5,719 research outputs found
Measuring the Health and Development of School-age Zimbabwean Children
Health, growth and development during mid-childhood (from 5 to 14 years) are poorly characterised, and this period has been termed the ‘missing middle’. This thesis describes the piloting and application of the School-Age Health, Activity, Resilience, Anthropometry and Neurocognitive (SAHARAN) toolbox to measure growth, cognitive and physical function amongst the SHINE cohort in rural Zimbabwe. The SHINE cluster-randomised trial tested the effects of a household WASH intervention and/or infant and young child feeding (IYCF) on child stunting and anaemia at age 18 months in rural Zimbabwe. SHINE showed that IYCF modestly increased linear growth and reduced stunting by age 18 months, while WASH had no effects. The SAHARAN toolbox was used to measure 1000 HIV-unexposed children (250 in each intervention arm), and 275 HIV-exposed children within the SHINE cohort to evaluate long-term outcomes. Children were re-enrolled at age seven years to evaluate growth, body composition, cognitive and physical function. Four main findings are presented from the SAHARAN toolbox measurements of this cohort. Firstly, child sex, growth and contemporary environmental conditions are associated with school-age physical and cognitive function at seven years. Secondly, early-life growth and baseline environmental conditions suggest the impact of early-life trajectories on multiple aspects of school-age growth, physical and cognitive function. Thirdly, the long-term impact of HIV-exposure in pregnancy is explored, which indicate reduced cognitive function, cardiovascular fitness and head circumference by age 7 years. Finally, associations with the SHINE trial early life interventions are explored, demonstrating that the SHINE early-life nutrition intervention has minimal impact by 7 years of age, except marginally stronger handgrip strength. The public health implications advocate that child interventions need to be earlier (including antenatal), broader (incorporating nurturing care), deeper (providing transformational WASH) and longer (supporting throughout childhood), as well as targeting particularly vulnerable groups such as children born HIV-free
Perilous and unaccountable: the positive relationship between dominance and moral hazard behaviors
Moral hazard involves a context where decision-makers engage in behaviors that prioritize self-interest while allowing the associated risk to be primarily borne by others. Such decision-making can lead to catastrophic consequences, as seen in the 2008 global financial crisis after hedge fund managers indiscriminately invested their clients’ money in subprime mortgages. This research examines which decision-makers are most likely to engage in moral hazard decision-making and the psychological mechanism driving this behavior. Drawing on the dual model of social influence, we posit that individuals associated with dominance, but not prestige, will engage in greater moral hazard behaviors. We further contend that these behaviors are driven by dominant decision-makers’ enhanced focus on end goals (outcomes) rather than the means (process) that they use to pursue such goals. We find support for our hypotheses across 13 studies (*NObservations* = 26,880; of which eight were pre-registered and six studies are reported in the Supplementary Information (SI)), using both correlational and experimental designs. Additionally, we vary the moral hazard context (e.g., a financial setting, a health and safety issue, etc.) and capture both behavioral intentions and actual behaviors, while also ruling out several alternative explanations. These findings demonstrate that dominant decision-makers engage in moral hazard behaviors because of their tendency to prioritize outcomes over processes
An examination of the verbal behaviour of intergroup discrimination
This thesis examined relationships between psychological flexibility, psychological inflexibility, prejudicial attitudes, and dehumanization across three cross-sectional studies with an additional proposed experimental study. Psychological flexibility refers to mindful attention to the present moment, willing acceptance of private experiences, and engaging in behaviours congruent with one’s freely chosen values. Inflexibility, on the other hand, indicates a tendency to suppress unwanted thoughts and emotions, entanglement with one’s thoughts, and rigid behavioural patterns. Study 1 found limited correlations between inflexibility and sexism, racism, homonegativity, and dehumanization. Study 2 demonstrated more consistent positive associations between inflexibility and prejudice. And Study 3 controlled for right-wing authoritarianism and social dominance orientation, finding inflexibility predicted hostile sexism and racism beyond these factors. While showing some relationships, particularly with sexism and racism, psychological inflexibility did not consistently correlate with varied prejudices across studies.
