Real-Time In Vivo Intraocular Pressure Monitoring using an Optomechanical Implant and an Artificial Neural Network

Optimized glaucoma therapy requires frequent monitoring and timely lowering of elevated intraocular pressure (IOP). A recently developed microscale IOP-monitoring implant, when illuminated with broadband light, reflects a pressure-dependent optical spectrum that is captured and converted to measure IOP. However, its accuracy is limited by background noise and the difficulty of modeling non-linear shifts of the spectra with respect to pressure changes. Using an end-to-end calibration system to train an artificial neural network (ANN) for signal demodulation we improved the speed and accuracy of pressure measurements obtained with an optically probed IOP-monitoring implant and make it suitable for real-time in vivo IOP monitoring. The ANN converts captured optical spectra into corresponding IOP levels. We achieved an IOP-measurement accuracy of ±0.1 mmHg at a measurement rate of 100 Hz, which represents a ten-fold improvement from previously reported values. This technique allowed real-time tracking of artificially induced sub-1 s transient IOP elevations and minor fluctuations induced by the respiratory motion of the rabbits during in vivo monitoring. All in vivo sensor readings paralleled those obtained concurrently using a commercial tonometer and showed consistency within ±2 mmHg. Real-time processing is highly useful for IOP monitoring in clinical settings and home environments and improves the overall practicality of the optical IOP-monitoring approach

Real-Time In Vivo Intraocular Pressure Monitoring using an Optomechanical Implant and an Artificial Neural Network

Optimized glaucoma therapy requires frequent monitoring and timely lowering of elevated intraocular pressure (IOP). A recently developed microscale IOP-monitoring implant, when illuminated with broadband light, reflects a pressure-dependent optical spectrum that is captured and converted to measure IOP. However, its accuracy is limited by background noise and the difficulty of modeling non-linear shifts of the spectra with respect to pressure changes. Using an end-to-end calibration system to train an artificial neural network (ANN) for signal demodulation we improved the speed and accuracy of pressure measurements obtained with an optically probed IOP-monitoring implant and make it suitable for real-time in vivo IOP monitoring. The ANN converts captured optical spectra into corresponding IOP levels. We achieved an IOP-measurement accuracy of ±0.1 mmHg at a measurement rate of 100 Hz, which represents a ten-fold improvement from previously reported values. This technique allowed real-time tracking of artificially induced sub-1 s transient IOP elevations and minor fluctuations induced by the respiratory motion of the rabbits during in vivo monitoring. All in vivo sensor readings paralleled those obtained concurrently using a commercial tonometer and showed consistency within ±2 mmHg. Real-time processing is highly useful for IOP monitoring in clinical settings and home environments and improves the overall practicality of the optical IOP-monitoring approach

Multirate Frequency Transformations: Wideband AM-FM Demodulation with Applications to Signal Processing and Communications

The AM-FM (amplitude & frequency modulation) signal model finds numerous applications in image processing, communications, and speech processing. The traditional approaches towards demodulation of signals in this category are the analytic signal approach, frequency tracking, or the energy operator approach. These approaches however, assume that the amplitude and frequency components are slowly time-varying, e.g., narrowband and incur significant demodulation error in the wideband scenarios. In this thesis, we extend a two-stage approach towards wideband AM-FM demodulation that combines multirate frequency transformations (MFT) enacted through a combination of multirate systems with traditional demodulation techniques, e.g., the Teager-Kasiser energy operator demodulation (ESA) approach to large wideband to narrowband conversion factors. The MFT module comprises of multirate interpolation and heterodyning and converts the wideband AM-FM signal into a narrowband signal, while the demodulation module such as ESA demodulates the narrowband signal into constituent amplitude and frequency components that are then transformed back to yield estimates for the wideband signal. This MFT-ESA approach is then applied to the various problems of: (a) wideband image demodulation and fingerprint demodulation, where multidimensional energy separation is employed, (b) wideband first-formant demodulation in vowels, and (c) wideband CPM demodulation with partial response signaling, to demonstrate its validity in both monocomponent and multicomponent scenarios as an effective multicomponent AM-FM signal demodulation and analysis technique for image processing, speech processing, and communications based applications

Proceedings of the Second International Mobile Satellite Conference (IMSC 1990)

Presented here are the proceedings of the Second International Mobile Satellite Conference (IMSC), held June 17-20, 1990 in Ottawa, Canada. Topics covered include future mobile satellite communications concepts, aeronautical applications, modulation and coding, propagation and experimental systems, mobile terminal equipment, network architecture and control, regulatory and policy considerations, vehicle antennas, and speech compression

