Theoretical description of a DNA-linked nanoparticle self-assembly

Nanoparticles tethered with DNA strands are promising building blocks for bottom-up nanotechnology, and a theoretical understanding is important for future development. Here we build on approaches developed in polymer physics to provide theoretical descriptions for the equilibrium clustering and dynamics, as well as the self-assembly kinetics of DNA-linked nanoparticles. Striking agreement is observed between the theory and molecular modeling of DNA tethered nanoparticles.Comment: Accepted for publication in Physical Review Letter

Introduction to nanotechnology in eco-efficient construction

This chapter briefly reviews recent developments on the field of nanotechnology. Patent production by top countries are reviewed.  Some nanotech limitations are highlighted. The case of nanotechnology influence on the development of eco-efficient construction and building materials and its contribution for 2030 agenda for sustainable development is briefly addressed. A book outline is included.(undefined)info:eu-repo/semantics/publishedVersio

Steps to Designing AI-Empowered Nanotechnology: A Value Sensitive Design Approach

Advanced nanotechnology promises to be one of the fundamental transformational emerging technologies alongside others such as artificial intelligence, biotechnology, and other informational and cognitive technologies. Although scholarship on nanotechnology, particularly advanced nanotechnology such as molecular manufacturing has nearly ceased in the last decade, normal nanotechnology that is building the foundations for more advanced versions has permeated many industries and commercial products and has become a billion dollar industry. This paper acknowledges the socialtechnicity of advanced nanotechnology and proposes how its convergence with other enabling technologies like AI can be anticipated and designed with human values in mind. Preliminary guidelines inspired by the Value Sensitive Design approach to technology design are proposed for molecular manufacturing in the age of artificial intelligence

Programing strand displacement reaction pathways using small molecular DNA binders

DNA has been used in nature as carriers of heredity information for billions of years. The last four decades have witnessed the success of DNA nanotechnology, an interdisciplinary research area in which DNA is used as a synthetic engineering tool rather than a carrier of genetic information. The growth of DNA nanotechnology crosses the boundaries between physics, chemistry, biology and computer science and enables DNA to function as an electronic component, substrate, drug delivery vector and data storage unit. The hybridization of DNA strictly follows the by Watson-Crick rule; thus, DNA base pairs are the most reliable and predictable building block in the true nanometer range. New methods and designs for controlling DNA hybridization have always provided the most essential momentum for the development of DNA nanotechnology. When small molecules bind to the double helical structure of DNA, either through intercalation or minor groove binding, the stability and functionality of DNA may be significantly altered, which is a fundamental basis for many therapeutic and sensing applications. Herein, we reveal, for the first time, that small molecular DNA binders may also be used to program the reaction pathways of toehold-mediated DNA strand displacement, an elementary building block in DNA nanotechnology

Multiple light scattering and near-field effects in a fractal tree-like ensamble of dielectric nanoparticles

We numerically study light scattering and absorption in self-similar aggregates of dielectric nanoparticles, as generated by simulated ballistic deposition upon a surface starting from a single seed particle. The resulting structure exhibits a complex tree-like shape, intended to mimic the morphologic properties of building blocks of real nanostructured thin films produced by means of fine controlled physical deposition processes employed in nanotechnology. The relationship of scattering and absorption cross sections to morphology is investigated within a computational scheme which thoroughly takes into account both multiple scattering and near-field effects. Numerical results are compared with a pre-existing single scattering limited analytical treatment of light scattering in fractal aggregates of small dielectric particles.Comment: 10 pages, 9 figures. Accepted for publication in Physical Review

Controlling the assembly of coiled-coil peptide nanotubes

An ability to control the assembly of peptide nanotubes (PNTs) would provide biomaterials for applications in nanotechnology and synthetic biology. Recently, we presented a modular design for PNTs using α-helical barrels with tunable internal cavities as building blocks. These first-generation designs thicken beyond single PNTs. Herein we describe strategies for controlling this lateral association, and also for the longitudinal assembly. We show that PNT thickening is pH sensitive, and can be reversed under acidic conditions. Based on this, repulsive charge interactions are engineered into the building blocks leading to the assembly of single PNTs at neutral pH. The building blocks are modified further to produce covalently linked PNTs via native chemical ligation, rendering ca. 100 nm-long nanotubes. Finally, we show that small molecules can be sequestered within the interior lumens of single PNTs

The Eco Office: Dynamic and Homeostatic Facades inspired by BIOMORPHIM, BIOMIMICRY, and BIOPHILIA

"Come forth into the light of things, Let Nature be your teacher.” ~ William Wordsworth The focus of this dissertation research is to extend and increase an understanding of sustainable building envelope design strategies, with specific focus on transfer of light, air, and heat, within a tropical site setting/context. Biomimetic architecture is a process that is primarily driven by inspiration from natural systems and organisms. Designs and patterns found in nature are often resolved at the “macro” as well as at the “micro/nano” molecular levels, which prompts further investigation into present-day advancements in material science and nanotechnological concepts. Nanotechnology is a way of looking closer at systems and material structures and properties; the translation from biomimetic architecture to the nano-molecular scale of materials thus promotes sustainability in buildings, by providing ways and means to incorporate new technologies and novel material systems into the architectural design of building facades, that will further aid with the successful implementation of passive design strategies, in order to establish comfortable interior lighting, ventilation, and thermal conditions. Extensive literature reviews and material research are utilized for the bio-tonano design process and analyses. Performance of design modules created has been tested using design simulations and reiterative analysis processes. “Taking cues from Nature – creation of responsive (environment and human responsive) architecture” – is the idea that is the primary motivation behind the research focus. The key goal of this research is to propose alternative futures in building envelope design, for a site in Honolulu, which would serve as a digital prototype for similar such investigations into integrating nature-inspired macro and nanotechnology structures and materials into building systems design. Psychophysiology (the mind-body-interaction) and experimental testing is used as part of the final testing and analysis, to assess people’s responses to nature-inspired design and emerging building technologies

Flexible Use And Aplication Of Energy Efficiency Measures In Existing Multi-Residential Buildings

Recent trends in energy efficiency around the world and implementation of flexible housing are taking a big burst of development. Nanotechnology and thermal insulation materials along with photovoltaic panels will be explored in residential facilities. Needs for higher comfort and the socio-economic situation ask for research, use of eco systems and innovative solutions. The case study will be the collective residential building near the Swiss Diamond Hotel in Mother Teresa Square in Prishtina. Some of the proposed interventions will be manoeuvrings with flexible housing units, intervention on the facade with the nanotechnology insulating material as well as covering one part of the facility with photovoltaic panels. This research is based on analysing the location, facility use, orientation, surrounding site. The proposed concepts are in complete harmony with the reasonabilityof the investment. Applying these measures, besides economic, ecological and comfort benefits will also affect the adaptation of the building with the surrounding buildings