6 research outputs found

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    An Assessment of the Factors that Affect the Level of Perception of Office Politics

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    The culture of an organization is often the primary indicator of the expected and accepted employee behavior. Organizations with weak directives, poor communication, and ineffectively managed cultures are breeding grounds for the negative dysfunctional interpersonal dynamics referred as office politics. Studies indicate that considerable time and energy are lost to solving problematic issues originating from the influences of office politics in organizations with weak cultural expectations. Therefore, it is conceivable that developing a positive organizational culture that facilitates certain values is an important step in eliminating the ill effects of office politics. The purpose of this quantitative non-experimental study was to ascertain the degree and impact of the perceptions held by top-level fie administrators on the phenomenon of office politics . In addition, the role of office politics was examined as it relates to the established culture and climate of their organizations. The preliminary aspect of this investigation entailed the assessment of contemporary and classic literature of theoretical perspectives and empirical studies on Office Politics, Ethics, and Organizational Culture. The sample was one of convenience comprised of 155 fire chiefs of metropolitan fire rescue departments in the United States with a minimum staffing strength of 400 professional firefighters and was not generalized to any other group. The instruments chosen for this study were: (a) the Perceptions of Organizational Politics Scale (POPS; Kacrnar & Ferris, 1991), (b) the Abridge Job Descriptive Index (AJDI; Bowling Green, 2000), (c) the Job in General (JIG) Scale, (d) the Stress in General Scale (SIG; Bowling Green, 1985; Parra & Smith, 1995), and (e) the Intention to Quit (ITQ) Scale. The five scalel69-item survey was supplemented with a brief 11 -item personal demographic questionnaire. The collected data was subjected to descriptive, cross tabulation, correlation, and multi-regression analyses to inquire into the affects of a set on independent variables (stress, job satisfaction, employee\u27s turnover/retention, etc.) on the dependent variable of the Perception of Office Politics. The results suggest that the independent variables with the most definite influence on the dependent variable are: (a) department size, (b) work stress (measured by the SIG), and (c) general job satisfaction (measured by theAJD1)

    CPA letter, 1998

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    https://egrove.olemiss.edu/aicpa_news/1142/thumbnail.jp

    Development of transition state analogues targeting chitinases and oligosaccharyl transferase

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    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2006.Vita.Includes bibliographical references.Oligosaccharyl transferase (OT) plays a central role in the biosynthesis of asparagine-linked glycoproteins in eukaryotic systems. The glycosylation step catalyzed by OT involves the co-translational transfer of a tetradecasaccharide from a dolichyl-pyrophosphate carrier to an asparagine side-chain within the Asn-Xaa-Ser/Thr sequence of a nascent polypeptide. Chitinases, which was emerged as a therapeutic target in combating asthma, are [beta]-1,4-N-acetylglucosaminidases that hydrolyze chitin to generate the disaccharide chitobiose Although the reactions catalyzed by the two enzymes follow different pathways, they are believed to share similar transition states involving an oxocarbenium ion. To understand the mechanism of OT and discover potent and selective inhibitors against different chitinases, our intent was to utilize the common transition state analogue for both enzymes and systematically introduce additional binding determinants. The pseudo-disaccharides containing an imino sugar were designed to target the oxocarbenium ion like transition state. The pseudo-disaccharides containing imino sugar were synthesized and evaluated at inhibitors for OT and chitinases.(cont.) Highlights and supporting studies from this work include: (1) the use of the Amadori rearrangement to generate the acyclic substrate; (2) the glycosylation of [beta]-hydroxy ketone; (3) the intramolecular reductive amination between the in-situ generated amine from azido and ketone moieties; (4) the determination of the stereo-chemical outcome by NOE difference experiments. The pseudo-disaccharides containing imino sugars exhibited IC50s in the low micromolar range versus chitinase, yet significant inhibitory activity against OT was not observed.by Seungjib Choi.Ph.D

    A mental revolution: scientific management since Taylor

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    (print) viii, 249 p. ; 24 cmINTRODUCTION p. 1 -- DANIEL NELSON - Scientific Management in Retrospect p. 5 -- DAVID J. GOLDBERG - Richard A. Feiss, Mary Barnett Gilson, and Scientific Management at Joseph & Feiss, 1909-1925 p. 40 -- BRIAN PRICE - Frank and Lillian Gilbreth and the Motion Study Controversy, 1907-1930 p. 58 -- DANIEL NELSON - Scientific Management and the Transformation of University Business Education p. 77 -- GUY ALCHON - Mary Van Kleeck and Scientific Management p. 102 -- KATHY BURGESS - Organized Production and Unorganized Labor : Management Strategy and Labor Activism at the Link-Belt Company, 1900-1940 p. 130 -- STEVEN KREIS - The Diffusion of Scientific Management : The Bedaux Company in America and Britain, 1926-1945 p. 156 -- JOHN C. RUMM - Scientific Management and Industrial Engineering at Du Pont p. 175 -- STEPHEN P. WARING - Peter Drucker, MBO, and the Corporatist Critique of Scientific Management p. 205 -- EPILOGUE p. 237 -- NOTES ON CONTRIBUTORS p. 241 -- INDEX p. 24
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