2016 IMSAloquium, Student Investigation Showcase

Welcome to the twenty-eighth year of the Student Inquiry and Research Program (SIR)! This is a program that is as old as IMSA. The SIR program represents our unending dedication to enabling our students to learn what it is to be an innovator and to make contributions to what is known on Earth.https://digitalcommons.imsa.edu/archives_sir/1026/thumbnail.jp

Measuring Behavior 2018 Conference Proceedings

These proceedings contain the papers presented at Measuring Behavior 2018, the 11th International Conference on Methods and Techniques in Behavioral Research. The conference was organised by Manchester Metropolitan University, in collaboration with Noldus Information Technology. The conference was held during June 5th – 8th, 2018 in Manchester, UK. Building on the format that has emerged from previous meetings, we hosted a fascinating program about a wide variety of methodological aspects of the behavioral sciences. We had scientific presentations scheduled into seven general oral sessions and fifteen symposia, which covered a topical spread from rodent to human behavior. We had fourteen demonstrations, in which academics and companies demonstrated their latest prototypes. The scientific program also contained three workshops, one tutorial and a number of scientific discussion sessions. We also had scientific tours of our facilities at Manchester Metropolitan Univeristy, and the nearby British Cycling Velodrome. We hope this proceedings caters for many of your interests and we look forward to seeing and hearing more of your contributions

Life Sciences Program Tasks and Bibliography for FY 1997

This document includes information on all peer reviewed projects funded by the Office of Life and Microgravity Sciences and Applications, Life Sciences Division during fiscal year 1997. This document will be published annually and made available to scientists in the space life sciences field both as a hard copy and as an interactive internet web page

Primate Ventromedial Prefrontal Cortex and the Physiological and Behavioural Dysfunction Characteristic of Mood and Anxiety Disorders

The heterogeneity intrinsic to the ventromedial prefrontal cortex (vmPFC) is evidenced in both its anatomy and implicated function: vmPFC subregions have roles in positive affect, negative affect and autonomic/endocrine regulation. Whether different subregions serve fundamentally different functions, or whether they perform similar computations on different inputs, remains unclear. Nevertheless, the role of the vmPFC in psychopathology is widely appreciated – in mood and anxiety disorders, over-activity within constituent regions of the vmPFC is consistently implicated in symptomatology, together with its normalisation following successful treatment. However, the precise locus of change varies between studies. The work presented in this thesis investigates the causal contributions of over-activity within two key subregions of the vmPFC – the subgenual anterior cingulate cortex (sgACC, area 25) and perigenual anterior cingulate cortex (pgACC, area 32) – in discrete dimensions of behaviour and physiology affected in psychiatric disorders. Specifically, the impact of over-activity is assessed on (i) baseline physiological function; (ii) the regulation of anticipatory, motivational and consummatory aspects of reward-related behaviour; and (iii) negative affect including fear learning, stress recovery and the intolerance of uncertainty. To provide further insight into the mechanism of action of antidepressants, the efficacy of selected treatments is tested on changes induced by over-activity of these regions. Beyond the direct relevance of the results presented here to psychiatric disorders and their treatment, the thesis aims to emphasise the importance of broader themes associated with the measurement and quantification of emotion in preclinical animal studies. First, a multi-faceted approach is utilised enabling quantification of both the autonomic and behavioural aspects of emotion. In so doing, the experiments maintain relevance to studies which assess these correlates in isolation, both in humans (which typically measure subjective responses and physiology) and in rodents (which frequently assess behaviour in isolation). The assessment of more than one dimension of emotion confers these studies with improved power to detect maladaptive changes. Second, the experiments described were conducted in the marmoset, a new-world primate. The extensive anatomical homology between marmoset and human prefrontal cortex facilitates the forward-translation of functional results. In combination with the appropriate assays, this renders marmosets as an invaluable species to study the causal contributions of vmPFC subregions to symptoms of psychiatric disorders. I believe that the results of these experiments provide important insights into the causal role primate vmPFC has in relation to the behavioural and physiological aspects of psychiatric symptomatology. Most importantly, I hope that they serve as the foundation for future work to further elucidate the neuropathological processes underlying mental disorders.MRC DTP Studentshi

