Focal Spot, Spring 1995

https://digitalcommons.wustl.edu/focal_spot_archives/1069/thumbnail.jp

Complexity Reduction in Image-Based Breast Cancer Care

The diversity of malignancies of the breast requires personalized diagnostic and therapeutic decision making in a complex situation. This thesis contributes in three clinical areas: (1) For clinical diagnostic image evaluation, computer-aided detection and diagnosis of mass and non-mass lesions in breast MRI is developed. 4D texture features characterize mass lesions. For non-mass lesions, a combined detection/characterisation method utilizes the bilateral symmetry of the breast s contrast agent uptake. (2) To improve clinical workflows, a breast MRI reading paradigm is proposed, exemplified by a breast MRI reading workstation prototype. Instead of mouse and keyboard, it is operated using multi-touch gestures. The concept is extended to mammography screening, introducing efficient navigation aids. (3) Contributions to finite element modeling of breast tissue deformations tackle two clinical problems: surgery planning and the prediction of the breast deformation in a MRI biopsy device

Deep-learning framework to detect lung abnormality - A study with chest X-Ray and lung CT scan images

Lung abnormalities are highly risky conditions in humans. The early diagnosis of lung abnormalities is essential to reduce the risk by enabling quick and efficient treatment. This research work aims to propose a Deep-Learning (DL) framework to examine lung pneumonia and cancer. This work proposes two different DL techniques to assess the considered problem: (i) The initial DL method, named a modified AlexNet (MAN), is proposed to classify chest X-Ray images into normal and pneumonia class. In the MAN, the classification is implemented using with Support Vector Machine (SVM), and its performance is compared against Softmax. Further, its performance is validated with other pre-trained DL techniques, such as AlexNet, VGG16, VGG19 and ResNet50. (ii) The second DL work implements a fusion of handcrafted and learned features in the MAN to improve classification accuracy during lung cancer assessment. This work employs serial fusion and Principal Component Analysis (PCA) based features selection to enhance the feature vector. The performance of this DL frame work is tested using benchmark lung cancer CT images of LIDC-IDRI and classification accuracy (97.27%) is attained. (c) 2019 Elsevier B.V

Automatic detection and classification of nasopharyngeal carcinoma on PET/CT with support vector machine

Purpose: Positron emission tomography/computed tomography (PET/CT) has established values for imaging of head and neck cancers, including the nasopharyngeal carcinoma (NPC), utilizing both morphologic and functional information. In this paper, we introduce a computerized system for automatic detection of NPC, targeting both the primary tumor and regional nodal metastasis, on PET/CT. Methods: Candidate lesions were extracted based on the features from both PET and CT images and a priori knowledge of anatomical features and subsequently classified by a support vector machine algorithm. The system was validated with 25 PET/CT examinations from 10 patients suffering from NPC. Lesions manually contoured by experienced radiologists were used as the gold standard. Results: Results showed that the system successfully identified all 53 hypermetabolic lesions larger than 1 cm in size and excluded normal physiological uptake in brown fat, muscles, bone marrow, brain, and salivary glands. Conclusion: The system combined both imaging features and a priori clinical knowledge for classification between pathological and physiological uptake. Preliminary results showed that the system was highly accurate and promising for adoption in clinical use. © The Author(s) 2011.published_or_final_versionSpringer Open Choice, 25 May 201

From Concept to Market: Surgical Robot Development

Surgical robotics and supporting technologies have really become a prime example of modern applied information technology infiltrating our everyday lives. The development of these systems spans across four decades, and only the last few years brought the market value and saw the rising customer base imagined already by the early developers. This chapter guides through the historical development of the most important systems, and provide references and lessons learnt for current engineers facing similar challenges. A special emphasis is put on system validation, assessment and clearance, as the most commonly cited barrier hindering the wider deployment of a system

BRAIM: A computer-aided diagnosis system for neurodegenerative diseases and brain lesion monitoring from volumetric analyses

[EN] Background and objective: This paper presents BRAIM, a computer-aided diagnosis (CAD) system to help clinicians in diagnosing and treatment monitoring of brain diseases from magnetic resonance image processing. BRAIM can be used for early diagnosis of neurodegenerative diseases such as Parkinson, Alzheimer or Multiple Sclerosis and also for brain lesion diagnosis and monitoring. Methods: The developed CAD system includes different user-friendly tools for segmenting and determining whole brain and brain structure volumes in an easy and accurate way. Specifically, three types of measurements can be performed: (1) total volume of white, gray matter and cerebrospinal fluid; (2) brain structure volumes (volume of putamen, thalamus, hippocampus and caudate nucleus); and (3) brain lesion volumes. Results: As a proof of concept, some study cases were analyzed with the presented system achieving promising results. In addition to be used to quantify treatment effectiveness in patients with brain lesions, it was demonstrated that BRAIM is able to classify a subject according to the brain volume measurements using as reference a healthy control database created for this purpose. Conclusions: The CAD system presented in this paper simplifies the daily work of clinicians and provides them with objective and quantitative volume data for prospective and retrospective analyses. (C) 2017 Elsevier B.V. All rights reserved.This work has been supported by the Centro para el Desarrollo Tecnologico Industrial (CDTI) under the project BRAIM (IDI-20130020)Morales, S.; Bernabeu-Sanz, A.; López-Mir, F.; Gonzalez, P.; Luna, L.; Naranjo Ornedo, V. (2017). BRAIM: A computer-aided diagnosis system for neurodegenerative diseases and brain lesion monitoring from volumetric analyses. Computer Methods and Programs in Biomedicine. 145:167-179. https://doi.org/10.1016/j.cmpb.2017.04.006S16717914

NASA Image Processing Technology Applied to Medicine: Ten Unsolved Problems in Medical Imaging

The solutions to current diagnostic imaging problems will be found, at least in part, in digital image processing technology developed by NASA. The adaptation of appropriate technology that can be applied clinically to improve the care of patients is a major concern of radiologists. We have considered ten problems with clinical significance in diagnostic medical imaging, and discuss the impact of NASA image processing technology presently and predict future developments in this area

On The Potential of Image Moments for Medical Diagnosis

Medical imaging is widely used for diagnosis and postoperative or post-therapy monitoring. The ever-increasing number of images produced has encouraged the introduction of automated methods to assist doctors or pathologists. In recent years, especially after the advent of convolutional neural networks, many researchers have focused on this approach, considering it to be the only method for diagnosis since it can perform a direct classification of images. However, many diagnostic systems still rely on handcrafted features to improve interpretability and limit resource consumption. In this work, we focused our efforts on orthogonal moments, first by providing an overview and taxonomy of their macrocategories and then by analysing their classification performance on very different medical tasks represented by four public benchmark data sets. The results confirmed that convolutional neural networks achieved excellent performance on all tasks. Despite being composed of much fewer features than those extracted by the networks, orthogonal moments proved to be competitive with them, showing comparable and, in some cases, better performance. In addition, Cartesian and harmonic categories provided a very low standard deviation, proving their robustness in medical diagnostic tasks. We strongly believe that the integration of the studied orthogonal moments can lead to more robust and reliable diagnostic systems, considering the performance obtained and the low variation of the results. Finally, since they have been shown to be effective on both magnetic resonance and computed tomography images, they can be easily extended to other imaging techniques