ANALYSIS OF GOVERNANCE, EXTERNAL GUARANTEE, COMPANY CHARACTERISTICS AND RESURRECTION SUSTAINABILITY REPORT

Thie research purpose to analyze the governance, external assurance, firm-level characteristics and financial distress on the sustainability reporting. The method used in this study is multiple regression analysis using Eviews 9. The samples used in this research are 242 which the data of 121 manufacturing companies listed on the Indonesia Stock Exchange from 2014-2015. The result shows that the governance committee, the sustainability report of the assurance provider, the number of members on the audit committee and the number of members on the board of directors as firm-level characteristics have a significant positive effect on sustainability reporting. Financial distress has a significant negative effect on sustainability reporting. Operating cash flow has no significant effect on sustainability reporting, whereas log total assets have a significant positive effect on sustainability reportin

Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia

Analysis of 3D chromatin architecture in T-ALL identifies differences in intra-TAD interactions and TAD boundary insulation. Inhibition of oncogenic signal transduction or epigenetic regulation can alter specific 3D interactions. Differences in three-dimensional (3D) chromatin architecture can influence the integrity of topologically associating domains (TADs) and rewire specific enhancer-promoter interactions, impacting gene expression and leading to human disease. Here we investigate the 3D chromatin architecture in T cell acute lymphoblastic leukemia (T-ALL) by using primary human leukemia specimens and examine the dynamic responses of this architecture to pharmacological agents. Systematic integration of matched in situ Hi-C, RNA-seq and CTCF ChIP-seq datasets revealed widespread differences in intra-TAD chromatin interactions and TAD boundary insulation in T-ALL. Our studies identify and focus on a TAD 'fusion' event associated with absence of CTCF-mediated insulation, enabling direct interactions between the MYC promoter and a distal super-enhancer. Moreover, our data also demonstrate that small-molecule inhibitors targeting either oncogenic signal transduction or epigenetic regulation can alter specific 3D interactions found in leukemia. Overall, our study highlights the impact, complexity and dynamic nature of 3D chromatin architecture in human acute leukemia

ANALISIS TATA KELOLA, JAMINAN EKSTERNAL, KARAKTERISTIK PERUSAHAAN DAN KEBANGKRUTAN TERHADAP LAPORAN KEBERLANJUTAN (Studi Empiris pada Perusahaan Manufaktur yang Tercatat di Bursa Efek Indonesia)

The research purposed to analyze the governance, external assurance, firm-level characteristics and financial distress on the sustainability reporting. The method used in this study are multiple regression analysis using Eviews 9. The samples used in this research are 242 which is the data of 121 manufacturing companies listed in Indonesia Stock Exchange from 2014-2015. The results show that governance committee, sustainability report assurance provider, number of members on the audit committee and the number of members on the board of directors as firm-level characteristics have a significant positive effect on the sustainability reporting. Financial distress has a significant negative effect on the sustainability reporting. Operating cash flow has not a significant effect on the sustainability reporting, whereas log total asset has significant positive effect on the sustainability reporting

A Methodology to Analyze the Presence of Sustainability in Engineering Curricula. Case of Study: Ten Spanish Engineering Degree Curricula

This paper presents a methodology to analyze the sustainability presence level in the curriculum of an engineering degree. The methodology is applied to ten engineering degrees of the Spanish university system, taught in three di erent universities. The design used for the research is quantitative and correlational. The analytical instrument used is the engineering sustainability map, which contains the learning outcomes related to sustainability that are expected of engineering students upon completion of their studies. The methodology is used to analyze the curricula of the ten engineering degrees in order to identify what learning outcomes of the engineering sustainability map are developed in each degree. The results indicate that the sustainability competency least present in all the degrees is the “participation in community processes that promotes sustainability,” with an average presence of 23.3%, while the most present is the “application of ethical principles related to the values of sustainability in personal and professional behavior,” with an average presence of 76.6%. In general, learning outcomes related to sustainability have an average presence of 52.1%, so practically half of the cells in the ten engineering sustainability maps are not developed in the degrees under study

Molecular identification of differentially expressed Zinc related genes in cultivated bread wheat

Zinc (Zn) is an essential micronutrient required for adequate growth of plant species. Zinc is particularly needed for structural and functional integrity of enzymes and biological membranes and directly involved in synthesis of protein. Consequently, Zn deficiency results in severe decreases in growth and yield. Among the crop species, wheat is very sensitive to Zn deficiency. There is very limited information on the molecular mechanisms affecting expression of high Zn deficiency tolerance. Our objective in this study is, therefore, to identify the differentially expressed cDNA fragments in response to varying levels of Zn applications in a tolerant cultivated wheat genotype. For this purpose, we performed a screening experiment by using a number of cultivated bread wheat genotypes which displayed a considerable variation in response to Zn deficiency. Among various modern bread wheat genotypes tested, Bezostaja was selected as the most tolerant genotype. mRNA differential display method has been used to study the expression profile of Bezostaja genotype exposed to different Zn treatments. We observed 20 differentially expressed cDNA bands by using mRNA differential display. Out of 20 cDNA fragments that were isolated, cloned and sequenced, 14 cDNAs displayed similarity with previously identified metal Zn binding proteins and enzymes such as; alcohol dehydrogenase, cystathionine gamma synthase, and cation diffusion facilitator family transporter containing protein

RUNX1 Is an Oncogenic Transcription Factor that Regulates MYB and MYC Enhancer Activity in T-ALL

RUNX1, a transcription factor required for hematopoiesis and lymphocyte differentiation, is one of the most commonly targeted genes in hematopoietic malignancies. Mutations in the RUNX1 gene are associated with a poor prognosis in a subset of T cell acute lymphoblastic leukemia (T-ALL) and RUNX1 has been proposed as a tumor suppressor in TLX1/3-transformed human T-ALL. Recent ChIP-seq studies in human T-ALL cell lines demonstrated that a large portion of TAL1- and NOTCH1- bound regions contain RUNX binding sites in promoter or enhancer regions, suggesting oncogenic roles for RUNX1 in T-ALL. To interrogate RUNX1 functions in leukemogenesis, we depleted RUNX1 in a T-ALL mouse model and in human T-ALL cell lines. We found that RUNX1 is required for the maintenance of mouse T-ALL growth in vivo and the survival of human T-ALL cell lines in vitro. In addition, inhibition of the RUNX1 activity with a small molecule inhibitor impairs the growth of human T-ALL cell lines and primary patient samples. RUNX1 depletion reduces the expression of a subset of TAL1- and NOTCH1- regulated genes including the MYB and MYC oncogenes, respectively. We demonstrate that RUNX1 regulates transcription factor binding and acetylation of H3K27 at the Myb and Myc enhancer loci. These studies provide genetic and pharmacological evidences that RUNX1 supports T-ALL cell survival and suggest RUNX1 inhibitor as a therapeutic strategy in T-ALL treatment

The Texan

Texas Student Medi

The Ursinus Weekly, November 26, 1909

Historical-Political group meeting • History class at Penn • Football • Society notes • Gossip • Handel Choral Society • Professor Riddle honoredhttps://digitalcommons.ursinus.edu/weekly/2816/thumbnail.jp

Xavier University Newswire

A searchable electronic archive of the Xaverian News student newspaper from Xavier University in Cincinnati, Ohiohttps://www.exhibit.xavier.edu/student_newspaper/1213/thumbnail.jp