The proposed randomized controlled trial aims to evaluate an Acceptance and Commitment Therapy intervention to reduce sexism through enhanced psychological flexibility. Overall, findings provide mixed support for the utility of flexibility-based skills in addressing complex societal prejudices. Research should continue examining flexibility integrated with socio-cultural approaches to promote equity
In the name of status:Adolescent harmful social behavior as strategic self-regulation
Adolescent harmful social behavior is behavior that benefits the person that exhibits it but could harm (the interest of) another. The traditional perspective on adolescent harmful social behavior is that it is what happens when something goes wrong in the developmental process, classifying such behaviors as a self-regulation failure. Yet, theories drawing from evolution theory underscore the adaptiveness of harmful social behavior and argue that such behavior is enacted as a means to gain important resources for survival and reproduction; gaining a position of power This dissertation aims to examine whether adolescent harmful social behavior can indeed be strategic self-regulation, and formulated two questions: Can adolescent harmful social behavior be seen as strategic attempts to obtain social status? And how can we incorporate this status-pursuit perspective more into current interventions that aim to reduce harmful social behavior? To answer these questions, I conducted a meta-review, a meta-analysis, two experimental studies, and an individual participant data meta-analysis (IPDMA). Meta-review findings of this dissertation underscore that when engaging in particular behavior leads to the acquisition of important peer-status-related goals, harmful social behavior may also develop from adequate self-regulation. Empirical findings indicate that the prospect of status affordances can motivate adolescents to engage in harmful social behavior and that descriptive and injunctive peer norms can convey such status prospects effectively. IPDMA findings illustrate that we can reach more adolescent cooperation and collectivism than we are currently promoting via interventions. In this dissertation, I argue we can do this in two ways. One, teach adolescents how they can achieve status by behaving prosocially. And two, change peer norms that reward harmful social behavior with popularity
Age-related positivity effect in emotional memory consolidation from middle age to late adulthood
Background: While younger adults are more likely to attend to, process, and remember negative relative to positive information, healthy older adults show the opposite pattern. The current study evaluates when, exactly, this positivity shift begins, and how it influences memory performance for positive, negative, and neutral information. Methods: A total of 274 healthy early middle-aged (35–47), late middle-aged (48–59), and older adults (>59) viewed scenes consisting of a negative, positive, or a neutral object placed on a plausible neutral background, and rated each scene for its valence and arousal. After 12 h spanning a night of sleep (n = 137) or a day of wakefulness (n = 137), participants completed an unexpected memory test during which they were shown objects and backgrounds separately and indicated whether the scene component was the “same,” “similar,” or “new” to what they viewed during the study session. Results and conclusions: We found that both late middle-aged and older adults rated positive and neutral scenes more positively compared to early middle-aged adults. However, only older adults showed better memory for positive objects relative to negative objects, and a greater positive memory trade-off magnitude (i.e., remembering positive objects at the cost of their associated neutral backgrounds) than negative memory trade-off magnitude (i.e., remembering negative objects at the cost of their associated neutral backgrounds). Our findings suggest that while the positivity bias may not emerge in memory until older adulthood, a shift toward positivity in terms of processing may begin in middle age
Spatial epidemiology of a highly transmissible disease in urban neighbourhoods: Using COVID-19 outbreaks in Toronto as a case study
The emergence of infectious diseases in an urban area involves a complex interaction between the socioecological processes in the neighbourhood and urbanization. As a result, such an urban environment can be the incubator of new epidemics and spread diseases more rapidly in densely populated areas than elsewhere. Most recently, the Coronavirus-19 (COVID-19) pandemic has brought unprecedented challenges around the world. Toronto, the capital city of Ontario, Canada, has been severely impacted by COVID-19. Understanding the spatiotemporal patterns and the key drivers of such patterns is imperative for designing and implementing an effective public health program to control the spread of the pandemic. This dissertation was designed to contribute to the global research effort on the COVID-19 pandemic by conducting spatial epidemiological studies to enhance our understanding of the disease's epidemiology in a spatial context to guide enhancing the public health strategies in controlling the disease.
