A Preventive Medicine Framework for Wearable Abiotic Glucose Detection System

In this work, we present a novel abiotic glucose fuel cell with battery-less remote access. In the presence of a glucose analyte, we characterized the power generation and biosensing capabilities. This system is developed on a flexible substrate in bacterial nanocellulose with gold nanoparticles used as a conductive ink for piezoelectric deposition based printing. The abiotic glucose fuel cell is constructed using colloidal platinum on gold (Au-co-Pt) and a composite of silver oxide nanoparticles and carbon nanotubes as the anodic and cathodic materials. At a concentration of 20 mM glucose, the glucose fuel cell produced a maximum open circuit voltage of 0.57 V and supplied a maximum short circuit current density of 0.581 mA/cm2 with a peak power density of 0.087 mW/cm2 . The system was characterized by testing its performance using electrochemical techniques like linear sweep voltammetry, cyclic voltammetry, chronoamperometry in the presence of various glucose level at the physiological temperatures. An open circuit voltage (Voc) of 0.43 V, short circuit current density (Isc) of 0.405 mA/cm2 , and maximum power density (Pmax) of 0.055 mW/cm2 at 0.23 V were achieved in the presence of 5 mM physiologic glucose. The results indicate that glucose fuel cells can be employed for the development of a self-powered glucose sensor. The glucose monitoring device demonstrated sensitivity of 1.87 uA/mMcm2 and a linear dynamic range of 1 mM to 45 mM with a correlation coefficient of 0.989 when utilized as a self-powered glucose sensor. For wireless communication, the incoming voltage from the abiotic fuel cell was fed to a low power microcontroller that enables battery less communication using NFC technology. The voltage translates to the NFC module as the digital signals, which are displayed on a custom-built android application. The digital signals are converted to respective glucose concentration using a correlation algorithm that allows data to be processed and recorded for further analysis. The android application is designed to record the time, date stamp, and other independent features (e.g. age, height, weight) with the glucose measurement to allow the end-user to keep track of their glucose levels regularly. Analytics based on in-vitro testing were conducted to build a machine learning model that enables future glucose prediction for 15, 30 or 60 minutes

Smart bandage with wireless strain and temperature sensors and battery-less NFC tag

This paper presents a smart bandage with wireless strain and temperature sensors and a battery-less Near Field Communication tag. Both sensors are based on conductive poly (3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) polymer. The highly sensitive strain sensor consists of a microfluidic channel filled with PEDOT:PSS in Polydimethylsiloxane (PDMS) substrate. The strain sensor shows 3 order ( 1250) increase in the resistance for 10% strain and considerably high gauge factor of 12500. The sensor was tested for 30% strain, which is more than typical stretching of human skin or body parts such as chest expansion during respiration. The strain sensor was also tested for different bending and the electrical resolution was 150% per degree of free bending and 12k% per percentage of stretching. The resistive temperature sensor, fabricated on a Polyvinyl Chloride (PVC) substrate, showed a 60% decrease in resistance when the temperature changed from 25.C to 85.C and a sensitivity of 1% per.C. As a proof of concept, the sensors and NFC tag were integrated on wound dressing to obtain wearable systems with smart bandage form-factor. The sensors can be operated and read from distance of 25 mm with a user-friendly smartphone application developed for powering the system as well as real-time acquisition of sensors data. Finally, we demonstrate the potential use of smart bandage in healthcare applications such as assessment of wound status or respiratory diseases such as asthma and COVID-19, where monitoring via wearable strain (e.g., respiratory volume) and temperature sensors is critical

Battery-less near field communications (nfc) sensors for internet of things (iot) applications

