Validity and sensitivity of a human cranial finite element model: Implications for comparative studies of biting performance

Finite element analysis (FEA) is a modelling technique increasingly used in anatomical studies investigating skeletal form and function. In the case of the cranium this approach has been applied to both living and fossil taxa to (for example) investigate how form relates to function or infer diet or behaviour. However, FE models of complex musculoskeletal structures always rely on simplified representations because it is impossible completely to image and represent every detail of skeletal morphology, variations in material properties and the complexities of loading at all spatial and temporal scales. The effects of necessary simplifications merit investigation. To this end, this study focuses on one aspect, model geometry, which is particularly pertinent to fossil material where taphonomic processes often destroy the finer details of anatomy or in models built from clinical CTs where the resolution is limited and anatomical details are lost. We manipulated the details of a finite element (FE) model of an adult human male cranium and examined the impact on model performance. First, using digital speckle interferometry, we directly measured strains from the infraorbital region and frontal process of the maxilla of the physical cranium under simplified loading conditions, simulating incisor biting. These measured strains were then compared with predicted values from FE models with simplified geometries that included modifications to model resolution, and how cancellous bone and the thin bones of the circum-nasal and maxillary regions were represented. Distributions of regions of relatively high and low principal strains and principal strain vector magnitudes and directions, predicted by the most detailed FE model, are generally similar to those achieved in vitro. Representing cancellous bone as solid cortical bone lowers strain magnitudes substantially but the mode of deformation of the FE model is relatively constant. In contrast, omitting thin plates of bone in the circum-nasal region affects both mode and magnitude of deformation. Our findings provide a useful frame of reference with regard to the effects of simplifications on the performance of FE models of the cranium and call for caution in the interpretation and comparison of FEA results

A fast and robust patient specific Finite Element mesh registration technique: application to 60 clinical cases

Finite Element mesh generation remains an important issue for patient specific biomechanical modeling. While some techniques make automatic mesh generation possible, in most cases, manual mesh generation is preferred for better control over the sub-domain representation, element type, layout and refinement that it provides. Yet, this option is time consuming and not suited for intraoperative situations where model generation and computation time is critical. To overcome this problem we propose a fast and automatic mesh generation technique based on the elastic registration of a generic mesh to the specific target organ in conjunction with element regularity and quality correction. This Mesh-Match-and-Repair (MMRep) approach combines control over the mesh structure along with fast and robust meshing capabilities, even in situations where only partial organ geometry is available. The technique was successfully tested on a database of 5 pre-operatively acquired complete femora CT scans, 5 femoral heads partially digitized at intraoperative stage, and 50 CT volumes of patients' heads. The MMRep algorithm succeeded in all 60 cases, yielding for each patient a hex-dominant, Atlas based, Finite Element mesh with submillimetric surface representation accuracy, directly exploitable within a commercial FE software

Mechanistic and pathological study of the genesis, growth, and rupture of abdominal aortic aneurysms

Postprint (published version

Modeling elastic wave propagation in fluid-filled boreholes drilled in nonhomogeneous media: BEM – MLPG versus BEM-FEM coupling

The efficiency of two coupling formulations, the boundary element method (BEM)-meshless local Petrov–Galerkin (MLPG) versus the BEM-finite element method (FEM), used to simulate the elastic wave propagation in fluid-filled boreholes generated by a blast load, is compared. The longitudinal geometry is assumed to be invariant in the axial direction (2.5D formulation). The material properties in the vicinity of the borehole are assumed to be nonhomogeneous as a result of the construction process and the ageing of the material. In both models, the BEM is used to tackle the propagation within the fluid domain inside the borehole and the unbounded homogeneous domain. The MLPG and the FEM are used to simulate the confined, damaged, nonhomogeneous, surrounding borehole, thus utilizing the advantages of these methods in modeling nonhomogeneous bounded media. In both numerical techniques the coupling is accomplished directly at the nodal points located at the common interfaces. Continuity of stresses and displacements is imposed at the solid–solid interface, while continuity of normal stresses and displacements and null shear stress are prescribed at the fluid–solid interface. The performance of each coupled BEM-MLPG and BEM-FEM approach is determined using referenced results provided by an analytical solution developed for a circular multi-layered subdomain. The comparison of the coupled techniques is evaluated for different excitation frequencies, axial wavenumbers and degrees of freedom (nodal points).Ministerio de Economía y Competitividad BIA2013-43085-PCentro Informático Científico de Andalucía (CICA