11,797 research outputs found

    Exploring Potential Domains of Agroecological Transformation in the United States

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    There is now substantial evidence that agroecology constitutes a necessary pathway towards socially just and ecologically resilient agrifood systems. In the United States, however, agroecology remains relegated to the margins of research and policy spaces. This dissertation explores three potential domains of agroecological transformation in the US. Domains of transformation are sites of contestation in which agroecology interfaces with the industrial agrifood system; these material and conceptual spaces may point to important pathways for scaling agroecology. To explore this concept, I examine formal agroecology education (Chapter 1), extension services and statewide discourses around soil health (Chapter 2), and models of farmland access not based on private property (Chapter 3). While these constitute three distinct topics, I seek to demonstrate that they are linked by similar forces that enable and constrain the extent to which these domains can be sites of agroecological transformation. First, I use case study methodology to explore the evolution of an advanced undergraduate agroecology course at the University of Vermont. I examine how course content and pedagogy align with a transformative framing of agroecology as inherently transdisciplinary, participatory, action-oriented, and political. I find that student-centered pedagogies and experiential education on farms successfully promote transformative learning whereby students shift their understanding of agrifood systems and their role(s) within them. In my second chapter, I zoom out to consider soil health discourses amongst farmers and extension professionals in Vermont. Using co-created mental models and participatory analysis, I find that a singular notion of soil health based on biological, chemical, and physical properties fails to capture the diverse ways in which farmers and extension professionals understand soil health. I advocate for a principles-based approach to soil health that includes social factors and may provide a valuable heuristic for mobilizing knowledge towards agroecology transition pathways. My third chapter, conducted in collaboration with the national non-profit organization Agrarian Trust, considers equitable farmland access. Through semi-structured interviews with 13 farmers and growers across the US, I explore both farmer motivations for engaging with alternative land access models (ALAMs) and the potential role(s) these models may play within broader transformation processes. I argue that ALAMs constitute material and conceptual ‘third spaces’ within which the private property regime is challenged and new identities and language around land ownership can emerge; as such, ALAMs may facilitate a (re)imagining of land-based social-ecological relationships. I conclude the dissertation by identifying conceptual and practical linkages across the domains explored in Chapters 1-3. I pay particular attention to processes that challenge neoliberal logics, enact plural ways of knowing, and prefigure just futures. In considering these concepts, I apply an expansive notion of pedagogy to explore how processes of teaching and (un)learning can contribute to cultivating foundational capacities for transition processes

    Estudo da remodelagem reversa miocárdica através da análise proteómica do miocárdio e do líquido pericárdico