L’ implementació de la tecnologia de comunicació de camp proper (NFC) en els telèfons intel·ligents no para de créixer degut a l’ús d’aquesta per fer pagaments, això, junt amb el fet de poder aprofitar l’energia generada pel mòbil no només per la comunicació, sinó també per transmetre energia, el baix cost dels xips NFC, i el fet de que els telèfons tinguin connectivitat amb internet, possibilita i fa molt interesant el disseny d’etiquetes sense bateria incorporant-hi sensors i poder enviar la informació al núvol, dins del creixent escenari de l’internet de les coses (IoT). La present Tesi estudia la viabilitat d’aquests sensors, analitzant la màxima distància entre lector i sensor per proveir la potència necessària, presenta tècniques per augmentar el rang d’operació, i analitza els efectes de certs materials quan aquests estan propers a les antenes. Diversos sensors han estat dissenyats i analitzats i son presentats en aquest treball. Aquests son: Una etiqueta que mesura la humitat de la terra, la temperatura i la humitat relativa de l’aire per controlar les condicions de plantes. Un sensor per detectar la humitat en bolquers, imprès en material flexible que s’adapta a la forma del bolquer. Dues aplicacions, una per estimació de pH i una altre per avaluar el grau de maduració de fruites, basats en un sensor de color. I, per últim, s’estudia la viabilitat de sensors en implants per aplicacions mèdiques, analitzant l’efecte del cos i proposant un sistema per augmentar la profunditat a la que aquests es poden llegir utilitzant un telèfon mòbil. Tots aquests sensors poden ser alimentats i llegits per qualsevol dispositiu que disposin de connexió NFC.La implementación de la tecnología de comunicaciones de campo cercano (NFC) en los teléfonos inteligentes no para de crecer debido al uso de esta para llevar a cabo pagos, esto, junto con el hecho de poder aprovechar la energía generada por el móvil no sólo para la comunicación, sino también para transmitir energía, el bajo coste de los chips NFC, i el hecho que los teléfonos tengan conectividad a internet, posibilita y hace muy interesante el diseño de etiquetas sin batería que incorporen sensores i poder enviar la información a la nube, enmarcado en el creciente escenario del internet de las cosas (IoT). La presente Tesis estudia la viabilidad de estos sensores, analizando la máxima distancia entre lector i sensor para proveer la potencia necesaria, presenta técnicas para aumentar el rango de operación, y analiza los efectos de ciertos materiales cuando estos están cerca de las antenas. Varios sensores han sido diseñados y analizados y son presentados en este trabajo. Estos son: Una etiqueta que mide la humedad de la tierra, la temperatura y la humedad relativa del aire para controlar las condiciones de plantas. Un sensor para detectar la humedad en pañales, impreso en material flexible que se adapta a la forma del pañal. Dos aplicaciones, una para estimación de pH y otra para evaluar el grado de maduración de frutas, basados en un sensor de color. Y, por último, se estudia la viabilidad de sensores en implantes para aplicaciones médicas, analizando el efecto del cuerpo y proponiendo un sistema para aumentar la profundidad a la que estos se pueden leer usando un teléfono móvil. Todos estos sensores pueden ser alimentados y leídos por cualquier dispositivo que disponga de conexión NFC.The implementation of near field communication (NFC) technology into smartphones grows rapidly due the use of this technology as a payment system. This, altogether with the fact that the energy generated by the phone can be used not only to communicate but for power transfer as well, the low-cost of the NFC chips, and the fact that the smartphones have connectivity to internet, makes possible and very interesting the design of battery-less sensing tags which information can be sent to the cloud, within the growing internet of things (IoT) scenario. This Thesis studies the feasibility of these sensors, analysing the maximum distance between reader and sensor to provide the necessary power, presents techniques to increase the range of operation, and analyses the effects of certain materials when they are near to the antennas. Several sensors have been designed and analysed and are presented in this work. These are: a tag that measures the soil moisture, the temperature and the relative humidity of the air to control the conditions of plants. A moisture sensor for diapers, printed on flexible material that adapts to the diaper shape. Two applications, one for pH estimation and another for assessing the degree of fruit ripening, based on a colour sensor. And finally, the feasibility of sensors in implants for medical applications is studied, analysing the effect of the body and proposing a system to increase the depth at which they can be read using a mobile phone. All of these sensors can be powered and read by any NFC enabled device

