The Complementary Brain: From Brain Dynamics To Conscious Experiences

How do our brains so effectively achieve adaptive behavior in a changing world? Evidence is reviewed that brains are organized into parallel processing streams with complementary properties. Hierarchical interactions within each stream and parallel interactions between streams create coherent behavioral representations that overcome the complementary deficiencies of each stream and support unitary conscious experiences. This perspective suggests how brain design reflects the organization of the physical world with which brains interact, and suggests an alternative to the computer metaphor suggesting that brains are organized into independent modules. Examples from perception, learning, cognition, and action are described, and theoretical concepts and mechanisms by which complementarity is accomplished are summarized.Defense Advanced Research Projects and the Office of Naval Research (N00014-95-1-0409); National Science Foundation (ITI-97-20333); Office of Naval Research (N00014-95-1-0657

Stabilization over power-constrained parallel Gaussian channels

This technical note is concerned with state-feedback stabilization of multi-input systems over parallel Gaussian channels subject to a total power constraint. Both continuous-time and discrete-time systems are treated under the framework of H2 control, and necessary/sufficient conditions for stabilizability are established in terms of inequalities involving unstable plant poles, transmitted power, and noise variances. These results are further used to clarify the relationship between channel capacity and stabilizability. Compared to single-input systems, a range of technical issues arise. In particular, in the multi-input case, the optimal controller has a separation structure, and the lower bound on channel capacity for some discrete-time systems is unachievable by linear time-invariant (LTI) encoders/decoder

The Complementary Brain: A Unifying View of Brain Specialization and Modularity

Defense Advanced Research Projects Agency and Office of Naval Research (N00014-95-I-0409); National Science Foundation (ITI-97-20333); Office of Naval Research (N00014-95-I-0657

Lecture Notes on Network Information Theory

These lecture notes have been converted to a book titled Network Information Theory published recently by Cambridge University Press. This book provides a significantly expanded exposition of the material in the lecture notes as well as problems and bibliographic notes at the end of each chapter. The authors are currently preparing a set of slides based on the book that will be posted in the second half of 2012. More information about the book can be found at http://www.cambridge.org/9781107008731/. The previous (and obsolete) version of the lecture notes can be found at http://arxiv.org/abs/1001.3404v4/

Elucidation of molecular kinetic schemes from macroscopic traces using system identification

Overall cellular responses to biologically-relevant stimuli are mediated by networks of simpler lower-level processes. Although information about some of these processes can now be obtained by visualizing and recording events at the molecular level, this is still possible only in especially favorable cases. Therefore the development of methods to extract the dynamics and relationships between the different lower-level (microscopic) processes from the overall (macroscopic) response remains a crucial challenge in the understanding of many aspects of physiology. Here we have devised a hybrid computational-analytical method to accomplish this task, the SYStems-based MOLecular kinetic scheme Extractor (SYSMOLE). SYSMOLE utilizes system-identification input-output analysis to obtain a transfer function between the stimulus and the overall cellular response in the Laplace-transformed domain. It then derives a Markov-chain state molecular kinetic scheme uniquely associated with the transfer function by means of a classification procedure and an analytical step that imposes general biological constraints. We first tested SYSMOLE with synthetic data and evaluated its performance in terms of its rate of convergence to the correct molecular kinetic scheme and its robustness to noise. We then examined its performance on real experimental traces by analyzing macroscopic calcium-current traces elicited by membrane depolarization. SYSMOLE derived the correct, previously known molecular kinetic scheme describing the activation and inactivation of the underlying calcium channels and correctly identified the accepted mechanism of action of nifedipine, a calcium-channel blocker clinically used in patients with cardiovascular disease. Finally, we applied SYSMOLE to study the pharmacology of a new class of glutamate antipsychotic drugs and their crosstalk mechanism through a heteromeric complex of G protein-coupled receptors. Our results indicate that our methodology can be successfully applied to accurately derive molecular kinetic schemes from experimental macroscopic traces, and we anticipate that it may be useful in the study of a wide variety of biological systems

Random Access Game in Fading Channels with Capture: Equilibria and Braess-like Paradoxes

The Nash equilibrium point of the transmission probabilities in a slotted ALOHA system with selfish nodes is analyzed. The system consists of a finite number of heterogeneous nodes, each trying to minimize its average transmission probability (or power investment) selfishly while meeting its average throughput demand over the shared wireless channel to a common base station (BS). We use a game-theoretic approach to analyze the network under two reception models: one is called power capture, the other is called signal to interference plus noise ratio (SINR) capture. It is shown that, in some situations, Braess-like paradoxes may occur. That is, the performance of the system may become worse instead of better when channel state information (CSI) is available at the selfish nodes. In particular, for homogeneous nodes, we analytically present that Braess-like paradoxes occur in the power capture model, and in the SINR capture model with the capture ratio larger than one and the noise to signal ratio sufficiently small.Comment: 30 pages, 5 figure

Elements of Cellular Blind Interference Alignment --- Aligned Frequency Reuse, Wireless Index Coding and Interference Diversity

We explore degrees of freedom (DoF) characterizations of partially connected wireless networks, especially cellular networks, with no channel state information at the transmitters. Specifically, we introduce three fundamental elements --- aligned frequency reuse, wireless index coding and interference diversity --- through a series of examples, focusing first on infinite regular arrays, then on finite clusters with arbitrary connectivity and message sets, and finally on heterogeneous settings with asymmetric multiple antenna configurations. Aligned frequency reuse refers to the optimality of orthogonal resource allocations in many cases, but according to unconventional reuse patterns that are guided by interference alignment principles. Wireless index coding highlights both the intimate connection between the index coding problem and cellular blind interference alignment, as well as the added complexity inherent to wireless settings. Interference diversity refers to the observation that in a wireless network each receiver experiences a different set of interferers, and depending on the actions of its own set of interferers, the interference-free signal space at each receiver fluctuates differently from other receivers, creating opportunities for robust applications of blind interference alignment principles