New Developments in Genetic/Genomic Testing: Implications for Population Health

This Forum presentation provides an overview on current trends in genetic testing and explores ways in which genetic testing is regulated and reimbursed in the U.S. The presentation also includes and explanation of how genetic tests are assessed in terms of evidence, including challenges and pitfalls. An understanding of how the implications of genetic testing on population help is discussed. Vivian Coates, MBA, is Vice President of Information Services and Health Technology Assessment at ECRI Institute where developed and leads ECRI Institute’s evidence-based medicine and health technology assessment program, including the Evidence-based Practice Center (EPC) and the Health Technology Assessment Information Service (HTAIS) for health plans, hospitals/health systems and health policymakers. She initiates and fosters relationships with users of comparative effectiveness and health technology assessment information to promote evidence-based approaches for clinical practice guideline development, healthcare coverage, purchasing, delivery, and policy making. Ms. Coates’ most recent initiative is the development of ECRI’s personalized medicine resource on genetic/genomic testing, ECRIgene. This interactive database includes critical information on hundreds of genetic, genomic and proteomic tests meeting ECRI’s criteria for inclusion. Presentation: 50:3

Interference and intrusion in wireless sensor networks

Wireless sensor network (WSN) systems for safety-critical, space and Internet of Things applications have recently begun to adopt open standards and commercial-off-the-shelf equipment, and persistently face challenges of malicious intrusion and spectrum coexistence. These threats are explored through Monte-Carlo simulation and benchtop testing, including matched protocol interference and sophisticated, interactive intrusion attacks. The need for expanding intrusion detection via a more holistic approach, whilst simultaneously improving WSN security, is illustrated. Discussions on WSN security, vulnerabilities, and attacks are also provided

Towards critical event monitoring, detection and prediction for self-adaptive future Internet applications

The Future Internet (FI) will be composed of a multitude of diverse types of services that offer flexible, remote access to software features, content, computing resources, and middleware solutions through different cloud delivery models, such as IaaS, PaaS and SaaS. Ultimately, this means that loosely coupled Internet services will form a comprehensive base for developing value added applications in an agile way. Unlike traditional application development, which uses computing resources and software components under local administrative control, FI applications will thus strongly depend on third-party services. To maintain their quality of service, those applications therefore need to dynamically and autonomously adapt to an unprecedented level of changes that may occur during runtime. In this paper, we present our recent experiences on monitoring, detection, and prediction of critical events for both software services and multimedia applications. Based on these findings we introduce potential directions for future research on self-adaptive FI applications, bringing together those research directions

Ten Simple Rules for Reproducible Research in Jupyter Notebooks

Reproducibility of computational studies is a hallmark of scientific methodology. It enables researchers to build with confidence on the methods and findings of others, reuse and extend computational pipelines, and thereby drive scientific progress. Since many experimental studies rely on computational analyses, biologists need guidance on how to set up and document reproducible data analyses or simulations. In this paper, we address several questions about reproducibility. For example, what are the technical and non-technical barriers to reproducible computational studies? What opportunities and challenges do computational notebooks offer to overcome some of these barriers? What tools are available and how can they be used effectively? We have developed a set of rules to serve as a guide to scientists with a specific focus on computational notebook systems, such as Jupyter Notebooks, which have become a tool of choice for many applications. Notebooks combine detailed workflows with narrative text and visualization of results. Combined with software repositories and open source licensing, notebooks are powerful tools for transparent, collaborative, reproducible, and reusable data analyses

