Guidelines for the recording and evaluation of pharmaco-EEG data in man: the International Pharmaco-EEG Society (IPEG)

The International Pharmaco-EEG Society (IPEG) presents updated guidelines summarising the requirements for the recording and computerised evaluation of pharmaco-EEG data in man. Since the publication of the first pharmaco-EEG guidelines in 1982, technical and data processing methods have advanced steadily, thus enhancing data quality and expanding the palette of tools available to investigate the action of drugs on the central nervous system (CNS), determine the pharmacokinetic and pharmacodynamic properties of novel therapeutics and evaluate the CNS penetration or toxicity of compounds. However, a review of the literature reveals inconsistent operating procedures from one study to another. While this fact does not invalidate results per se, the lack of standardisation constitutes a regrettable shortcoming, especially in the context of drug development programmes. Moreover, this shortcoming hampers reliable comparisons between outcomes of studies from different laboratories and hence also prevents pooling of data which is a requirement for sufficiently powering the validation of novel analytical algorithms and EEG-based biomarkers. The present updated guidelines reflect the consensus of a global panel of EEG experts and are intended to assist investigators using pharmaco-EEG in clinical research, by providing clear and concise recommendations and thereby enabling standardisation of methodology and facilitating comparability of data across laboratories

Detecting number processing and mental calculation in patients with disorders of consciousness using a hybrid brain-computer interface system

Background: For patients with disorders of consciousness such as coma, a vegetative state or a minimally conscious state, one challenge is to detect and assess the residual cognitive functions in their brains. Number processing and mental calculation are important brain functions but are difficult to detect in patients with disorders of consciousness using motor response-based clinical assessment scales such as the Coma Recovery Scale-Revised due to the patients' motor impairments and inability to provide sufficient motor responses for number- and calculation-based communication. Methods: In this study, we presented a hybrid brain-computer interface that combines P300 and steady state visual evoked potentials to detect number processing and mental calculation in Han Chinese patients with disorders of consciousness. Eleven patients with disorders of consciousness who were in a vegetative state (n = 6) or in a minimally conscious state (n = 3) or who emerged from a minimally conscious state (n = 2) participated in the brain-computer interface-based experiment. During the experiment, the patients with disorders of consciousness were instructed to perform three tasks, i.e., number recognition, number comparison, and mental calculation, including addition and subtraction. In each experimental trial, an arithmetic problem was first presented. Next, two number buttons, only one of which was the correct answer to the problem, flickered at different frequencies to evoke steady state visual evoked potentials, while the frames of the two buttons flashed in a random order to evoke P300 potentials. The patients needed to focus on the target number button (the correct answer). Finally, the brain-computer interface system detected P300 and steady state visual evoked potentials to determine the button to which the patients attended, further presenting the results as feedback. Results: Two of the six patients who were in a vegetative state, one of the three patients who were in a minimally conscious state, and the two patients that emerged from a minimally conscious state achieved accuracies significantly greater than the chance level. Furthermore, P300 potentials and steady state visual evoked potentials were observed in the electroencephalography signals from the five patients. Conclusions: Number processing and arithmetic abilities as well as command following were demonstrated in the five patients. Furthermore, our results suggested that through brain-computer interface systems, many cognitive experiments may be conducted in patients with disorders of consciousness, although they cannot provide sufficient behavioral responses. © 2015 Li et al

Fatigue Driving Detection Method Based on IPPG Technology

Physiological signal index can accurately reflect the degree of fatigue, but the contact detection method will greatly affect the driver\u27s driving. This paper presents a non-contact method for detecting tired driving. It uses cameras and other devices to collect information about the driver\u27s face. By recording facial changes over a period and processing the captured video, pulse waves are extracted. Then the frequency domain index and nonlinear index of heart rate variability were extracted by pulse wave characteristics. Finally, the experiment proves that the method can clearly judge whether the driver is tired. In this study, the Imaging Photoplethysmography (IPPG) technology was used to realise non-contact driver fatigue detection. Compared with the non-contact detection method through identifying drivers\u27 blinking and yawning, the physiological signal adopted in this paper is more convincing. Compared with other methods that detect physiological signals to judge driver fatigue, the method in this paper has the advantages of being non-contact, fast, convenient and available for the cockpit environment

