206,418 research outputs found

    Does equity analyst research lack rigor and objectivity? Evidence from conference call questions and research notes

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    Research questions the rigor and objectivity of analysts’ research due to the institutional structures in which they operate (Fogarty and Rogers, 2005 Accounting, Organisations and Society). However, insights from psychology highlight the need to condition this conclusion on the incentives for attributional search. Based on social cognition theory, we test whether the degree of diligence and criticality evident in analyst research is higher (lower) for negative(nonnegative) schema-discrepant events. We evaluate this prediction against the null hypothesis that analyst research consistently lacks rigor and objectivity. We use earnings surprises as our schema-discrepant conditioning event, and examine the content of analysts’ conference call questions and research notes to assess the properties of their research. We find that levels of rigor and objectivity are statistically and economically higher for research conducted in response to negative earnings surprises. Findings are consistent with analysts’ innate cognitive processing response counteracting institutional considerations when attributional search incentives are strong. Results also reveal non-trivial levels of rigor and objectivity in response to non-negative schema-discrepant earnings news. Differences in the properties of analysts’ work are also evident for spoken and written modalities

    Ectopic A-lattice seams destabilize microtubules

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    Natural microtubules typically include one A-lattice seam within an otherwise helically symmetric B-lattice tube. It is currently unclear how A-lattice seams influence microtubule dynamic instability. Here we find that including extra A-lattice seams in GMPCPP microtubules, structural analogues of the GTP caps of dynamic microtubules, destabilizes them, enhancing their median shrinkage rate by >20-fold. Dynamic microtubules nucleated by seeds containing extra A-lattice seams have growth rates similar to microtubules nucleated by B-lattice seeds, yet have increased catastrophe frequencies at both ends. Furthermore, binding B-lattice GDP microtubules to a rigor kinesin surface stabilizes them against shrinkage, whereas microtubules with extra A-lattice seams are stabilized only slightly. Our data suggest that introducing extra A-lattice seams into dynamic microtubules destabilizes them by destabilizing their GTP caps. On this basis, we propose that the single A-lattice seam of natural B-lattice MTs may act as a trigger point, and potentially a regulation point, for catastrophe

    Do Childhood Vaccines Have Non-Specific Effects on Mortality

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    A recent article by Kristensen et al. suggested that measles vaccine and bacille Calmette–Guérin (BCG) vaccine might\ud reduce mortality beyond what is expected simply from protection against measles and tuberculosis. Previous reviews of the potential effects of childhood vaccines on mortality have not considered methodological features of reviewed studies. Methodological considerations play an especially important role in observational assessments, in which selection factors for vaccination may be difficult to ascertain. We reviewed 782 English language articles on vaccines and childhood mortality and found only a few whose design met the criteria for methodological rigor. The data reviewed suggest that measles vaccine delivers its promised reduction in mortality, but there is insufficient evidence to suggest a mortality benefit above that caused by its effect on measles disease and its sequelae. Our review of the available data in the literature reinforces how difficult answering these considerations has been and how important study design will be in determining the effect of specific vaccines on all-cause mortality.\u

    Development of a User-Friendly Shelf-Life Model to Evaluate the Suitability of Sustainable Materials in Roasted and Ground Coffee Fractional Packs

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    Roasted and ground coffee is a shelf stable product yet quite sensitive to oxidative staling. A consumer acceptance-based shelf-life modeling system was proposed with intent for the rapid determination of suitable coffee packages. This model requires as input the oxygen consumption rate (OCR) of the coffee, barrier values of packages, and the size of the packaging. Within the time period tested, it was shown that this model accurately predicted the oxygen uptake of coffee over time. Four bio-based packaging systems with barrier layers including mPLA, mPE, mcellophane, and paper were compared against a control (mPET). These materials displayed a range of effectiveness in containing moisture and oxygen. It was determined that no materials, including the control, were able deliver a 6-month shelf life of roasted and ground coffee in a non-modified atmosphere at high sensorial rigor. However, the mPET and mcellophane materials could sustain a 6-month shelf life at medium sensorial rigor, and that all materials could sustain a 6-month shelf life at low sensorial rigor. High, medium, and low sensorial rigor were defined as an oxygen uptake of 150, 225, and 300 μg per gram of coffee, respectively. Additional research is needed to measure consumer acceptance more precisely over time with this model