Distance learning of foreign languages

doi: 10.1017/S0261444806003727This article provides a critical overview of the field of distance language learning, challenging the way in which the field is often narrowly conceptualised as the development of technology-mediated language learning opportunities. Early sections focus on issues of concept and definition and both theoretical and pedagogical perspectives on the field. Emphasis is placed on evident shifts from a concern with structural and organisational issues to a focus on transactional issues associated with teaching/learning opportunities within emerging paradigms for distance language learning. The next section reviews choices and challenges in incorporating technology into distance language learning environments, foregrounding decisions about technology made in particular sociocultural contexts, the contribution of ‘low-end’ technologies and research directions in developing new learning spaces and in using online technologies. The investigation of learner contributions to distance language learning is an important avenue of enquiry in the field, given the preoccupation with technology and virtual learning environments, and this is the subject of section six. The two final sections identify future research directions and provide a series of conclusions about research and practice in distance language learning as technology-mediated interactions increasingly come to influence the way we think about the processes of language learning and teaching

Changing the way we learn: towards agile learning and co-operation

This paper addresses the need for learning and competence development in industrial organizations. The people that enter professional organizations today are part of a gamer generation that have some or much experience with on-line games. Therefore they are more open to e-learning and in general more open to access anything on-line. At the same time industrial organizations experience a pressure on their ability to train employees faster due to the increase in complexity. We argue that games are not yet mature enough to support this training challenge as stand alone efforts. But games can support the training and competence development in a synchronized setup with other means

Exploring Research through Design in Animal-Computer Interaction

This paper explores Research through Design (RtD) as a potential methodology for developing new interactive experiences for animals. We present an example study from an on-going project and examine whether RtD offers an appropriate framework for developing knowledge in the context of Animal-Computer Interaction, as well as considering how best to document such work. We discuss the design journey we undertook to develop interactive systems for captive elephants and the extent to which RtD has enabled us to explore concept development and documentation of research. As a result of our explorations, we propose that particular aspects of RtD can help ACI researchers gain fresh perspectives on the design of technology-enabled devices for non-human animals. We argue that these methods of working can support the investigation of particular and complex situations where no idiomatic interactions yet exist, where collaborative practice is desirable and where the designed objects themselves offer a conceptual window for future research and development

Lessons Learned from a Decade of Providing Interactive, On-Demand High Performance Computing to Scientists and Engineers

For decades, the use of HPC systems was limited to those in the physical sciences who had mastered their domain in conjunction with a deep understanding of HPC architectures and algorithms. During these same decades, consumer computing device advances produced tablets and smartphones that allow millions of children to interactively develop and share code projects across the globe. As the HPC community faces the challenges associated with guiding researchers from disciplines using high productivity interactive tools to effective use of HPC systems, it seems appropriate to revisit the assumptions surrounding the necessary skills required for access to large computational systems. For over a decade, MIT Lincoln Laboratory has been supporting interactive, on-demand high performance computing by seamlessly integrating familiar high productivity tools to provide users with an increased number of design turns, rapid prototyping capability, and faster time to insight. In this paper, we discuss the lessons learned while supporting interactive, on-demand high performance computing from the perspectives of the users and the team supporting the users and the system. Building on these lessons, we present an overview of current needs and the technical solutions we are building to lower the barrier to entry for new users from the humanities, social, and biological sciences.Comment: 15 pages, 3 figures, First Workshop on Interactive High Performance Computing (WIHPC) 2018 held in conjunction with ISC High Performance 2018 in Frankfurt, German

Benefits, Limitations and Best Practices of Online Coursework…Should Accounting Programs Jump on Board?

The evolution of online teaching has evolved as quickly and vivaciously as the adoption of the World Wide Web. While there were and are skeptics, research shows that not only is online learning more convenient and makes educational available anytime and anywhere, it has the potential, in some cases, to be an improved tool for educating. To ensure maximized learning outcomes, and to experience the blessing and not the curse of online coursework, it is critical that universities embrace it wholeheartedly and follow online pedagogical best practices in developing and executing online courses. In addition, there are some courses where special forethought should be made to ensure online learning is effective. Courses that are more computational necessitate this consideration. This document serves to provide strategies and best practices on how to obtain excellence and maximized outcomes from online education. It examines research to date and outlines: the benefits and challenges of online learning, strategies and best practices for online educating, and considerations for online accounting coursework