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    Valve replacement remains as the standard therapeutic option for aortic stenosis patients, aiming at abolishing pressure overload and triggering myocardial reverse remodeling. However, despite the instant hemodynamic benefit, not all patients show complete regression of myocardial hypertrophy, being at higher risk for adverse outcomes, such as heart failure. The current comprehension of the biological mechanisms underlying an incomplete reverse remodeling is far from complete. Furthermore, definitive prognostic tools and ancillary therapies to improve the outcome of the patients undergoing valve replacement are missing. To help abridge these gaps, a combined myocardial (phospho)proteomics and pericardial fluid proteomics approach was followed, taking advantage of human biopsies and pericardial fluid collected during surgery and whose origin anticipated a wealth of molecular information contained therein. From over 1800 and 750 proteins identified, respectively, in the myocardium and in the pericardial fluid of aortic stenosis patients, a total of 90 dysregulated proteins were detected. Gene annotation and pathway enrichment analyses, together with discriminant analysis, are compatible with a scenario of increased pro-hypertrophic gene expression and protein synthesis, defective ubiquitinproteasome system activity, proclivity to cell death (potentially fed by complement activity and other extrinsic factors, such as death receptor activators), acute-phase response, immune system activation and fibrosis. Specific validation of some targets through immunoblot techniques and correlation with clinical data pointed to complement C3 β chain, Muscle Ring Finger protein 1 (MuRF1) and the dual-specificity Tyr-phosphorylation regulated kinase 1A (DYRK1A) as potential markers of an incomplete response. In addition, kinase prediction from phosphoproteome data suggests that the modulation of casein kinase 2, the family of IκB kinases, glycogen synthase kinase 3 and DYRK1A may help improve the outcome of patients undergoing valve replacement. Particularly, functional studies with DYRK1A+/- cardiomyocytes show that this kinase may be an important target to treat cardiac dysfunction, provided that mutant cells presented a different response to stretch and reduced ability to develop force (active tension). This study opens many avenues in post-aortic valve replacement reverse remodeling research. In the future, gain-of-function and/or loss-of-function studies with isolated cardiomyocytes or with animal models of aortic bandingdebanding will help disclose the efficacy of targeting the surrogate therapeutic targets. Besides, clinical studies in larger cohorts will bring definitive proof of complement C3, MuRF1 and DYRK1A prognostic value.A substituição da válvula aórtica continua a ser a opção terapêutica de referência para doentes com estenose aórtica e visa a eliminação da sobrecarga de pressão, desencadeando a remodelagem reversa miocárdica. Contudo, apesar do benefício hemodinâmico imediato, nem todos os pacientes apresentam regressão completa da hipertrofia do miocárdio, ficando com maior risco de eventos adversos, como a insuficiência cardíaca. Atualmente, os mecanismos biológicos subjacentes a uma remodelagem reversa incompleta ainda não são claros. Além disso, não dispomos de ferramentas de prognóstico definitivos nem de terapias auxiliares para melhorar a condição dos pacientes indicados para substituição da válvula. Para ajudar a resolver estas lacunas, uma abordagem combinada de (fosfo)proteómica e proteómica para a caracterização, respetivamente, do miocárdio e do líquido pericárdico foi seguida, tomando partido de biópsias e líquidos pericárdicos recolhidos em ambiente cirúrgico. Das mais de 1800 e 750 proteínas identificadas, respetivamente, no miocárdio e no líquido pericárdico dos pacientes com estenose aórtica, um total de 90 proteínas desreguladas foram detetadas. As análises de anotação de genes, de enriquecimento de vias celulares e discriminativa corroboram um cenário de aumento da expressão de genes pro-hipertróficos e de síntese proteica, um sistema ubiquitina-proteassoma ineficiente, uma tendência para morte celular (potencialmente acelerada pela atividade do complemento e por outros fatores extrínsecos que ativam death receptors), com ativação da resposta de fase aguda e do sistema imune, assim como da fibrose. A validação de alguns alvos específicos através de immunoblot e correlação com dados clínicos apontou para a cadeia β do complemento C3, a Muscle Ring Finger protein 1 (MuRF1) e a dual-specificity Tyr-phosphoylation regulated kinase 1A (DYRK1A) como potenciais marcadores de uma resposta incompleta. Por outro lado, a predição de cinases a partir do fosfoproteoma, sugere que a modulação da caseína cinase 2, a família de cinases do IκB, a glicogénio sintase cinase 3 e da DYRK1A pode ajudar a melhorar a condição dos pacientes indicados para intervenção. Em particular, a avaliação funcional de cardiomiócitos DYRK1A+/- mostraram que esta cinase pode ser um alvo importante para tratar a disfunção cardíaca, uma vez que os miócitos mutantes responderam de forma diferente ao estiramento e mostraram uma menor capacidade para desenvolver força (tensão ativa). Este estudo levanta várias hipóteses na investigação da remodelagem reversa. No futuro, estudos de ganho e/ou perda de função realizados em cardiomiócitos isolados ou em modelos animais de banding-debanding da aorta ajudarão a testar a eficácia de modular os potenciais alvos terapêuticos encontrados. Além disso, estudos clínicos em coortes de maior dimensão trarão conclusões definitivas quanto ao valor de prognóstico do complemento C3, MuRF1 e DYRK1A.Programa Doutoral em Biomedicin

    TOWARDS AN UNDERSTANDING OF EFFORTFUL FUNDRAISING EXPERIENCES: USING INTERPRETATIVE PHENOMENOLOGICAL ANALYSIS IN FUNDRAISING RESEARCH

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    Physical-activity oriented community fundraising has experienced an exponential growth in popularity over the past 15 years. The aim of this study was to explore the value of effortful fundraising experiences, from the point of view of participants, and explore the impact that these experiences have on people’s lives. This study used an IPA approach to interview 23 individuals, recognising the role of participants as proxy (nonprofessional) fundraisers for charitable organisations, and the unique organisation donor dynamic that this creates. It also bought together relevant psychological theory related to physical activity fundraising experiences (through a narrative literature review) and used primary interview data to substantiate these. Effortful fundraising experiences are examined in detail to understand their significance to participants, and how such experiences influence their connection with a charity or cause. This was done with an idiographic focus at first, before examining convergences and divergences across the sample. This study found that effortful fundraising experiences can have a profound positive impact upon community fundraisers in both the short and the long term. Additionally, it found that these experiences can be opportunities for charitable organisations to create lasting meaningful relationships with participants, and foster mutually beneficial lifetime relationships with them. Further research is needed to test specific psychological theory in this context, including self-esteem theory, self determination theory, and the martyrdom effect (among others)

    Walking with the Earth: Intercultural Perspectives on Ethics of Ecological Caring

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    It is commonly believed that considering nature different from us, human beings (qua rational, cultural, religious and social actors), is detrimental to our engagement for the preservation of nature. An obvious example is animal rights, a deep concern for all living beings, including non-human living creatures, which is understandable only if we approach nature, without fearing it, as something which should remain outside of our true home. “Walking with the earth” aims at questioning any similar preconceptions in the wide sense, including allegoric-poetic contributions. We invited 14 authors from 4 continents to express all sorts of ways of saying why caring is so important, why togetherness, being-with each others, as a spiritual but also embodied ethics is important in a divided world

    Chinese Benteng Women’s Participation in Local Development Affairs in Indonesia: Appropriate means for struggle and a pathway to claim citizen’ right?