Comprised of three original research manuscripts, this dissertation focuses on the spatial epidemiology of COVID-19 at a neighbourhood scale in Toronto. Each manuscript makes scientific contributions and enhances our knowledge of how interactions between different socioecological processes in the neighbourhood and urbanization can influence spatial spread and patterns of COVID-19 in Toronto with the application of novel and advanced methodological approaches. The findings of the outcomes of the analyses are intended to contribute to the public health policy that informs neighbourhood-based disease intervention initiatives by the public health authorities, local government, and policymakers.
The first manuscript analyzes the globally and locally variable socioeconomic drivers of COVID-19 incidence and examines how these relationships vary across different neighbourhoods. In the global model, lower levels of education and the percentage of immigrants were found to have a positive association with increased risk for COVID-19. This study provides the methodological framework for identifying the local variations in the association between risk for COVID-19 and socioeconomic factors in an urban environment by applying a local multiscale geographically weighted regression (MGWR) modelling approach. The MGWR model is an improvement over the methods used in earlier studies of COVID-19 in identifying local variations of COVID-19 by incorporating a correction factor for the multiple testing problem in the geographically weighted regression models.
The second manuscript quantifies the associations between COVID-19 cases and urban socioeconomic and land surface temperature (LST) at the neighbourhood scale in Toronto. Four spatiotemporal Bayesian hierarchical models with spatial, temporal, and varying space-time interaction terms are compared. The results of this study identified the seasonal trends of COVID-19 risk, where the spatiotemporal trends show increasing, decreasing, or stable patterns, and identified area-specific spatial risk for targeted interventions. Educational level and high land surface temperature are shown to have a positive association with the risk for COVID-19. In this study, high spatial and temporal resolution satellite images were used to extract LST, and atmospheric corrections methods were applied to these images by adopting a land surface emissivity (LSE) model, which provided a high estimation accuracy. The methodological approach of this work will help researchers understand how to acquire long time-series data of LST at a spatial scale from satellite images, develop methodological approaches for atmospheric correction and create the environmental data with a high estimation accuracy to fit into modelling disease. Applying to policy, the findings of this study can inform the design and implementation of urban planning strategies and programs to control disease risks.
The third manuscript developed a novel approach for visualization of the spread of infectious disease outbreaks by incorporating neighbourhood networks and the time-series data of the disease at the neighbourhood level. The findings of the model provide an understanding of the direction and magnitude of spatial risk for the outbreak and guide for the importance of early intervention in order to stop the spread of the outbreak. The manuscript also identified hotspots using incidence rate and disease persistence, the findings of which may inform public health planners to develop priority-based intervention plans in a resource constraint situation
Genomic architecture of selection for adaptation to challenging environments in aquaculture
Aquaculture, including freshwater and marine farming, has been important for global fish production during the past few decades. However, climate change presents a major risk threatening both quality and quantity of aquaculture production. The environmental stressors in aquaculture resulting from climate change, are temperature rise, salinity changes, sea level rise, acidification and changes of other chemical properties and changes of oxygen levels. Although a reasonable genetic gain can be achieved by selective breeding, this genetic response may not be enough to adapt fish species to the effects of climate change. Marker assisted selection focusing on specific genes or alleles that allow fish to cope with
these changes would allow more rapid adaptation of fish to these new environments. In this thesis, I focused on three essential environmental stressors - dissolved oxygen, salinity and temperature as primarily determined in aquaculture production. The main objective is to provide insight in the genomic architecture underlying the mechanism of adaptation to challenging environments of aquaculture
species under farming conditions. First, I determined candidate QTL associated with phenotypic variation during adaptation to hypoxia or normoxia. I identified overrepresented pathways that could explain the genetic regulation of hypoxia on growth. To identify fish with better hypoxia tolerance and growth under a hypoxic environment, I quantified the genetic correlations between an indicator trait for hypoxia tolerance (critical swimming performance) and growth. Moreover, the genomic architecture associated with swimming performance was demonstrated, while the effect of significant QTLs on growth was estimated. Beyond applying genome-wide association studies, I used selection signatures to identify QTLs and