Analysis and improved design considerations for airborne pulse Doppler radar signal processing in the detection of hazardous windshear

High resolution windspeed profile measurements are needed to provide reliable detection of hazardous low altitude windshear with an airborne pulse Doppler radar. The system phase noise in a Doppler weather radar may degrade the spectrum moment estimation quality and the clutter cancellation capability which are important in windshear detection. Also the bias due to weather return Doppler spectrum skewness may cause large errors in pulse pair spectral parameter estimates. These effects are analyzed for the improvement of an airborne Doppler weather radar signal processing design. A method is presented for the direct measurement of windspeed gradient using low pulse repetition frequency (PRF) radar. This spatial gradient is essential in obtaining the windshear hazard index. As an alternative, the modified Prony method is suggested as a spectrum mode estimator for both the clutter and weather signal. Estimation of Doppler spectrum modes may provide the desired windshear hazard information without the need of any preliminary processing requirement such as clutter filtering. The results obtained by processing a NASA simulation model output support consideration of mode identification as one component of a windshear detection algorithm

Ultra low power circuits for a miniature apnoea detection device

Imperial Users onl

Toward an interpretive framework of two-dimensional speech-signal processing

Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, 2011.Cataloged from PDF version of thesis.Includes bibliographical references (p. 177-179).Traditional representations of speech are derived from short-time segments of the signal and result in time-frequency distributions of energy such as the short-time Fourier transform and spectrogram. Speech-signal models of such representations have had utility in a variety of applications such as speech analysis, recognition, and synthesis. Nonetheless, they do not capture spectral, temporal, and joint spectrotemporal energy fluctuations (or "modulations") present in local time-frequency regions of the time-frequency distribution. Inspired by principles from image processing and evidence from auditory neurophysiological models, a variety of twodimensional (2-D) processing techniques have been explored in the literature as alternative representations of speech; however, speech-based models are lacking in this framework. This thesis develops speech-signal models for a particular 2-D processing approach in which 2-D Fourier transforms are computed on local time-frequency regions of the canonical narrowband or wideband spectrogram; we refer to the resulting transformed space as the Grating Compression Transform (GCT). We argue for a 2-D sinusoidal-series amplitude modulation model of speech content in the spectrogram domain that relates to speech production characteristics such as pitch/noise of the source, pitch dynamics, formant structure and dynamics, and offset/onset content. Narrowband- and wideband-based models are shown to exhibit important distinctions in interpretation and oftentimes "dual" behavior. In the transformed GCT space, the modeling results in a novel taxonomy of signal behavior based on the distribution of formant and onset/offset content in the transformed space via source characteristics. Our formulation provides a speech-specific interpretation of the concept of "modulation" in 2-D processing in contrast to existing approaches that have done so either phenomenologically through qualitative analyses and/or implicitly through data-driven machine learning approaches. One implication of the proposed taxonomy is its potential for interpreting transformations of other time-frequency distributions such as the auditory spectrogram which is generally viewed as being "narrowband"/"wideband" in its low/high-frequency regions. The proposed signal model is evaluated in several ways. First, we perform analysis of synthetic speech signals to characterize its properties and limitations. Next, we develop an algorithm for analysis/synthesis of spectrograms using the model and demonstrate its ability to accurately represent real speech content. As an example application, we further apply the models in cochannel speaker separation, exploiting the GCT's ability to distribute speaker-specific content and often recover overlapping information through demodulation and interpolation in the 2-D GCT space. Specifically, in multi-pitch estimation, we demonstrate the GCT's ability to accurately estimate separate and crossing pitch tracks under certain conditions. Finally, we demonstrate the model's ability to separate mixtures of speech signals using both prior and estimated pitch information. Generalization to other speech-signal processing applications is proposed.by Tianyu Tom Wang.Ph.D

Proceedings of the Third International Mobile Satellite Conference (IMSC 1993)

Satellite-based mobile communications systems provide voice and data communications to users over a vast geographic area. The users may communicate via mobile or hand-held terminals, which may also provide access to terrestrial cellular communications services. While the first and second International Mobile Satellite Conferences (IMSC) mostly concentrated on technical advances, this Third IMSC also focuses on the increasing worldwide commercial activities in Mobile Satellite Services. Because of the large service areas provided by such systems, it is important to consider political and regulatory issues in addition to technical and user requirements issues. Topics covered include: the direct broadcast of audio programming from satellites; spacecraft technology; regulatory and policy considerations; advanced system concepts and analysis; propagation; and user requirements and applications