Theory-based Explorations of Associations between Human Brain Structure and Intelligence from Childhood to Early Adulthood

Intelligence is often defined as the ability of an agent to learn, adapt to its environment, and solve novel challenges. However, despite over 100 years of theoretical development (e.g., general intelligence), widespread explanatory power (up to 50% of variance in cognitive scores), and the ability of intelligence measures to predict important life outcomes such as educational achievement and mortality, the exact configuration and neural correlates of cognitive ability remain poorly understood. This dissertation aims to make progress in this pursuit by exploring how human brain structure and intelligence correlate and co-develop with each other from childhood to early adulthood (ages 5 – 22 years). This endeavour is undertaken in three large cohorts (N range: 337 – 2072), guided by theory (e.g., crystallised and fluid intelligence), and implemented using rigorous, cutting-edge quantitative methods (i.e., structural equation modelling and network science). The results of this research provide robust evidence that the brain-behaviour relationships in intelligence are complex (i.e., consists of many independent yet interacting parts) and change nonlinearly during development. The first study sought to elucidate the factorial structure and white matter substrates of child and adolescent intelligence using two cross-sectional, developmental samples (CALM: N = 551 (N = 165 neuroimaging), age range: 5 – 18 years; NKI-Rockland: N = 337 (N = 65 neuroimaging), age range: 6 – 18 years). In both samples, it was found (using structural equation modelling (SEM)) that cognitive ability is best modelled as two separable yet related constructs, crystallised and fluid intelligence, which became more distinct (i.e., less correlated) across development, in line with the age differentiation hypothesis. Further analyses revealed that white matter microstructure, most prominently of the superior longitudinal fasciculus, was strongly associated with crystallised (gc) and fluid (gf) abilities. Finally, SEM trees, which combines traditional SEM with decision trees, provided evidence for developmental reorganisation of gc and gf and their white matter substrates such that the relationships among these factors dropped between ages 7 – 8 years before increasing around age 10. Together, these results suggested that shortly before puberty marks a pivotal phase of change in the neurocognitive architecture of intelligence. The second study builds upon the first by again examining the neurocognitive structure of intelligence, this time from a network perspective. The network or mutualism theory of intelligence presupposes direct (statistical) interactions among cognitive abilities (e.g., maths, memory, and vocabulary) throughout development. Therefore, this project used network analytic methods (specifically graphical LASSO) to simultaneously model brain-behaviour relationships essential for general intelligence in a large (behavioural, N = 805; cortical volume, N = 246; fractional anisotropy, N = 165), developmental (ages 5 – 18 years) cohort of struggling learners (CALM). Results indicated that both the single-layer (cognitive or neural nodes) and multilayer (combined cognitive and neural variables) networks consisted of mostly positive, small partial correlations, providing further support for the mutualism/network theory of cognitive ability. Moreover, using community detection (i.e., the Walktrap algorithm) and calculating node centrality (absolute strength and bridge strength), convergent evidence suggested that subsets of both cognitive and neural nodes play an intermediary role ‘between’ brain and behaviour. Overall, these findings suggest specific behavioural and neural variables that may have greater influence among (or might be more influenced by) other nodes within general intelligence. The final study investigated the longitudinal relationships between human cortical grey matter structure and measures of decision-making, risk-related behaviours, and spatial working memory from adolescence to early adulthood (ages 14 – 22 years). In the IMAGEN study (maximum N across time points/waves = 2072), latent growth curve models were used to estimate the baseline and longitudinal associations between behavioural measures and cortical surface area, thickness, and volume. Univariate models (only behavioural or neural measures) revealed that performance in decision-making, risk-related behaviours, and spatial working memory, as well as brain structure changed nonlinearly from mid-adolescence (age 14) to early adulthood (age 22). Furthermore, bivariate models (combined behavioural and neural measures) provided evidence for adaptive reorganisation (behaviour intercept predicts changes in brain structure) but not structural scaffolding (brain structure intercept predicts changes in behaviour). Furthermore, findings suggested that there were no correlated changes between behavioural and brain structure slopes (rates of change from mid-adolescence to early adulthood). This dissertation concludes by summarising the core results, addressing key limitations, and discussing avenues for future research. Taken together, this thesis hopes to convince cognitive neuroscientists that to understand cognitive ability and its neural determinants, they (we) must work more diligently toward building coherent, rigorous, and testable neurocognitive theories of intelligence—particularly under the conceptual and analytic paradigm of complex systems.The Cambridge Commonwealth, European & International Trus

Structural brain complexity and cognitive decline in late life : A longitudinal study in the Aberdeen 1936 Birth Cohort