Wideband Spectrum Sensing for Dynamic Spectrum Sharing

The proliferation of wireless devices grows exponentially, demanding more and more data communication capacity over wireless links. Radio spectrum is a scarce resource, and traditional wireless networks deployed by Mobile Network Operators (MNO) are based on an exclusive spectrum band allocation. However, underutilization of some licensed bands in time and geographic domains has been reported, especially in rural areas or areas away from high population density zones. This coexistence of increasingly high data communication needs and spectrum underutilization is an incomprehensible scenario. A more rational and efficient use of the spectrum is the possibility of Licensed Users (known as Primary Users – PU) to lease the spectrum, when not in use, to Unlicensed Users (known as Secondary Users – SU), or allowing the SU to opportunistically use the spectrum after sensing and verifying that the PU is idle. In this latter case, the SU must stop transmitting when the PU becomes active. This thesis addresses the spectrum sensing task, which is essential to provide dynamic spectrum sharing between PUs and SUs. We show that the Spectral Correlation Function (SCF) and the Spectral Coherence Function (SCoF) can provide a robust signal detection algorithm by exploiting the cyclostationary characteristics of the data communication signal. We enhance the most used algorithm to compute de SCF - the FAM (FFT Accumulation Method) algorithm – to efficiently compute the SCF in a local/zoomed region of the support ( ; ) plane (frequency/cycle frequency plane). This will provide the quick identification of spectral bands in use by PUs or free, in a wideband sampling scenario. Further, the characterization of the probability density of the estimates of the SCF and SCoF when only noise is present, using the FAM algorithm, will allow the definition of an adaptive threshold to develop a blind (with respect to the noise statistics) Constant False Alarm Rate (CFAR) detector (using the SCoF) and also a CFAR and a Constant Detection Rate (CDR) detector when that characterization is used to obtain an estimate of the background noise variance (using the SCF).A proliferação de dispositivos sem fios cresce de forma exponencial, exigindo cada vez mais capacidade de comunicação de dados através de ligações sem fios. O espectro radioelétrico é um recurso escasso, e as redes sem fios tradicionais implantadas pelos Operadores de Redes Móveis baseiam-se numa atribuição exclusiva de bandas do espectro. No entanto, tem sido relatada a subutilização de algumas bandas licenciadas quer ao longo do tempo, quer na sua localização geográfica, especialmente em áreas rurais, e em áreas longe de zonas de elevada densidade populacional. A coexistência da necessidade cada vez maior de comunicação de dados, e a subutilização do espectro é um cenário incompreensível. Uma utilização mais racional e eficiente do espectro pressupõe a possibilidade dos Utilizadores Licenciados (conhecidos como Utilizadores Primários – Primary Users - PU) alugarem o espectro, quando este não está a ser utilizado, a Utilizadores Não Licenciados (conhecidos como Utilizadores Secundários – Secondary Users - SU), ou permitir ao SU utilizar oportunisticamente o espectro após a deteção e verificação de que o PU está inativo. Neste último caso, o SU deverá parar de transmitir quando o PU ficar ativo. Nesta tese é abordada a tarefa de deteção espectral, que é essencial para proporcionar a partilha dinâmica do espectro entre PUs e SUs. Mostra-se que a Função de Correlação Espectral (Spectral Correlation Function - SCF) e a Função de Coerência Espectral (Spectral Coherence Function - SCoF) permitem o desenvolvimento de um algoritmo robusto de deteção de sinal, explorando as características ciclo-estacionárias dos sinais de comunicação de dados. Propõe-se uma melhoria ao algoritmo mais utilizado para cálculo da SCF – o método FAM (FFT Accumulation Method) - para permitir o cálculo mais eficiente da SCF numa região local/ampliada do plano de suporte / (plano de frequência/frequência de ciclo). Esta melhoria permite a identificação rápida de bandas espectrais em uso por PUs ou livres, num cenário de amostragem de banda larga. Adicionalmente, é feita a caracterização da densidade de probabilidade das estimativas da SCF e SCoF quando apenas o ruído está presente, o que permite a definição de um limiar adaptativo, para desenvolver um detetor de Taxa de Falso Alarme Constante (Constant False Alarm Rate – CFAR) sem conhecimento do ruído de fundo (usando a SCoF) e também um detetor CFAR e Taxa de Deteção Constante (Constant Detection Rate – CDR), quando se utiliza aquela caracterização para obter uma estimativa da variância do ruído de fundo (usando a SCF)

A wide area system for power transmission security enhancement using a process systems approach

Imperial Users onl

Classification Of Civilian Vehicle Sounds Using A Large Database Of Vehicle Sounds

We have completed the building of an extensive database of civilian vehicle sounds. The database consists of correlated acoustic and seismic signatures of a large number (exceeding 850) of civilian vehicles. Each acoustic signature is obtained through two high-quality microphones separated by 25 feet, and whose signals are exactly synchronized. In this work, spectral and tristimulus features of civilian vehicle sounds are computed and then submitted to further processing using principal component analysis. The “super†features, derived after principal component analysis is performed, are then used for classification. In this research effort, the performance of the quadratic classifier with that of the neural network classifier is compared. Results presented here show that the neural network classifier out-performs the quadratic classifier in distinguishing different and same branded vehicle sounds. The classification usually has small (at times 0%) classification errors