Breast Cancer: Modelling and Detection

This paper reviews a number of the mathematical models used in cancer modelling and then chooses a specific cancer, breast carcinoma, to illustrate how the modelling can be used in aiding detection. We then discuss mathematical models that underpin mammographic image analysis, which complements models of tumour growth and facilitates diagnosis and treatment of cancer. Mammographic images are notoriously difficult to interpret, and we give an overview of the primary image enhancement technologies that have been introduced, before focusing on a more detailed description of some of our own recent work on the use of physics-based modelling in mammography. This theoretical approach to image analysis yields a wealth of information that could be incorporated into the mathematical models, and we conclude by describing how current mathematical models might be enhanced by use of this information, and how these models in turn will help to meet some of the major challenges in cancer detection

Development and validation of 'AutoRIF': Software for the automated analysis of radiation-induced foci

Copyright @ 2012 McVean et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.This article has been made available through the Brunel Open Access Publishing Fund.Background: The quantification of radiation-induced foci (RIF) to investigate the induction and subsequent repair of DNA double strands breaks is now commonplace. Over the last decade systems specific for the automatic quantification of RIF have been developed for this purpose, however to ask more mechanistic questions on the spatio-temporal aspects of RIF, an automated RIF analysis platform that also quantifies RIF size/volume and relative three-dimensional (3D) distribution of RIF within individual nuclei, is required. Results: A java-based image analysis system has been developed (AutoRIF) that quantifies the number, size/volume and relative nuclear locations of RIF within 3D nuclear volumes. Our approach identifies nuclei using the dynamic Otsu threshold and RIF by enhanced Laplacian filtering and maximum entropy thresholding steps and, has an application ‘batch optimisation’ process to ensure reproducible quantification of RIF. AutoRIF was validated by comparing output against manual quantification of the same 2D and 3D image stacks with results showing excellent concordance over a whole range of sample time points (and therefore range of total RIF/nucleus) after low-LET radiation exposure. Conclusions: This high-throughput automated RIF analysis system generates data with greater depth of information and reproducibility than that which can be achieved manually and may contribute toward the standardisation of RIF analysis. In particular, AutoRIF is a powerful tool for studying spatio-temporal relationships of RIF using a range of DNA damage response markers and can be run independently of other software, enabling most personal computers to perform image analysis. Future considerations for AutoRIF will likely include more complex algorithms that enable multiplex analysis for increasing combinations of cellular markers.This article is made available through the Brunel Open Access Publishing Fund

Roadmap on optical security

Postprint (author's final draft

Image enhancement using fuzzy intensity measure and adaptive clipping histogram equalization

Image enhancement aims at processing an input image so that the visual content of the output image is more pleasing or more useful for certain applications. Although histogram equalization is widely used in image enhancement due to its simplicity and effectiveness, it changes the mean brightness of the enhanced image and introduces a high level of noise and distortion. To address these problems, this paper proposes image enhancement using fuzzy intensity measure and adaptive clipping histogram equalization (FIMHE). FIMHE uses fuzzy intensity measure to first segment the histogram of the original image, and then clip the histogram adaptively in order to prevent excessive image enhancement. Experiments on the Berkeley database and CVF-UGR-Image database show that FIMHE outperforms state-of-the-art histogram equalization based methods

Single-shot compressed ultrafast photography: a review

Compressed ultrafast photography (CUP) is a burgeoning single-shot computational imaging technique that provides an imaging speed as high as 10 trillion frames per second and a sequence depth of up to a few hundred frames. This technique synergizes compressed sensing and the streak camera technique to capture nonrepeatable ultrafast transient events with a single shot. With recent unprecedented technical developments and extensions of this methodology, it has been widely used in ultrafast optical imaging and metrology, ultrafast electron diffraction and microscopy, and information security protection. We review the basic principles of CUP, its recent advances in data acquisition and image reconstruction, its fusions with other modalities, and its unique applications in multiple research fields

Multimodal enhancement-fusion technique for natural images.

Masters Degree. University of KwaZulu-Natal, Durban.This dissertation presents a multimodal enhancement-fusion (MEF) technique for natural images. The MEF is expected to contribute value to machine vision applications and personal image collections for the human user. Image enhancement techniques and the metrics that are used to assess their performance are prolific, and each is usually optimised for a specific objective. The MEF proposes a framework that adaptively fuses multiple enhancement objectives into a seamless pipeline. Given a segmented input image and a set of enhancement methods, the MEF applies all the enhancers to the image in parallel. The most appropriate enhancement in each image segment is identified, and finally, the differentially enhanced segments are seamlessly fused. To begin with, this dissertation studies targeted contrast enhancement methods and performance metrics that can be utilised in the proposed MEF. It addresses a selection of objective assessment metrics for contrast-enhanced images and determines their relationship with the subjective assessment of human visual systems. This is to identify which objective metrics best approximate human assessment and may therefore be used as an effective replacement for tedious human assessment surveys. A subsequent human visual assessment survey is conducted on the same dataset to ascertain image quality as perceived by a human observer. The interrelated concepts of naturalness and detail were found to be key motivators of human visual assessment. Findings show that when assessing the quality or accuracy of these methods, no single quantitative metric correlates well with human perception of naturalness and detail, however, a combination of two or more metrics may be used to approximate the complex human visual response. Thereafter, this dissertation proposes the multimodal enhancer that adaptively selects the optimal enhancer for each image segment. MEF focusses on improving chromatic irregularities such as poor contrast distribution. It deploys a concurrent enhancement pathway that subjects an image to multiple image enhancers in parallel, followed by a fusion algorithm that creates a composite image that combines the strengths of each enhancement path. The study develops a framework for parallel image enhancement, followed by parallel image assessment and selection, leading to final merging of selected regions from the enhanced set. The output combines desirable attributes from each enhancement pathway to produce a result that is superior to each path taken alone. The study showed that the proposed MEF technique performs well for most image types. MEF is subjectively favourable to a human panel and achieves better performance for objective image quality assessment compared to other enhancement methods

Electrification of Smart Cities

Electrification plays a key role in decarbonizing energy consumption for various sectors, including transportation, heating, and cooling. There are several essential infrastructures for a smart city, including smart grids and transportation networks. These infrastructures are the complementary solutions to successfully developing novel services, with enhanced energy efficiency and energy security. Five papers are published in this Special Issue that cover various key areas expanding the state-of-the-art in smart cities’ electrification, including transportation, healthcare, and advanced closed-circuit televisions for smart city surveillance

HDR imaging techniques applied to a Schlieren set-up for aerodynamics studies

La tecnica schlieren rivela i cambiamenti di densità in un flusso. Per visualizzare deboli dettagli è necessario usare alte sensibilità, ma ciò fa saturare le regioni più intense con conseguente perdita di informazioni. La tecnica fotografica dell'HDR è stata applicata ad un apparato schlieren per ripristinare queste aree sature e visualizzare dettagli deboli e intensi del flusso in una singola foto. Sono stati studiati flussi subsonici e supersonici, stazionari e non