammonium nitrate in a double maize-oats cropping system

The application of fertilizers as a topdressing in maize raises serious concerns because too much fertilizer is retained in the upper leaves, causing burning to the tissues. In this study, the use of a controlled-release and a stabilized fertilizer (with 3, 4-dimethylpyrazole phosphate) was compared with the application of a conventional fertilizer split into two equivalent applications in a forage maize-oats cropping system. In maize, 100 and 200 kg N ha 1 of different fertilizers were used in addition to an unfertilized control. The oat crop was not fertilized, since it served only as a winter catch crop. Maize dry matter (DM) yield increased significantly with N rate only in 2019, being the second growing season, with the control showing the lowest average value (7.1 t ha 1). The most fertilized treatments (200 kg N ha 1) gave the highest DM yields, ranging between 14.2 and 16.7 t ha 1, but with no significant differences between them. Oats had a relevant role as a catch crop recovering residual N that could have potentially been lost from the soil. Stalk nitrate concentration proved to be very sensitive to N fertilization (varying from 150.4 to 1945.6mg kg 1 in 2018 and 494.9 to 1574.9mg kg 1 in 2019), showing great potential as a tool of N management. These three fertilization strategies seem to be valid options that farmers can consider, after incorporating technical-economic information related to equipment suitability and the price of fertilizers.The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) and European Regional Development Fund (ERDF) under Programme PT2020 for financial support to CIMO (UIDB/00690/2020).info:eu-repo/semantics/publishedVersio

Controlled release of free-falling test models

Releasing device, powered by a drill motor through an adjustable speed reducer, has a spinning release head with three retractable spring-loaded fingers. The fingers are retracted by manual triggering of a cable at the motor end of the unit