27,593 research outputs found
National Mesothelioma Virtual Bank: A standard based biospecimen and clinical data resource to enhance translational research
Background: Advances in translational research have led to the need for well characterized biospecimens for research. The National Mesothelioma Virtual Bank is an initiative which collects annotated datasets relevant to human mesothelioma to develop an enterprising biospecimen resource to fulfill researchers' need. Methods: The National Mesothelioma Virtual Bank architecture is based on three major components: (a) common data elements (based on College of American Pathologists protocol and National North American Association of Central Cancer Registries standards), (b) clinical and epidemiologic data annotation, and (c) data query tools. These tools work interoperably to standardize the entire process of annotation. The National Mesothelioma Virtual Bank tool is based upon the caTISSUE Clinical Annotation Engine, developed by the University of Pittsburgh in cooperation with the Cancer Biomedical Informatics Gridâą (caBIGâą, see http://cabig.nci.nih.gov). This application provides a web-based system for annotating, importing and searching mesothelioma cases. The underlying information model is constructed utilizing Unified Modeling Language class diagrams, hierarchical relationships and Enterprise Architect software. Result: The database provides researchers real-time access to richly annotated specimens and integral information related to mesothelioma. The data disclosed is tightly regulated depending upon users' authorization and depending on the participating institute that is amenable to the local Institutional Review Board and regulation committee reviews. Conclusion: The National Mesothelioma Virtual Bank currently has over 600 annotated cases available for researchers that include paraffin embedded tissues, tissue microarrays, serum and genomic DNA. The National Mesothelioma Virtual Bank is a virtual biospecimen registry with robust translational biomedical informatics support to facilitate basic science, clinical, and translational research. Furthermore, it protects patient privacy by disclosing only de-identified datasets to assure that biospecimens can be made accessible to researchers. © 2008 Amin et al; licensee BioMed Central Ltd
Capture and Reuse of Knowledge in ICT-based Decisional Environments
Health care practitioners continually confront with a wide range of challenges, seeking to making difficult diagnoses, avoiding errors, ensuring highest quality, maximizing efficacy and reducing costs. Information technology has the potential to reduce clinical errors and to im-prove the decision making in the clinical milieu. This paper presents a pilot development of a clinical decision support systems (CDSS) entitled MEDIS that was designed to incorporate knowledge from heterogeneous environments with the purpose of increasing the efficiency and the quality of the decision making process, and reducing costs based on advances of in-formation technologies, especially under the impact of the transition towards the mobile space. The system aims to capture and reuse knowledge in order to provide real-time access to clinical knowledge for a variety of users, including medical personnel, patients, teachers and students.Clinical Decision Support Systems, Knowledge Management, Knowledge Interoperability, Mobile Interface, Object-relational Mapping
Security oriented e-infrastructures supporting neurological research and clinical trials
The neurological and wider clinical domains stand to gain greatly from the vision of the grid in providing seamless yet secure access to distributed, heterogeneous computational resources and data sets. Whilst a wealth of clinical data exists within local, regional and national healthcare boundaries, access to and usage of these data sets demands that fine grained security is supported and subsequently enforced. This paper explores the security challenges of the e-health domain, focusing in particular on authorization. The context of these explorations is the MRC funded VOTES (Virtual Organisations for Trials and Epidemiological Studies) and the JISC funded GLASS (Glasgow early adoption of Shibboleth project) which are developing Grid infrastructures for clinical trials with case studies in the brain trauma domain
Incorporation of two terminology projects into a system for information retrieval using NLP for term expansion
In this paper, we will discuss two medical terminology projects at the University College of Ghent, Faculty of translation studies, and the benefits of combining them to provide Dutch professionals and laymen with better access to information in biomedical databases. Our first project, the MeSH Termbase Project (MTB) is aimed at health care professionals, medical translators and also patients in need of language support. The main aim of our second project, the Multilingual Glossary of Technical and Popular Medical Terms, is the simplification of the terminology used in patient information leaflets
Medical Virtual Public Services
The healthcare enterprises are very disconnected. This paper intends to propose a solution that will provide citizens, businesses and medical enterprises with improved access to medical virtual public services. Referred medical services are based on existing national medical Web services and which support medically required services provided by physicians and supplementary health care practitioners, laboratory services and diagnostic procedures, clinics and hospitalsâ services. Requirements and specific rules of these medical services are considered, and personalization of user preferences will to be supported. The architecture is based on adaptable process management technologies, allowing for virtual services which are dynamically combined from existing national medical services. In this way, a comprehensive workflow process is set up, allowing for service-level agreements, an audit trail and explanation of the process to the end user. The process engine operates on top of a virtual repository, providing a high-level semantic view of information retrieved from heterogeneous information sources, such as national sources of medical services. The system relies on a security framework to ensure all high-level security requirements are met. Systemâs architecture is business oriented: it focuses on Service Oriented Architecture - SOA concepts, asynchronously combining Web services, Business Process Management â BPM rules and BPEL standards.Business Process Management, Service Oriented Architecture, Application Integration, Web services, information technologies, virtual repository, database.