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    It had been more than two decades passing by aftermath the devastating Asia’s Financial Crisis in 1997, subsequently followed by Suharto’s step down from his presidential throne which he occupied for more than three decades. The financial turmoil turned to a political disaster furthermore has led to massive looting that severely impacted Indonesians of Chinese descendant, including unresolved mystery of the most atrocious sexual violation against women and covert killings of students and democracy activists in this country. Since then, precisely aftermath May 1998, which publicly known as “Reformasi”1, Indonesia underwent political reform that eventually corresponded positively to its macroeconomic growth. Twenty years later, in 2018, Indonesia captured worldwide attention because it has successfully hosted two internationally renowned events, namely the Asian Games 2018 – the most prestigious sport events in Asia – conducted in Jakarta and Palembang; and the IMF/World Bank Annual Meeting 2018 in Bali. Particularly in the IMF/World Bank Annual Meeting, this event has significantly elevated Indonesia’s credibility and international prestige in the global economic powerplay as one of the nations with promising growth and openness. However, the narrative about poverty and inequality, including increasing racial tension, religious conservatism, and sexual violation against women are superseded by friendly climate for foreign investment and eventually excessive glorification of the nation’s economic growth. By portraying the image of promising new economic power, as rhetorically promised by President Joko Widodo during his presidential terms, Indonesia has swept the growing inequality in this highly stratified society that historically compounded with religious and racial tension under the carpet of digital economy.Arte y Humanidade

    Equity research - EDP Renováveis S.A. : the value of financial flexibility

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    Mestrado Bolonha em FinançasThe present document is the report of an Equity Research of EDP Renováveis, S.A. (EDPR). EDPR is a leading global renewable energy company, that develops, constructs, and operates onshore wind farms, solar energy plants, and offshore wind projects to deliver clean energy to its customers in over 20 countries. This report applies a DCF FCFF Sum-of-the-Parts approach to capture all the characteristics and risks of each segment. We issue a buy recommendation for EDPR, with a 2022YE price target of €24.7/share. This valuation implies a 24% upside potential from the January 12th, 2022 closing price of €19.9, with medium-low risk. Other valuation approaches were used to confirm the robustness of the analysis. Additionally, the valuation was subject to multiple sensitivity analyses to address its risk. Following the original research, a complementary approach was carried out to analyse EDPR’s Financial Flexibility. By using a Real Options approach with the BlackScholes-Merton model, we value the benefits of staying underlevered and provide a framework to support management’s decisions on the design of the capital structure. Our analysis shows that companies with certain characteristics may benefit a lot from financial flexibility. Specifically, EDPR distinguishes itself from its peers by maintaining flexibility in a current scenario of growth and uncertainty. The value of financial flexibility is not usually accounted for explicitly in the stock price. Thus, we update our recommendation to capture EDPR’s unique strategy in its industry. The report was finalized on January 16th, 2022. By March 2022, an updated snapshot was created, to reflect the impacts of the military invasion of Ukraine.O presente documento consiste num relatório de Equity Research sobre a EDP Renováveis, S.A. (EDPR). A EDPR é uma empresa líder global de energia renovável, que desenvolve, constrói e opera parques eólicos onshore, parques de energia solar e projetos eólicos offshore para fornecer energia limpa aos seus clientes. Neste relatório é aplicada uma abordagem DCF FCFF Soma das Partes de modo a capturar todas as características e riscos de cada segmento. Emitimos uma recomendação de compra para a EDPR, com um preço-alvo de €24.7/ação no final do ano de 2022. Esta avaliação implica um potencial de valorização de 24%, face ao preço de fecho a 12 de Janeiro de 2022 de €19.9, com um nível de risco médio-baixo. Outros métodos de avaliação foram usados para confirmar a robustez da análise. Adicionalmente, a avaliação foi sujeita a várias análises de sensibilidade a fim de abordar o seu risco. Foi realizada uma abordagem complementar para analisar a Flexibilidade Financeira da EDPR. Usando uma abordagem de Real Options com o modelo Black-ScholesMerton, avaliamos os benefícios de permanecer sob-alavancado e fornecemos uma estrutura para apoiar as decisões da gestão no que diz respeito à estrutura de capital. A nossa análise mostra que empresas com certas características podem beneficiar bastante ao mostrar flexibilidade financeira. Especificamente, a EDPR distingue-se dos seus peers ao manter flexibilidade num cenário atual de crescimento e incerteza. Normalmente, o valor da flexibilidade financeira não é incorporado explicitamente no preço da ação. Logo, atualizamos a nossa recomendação de modo a capturar a estratégia diferenciadora da EDPR na sua indústria. Este relatório foi finalizado no dia 16 de janeiro de 2022. Em março de 2022, foi criado um snapshot atualizado, para refletir os impactos da invasão militar à Ucrânia.info:eu-repo/semantics/publishedVersio

    Human Rights practitioners’ approach to refugees and migrants. A therapeutic psychosocial perspective.