Copyright © 2014 Elsevier Inc. All rights reserved.Peer reviewedPostprin

Rethinking Phylogeny and Ontogeny in Hominin Brain Evolution

Theories of hominin and human cognitive evolution have traditionally focused on the phylogeny of the human brain, and on comparisons of human and primate brains in relation to social or ecological variables. Far less attention has been paid to ontogenetic processes, despite the recognition that experience has a profound influence on adult cognition. In this paper we discuss the interplay between phylogeny and ontogeny by examining relationships between human brain size, developmental scheduling and cognition. The correlates of large brains include not only altered subsistence and life-history strategies to meet associated energetic costs, but also on macro- and micro-scale structural adaptations required to meet increased processing costs. This means that larger brains are of necessity more highly interconnected brains, with higher degrees of folding of the neocortex (gyrification) and higher ratios of myelinated connections between neurons (white matter) to neurons themselves (grey matter). Here we argue that the combination of these evolutionary trends underpins the complexity of human behaviour, as the neural circuits involved in cognitive mechanisms such as the mirror neuron system (the system governing motor emulation and imitation) and theory of mind (fundamental in social cognition) mature only slowly, and require considerable socially-scaffolded experience to develop to their full potential. These abilities are likely to be fundamental in characteristically human behaviours such as the cultural transmission of complex forms of tool manufacture and use, attested to in the archaeological record. Their elaborated modern human forms, we argue, are possible only in the context of the evolution of relatively slower trajectories of brain growth and hence longer periods during which the growing brain can be influenced by experience among modern humans relative to other primates. Here we review some of the differences in ontogenetic brain development between humans and other primates, and compare the rates and trajectories of neural development between ourselves and our closest living relatives the chimpanzees to suggest that the human pattern of expanded periods of growth coupled with slower trajectories of neural development is likely to have been of huge significance during hominin evolution. In addition, we discuss fossil and archaeological proxies which might allow the reconstruction of evolutionary patterns of development, suggesting that it is only post-Homo erectus and specifically among Homo heidelbergensis and Homo neanderthalensis populations that developmental patterns approximate those of modern humans, arguing for a similar – but not identical – role for socially-scaffolded learning of complex technical skills as among modern groups in these species

Increased ventral striatal volume in college-aged binge drinkers

BACKGROUND Binge drinking is a serious public health issue associated with cognitive, physiological, and anatomical differences from healthy individuals. No studies, however, have reported subcortical grey matter differences in this population. To address this, we compared the grey matter volumes of college-age binge drinkers and healthy controls, focusing on the ventral striatum, hippocampus and amygdala. METHOD T1-weighted images of 19 binge drinkers and 19 healthy volunteers were analyzed using voxel-based morphometry. Structural data were also covaried with Alcohol Use Disorders Identification Test (AUDIT) scores. Cluster-extent threshold and small volume corrections were both used to analyze imaging data. RESULTS Binge drinkers had significantly larger ventral striatal grey matter volumes compared to controls. There were no between group differences in hippocampal or amygdalar volume. Ventral striatal, amygdalar, and hippocampal volumes were also negatively related to AUDIT scores across groups. CONCLUSIONS Our findings stand in contrast to the lower ventral striatal volume previously observed in more severe forms of alcohol use disorders, suggesting that college-age binge drinkers may represent a distinct population from those groups. These findings may instead represent early sequelae, compensatory effects of repeated binge and withdrawal, or an endophenotypic risk factor

Adolescence as a Sensitive Period of Brain Development

Most research on sensitive periods has focussed on early sensory, motor, and language development, but it has recently been suggested that adolescence might represent a second ‘window of opportunity’ in brain development. Here, we explore three candidate areas of development that are proposed to undergo sensitive periods in adolescence: memory, the effects of social stress, and drug use. We describe rodent studies, neuroimaging, and large-scale behavioural studies in humans that have yielded data that are consistent with heightened neuroplasticity in adolescence. Critically however, concrete evidence for sensitive periods in adolescence is mostly lacking. To provide conclusive evidence, experimental studies are needed that directly manipulate environmental input and compare effects in child, adolescent, and adult groups

The envirome and the connectome: exploring the structural noise in the human brain associated with socioeconomic deprivation

Complex cognitive functions are widely recognized to be the result of a number of brain regions working together as large-scale networks. Recently, complex network analysis has been used to characterize various structural properties of the large scale network organization of the brain. For example, the human brain has been found to have a modular architecture i.e. regions within the network form communities (modules) with more connections between regions within the community compared to regions outside it. The aim of this study was to examine the modular and overlapping modular architecture of the brain networks using complex network analysis. We also examined the association between neighborhood level deprivation and brain network structure – modularity and grey nodes. We compared network structure derived from anatomical MRI scans of 42 middle-aged neurologically healthy men from the least (LD) and the most deprived (MD) neighborhoods of Glasgow with their corresponding random networks. Cortical morphological covariance networks were constructed from the cortical thickness derived from the MRI scans of the brain. For a given modularity threshold, networks derived from the MD group showed similar number of modules compared to their corresponding random networks, while networks derived from the LD group had more modules compared to their corresponding random networks. The MD group also had fewer grey nodes – a measure of overlapping modular structure. These results suggest that apparent structural difference in brain networks may be driven by differences in cortical thicknesses between groups. This demonstrates a structural organization that is consistent with a system that is less robust and less efficient in information processing. These findings provide some evidence of the relationship between socioeconomic deprivation and brain network topology

Longitudinal measurement of the developing grey matter in preterm subjects using multi-modal MRI.

Preterm birth is a major public health concern, with the severity and occurrence of adverse outcome increasing with earlier delivery. Being born preterm disrupts a time of rapid brain development: in addition to volumetric growth, the cortex folds, myelination is occurring and there are changes on the cellular level. These neurological events have been imaged non-invasively using diffusion-weighted (DW) MRI. In this population, there has been a focus on examining diffusion in the white matter, but the grey matter is also critically important for neurological health. We acquired multi-shell high-resolution diffusion data on 12 infants born at ≤28weeks of gestational age at two time-points: once when stable after birth, and again at term-equivalent age. We used the Neurite Orientation Dispersion and Density Imaging model (NODDI) (Zhang et al., 2012) to analyse the changes in the cerebral cortex and the thalamus, both grey matter regions. We showed region-dependent changes in NODDI parameters over the preterm period, highlighting underlying changes specific to the microstructure. This work is the first time that NODDI parameters have been evaluated in both the cortical and the thalamic grey matter as a function of age in preterm infants, offering a unique insight into neuro-development in this at-risk population