genes contributing to salinity tolerance. In addition, I also compared the genome of the saline-tolerant and highly productive tilapia “Sukamandi”, that was developed by the aquaculture research institute in Indonesia, to that of blue tilapia and Nile tilapia, to identify the QTLs contributing to salinity tolerance. Finally, I investigated QTLs associated with growth-related traits and organ weights at two distinct
commercial Mediterranean product sites differing in temperature (farms in Spain and Greece). Overall, this thesis considerably adds to insight into how fish adapt to challenging environments, which will aid marker-assisted selection for improved resilience of aquaculture species under climate change
Effects of municipal smoke-free ordinances on secondhand smoke exposure in the Republic of Korea
ObjectiveTo reduce premature deaths due to secondhand smoke (SHS) exposure among non-smokers, the Republic of Korea (ROK) adopted changes to the National Health Promotion Act, which allowed local governments to enact municipal ordinances to strengthen their authority to designate smoke-free areas and levy penalty fines. In this study, we examined national trends in SHS exposure after the introduction of these municipal ordinances at the city level in 2010.MethodsWe used interrupted time series analysis to assess whether the trends of SHS exposure in the workplace and at home, and the primary cigarette smoking rate changed following the policy adjustment in the national legislation in ROK. Population-standardized data for selected variables were retrieved from a nationally representative survey dataset and used to study the policy action’s effectiveness.ResultsFollowing the change in the legislation, SHS exposure in the workplace reversed course from an increasing (18% per year) trend prior to the introduction of these smoke-free ordinances to a decreasing (−10% per year) trend after adoption and enforcement of these laws (β2 = 0.18, p-value = 0.07; β3 = −0.10, p-value = 0.02). SHS exposure at home (β2 = 0.10, p-value = 0.09; β3 = −0.03, p-value = 0.14) and the primary cigarette smoking rate (β2 = 0.03, p-value = 0.10; β3 = 0.008, p-value = 0.15) showed no significant changes in the sampled period. Although analyses stratified by sex showed that the allowance of municipal ordinances resulted in reduced SHS exposure in the workplace for both males and females, they did not affect the primary cigarette smoking rate as much, especially among females.ConclusionStrengthening the role of local governments by giving them the authority to enact and enforce penalties on SHS exposure violation helped ROK to reduce SHS exposure in the workplace. However, smoking behaviors and related activities seemed to shift to less restrictive areas such as on the streets and in apartment hallways, negating some of the effects due to these ordinances. Future studies should investigate how smoke-free policies beyond public places can further reduce the SHS exposure in ROK
Connecting the Dots in Trustworthy Artificial Intelligence: From AI Principles, Ethics, and Key Requirements to Responsible AI Systems and Regulation
Trustworthy Artificial Intelligence (AI) is based on seven technical
requirements sustained over three main pillars that should be met throughout
the system's entire life cycle: it should be (1) lawful, (2) ethical, and (3)
robust, both from a technical and a social perspective. However, attaining
truly trustworthy AI concerns a wider vision that comprises the trustworthiness
of all processes and actors that are part of the system's life cycle, and
considers previous aspects from different lenses. A more holistic vision
contemplates four essential axes: the global principles for ethical use and
development of AI-based systems, a philosophical take on AI ethics, a
risk-based approach to AI regulation, and the mentioned pillars and
requirements. The seven requirements (human agency and oversight; robustness
and safety; privacy and data governance; transparency; diversity,
non-discrimination and fairness; societal and environmental wellbeing; and
accountability) are analyzed from a triple perspective: What each requirement
for trustworthy AI is, Why it is needed, and How each requirement can be
implemented in practice. On the other hand, a practical approach to implement
trustworthy AI systems allows defining the concept of responsibility of
AI-based systems facing the law, through a given auditing process. Therefore, a
responsible AI system is the resulting notion we introduce in this work, and a
concept of utmost necessity that can be realized through auditing processes,
subject to the challenges posed by the use of regulatory sandboxes. Our
multidisciplinary vision of trustworthy AI culminates in a debate on the
diverging views published lately about the future of AI. Our reflections in
this matter conclude that regulation is a key for reaching a consensus among
these views, and that trustworthy and responsible AI systems will be crucial
for the present and future of our society.Comment: 30 pages, 5 figures, under second revie
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