Activation of the pro-resolving receptor Fpr2 attenuates inflammatory microglial activation

Poster number: P-T099 Theme: Neurodegenerative disorders & ageing Activation of the pro-resolving receptor Fpr2 reverses inflammatory microglial activation Authors: Edward S Wickstead - Life Science & Technology University of Westminster/Queen Mary University of London Inflammation is a major contributor to many neurodegenerative disease (Heneka et al. 2015). Microglia, as the resident immune cells of the brain and spinal cord, provide the first line of immunological defence, but can become deleterious when chronically activated, triggering extensive neuronal damage (Cunningham, 2013). Dampening or even reversing this activation may provide neuronal protection against chronic inflammatory damage. The aim of this study was to determine whether lipopolysaccharide (LPS)-induced inflammation could be abrogated through activation of the receptor Fpr2, known to play an important role in peripheral inflammatory resolution. Immortalised murine microglia (BV2 cell line) were stimulated with LPS (50ng/ml) for 1 hour prior to the treatment with one of two Fpr2 ligands, either Cpd43 or Quin-C1 (both 100nM), and production of nitric oxide (NO), tumour necrosis factor alpha (TNFα) and interleukin-10 (IL-10) were monitored after 24h and 48h. Treatment with either Fpr2 ligand significantly suppressed LPS-induced production of NO or TNFα after both 24h and 48h exposure, moreover Fpr2 ligand treatment significantly enhanced production of IL-10 48h post-LPS treatment. As we have previously shown Fpr2 to be coupled to a number of intracellular signaling pathways (Cooray et al. 2013), we investigated potential signaling responses. Western blot analysis revealed no activation of ERK1/2, but identified a rapid and potent activation of p38 MAP kinase in BV2 microglia following stimulation with Fpr2 ligands. Together, these data indicate the possibility of exploiting immunomodulatory strategies for the treatment of neurological diseases, and highlight in particular the important potential of resolution mechanisms as novel therapeutic targets in neuroinflammation. References Cooray SN et al. (2013). Proc Natl Acad Sci U S A 110: 18232-7. Cunningham C (2013). Glia 61: 71-90. Heneka MT et al. (2015). Lancet Neurol 14: 388-40

Décoder l’habileté perceptive dans le cerveau humain : contenu représentationnel et computations cérébrales