Sustainable packaging in the healthcare industry

The recycling of plastics tends to lag behind other packaging materials. The research investigates opportunities to improve the capture of valuable packaging polymers and to preserve their specification during recycle operations, thus increasing second user opportunity. The legislative and policy drivers on the sustainable use of plastics are described and discussed with particular reference to achieving sustainability, reuse and recycle of healthcare packaging materials. Four strategic methods of achieving improvements in sustainability, reuse and recycle are developed to represent aspects of sorting of materials, collection of recyclables, replacement of unsustainable packaging materials and measurement of the environmental impacts of packaging and changes in packaging, using examples of packaging from GlaxoSmithKline consumer healthcare and medical products. The use of radio frequency identification methodology as a means of separating high quality plastics and individual reusable devices from mixed waste streams has been developed and trialled under simulated materials recycling and separation conditions. The use of Reverse Vending Machines (RVM's) designed to capture high quality polyethylene terephthalate polymers is described along with results of successful trials on this method of capture in the out of home consumption sector. Recovered material is suitable for reuse in food grade applications after reprocessing. A novel biodegradable packaging material has been successfully developed from sources of green waste as an alternative to existing polymer packaging materials for transport of vaccines, and provides results that are extendable to the replacement of other types of packaging over a wide range of consumer goods. The material also offers intangible benefits to a business in terms of claims that can be made within a corporate social responsibility (CSR) report. Life cycle analysis methodologies have been used to illustrate the environmental benefits that can be achieved by reuse of polypropylene as an example of a widely used packaging polymer with potential for reuse in other industrial sectors. The implications of the results obtained in this work should be of value in the future eco-design of polymer products designed to make end-of-life recovery and recycle more efficient and environmentally beneficial

Laser-assisted processing of multilayer films for inexpensive and flexible biomedical microsystems

Flexible/stretchable electronics offer ideal properties for emerging health monitoring devices that can seamlessly integrate with the soft, curvilinear, and dynamic surfaces of the human body. The resulting capabilities have allowed novel devices for monitoring physiological parameters, improving surgical procedures, and human-machine interfaces. While the attractiveness of these devices are indubitable, their fabrication by conventional cleanroom techniques makes them expensive and incompatible with rapid large-scale (e.g., roll-to-roll) production. The purpose of this research is to develop inexpensive fabrication technologies using low-cost commercial films such as polyimide, paper, and metalized paper that can be utilized for developing various flexible/stretchable physical and chemical sensors for wearable and lab-on-chip applications. The demonstrated techniques focus on an array of laser assisted surfaces modification and micromachining strategies with the two commonly used CO2 and Nd: YAG laser systems. The first section of this dissertation demonstrates the use of localized pulsed CO2 laser irradiation to selectively convert thermoset polymer films (e.g., polyimide) into electrically conductive highly porous carbon micro/nanostructures.Thisprocessprovidesauniqueandfacileapproachfordirect writing of carbonized conductive patterns on flexible polyimide sheets in ambient conditions, eliminating complexities of current methods such as expensive CVD processes and complicated formulation/preparation of conductive carbon based inks used in ink jet printing. The highly porous laser carbonized layer can be transferred to stretchable elastomer or further functionalized with various chemical substances such as ionic solutions, nanoparticles, and chemically conductive polymers to create different mechanical and chemical sensors. The second section of this dissertation describes the use of laser ablation for selective removal of material from multilayer films such as ITO-coated PET, parchment paper, and metalized paper to create disposable diagnostic platforms and in-vitro models for lab-on-chip based studies. The ablated areas were analyzed using electrical, mechanical, and surface analysis tools to understand change in physical structure and chemical properties of the laser ablated films. As proof-of-concept demonstrations of these technologies, four different devices are presented here: mechanical, electrochemical, and environmental sensors along with an in-vitro cell culture platform. All four devices are designed, fabricated, and characterized to highlight the capability of commercial laser processing systems in the production of the next generation, low-cost and flexible biomedical devices

Sistemas eficientes de transmissão de energia sem-fios e identificação por radiofrequência