A systematic literature review of cloud computing in eHealth
Cloud computing in eHealth is an emerging area for only few years. There
needs to identify the state of the art and pinpoint challenges and possible
directions for researchers and applications developers. Based on this need, we
have conducted a systematic review of cloud computing in eHealth. We searched
ACM Digital Library, IEEE Xplore, Inspec, ISI Web of Science and Springer as
well as relevant open-access journals for relevant articles. A total of 237
studies were first searched, of which 44 papers met the Include Criteria. The
studies identified three types of studied areas about cloud computing in
eHealth, namely (1) cloud-based eHealth framework design (n=13); (2)
applications of cloud computing (n=17); and (3) security or privacy control
mechanisms of healthcare data in the cloud (n=14). Most of the studies in the
review were about designs and concept-proof. Only very few studies have
evaluated their research in the real world, which may indicate that the
application of cloud computing in eHealth is still very immature. However, our
presented review could pinpoint that a hybrid cloud platform with mixed access
control and security protection mechanisms will be a main research area for
developing citizen centred home-based healthcare applications
Virtual Clinical Trials: One Step Forward, Two Steps Back
Virtual clinical trials have entered the medical research landscape. Todayâs clinical trials recruit subjects online, obtain informed consent online, send treatments such as medications or devices to the subjectsâ homes, and require subjects to record their responses online. Virtual clinical trials could be a way to democratize clinical research and circumvent geographical limitations by allowing access to clinical research for people who live far from traditional medical research centers. But virtual clinical trials also depart dramatically from traditional medical research studies in ways that can harm individuals and the public at large. This article addresses the issues presented by virtual clinical trials with regard to: (1) recruitment methods; (2) informed consent; (3) confidentiality; (4) potential risks to the subjects; and (5) the safety and efficacy of treatments that are approved
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Computerization of workflows, guidelines and care pathways: a review of implementation challenges for process-oriented health information systems
There is a need to integrate the various theoretical frameworks and formalisms for modeling clinical guidelines, workflows, and pathways, in order to move beyond providing support for individual clinical decisions and toward the provision of process-oriented, patient-centered, health information systems (HIS). In this review, we analyze the challenges in developing process-oriented HIS that formally model guidelines, workflows, and care pathways. A qualitative meta-synthesis was performed on studies published in English between 1995 and 2010 that addressed the modeling process and reported the exposition of a new methodology, model, system implementation, or system architecture. Thematic analysis, principal component analysis (PCA) and data visualisation techniques were used to identify and cluster the underlying implementation âchallengeâ themes. One hundred and eight relevant studies were selected for review. Twenty-five underlying âchallengeâ themes were identified. These were clustered into 10 distinct groups, from which a conceptual model of the implementation process was developed. We found that the development of systems supporting individual clinical decisions is evolving toward the implementation of adaptable care pathways on the semantic web, incorporating formal, clinical, and organizational ontologies, and the use of workflow management systems. These architectures now need to be implemented and evaluated on a wider scale within clinical settings
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