Semileptonic decays of the Higgs boson at the Tevatron

We examine the prospects for extending the Tevatron reach for a Standard Model Higgs boson by including the semileptonic Higgs boson decays h --> WW --> l nu jj for M_h >~ 2 M_W, and h --> W jj --> l nu jj for M_h <~ 2 M_W, where j is a hadronic jet. We employ a realistic simulation of the signal and backgrounds using the Sherpa Monte Carlo event generator. We find kinematic selections that enhance the signal over the dominant W+jets background. The resulting sensitivity could be an important addition to ongoing searches, especially in the mass range 120 <~ M_h <~ 150 GeV. The techniques described can be extended to Higgs boson searches at the Large Hadron Collider.Comment: 68 pages, 19 figure

Chemoinformatics Research at the University of Sheffield: A History and Citation Analysis

This paper reviews the work of the Chemoinformatics Research Group in the Department of Information Studies at the University of Sheffield, focusing particularly on the work carried out in the period 1985-2002. Four major research areas are discussed, these involving the development of methods for: substructure searching in databases of three-dimensional structures, including both rigid and flexible molecules; the representation and searching of the Markush structures that occur in chemical patents; similarity searching in databases of both two-dimensional and three-dimensional structures; and compound selection and the design of combinatorial libraries. An analysis of citations to 321 publications from the Group shows that it attracted a total of 3725 residual citations during the period 1980-2002. These citations appeared in 411 different journals, and involved 910 different citing organizations from 54 different countries, thus demonstrating the widespread impact of the Group's work

Similarity-based virtual screening using 2D fingerprints

This paper summarises recent work at the University of Sheffield on virtual screening methods that use 2D fingerprint measures of structural similarity. A detailed comparison of a large number of similarity coefficients demonstrates that the well-known Tanimoto coefficient remains the method of choice for the computation of fingerprint-based similarity, despite possessing some inherent biases related to the sizes of the molecules that are being sought. Group fusion involves combining the results of similarity searches based on multiple reference structures and a single similarity measure. We demonstrate the effectiveness of this approach to screening, and also describe an approximate form of group fusion, turbo similarity searching, that can be used when just a single reference structure is available

The Evaluation Of Molecular Similarity And Molecular Diversity Methods Using Biological Activity Data

This paper reviews the techniques available for quantifying the effectiveness of methods for molecule similarity and molecular diversity, focusing in particular on similarity searching and on compound selection procedures. The evaluation criteria considered are based on biological activity data, both qualitative and quantitative, with rather different criteria needing to be used depending on the type of data available

A new problem in string searching

We describe a substring search problem that arises in group presentation simplification processes. We suggest a two-level searching model: skip and match levels. We give two timestamp algorithms which skip searching parts of the text where there are no matches at all and prove their correctness. At the match level, we consider Harrison signature, Karp-Rabin fingerprint, Bloom filter and automata based matching algorithms and present experimental performance figures.Comment: To appear in Proceedings Fifth Annual International Symposium on Algorithms and Computation (ISAAC'94), Lecture Notes in Computer Scienc