Tunable Neuromimetic Integrated System for Emulating Cortical Neuron Models

Nowadays, many software solutions are currently available for simulating neuron models. Less conventional than software-based systems, hardware-based solutions generally combine digital and analog forms of computation. In previous work, we designed several neuromimetic chips, including the Galway chip that we used for this paper. These silicon neurons are based on the Hodgkin–Huxley formalism and they are optimized for reproducing a large variety of neuron behaviors thanks to tunable parameters. Due to process variation and device mismatch in analog chips, we use a full-custom fitting method in voltage-clamp mode to tune our neuromimetic integrated circuits. By comparing them with experimental electrophysiological data of these cells, we show that the circuits can reproduce the main firing features of cortical cell types. In this paper, we present the experimental measurements of our system which mimic the four most prominent biological cells: fast spiking, regular spiking, intrinsically bursting, and low-threshold spiking neurons into analog neuromimetic integrated circuit dedicated to cortical neuron simulations. This hardware and software platform will allow to improve the hybrid technique, also called “dynamic-clamp,” that consists of connecting artificial and biological neurons to study the function of neuronal circuits

Parallel computing for brain simulation

[Abstract] Background: The human brain is the most complex system in the known universe, it is therefore one of the greatest mysteries. It provides human beings with extraordinary abilities. However, until now it has not been understood yet how and why most of these abilities are produced. Aims: For decades, researchers have been trying to make computers reproduce these abilities, focusing on both understanding the nervous system and, on processing data in a more efficient way than before. Their aim is to make computers process information similarly to the brain. Important technological developments and vast multidisciplinary projects have allowed creating the first simulation with a number of neurons similar to that of a human brain. Conclusion: This paper presents an up-to-date review about the main research projects that are trying to simulate and/or emulate the human brain. They employ different types of computational models using parallel computing: digital models, analog models and hybrid models. This review includes the current applications of these works, as well as future trends. It is focused on various works that look for advanced progress in Neuroscience and still others which seek new discoveries in Computer Science (neuromorphic hardware, machine learning techniques). Their most outstanding characteristics are summarized and the latest advances and future plans are presented. In addition, this review points out the importance of considering not only neurons: Computational models of the brain should also include glial cells, given the proven importance of astrocytes in information processing.Galicia. Consellería de Cultura, Educación e Ordenación Universitaria; GRC2014/049Galicia. Consellería de Cultura, Educación e Ordenación Universitaria; R2014/039Instituto de Salud Carlos III; PI13/0028

Hypothetical membrane mechanisms in essential tremor

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

SpiNNaker: Fault tolerance in a power- and area- constrained large-scale neuromimetic architecture

AbstractSpiNNaker is a biologically-inspired massively-parallel computer designed to model up to a billion spiking neurons in real-time. A full-fledged implementation of a SpiNNaker system will comprise more than 105 integrated circuits (half of which are SDRAMs and half multi-core systems-on-chip). Given this scale, it is unavoidable that some components fail and, in consequence, fault-tolerance is a foundation of the system design. Although the target application can tolerate a certain, low level of failures, important efforts have been devoted to incorporate different techniques for fault tolerance. This paper is devoted to discussing how hardware and software mechanisms collaborate to make SpiNNaker operate properly even in the very likely scenario of component failures and how it can tolerate system-degradation levels well above those expected

Trends and challenges in neuroengineering: toward "Intelligent" neuroprostheses through brain-"brain inspired systems" communication

Future technologies aiming at restoring and enhancing organs function will intimately rely on near-physiological and energy-efficient communication between living and artificial biomimetic systems. Interfacing brain-inspired devices with the real brain is at the forefront of such emerging field, with the term "neurobiohybrids" indicating all those systems where such interaction is established. We argue that achieving a "high-level" communication and functional synergy between natural and artificial neuronal networks in vivo, will allow the development of a heterogeneous world of neurobiohybrids, which will include "living robots" but will also embrace “intelligent” neuroprostheses for augmentation of brain function. The societal and economical impact of intelligent neuroprostheses is likely to be potentially strong, as they will offer novel therapeutic perspectives for a number of diseases, and going beyond classical pharmaceutical schemes. However, they will unavoidably raise fundamental ethical questions on the intermingling between man and machine and more specifically, on how deeply it should be allowed that brain processing is affected by implanted "intelligent" artificial systems. Following this perspective, we provide the reader with insights on ongoing developments and trends in the field of neurobiohybrids. We address the topic also from a "community building" perspective, showing through a quantitative bibliographic analysis, how scientists working on the engineering of brain-inspired devices and brain-machine interfaces are increasing their interactions. We foresee that such trend preludes to a formidable technological and scientific revolution in brain-machine communication and to the opening of new avenues for restoring or even augmenting brain function for therapeutic purposes

Six networks on a universal neuromorphic computing substrate

In this study, we present a highly configurable neuromorphic computing substrate and use it for emulating several types of neural networks. At the heart of this system lies a mixed-signal chip, with analog implementations of neurons and synapses and digital transmission of action potentials. Major advantages of this emulation device, which has been explicitly designed as a universal neural network emulator, are its inherent parallelism and high acceleration factor compared to conventional computers. Its configurability allows the realization of almost arbitrary network topologies and the use of widely varied neuronal and synaptic parameters. Fixed-pattern noise inherent to analog circuitry is reduced by calibration routines. An integrated development environment allows neuroscientists to operate the device without any prior knowledge of neuromorphic circuit design. As a showcase for the capabilities of the system, we describe the successful emulation of six different neural networks which cover a broad spectrum of both structure and functionality

Scalable event-driven modelling architectures for neuromimetic hardware

Neural networks present a fundamentally different model of computation from the conventional sequential digital model. Dedicated hardware may thus be more suitable for executing them. Given that there is no clear consensus on the model of computation in the brain, model flexibility is at least as important a characteristic of neural hardware as is performance acceleration. The SpiNNaker chip is an example of the emerging 'neuromimetic' architecture, a universal platform that specialises the hardware for neural networks but allows flexibility in model choice. It integrates four key attributes: native parallelism, event-driven processing, incoherent memory and incremental reconfiguration, in a system combining an array of general-purpose processors with a configurable asynchronous interconnect. Making such a device usable in practice requires an environment for instantiating neural models on the chip that allows the user to focus on model characteristics rather than on hardware details. The central part of this system is a library of predesigned, 'drop-in' event-driven neural components that specify their specific implementation on SpiNNaker. Three exemplar models: two spiking networks and a multilayer perceptron network, illustrate techniques that provide a basis for the library and demonstrate a reference methodology that can be extended to support third-party library components not only on SpiNNaker but on any configurable neuromimetic platform. Experiments demonstrate the capability of the library model to implement efficient on-chip neural networks, but also reveal important hardware limitations, particularly with respect to communications, that require careful design. The ultimate goal is the creation of a library-based development system that allows neural modellers to work in the high-level environment of their choice, using an automated tool chain to create the appropriate SpiNNaker instantiation. Such a system would enable the use of the hardware to explore abstractions of biological neurodynamics that underpin a functional model of neural computation.EThOS - Electronic Theses Online ServiceGBUnited Kingdo