    Moral and imoral in economical quantification

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    Could there be something immoral in economic measurements and quantification? Could there be immorality in statistics? It is often said that statistics is a lie, an untruth,a delusion. Lies are dishonoring and deeply immoral, and are incriminated by both religious and juridical norms. Where do these accusations against statistics come from? They derive from the obvious modern strive for excessive simplifications, from ignoring scientific rigor and from eluding theoretical principles by narrow pragmatic solutions. What is the critical point that shifts to economic thinking? In measurement: the formula. Who released it? Where and when was it released? By whom, where, when and how is it used? In quantification: aggregation and data systematization. We systemize and process data without asking ourselves how much of the economic and social content that we are studying remains in the shapes that we have built.quantifications; simplifications; formula; misinformation; delusion;

    Identifying Validity in Qualitative Research: A Literature Review

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    This paper explores multiple articles relating to qualitative research. Qualitative research has seen several transformation that aim to support contributions for this research development. As research, using a qualitative methodology rises to prevalence, this paper explores industry and academia use of this methodology. The paper review research based in the field of healthcare and social work. After analysis, the review of literature shows that a majority qualitative research are within the field healthcare (Johnson, 1999). The research conducted embraces a diverse collection of approaches to inquiry intended to generate knowledge actually grounded in human experience. The literature review also addressed “rigor” as a standard for valid research, and the impending presumption for flexibility as called for by pundits against qualitative research paradigm. It was argued that this call for rigidity could threaten the innovativeness and hence the meaning and quality of a qualitative research. The author then review and describe the concept of validity to a qualitative research paradigm and how it is applied as discussed by Creswell (2013). Creswell discusses five approach, narrative, Phenomenology, grounded theory, ethnography and case study, which we will review through the paper

    Postprint Copy of Years of Teaching Dangerously: Interfacing Thomas Cromwell in Canon and Fandom, Michael Drayton, “W.S.,” and Hilary Mantel

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    When Sir Thomas Bodley founded the Bodleian Library, he sought to keep “baggage books,” “riff-raff books,” and distasteful literature off the shelves. The question of keeping literature in or out of a library or canon is never simply about literature; it is also about class-based criticism and notions of defending culture and taste against unauthorized popular versions. Teaching dangerously opens the early modern classroom, theorizing it as a type of literary fandom that is both personally engaging and socially conscious: this type of teaching does not forget academic rigor; it remembers human impact, by enfolding scholarship and theory. Putting early modern texts into play alongside contemporary literature and social issues moves learning in unscripted, surprising, and dangerous directions. This article models these dangerous practices by interfacing affect theory with the fandom of Thomas Cromwell as he appears in Michael Drayton’s poem The Legend of Thomas Cromwell, the apocryphal “W.S.” drama The Life and Death of Thomas Cromwell, and Hilary Mantel’s novels Wolf Hall and Bring up the Bodies. This type of ‘magic’ is not so far removed from J.K. Rowling’s wizardry, and teaching dangerously with affect theory empowers classroom fandom that engages and changes the world as we know it

    Effects of antibodies against dynein and tubulin on the stiffness of flagellar axonemes

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    Antidynein antibodies, previously shown to inhibit flagellar oscillation and active sliding of axonemal microtubules, increase the bending resistance of axonemes measured under relaxing conditions, but not the bending resistance of axonemes measured under rigor conditions. These observations suggest that antidynein antibodies can stabilize rigor cross-bridges between outer-doublet microtubules, by interfering with ATP-induced cross-bridge detachment. Stabilization of a small number of cross-bridge appears to be sufficient to cause substantial inhibition of the frequency of flagellar oscillation. Antitubulin antibodies, previously shown to inhibit flagellar oscillation without inhibiting active sliding of axonemal microtubules, do not increase the static bending resistance of axonemes. However, we observed a viscoelastic effect, corresponding to a large increase in the immediate bending resistance. This immediate bending resistance increase may be sufficient to explain inhibition of flagellar oscillation; but several alternative explanations cannot yet be excluded
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