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    This thesis advances the argument that the best way to address the needs of involuntarily dislocated populations is to develop a combined framework that includes both psychosocial and therapeutic perspectives as well as human rights principles. Based on my professional experience as a refugee lawyer, I argue that only such a combined framework can adequately respond to the complexity of the refugee realities. Moreover, I demonstrate that, in some circumstances, the application only of human right rules can violate the same rights that they are meant to protect. I suggest that human rights practitioners are more likely to become aware of the real needs of those we help and, thus, provide them with targeted interventions, once we add a psychosocial perspective to our work. It is in this sense that our endeavours become therapeutic, which should be distinguished from offering them psychotherapy. The added therapeutic dimension also benefits refugees by rescuing them from developing victim identities. This empowering and participatory model of interaction also assists them with an awareness of their existing resources as well as of those new strengths they acquire from their exposure to adversity. Finally, they benefit from an improved level of self reflexivity and a deeper consideration of the socio-political and cultural contexts that act as background to the migratory experience. This study examines various possible applications of this proposed combined framework, ranging from the enrichment of the refugee lawyers curricula with tenets of psychosocial perspectives to the addition of a therapeutic dimension to the hearings of migration/asylum courts

    Understanding the Relationship among Durable Goods, Academic Achievement, and School Attendance in Colombia

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    A joint report from the United Nations Development Program and the Oxford Poverty and Human Development Initiative indicates that while the number of people living with less than 1.90adaydeclinedglobally,droppingfrom2billionin1990to736millionin2015,thenumberofpeoplewhoexperiencednonincomepovertyreached1.3billionin2020.Nonincomepoverty,referredtoasmultidimensionalpoverty,assessestheextenttowhichpeoplearedeprivedfromaccessingbasicservicessuchashealth,education,orattainingdecentlivingstandards,despitehavingincomelevelswellabove1.90 a day declined globally, dropping from 2 billion in 1990 to 736 million in 2015, the number of people who experienced non-income poverty reached 1.3 billion in 2020. Non-income poverty, referred to as multidimensional poverty, assesses the extent to which people are deprived from accessing basic services such as health, education, or attaining decent living standards, despite having income levels well above 1.90. Research on development and welfare economics points to assets as the missing piece in the poverty puzzle because they can build capacity. In general, assets can be used to generate income or to enhance quality of life. Income-generating assets such as bonds, credit, or home ownership help people gain economic stability, acquire other assets, and prepare for economic shocks. Quality-of-life-enhancing assets help people improve their living standards, develop agency, and participate in political as well as in social life. Examples of quality-of-life-enhancing assets include education, social capital, and durable goods such as TVs or computers. Most research on assets examines the relationship either between financial assets and poverty or between financial assets and education. An exploration of durable goods and education was the focus of this dissertation. Although not a nascent field, most studies in this area have focused on analyzing how durable goods relate to academic achievement and school attendance mainly in African and Asian countries. From a methodological standpoint, these studies have modeled durable goods utilizing a binary approach, where ownership of durable goods is measured as possession of any durable good, or as an index, using principal component analysis (PCA), which research suggests is not the most robust method for index creation. Such methodological decisions have provided only a partial understanding of the relationship between durable goods and education. For example, findings indicate that possession of durable goods improves achievement in reading, but not in math. However, further research is needed to assess whether different types of durable goods have differential effects on educational outcomes. Hence, this study explored the relationship among durable goods, academic achievement, and school attendance in Colombia through three methodological approaches to operationalize durable goods: inventory, attributional, and index approaches. Data come from the 2017 SABER test, a nation-wide examination that assesses reading and math skills, for fifth and ninth grade students, (N = 621,218). Students with complete durable goods information (N = 364,436) were included. This research added to the existing literature on this field by using different methodological approaches to model durable goods, including the construction of a durable goods index employing exploratory factor analysis (EFA), and by expanding the geographic scope to Latin America. By using hierarchical linear and nonlinear modeling, this study found that, overall, durable goods were positively associated with reading and math outcomes, particularly for fifth graders. Similarly, results indicated that students whose families owned washing machines, computers, or who had Internet access were more likely to go to school
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