16,746 research outputs found
Building a semantically annotated corpus of clinical texts
In this paper, we describe the construction of a semantically annotated corpus of clinical texts for use in the development and evaluation of systems for automatically extracting clinically significant information from the textual component of patient records. The paper details the sampling of textual material from a collection of 20,000 cancer patient records, the development of a semantic annotation scheme, the annotation methodology, the distribution of annotations in the final corpus, and the use of the corpus for development of an adaptive information extraction system. The resulting corpus is the most richly semantically annotated resource for clinical text processing built to date, whose value has been demonstrated through its use in developing an effective information extraction system. The detailed presentation of our corpus construction and annotation methodology will be of value to others seeking to build high-quality semantically annotated corpora in biomedical domains
Structural variation in generated health reports
We present a natural language generator that produces a range of medical reports on the clinical histories of
cancer patients, and discuss the problem of conceptual restatement in generating various textual views of the
same conceptual content. We focus on two features of our system: the demand for 'loose paraphrases' between
the various reports on a given patient, with a high degree of semantic overlap but some necessary amount of distinctive content; and the requirement for paraphrasing at primarily the discourse level
Knowledge-based best of breed approach for automated detection of clinical events based on German free text digital hospital discharge letters
OBJECTIVES:
The secondary use of medical data contained in electronic medical records, such as hospital discharge letters, is a valuable resource for the improvement of clinical care (e.g. in terms of medication safety) or for research purposes. However, the automated processing and analysis of medical free text still poses a huge challenge to available natural language processing (NLP) systems. The aim of this study was to implement a knowledge-based best of breed approach, combining a terminology server with integrated ontology, a NLP pipeline and a rules engine.
METHODS:
We tested the performance of this approach in a use case. The clinical event of interest was the particular drug-disease interaction "proton-pump inhibitor [PPI] use and osteoporosis". Cases were to be identified based on free text digital discharge letters as source of information. Automated detection was validated against a gold standard.
RESULTS:
Precision of recognition of osteoporosis was 94.19%, and recall was 97.45%. PPIs were detected with 100% precision and 97.97% recall. The F-score for the detection of the given drug-disease-interaction was 96,13%.
CONCLUSION:
We could show that our approach of combining a NLP pipeline, a terminology server, and a rules engine for the purpose of automated detection of clinical events such as drug-disease interactions from free text digital hospital discharge letters was effective. There is huge potential for the implementation in clinical and research contexts, as this approach enables analyses of very high numbers of medical free text documents within a short time period
Effective Feature Representation for Clinical Text Concept Extraction
Crucial information about the practice of healthcare is recorded only in
free-form text, which creates an enormous opportunity for high-impact NLP.
However, annotated healthcare datasets tend to be small and expensive to
obtain, which raises the question of how to make maximally efficient uses of
the available data. To this end, we develop an LSTM-CRF model for combining
unsupervised word representations and hand-built feature representations
derived from publicly available healthcare ontologies. We show that this
combined model yields superior performance on five datasets of diverse kinds of
healthcare text (clinical, social, scientific, commercial). Each involves the
labeling of complex, multi-word spans that pick out different healthcare
concepts. We also introduce a new labeled dataset for identifying the treatment
relations between drugs and diseases
Summarisation and visualisation of e-Health data repositories
At the centre of the Clinical e-Science Framework (CLEF) project is a repository of well organised,
detailed clinical histories, encoded as data that will be available for use in clinical care and in-silico
medical experiments. We describe a system that we have developed as part of the CLEF project, to perform the task of generating a diverse range of textual and graphical summaries of a patient’s clinical history from a data-encoded model, a chronicle, representing the record of the patient’s medical history. Although the focus of our current work is on cancer patients, the approach we
describe is generalisable to a wide range of medical areas
Knowledge will Propel Machine Understanding of Content: Extrapolating from Current Examples
Machine Learning has been a big success story during the AI resurgence. One
particular stand out success relates to learning from a massive amount of data.
In spite of early assertions of the unreasonable effectiveness of data, there
is increasing recognition for utilizing knowledge whenever it is available or
can be created purposefully. In this paper, we discuss the indispensable role
of knowledge for deeper understanding of content where (i) large amounts of
training data are unavailable, (ii) the objects to be recognized are complex,
(e.g., implicit entities and highly subjective content), and (iii) applications
need to use complementary or related data in multiple modalities/media. What
brings us to the cusp of rapid progress is our ability to (a) create relevant
and reliable knowledge and (b) carefully exploit knowledge to enhance ML/NLP
techniques. Using diverse examples, we seek to foretell unprecedented progress
in our ability for deeper understanding and exploitation of multimodal data and
continued incorporation of knowledge in learning techniques.Comment: Pre-print of the paper accepted at 2017 IEEE/WIC/ACM International
Conference on Web Intelligence (WI). arXiv admin note: substantial text
overlap with arXiv:1610.0770
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