Classification performance for covid patient prognosis from automatic ai segmentation—a single-center study

Background: COVID assessment can be performed using the recently developed individual risk score (prediction of severe respiratory failure in hospitalized patients with SARS-COV2 infection, PREDI-CO score) based on High Resolution Computed Tomography. In this study, we evaluated the possibility of automatizing this estimation using semi-supervised AI-based Radiomics, leveraging the possibility of performing non-supervised segmentation of ground-glass areas. Methods: We collected 92 from patients treated in the IRCCS Sant’Orsola-Malpighi Policlinic and public databases; each lung was segmented using a pre-trained AI method; ground-glass opacity was identified using a novel, non-supervised approach; radiomic measurements were collected and used to predict clinically relevant scores, with particular focus on mortality and the PREDI-CO score. We compared the prediction obtained through different machine learning approaches. Results: All the methods obtained a well-balanced accuracy (70%) on the PREDI-CO score but did not obtain satisfying results on other clinical characteristics due to unbalance between the classes. Conclusions: Semi-supervised segmentation, implemented using a combination of non-supervised segmentation and feature extraction, seems to be a viable approach for patient stratification and could be leveraged to train more complex models. This would be useful in a high-demand situation similar to the current pandemic to support gold-standard segmentation for AI training

Knowledge Base Population using Semantic Label Propagation

A crucial aspect of a knowledge base population system that extracts new facts from text corpora, is the generation of training data for its relation extractors. In this paper, we present a method that maximizes the effectiveness of newly trained relation extractors at a minimal annotation cost. Manual labeling can be significantly reduced by Distant Supervision, which is a method to construct training data automatically by aligning a large text corpus with an existing knowledge base of known facts. For example, all sentences mentioning both 'Barack Obama' and 'US' may serve as positive training instances for the relation born_in(subject,object). However, distant supervision typically results in a highly noisy training set: many training sentences do not really express the intended relation. We propose to combine distant supervision with minimal manual supervision in a technique called feature labeling, to eliminate noise from the large and noisy initial training set, resulting in a significant increase of precision. We further improve on this approach by introducing the Semantic Label Propagation method, which uses the similarity between low-dimensional representations of candidate training instances, to extend the training set in order to increase recall while maintaining high precision. Our proposed strategy for generating training data is studied and evaluated on an established test collection designed for knowledge base population tasks. The experimental results show that the Semantic Label Propagation strategy leads to substantial performance gains when compared to existing approaches, while requiring an almost negligible manual annotation effort.Comment: Submitted to Knowledge Based Systems, special issue on Knowledge Bases for Natural Language Processin

MD-IQA: Learning Multi-scale Distributed Image Quality Assessment with Semi Supervised Learning for Low Dose CT

Image quality assessment (IQA) plays a critical role in optimizing radiation dose and developing novel medical imaging techniques in computed tomography (CT). Traditional IQA methods relying on hand-crafted features have limitations in summarizing the subjective perceptual experience of image quality. Recent deep learning-based approaches have demonstrated strong modeling capabilities and potential for medical IQA, but challenges remain regarding model generalization and perceptual accuracy. In this work, we propose a multi-scale distributions regression approach to predict quality scores by constraining the output distribution, thereby improving model generalization. Furthermore, we design a dual-branch alignment network to enhance feature extraction capabilities. Additionally, semi-supervised learning is introduced by utilizing pseudo-labels for unlabeled data to guide model training. Extensive qualitative experiments demonstrate the effectiveness of our proposed method for advancing the state-of-the-art in deep learning-based medical IQA. Code is available at: https://github.com/zunzhumu/MD-IQA

Semi-Supervised Recurrent Neural Network for Adverse Drug Reaction Mention Extraction

Social media is an useful platform to share health-related information due to its vast reach. This makes it a good candidate for public-health monitoring tasks, specifically for pharmacovigilance. We study the problem of extraction of Adverse-Drug-Reaction (ADR) mentions from social media, particularly from twitter. Medical information extraction from social media is challenging, mainly due to short and highly information nature of text, as compared to more technical and formal medical reports. Current methods in ADR mention extraction relies on supervised learning methods, which suffers from labeled data scarcity problem. The State-of-the-art method uses deep neural networks, specifically a class of Recurrent Neural Network (RNN) which are Long-Short-Term-Memory networks (LSTMs) \cite{hochreiter1997long}. Deep neural networks, due to their large number of free parameters relies heavily on large annotated corpora for learning the end task. But in real-world, it is hard to get large labeled data, mainly due to heavy cost associated with manual annotation. Towards this end, we propose a novel semi-supervised learning based RNN model, which can leverage unlabeled data also present in abundance on social media. Through experiments we demonstrate the effectiveness of our method, achieving state-of-the-art performance in ADR mention extraction.Comment: Accepted at DTMBIO workshop, CIKM 2017. To appear in BMC Bioinformatics. Pls cite that versio

Unsupervised spectral sub-feature learning for hyperspectral image classification

Spectral pixel classification is one of the principal techniques used in hyperspectral image (HSI) analysis. In this article, we propose an unsupervised feature learning method for classification of hyperspectral images. The proposed method learns a dictionary of sub-feature basis representations from the spectral domain, which allows effective use of the correlated spectral data. The learned dictionary is then used in encoding convolutional samples from the hyperspectral input pixels to an expanded but sparse feature space. Expanded hyperspectral feature representations enable linear separation between object classes present in an image. To evaluate the proposed method, we performed experiments on several commonly used HSI data sets acquired at different locations and by different sensors. Our experimental results show that the proposed method outperforms other pixel-wise classification methods that make use of unsupervised feature extraction approaches. Additionally, even though our approach does not use any prior knowledge, or labelled training data to learn features, it yields either advantageous, or comparable, results in terms of classification accuracy with respect to recent semi-supervised methods

FSL-BM: Fuzzy Supervised Learning with Binary Meta-Feature for Classification

This paper introduces a novel real-time Fuzzy Supervised Learning with Binary Meta-Feature (FSL-BM) for big data classification task. The study of real-time algorithms addresses several major concerns, which are namely: accuracy, memory consumption, and ability to stretch assumptions and time complexity. Attaining a fast computational model providing fuzzy logic and supervised learning is one of the main challenges in the machine learning. In this research paper, we present FSL-BM algorithm as an efficient solution of supervised learning with fuzzy logic processing using binary meta-feature representation using Hamming Distance and Hash function to relax assumptions. While many studies focused on reducing time complexity and increasing accuracy during the last decade, the novel contribution of this proposed solution comes through integration of Hamming Distance, Hash function, binary meta-features, binary classification to provide real time supervised method. Hash Tables (HT) component gives a fast access to existing indices; and therefore, the generation of new indices in a constant time complexity, which supersedes existing fuzzy supervised algorithms with better or comparable results. To summarize, the main contribution of this technique for real-time Fuzzy Supervised Learning is to represent hypothesis through binary input as meta-feature space and creating the Fuzzy Supervised Hash table to train and validate model.Comment: FICC201