Machine learning with ensemble stacking model for automated sleep staging using dual-channel EEG signal

Abstract Sleep staging is an important part of diagnosing the different types of sleep-related disorders because any discrepancies in the sleep scoring process may cause serious health problems such as misinterpretations of sleep patterns, medication errors, and improper diagnosis. The best way of analyzing sleep staging is visual interpretations of the polysomnography (PSG) signals recordings from the patients, which is a quite tedious task, requires more domain experts, and time-consuming process. This proposed study aims to develop a new automated sleep staging system using the brain EEG signals. Based on a new automated sleep staging system based on an ensemble learning stacking model that integrates Random Forest (RF) and eXtreme Gradient Boosting (XGBoosting). Additionally, this proposed methodology considers the subjects' age, which helps analyze the S1 sleep stage properly. In this study, both linear (time and frequency) and non-linear features are extracted from the pre-processed signals. The most relevant features are selected using the ReliefF weight algorithm. Finally, the selected features are classified through the proposed two-layer stacking model. The proposed methodology performance is evaluated using the two most popular datasets, such as the Sleep-EDF dataset (S-EDF) and Sleep Expanded-EDF database (SE-EDF) under the Rechtschaffen & Kales (R&K) sleep scoring rules. The performance of the proposed method is also compared with the existing published sleep staging methods. The comparison results signify that the proposed sleep staging system has an excellent improvement in classification accuracy for the six-two sleep states classification. In the S-EDF dataset, the overall accuracy and Cohen's kappa coefficient score obtained by the proposed model is (91.10%, 0.87) and (90.68%, 0.86) with inclusion and exclusion of age feature using the Fpz-Cz channel, respectively. Similarly, the Pz-Oz channel's performance is (90.56%, 0.86) with age feature and (90.11%, 0.86) without age feature. The performed results with the SE-EDF dataset using Fpz-Cz channel is (81.32%, 0.77) and (81.06%, 0.76), using Pz-Oz channel with the inclusion and exclusion of the age feature, respectively. Similarly the model achieved an overall accuracy of 96.67% (CT-6), 96.60% (CT-5), 96.28% (CT-4),96.30% (CT-3) and 97.30% (CT-2) for with 16 selected features using S-EDF database. Similarly the model reported an overall accuracy of 85.85%, 84.98%, 85.51%, 85.37% and 87.40% for CT-6 to CT-2 with 18 selected features using SE-EDF database

Deep Convolutional Neural Networks for Interpretable Analysis of EEG Sleep Stage Scoring

Sleep studies are important for diagnosing sleep disorders such as insomnia, narcolepsy or sleep apnea. They rely on manual scoring of sleep stages from raw polisomnography signals, which is a tedious visual task requiring the workload of highly trained professionals. Consequently, research efforts to purse for an automatic stage scoring based on machine learning techniques have been carried out over the last years. In this work, we resort to multitaper spectral analysis to create visually interpretable images of sleep patterns from EEG signals as inputs to a deep convolutional network trained to solve visual recognition tasks. As a working example of transfer learning, a system able to accurately classify sleep stages in new unseen patients is presented. Evaluations in a widely-used publicly available dataset favourably compare to state-of-the-art results, while providing a framework for visual interpretation of outcomes.Comment: 8 pages, 1 figure, 2 tables, IEEE 2017 International Workshop on Machine Learning for Signal Processin

Detection of REM Sleep Behaviour Disorder by Automated Polysomnography Analysis

Evidence suggests Rapid-Eye-Movement (REM) Sleep Behaviour Disorder (RBD) is an early predictor of Parkinson's disease. This study proposes a fully-automated framework for RBD detection consisting of automated sleep staging followed by RBD identification. Analysis was assessed using a limited polysomnography montage from 53 participants with RBD and 53 age-matched healthy controls. Sleep stage classification was achieved using a Random Forest (RF) classifier and 156 features extracted from electroencephalogram (EEG), electrooculogram (EOG) and electromyogram (EMG) channels. For RBD detection, a RF classifier was trained combining established techniques to quantify muscle atonia with additional features that incorporate sleep architecture and the EMG fractal exponent. Automated multi-state sleep staging achieved a 0.62 Cohen's Kappa score. RBD detection accuracy improved by 10% to 96% (compared to individual established metrics) when using manually annotated sleep staging. Accuracy remained high (92%) when using automated sleep staging. This study outperforms established metrics and demonstrates that incorporating sleep architecture and sleep stage transitions can benefit RBD detection. This study also achieved automated sleep staging with a level of accuracy comparable to manual annotation. This study validates a tractable, fully-automated, and sensitive pipeline for RBD identification that could be translated to wearable take-home technology.Comment: 20 pages, 3 figure

A real-time Brain-Computer Interface (BCI) framework for sleep state stimulation using a deep-learning technique: proposal

