Algorithms for Scheduling Problems

This edited book presents new results in the area of algorithm development for different types of scheduling problems. In eleven chapters, algorithms for single machine problems, flow-shop and job-shop scheduling problems (including their hybrid (flexible) variants), the resource-constrained project scheduling problem, scheduling problems in complex manufacturing systems and supply chains, and workflow scheduling problems are given. The chapters address such subjects as insertion heuristics for energy-efficient scheduling, the re-scheduling of train traffic in real time, control algorithms for short-term scheduling in manufacturing systems, bi-objective optimization of tortilla production, scheduling problems with uncertain (interval) processing times, workflow scheduling for digital signal processor (DSP) clusters, and many more

A Hybrid Tabu/Scatter Search Algorithm for Simulation-Based Optimization of Multi-Objective Runway Operations Scheduling

As air traffic continues to increase, air traffic flow management is becoming more challenging to effectively and efficiently utilize airport capacity without compromising safety, environmental and economic requirements. Since runways are often the primary limiting factor in airport capacity, runway operations scheduling emerge as an important problem to be solved to alleviate flight delays and air traffic congestion while reducing unnecessary fuel consumption and negative environmental impacts. However, even a moderately sized real-life runway operations scheduling problem tends to be too complex to be solved by analytical methods, where all mathematical models for this problem belong to the complexity class of NP-Hard in a strong sense due to combinatorial nature of the problem. Therefore, it is only possible to solve practical runway operations scheduling problem by making a large number of simplifications and assumptions in a deterministic context. As a result, most analytical models proposed in the literature suffer from too much abstraction, avoid uncertainties and, in turn, have little applicability in practice. On the other hand, simulation-based methods have the capability to characterize complex and stochastic real-life runway operations in detail, and to cope with several constraints and stakeholders’ preferences, which are commonly considered as important factors in practice. This dissertation proposes a simulation-based optimization (SbO) approach for multi-objective runway operations scheduling problem. The SbO approach utilizes a discrete-event simulation model for accounting for uncertain conditions, and an optimization component for finding the best known Pareto set of solutions. This approach explicitly considers uncertainty to decrease the real operational cost of the runway operations as well as fairness among aircraft as part of the optimization process. Due to the problem’s large, complex and unstructured search space, a hybrid Tabu/Scatter Search algorithm is developed to find solutions by using an elitist strategy to preserve non-dominated solutions, a dynamic update mechanism to produce high-quality solutions and a rebuilding strategy to promote solution diversity. The proposed algorithm is applied to bi-objective (i.e., maximizing runway utilization and fairness) runway operations schedule optimization as the optimization component of the SbO framework, where the developed simulation model acts as an external function evaluator. To the best of our knowledge, this is the first SbO approach that explicitly considers uncertainties in the development of schedules for runway operations as well as considers fairness as a secondary objective. In addition, computational experiments are conducted using real-life datasets for a major US airport to demonstrate that the proposed approach is effective and computationally tractable in a practical sense. In the experimental design, statistical design of experiments method is employed to analyze the impacts of parameters on the simulation as well as on the optimization component’s performance, and to identify the appropriate parameter levels. The results show that the implementation of the proposed SbO approach provides operational benefits when compared to First-Come-First-Served (FCFS) and deterministic approaches without compromising schedule fairness. It is also shown that proposed algorithm is capable of generating a set of solutions that represent the inherent trade-offs between the objectives that are considered. The proposed decision-making algorithm might be used as part of decision support tools to aid air traffic controllers in solving the real-life runway operations scheduling problem

Advances in Evolutionary Algorithms

With the recent trends towards massive data sets and significant computational power, combined with evolutionary algorithmic advances evolutionary computation is becoming much more relevant to practice. Aim of the book is to present recent improvements, innovative ideas and concepts in a part of a huge EA field

Cost Factor Focused Scheduling and Sequencing: A Neoteric Literature Review

The hastily emergent concern from researchers in the application of scheduling and sequencing has urged the necessity for analysis of the latest research growth to construct a new outline. This paper focuses on the literature on cost minimization as a primary aim in scheduling problems represented with less significance as a whole in the past literature reviews. The purpose of this paper is to have an intensive study to clarify the development of cost-based scheduling and sequencing (CSS) by reviewing the work published over several parameters for improving the understanding in this field. Various parameters, such as scheduling models, algorithms, industries, journals, publishers, publication year, authors, countries, constraints, objectives, uncertainties, computational time, and programming languages and optimization software packages are considered. In this research, the literature review of CSS is done for thirteen years (2010-2022). Although CSS research originated in manufacturing, it has been observed that CSS research publications also addressed case studies based on health, transportation, railway, airport, steel, textile, education, ship, petrochemical, inspection, and construction projects. A detailed evaluation of the literature is followed by significant information found in the study, literature analysis, gaps identification, constraints of work done, and opportunities in future research for the researchers and experts from the industries in CSS