La capacité à reconnaître les visages de nos collègues, de nos amis et de nos proches est essentielle à notre réussite en tant qu'êtres sociaux. Notre cerveau accomplit cet exploit facilement et rapidement, dans une série d’opérations se déroulant en quelques dizaines de millisecondes à travers un vaste réseau cérébral du système visuel ventral. L’habileté à reconnaître les visages, par contre, varie considérablement d’une personne à l’autre. Certains individus, appelés «super-recognisers», sont capables de reconnaître des visages vus une seule fois dans la rue des années plus tôt. D’autres, appelés «prosopagnosiques», sont incapables de reconnaître le visage de leurs collègues ou leurs proches, même avec une vision parfaite. Une question simple reste encore largement sans réponse : quels mécanismes expliquent que certains individus sont meilleurs à reconnaître des visages? Cette thèse rapporte cinq articles étudiant les mécanismes perceptifs (articles 1, 2, 3) et cérébraux (articles 4, 5) derrière ces variations à travers différentes populations d’individus. L’article 1 décrit le contenu des représentations visuelles faciales chez une population avec un diagnostic de schizophrénie et d’anxiété sociale à l’aide d’une technique psychophysique Bubbles. Nous révélons pour la première fois les mécanismes en reconnaissance des expressions de cette population: un déficit de reconnaissance est accompagné par i) une sous-utilisation de la région des yeux des visages expressifs et ii) une sous-utilisation des détails fins. L’article 2 valide ensuite une nouvelle technique permettant de révéler simultanément le contenu visuel dans trois dimensions psychophysiques centrales pour le système visuel — la position, les fréquences spatiales, et l’orientation. L’article 3 a mesuré, à l'aide de cette nouvelle technique, le contenu représentationnel de 120 individus pendant la discrimination faciale du sexe et des expressions ( >500,000 observations). Nous avons observé de fortes corrélations entre l’habileté à discriminer le sexe et les expressions des visages, ainsi qu'entre l’habileté à discriminer le sexe et l’identité. Crucialement, plus un individu est habile en reconnaissance faciale, plus il utilise un contenu représentationnel similaire entre les tâches. L’article 4 a examiné les computations cérébrales de super-recognisers en utilisant l’électroencéphalographie haute-densité (EEG) et l’apprentissage automatique. Ces outils ont permis de décoder, pour la première fois, l’habileté en reconnaissance faciale à partir du cerveau avec jusqu’à 80% d’exactitude –– et ce à partir d’une seule seconde d’activité cérébrale. Nous avons ensuite utilisé la Representational Similarity Analysis (RSA) pour comparer les représentations cérébrales de nos participants à celles de modèles d’apprentissage profond visuels et langagiers. Les super-recognisers, comparé aux individus avec une habileté typique, ont des représentations cérébrales plus similaires aux computations visuelles et sémantiques de ces modèles optimaux. L’article 5 rapporte une investigation des computations cérébrales chez le cas le plus spécifique et documenté de prosopagnosie acquise, la patiente PS. Les mêmes outils computationnels et d’imagerie que ceux de l’article 4 ont permis i) de décoder les déficits d’identification faciale de PS à partir de son activité cérébrale EEG, et ii) de montrer pour la première fois que la prosopagnosie est associée à un déficit des computations visuelles de haut niveau et des computations cérébrales sémantiques.The ability to recognise the faces of our colleagues, friends, and family members is critical to our success as social beings. Our brains accomplish this feat with astonishing ease and speed, in a series of operations taking place in tens of milliseconds across a vast brain network of the visual system. The ability to recognise faces, however, varies considerably from one person to another. Some individuals, called "super-recognisers", are able to recognise faces seen only once years earlier. Others, called "prosopagnosics", are unable to recognise the faces of their colleagues or relatives, even with perfect vision and typical intelligence. A simple question remains largely unanswered: what mechanisms explain why some individuals are better at recognizing faces? This thesis reports five articles studying the perceptual (article 1, 2, 3) and neural (article 4, 5) mechanisms behind these variations across different populations of individuals. Article 1 describes the content of visual representations of faces in a population with a comorbid diagnosis of schizophrenia and social anxiety disorder using an established psychophysical technique, Bubbles. We reveal for the first time the perceptual mechanisms of expression recognition in this population: a recognition deficit is accompanied by i) an underutilization of the eye region of expressive faces and ii) an underutilization of fine details. Article 2 then validates a new psychophysical technique that simultaneously reveals the visual content in three dimensions central to the visual system — position, spatial frequencies, and orientation. We do not know, however, whether skilled individuals perform well across a variety of facial recognition tasks and, if so, how they accomplish this feat. Article 3 measured, using the technique validated in article 2, the perceptual representations of 120 individuals during facial discrimination of gender and expressions (total of >500,000 trials). We observed strong correlations between the ability to discriminate gender and facial expressions, as well as between the ability to discriminate gender and identify faces. More importantly, we found a positive correlation between individual ability and the similarity of perceptual representations used across these tasks. Article 4 examined differences in brain dynamics between super-recognizers and typical individuals using high-density electroencephalography (EEG) and machine learning. These tools allowed us to decode, for the first time, facial recognition ability from the brain with up to 80% accuracy — using a mere second of brain activity. We then used Representational Similarity Analysis (RSA) to compare our participants' brain representations to those of deep learning models of object and language classification. This showed that super-recognisers, compared to individuals with typical perceptual abilites, had brain representations more similar to the visual and semantic computations of these optimal models. Article 5 reports an investigation of brain computations in the most specific and documented case of acquired prosopagnosia, patient PS. The same computational tools used in article 4 enabled us to decode PS's facial identification deficits from her brain dynamics. Crucially, associations between brain deep learning models showed for the first time that prosopagnosia is associated with deficits in high-level visual and semantic brain computations

A right hemisphere advantage for processing blurred faces

No description supplie