Sleep disturbance can cause mental illnesses such as depression, hypertension, metabolic syndrome, and cognitive impairment. To date, various methods have been proposed as intervention measures for sleep disturbance, including taking a short mid-day nap. Falling asleep depends on several external factors, such as the ambience, temperature, sound, and lighting. On top of that, the factors that affect the quality and period of falling asleep can be subjective. The attempt to provide feedback based on the configuration of those external factors is time-consuming. Additionally, if those external factors are incorrectly configured, the intended short nap as a solution may have the opposite effects. As such, research on real-time sleep analysis plays an important role. However, the current study on deep-learning techniques regarding the sleep analysis that can give real-time results is still scarce compared to the offline sleep analysis. Therefore, this study aims to design and develop a real-time BCI framework for sleep state stimulation

A Real-Time Brain-Computer Interface (BCI) framework for sleep state stimulation using a deep-learning technique: proposal

Abstract— Sleep disturbance can cause mental illnesses such as depression, hypertension, metabolic syndrome, and cognitive impairment. To date, various methods have been proposed as intervention measures for sleep disturbance, including taking a short mid-day nap. Falling asleep depends on several external factors, such as the ambience, temperature, sound, and lighting. On top of that, the factors that affect the quality and period of falling asleep can be subjective. The attempt to provide feedback based on the configuration of those external factors is time-consuming. Additionally, if those external factors are incorrectly configured, the intended short nap as a solution may have the opposite effects. As such, research on real-time sleep analysis plays an important role. However, the current study on deep-learning techniques regarding the sleep analysis that can give real-time results is still scarce compared to the offline sleep analysis. Therefore, this study aims to design and develop a real-time BCI framework for sleep state stimulation

SleepEEGNet: Automated Sleep Stage Scoring with Sequence to Sequence Deep Learning Approach

Electroencephalogram (EEG) is a common base signal used to monitor brain activity and diagnose sleep disorders. Manual sleep stage scoring is a time-consuming task for sleep experts and is limited by inter-rater reliability. In this paper, we propose an automatic sleep stage annotation method called SleepEEGNet using a single-channel EEG signal. The SleepEEGNet is composed of deep convolutional neural networks (CNNs) to extract time-invariant features, frequency information, and a sequence to sequence model to capture the complex and long short-term context dependencies between sleep epochs and scores. In addition, to reduce the effect of the class imbalance problem presented in the available sleep datasets, we applied novel loss functions to have an equal misclassified error for each sleep stage while training the network. We evaluated the proposed method on different single-EEG channels (i.e., Fpz-Cz and Pz-Oz EEG channels) from the Physionet Sleep-EDF datasets published in 2013 and 2018. The evaluation results demonstrate that the proposed method achieved the best annotation performance compared to current literature, with an overall accuracy of 84.26%, a macro F1-score of 79.66% and Cohen's Kappa coefficient = 0.79. Our developed model is ready to test with more sleep EEG signals and aid the sleep specialists to arrive at an accurate diagnosis. The source code is available at https://github.com/SajadMo/SleepEEGNet

Emotion brain-computer interface using wavelet and recurrent neural networks

Brain-Computer Interface (BCI) has an intermediate tool that is usually obtained from EEG signal information. This paper proposed the BCI to control a robot simulator based on three emotions for five seconds by extracting a wavelet function in advance with Recurrent Neural Networks (RNN). Emotion is amongst variables of the brain that can be used to move external devices. BCI's success depends on the ability to recognize one person’s emotions by extracting their EEG signals. One method to appropriately recognize EEG signals as a moving signal is wavelet transformation. Wavelet extracted EEG signal into theta, alpha, and beta wave, and consider them as the input of the RNN technique. Connectivity between sequences is accomplished with Long Short-Term Memory (LSTM). The study also compared frequency extraction methods using Fast Fourier Transform (FFT). The results showed that by extracting EEG signals using Wavelet transformations, we could achieve a confident accuracy of 100% for the training data and 70.54% of new data. While the same RNN configuration without pre-processing provided 39% accuracy, even adding FFT would only increase it to 52%. Furthermore, by using features of the frequency filter, we can increase its accuracy from 70.54% to 79.3%. These results showed the importance of selecting features because of RNNs concern to sequenced its inputs. The use of emotional variables is still relevant for instructions on BCI-based external devices, which provide an average computing time of merely 0.235 seconds

Automatic neonatal sleep stage classification:A comparative study

Sleep is an essential feature of living beings. For neonates, it is vital for their mental and physical development. Sleep stage cycling is an important parameter to assess neonatal brain and physical development. Therefore, it is crucial to administer newborn's sleep in the neonatal intensive care unit (NICU). Currently, Polysomnography (PSG) is used as a gold standard method for classifying neonatal sleep patterns, but it is expensive and requires a lot of human involvement. Over the last two decades, multiple researchers are working on automatic sleep stage classification algorithms using electroencephalography (EEG), electrocardiography (ECG), and video. In this study, we present a comprehensive review of existing algorithms for neonatal sleep, their limitations and future recommendations. Additionally, a brief comparison of the extracted features, classification algorithms and evaluation parameters is reported in the proposed study