Flow pattern analysis for magnetic resonance velocity imaging

Blood flow in the heart is highly complex. Although blood flow patterns have been investigated by both computational modelling and invasive/non-invasive imaging techniques, their evolution and intrinsic connection with cardiovascular disease has yet to be explored. Magnetic resonance (MR) velocity imaging provides a comprehensive distribution of multi-directional in vivo flow distribution so that detailed quantitative analysis of flow patterns is now possible. However, direct visualisation or quantification of vector fields is of little clinical use, especially for inter-subject or serial comparison of changes in flow patterns due to the progression of the disease or in response to therapeutic measures. In order to achieve a comprehensive and integrated description of flow in health and disease, it is necessary to characterise and model both normal and abnormal flows and their effects. To accommodate the diversity of flow patterns in relation to morphological and functional changes, we have described in this thesis an approach of detecting salient topological features prior to analytical assessment of dynamical indices of the flow patterns. To improve the accuracy of quantitative analysis of the evolution of topological flow features, it is essential to restore the original flow fields so that critical points associated with salient flow features can be more reliably detected. We propose a novel framework for the restoration, abstraction, extraction and tracking of flow features such that their dynamic indices can be accurately tracked and quantified. The restoration method is formulated as a constrained optimisation problem to remove the effects of noise and to improve the consistency of the MR velocity data. A computational scheme is derived from the First Order Lagrangian Method for solving the optimisation problem. After restoration, flow abstraction is applied to partition the entire flow field into clusters, each of which is represented by a local linear expansion of its velocity components. This process not only greatly reduces the amount of data required to encode the velocity distribution but also permits an analytical representation of the flow field from which critical points associated with salient flow features can be accurately extracted. After the critical points are extracted, phase portrait theory can be applied to separate them into attracting/repelling focuses, attracting/repelling nodes, planar vortex, or saddle. In this thesis, we have focused on vortical flow features formed in diastole. To track the movement of the vortices within a cardiac cycle, a tracking algorithm based on relaxation labelling is employed. The constraints and parameters used in the tracking algorithm are designed using the characteristics of the vortices. The proposed framework is validated with both simulated and in vivo data acquired from patients with sequential MR examination following myocardial infarction. The main contribution of the thesis is in the new vector field restoration and flow feature abstraction method proposed. They allow the accurate tracking and quantification of dynamic indices associated with salient features so that inter- and intra-subject comparisons can be more easily made. This provides further insight into the evolution of blood flow patterns and permits the establishment of links between blood flow patterns and localised genesis and progression of cardiovascular disease.Open acces

Analysis and development of self localization and autonomous driving systems for the industrial and automotive environment.

The goal of the present thesis is dual. First the self localization problem is investigated in the industrial environment and a working prototype, consisting in an AGV able to perform self localization and autonomous driving under certain conditions, has been developed. Then the self localization problem is considered as a part of wider and currently very active research problem: the Simultaneous Localization And Mapping (SLAM), considered in the automotive environment.L'obiettivo della presente Tesi è duplice. Inizialmente il problema della self localization viene analizzato nel contesto industriale e un prototipo funzionante è stato realizzato, consistente in un AGV in grado di auto localizzarsi in certe condizioni. In seguito il problema della self localization è stato considerato come parte di un problema più ampio e ad oggi particolarmente: il Simultaneous Localization And Mapping (SLAM), nel contesto automobilistico

Vehicle trajectory prediction and generation using LSTM models and GANs

Vehicles’ trajectory prediction is a topic with growing interest in recent years, as there are applications in several domains ranging from autonomous driving to traffic congestion prediction and urban planning. Predicting trajectories starting from Floating Car Data (FCD) is a complex task that comes with different challenges, namely Vehicle to Infrastructure (V2I) interaction, Vehicle to Vehicle (V2V) interaction, multimodality, and generalizability. These challenges, especially, have not been completely explored by state-of-the-art works. In particular, multimodality and generalizability have been neglected the most, and this work attempts to fill this gap by proposing and defining new datasets, metrics, and methods to help understand and predict vehicle trajectories. We propose and compare Deep Learning models based on Long Short-Term Memory and Generative Adversarial Network architectures; in particular, our GAN-3 model can be used to generate multiple predictions in multimodal scenarios. These approaches are evaluated with our newly proposed error metrics N-ADE and N-FDE, which normalize some biases in the standard Average Displacement Error (ADE) and Final Displacement Error (FDE) metrics. Experiments have been conducted using newly collected datasets in four large Italian cities (Rome, Milan, Naples, and Turin), considering different trajectory lengths to analyze error growth over a larger number of time-steps. The results prove that, although LSTM-based models are superior in unimodal scenarios, generative models perform best in those where the effects of multimodality are higher. Space-time and geographical analysis are performed, to prove the suitability of the proposed methodology for real cases and management services

International Summerschool Computer Science 2014: Proceedings of Summerschool 7.7. - 13.7.2014

Proceedings of International Summerschool Computer Science 201

Proceedings of the 2011 Joint Workshop of Fraunhofer IOSB and Institute for Anthropomatics, Vision and Fusion Laboratory

This book is a collection of 15 reviewed technical reports summarizing the presentations at the 2011 Joint Workshop of Fraunhofer IOSB and Institute for Anthropomatics, Vision and Fusion Laboratory. The covered topics include image processing, optical signal processing, visual inspection, pattern recognition and classification, human-machine interaction, world and situation modeling, autonomous system localization and mapping, information fusion, and trust propagation in sensor networks

Dissipation and spontaneous symmetry breaking in brain dynamics

We compare the predictions of the dissipative quantum model of brain with neurophysiological data collected from electroencephalograms resulting from high-density arrays fixed on the surfaces of primary sensory and limbic areas of trained rabbits and cats. Functional brain imaging in relation to behavior reveals the formation of coherent domains of synchronized neuronal oscillatory activity and phase transitions predicted by the dissipative model.Comment: Restyled, slight changes in title and abstract, updated bibliography, J. Phys. A: Math. Theor. Vol. 41 (2008) in prin