Doutoramento em Engenharia EletrotécnicaIn the IoT context, where billions of connected objects are expected to be ubiquitously deployed worldwide, the frequent battery maintenance of ubiquitous wireless nodes is undesirable or even impossible. In these scenarios, passive-backscatter radios will certainly play a crucial role due to their low cost, low complexity and battery-free operation. However, as passive-backscatter devices are chiefly limited by the WPT link, its efficiency optimization has been a major research concern over the years, gaining even more emphasis in the IoT context. Wireless power transfer has traditionally been carried out using CW signals, and the efficiency improvement has commonly been achieved through circuit design optimization. This thesis explores a fundamentally different approach, in which the optimization is focused on the powering waveforms, rather than the circuits. It is demonstrated through theoretical analysis, simulations and measurements that, given their greater ability to overcome the built-in voltage of rectifying devices, high PAPR multi-sine (MS) signals are capable of more efficiently exciting energy harvesting circuits when compared to CWs. By using optimal MS signals to excite rectifying devices, remarkable RF-DC conversion efficiency gains of up to 15 dB with respect to CW signals were obtained. In order to show the effectiveness of this approach to improve the communication range of passive-backscatter systems, a MS front-end was integrated in a commercial RFID reader and a significant range extension of 25% was observed. Furthermore, a software-defined radio RFID reader, compliant with ISO18000-6C standard and with MS capability, was constructed from scratch. By interrogating passive RFID transponders with MS waveforms, a transponder sensitivity improvement higher than 3 dB was obtained for optimal MS signals. Since the amplification and transmission of high PAPR signals is critical, this work also proposes efficient MS transmitting architectures based on space power combining techniques. This thesis also addresses other not less important issues, namely self-jamming in passive RFID readers, which is the second limiting factor of passive-backscatter systems. A suitable self-jamming suppression scheme was first used for CW signals and then extended to MS signals, yielding a CW isolation up to 50 dB and a MS isolation up 60 dB. Finally, a battery-less remote control system was developed and integrated in a commercial TV device with the purpose of demonstrating a practical application of wireless power transfer and passive-backscatter concepts. This allowed battery-free control of four basic functionalities of the TV (CH+,CH-,VOL+,VOL-).No contexto da internet das coisas (IoT), onde são esperados bilhões de objetos conectados espalhados pelo planeta de forma ubíqua, torna-se impraticável uma frequente manutenção e troca de baterias dos dispositivos sem fios ubíquos. Nestes cenários, os sistemas radio backscatter passivos terão um papel preponderante dado o seu baixo custo, baixa complexidade e não necessidade de baterias nos nós móveis. Uma vez que a transmissão de energia sem fios é o principal aspeto limitativo nestes sistemas, a sua otimização tem sido um tema central de investigação, ganhando ainda mais ênfase no contexto IoT. Tradicionalmente, a transferência de energia sem-fios é feita através de sinais CW e a maximização da eficiência é conseguida através da otimização dos circuitos recetores. Neste trabalho explora-se uma abordagem fundamentalmente diferente, em que a otimização foca-se nas formas de onda em vez dos circuitos. Demonstra-se, teoricamente e através de simulações e medidas que, devido à sua maior capacidade em superar a barreira de potencial intrínseca dos dispositivos retificadores, os sinais multi-seno (MS) de elevado PAPR são capazes de excitar os circuitos de colheita de energia de forma mais eficiente quando comparados com o sinal CW tradicional. Usando sinais MS ótimos em circuitos retificadores, foram verificadas experimentalmente melhorias de eficiência de conversão RF-DC notáveis de até 15 dB relativamente ao sinal CW. A fim de mostrar a eficácia desta abordagem na melhoria da distância de comunicação de sistemas backscatter passivos, integrou-se um front-end MS num leitor RFID comercial e observou-se um aumento significativo de 25% na distância de leitura. Além disso, desenvolveu-se de raiz um leitor RFID baseado em software rádio, compatível com o protocolo ISO18000-6C e capaz de gerar sinais MS, com os quais interrogou-se transponders passivos, obtendo-se ganhos de sensibilidade dos transponders maiores que 3 dB. Uma vez que a amplificação de sinais de elevado PAPR é uma operação crítica, propôs-se também novas arquiteturas eficientes de transmissão baseadas na combinação de sinais em espaço livre. Esta tese aborda também outros aspetos não menos importantes, como o self-jamming em leitores RFID passivos, tido como o segundo fator limitativo neste tipo de sistemas. Estudou-se técnicas de cancelamento de self-jamming CW e estendeu-se o conceito a sinais MS, tendo-se obtido isolamentos entre o transmissor e o recetor de até 50 dB no primeiro caso e de até 60 dB no segundo. Finalmente, com o objetivo de demonstrar uma aplicação prática dos conceitos de transmissão de energia sem fios e comunicação backscatter, desenvolveu-se um sistema de controlo remoto sem pilhas, cujo protótipo foi integrado num televisor comercial a fim de controlar quatro funcionalidades básicas (CH+,CH-,VOL+,VOL-)