A Polyhedral Study of Mixed 0-1 Set

We consider a variant of the well-known single node fixed charge network flow set with constant capacities. This set arises from the relaxation of more general mixed integer sets such as lot-sizing problems with multiple suppliers. We provide a complete polyhedral characterization of the convex hull of the given set

Integrated Production and Distribution planning of perishable goods

Tese de doutoramento. Programa Doutoral em Engenharia Industrial e Gestão. Faculdade de Engenharia. Universidade do Porto. 201

DNA Chemical Reaction Network Design Synthesis and Compilation

The advantages of biomolecular computing include 1) the ability to interface with, monitor, and intelligently protect and maintain the functionality of living systems, 2) the ability to create computational devices with minimal energy needs and hazardous waste production during manufacture and lifecycle, 3) the ability to store large amounts of information for extremely long time periods, and 4) the ability to create computation analogous to human brain function. To realize these advantages over electronics, biomolecular computing is at a watershed moment in its evolution. Computing with entire molecules presents different challenges and requirements than computing just with electric charge. These challenges have led to ad-hoc design and programming methods with high development costs and limited device performance. At the present time, device building entails complete low-level detail immersion. We address these shortcomings by creation of a systems engineering process for building and programming DNA-based computing devices. Contributions of this thesis include numeric abstractions for nucleic acid sequence and secondary structure, and a set of algorithms which employ these abstractions. The abstractions and algorithms have been implemented into three artifacts: DNADL, a design description language; Pyxis, a molecular compiler and design toolset; and KCA, a simulation of DNA kinetics using a cellular automaton discretization. Our methods are applicable to other DNA nanotechnology constructions and may serve in the development of a full DNA computing model

Advanced Immunoinformatics Approaches for Precision Medicine

Genomic sequencing and other ’-omic’ technologies are slowly changing biomedical practice. As a result, patients now can be treated based on their molecular profile. Especially the immune system’s variability, in particular that of the human leukocyte antigen (HLA) gene cluster, makes such a paradigm indispensable when treating illnesses such as cancer, autoimmune diseases, or infectious diseases. It can be, however, costly and time-consuming to determine the HLA genotype with traditional means, as these methods do not utilize often pre-existing sequencing data. We therefore proposed an algorithmic approach that can use these data sources to infer the HLA genotype. HLA genotyping inference can be cast into a set covering problem under special biological constraints and can be solved efficiently via integer linear programming. Our proposed approach outperformed previously published methods and remains one of the most accurate methods to date. We then introduced two applications in which a HLA-based stratification is vital for the efficacy of the treatment and the reduction of its adverse effects. In the first example, we dealt with the optimal design of string-of-beads vaccines (SOB). We developed a mathematical model that maximizes the efficacy of such vaccines while minimizing their side effects based on a given HLA distribution. Comparisons of our optimally designed SOB with experimentally tested designs yielded promising results. In the second example, we considered the problem of anti-drug antibody (ADA) formation of biotherapeutics caused by HLA presented peptides. We combined a new statistical model for mutation effect prediction together with a quantitative measure of immunogenicity to formulate an optimization problem that finds alterations to reduce the risk of ADA formation. To efficiently solve this bi-objective problem, we developed a distributed solver that is up to 25-times faster than state-of-the art solvers. We used our approach to design the C2 domain of factor VIII, which is linked to ADA formation in hemophilia A. Our experimental evaluations of the proposed designs are encouraging and demonstrate the prospects of our approach. Bioinformatics is an integral part of modern biomedical research. The translation of advanced methods into clinical use is often complicated. To ease the translation, we developed a programming library for computational immunology and used it to implement a Galaxy-based web server for vaccine design and a KNIME extension for desktop PCs. These platforms allow researchers to develop their own immunoinformatics workflows utilizing the platform’s graphical programming capabilities

Particle Swarm Optimization

Particle swarm optimization (PSO) is a population based stochastic optimization technique influenced by the social behavior of bird flocking or fish schooling.PSO shares many similarities with evolutionary computation techniques such as Genetic Algorithms (GA). The system is initialized with a population of random solutions and searches for optima by updating generations. However, unlike GA, PSO has no evolution operators such as crossover and mutation. In PSO, the potential solutions, called particles, fly through the problem space by following the current optimum particles. This book represents the contributions of the top researchers in this field and will serve as a valuable tool for professionals in this interdisciplinary field