Single‐trial regression of spatial exploration behavior indicates posterior EEG alpha modulation to reflect egocentric coding

Learning to navigate uncharted terrain is a key cognitive ability that emerges as a deeply embodied process, with eye movements and locomotion proving most useful to sample the environment. We studied healthy human participants during active spatial learning of room-scale virtual reality (VR) mazes. In the invisible maze task, participants wearing a wireless electroencephalography (EEG) headset were free to explore their surroundings, only given the objective to build and foster a mental spatial representation of their environment. Spatial uncertainty was resolved by touching otherwise invisible walls that were briefly rendered visible inside VR, similar to finding your way in the dark. We showcase the capabilities of mobile brain/body imaging using VR, demonstrating several analysis approaches based on general linear models (GLMs) to reveal behavior-dependent brain dynamics. Confirming spatial learning via drawn sketch maps, we employed motion capture to image spatial exploration behavior describing a shift from initial exploration to subsequent exploitation of the mental representation. Using independent component analysis, the current work specifically targeted oscillations in response to wall touches reflecting isolated spatial learning events arising in deep posterior EEG sources located in the retrosplenial complex. Single-trial regression identified significant modulation of alpha oscillations by the immediate, egocentric, exploration behavior. When encountering novel walls, as well as with increasing walking distance between subsequent touches when encountering novel walls, alpha power decreased. We conclude that these oscillations play a prominent role during egocentric evidencing of allocentric spatial hypotheses

Neural basis of route-planning and goal-coding during flexible navigation

Animals and humans are remarkable in their ability to flexibly adapt to changes in their surroundings. Navigational flexibility may take many forms and in this thesis we investigate its neural and behavioral underpinnings using a variety of methods and tasks tailored to each specific research aim. These methods include functional resonance magnetic imaging (fMRI), freely moving virtual reality, desktop virtual reality, large-scale online testing, and computational modelling. First, we reanalysed previously collected rodent data in the lab to better under- stand behavioural bias that may occur during goal-directed navigation tasks. Based on finding some biases we designed a new approach of simulating results on maze configurations prior to data collection to select the ideal mazes for our task. In a parallel line of methods development, we designed a freely moving navigation task using large-scale wireless virtual reality in a 10x10 space. We compared human behaviour to that of a select number of reinforcement learning agents to investigate the feasibility of computational modelling approaches to freely moving behaviour. Second, we further developed our new approach of simulating results on maze configuration to design a novel spatial navigation task used in a parallel experiment in both rats and humans. We report the human findings using desktop virtual reality and fMRI. We identified a network of regions including hippocampal, caudate nu- cleus, and lateral orbitofrontal cortex involvement in learning hidden goal locations. We also identified a positive correlation between Euclidean goal distance and brain activity in the caudate nucleus during ongoing navigation. Third, we developed a large online testing paradigm to investigate the role of home environment on wayfinding ability. We extended previous reports that street network complexity is beneficial in improving wayfinding ability as measured using a previously reported virtual navigation game, Sea Hero Quest, as well as in a novel virtual navigation game, City Hero Quest. We also report results of a navigational strategies questionnaire that highlights differences of growing up inside and outside cities in the United States and how this relates to wayfinding ability. Fourth, we investigate route planning in a group of expert navigators, licensed London taxi drivers. We designed a novel mental route planning task, probing 120 different routes throughout the extensive street network of London. We find hip- pocampal and retrosplenial involvement in route planning. We also identify the frontopolar cortex as one of several brain regions parametrically modulated by plan- ning demand. Lastly, I summarize the findings from these studies and how they all come to provide different insights into our remarkable ability to flexibly adapt to naviga- tional challenges in our environment

Making a stronger case for comparative research to investigate the behavioral and neurological bases of three-dimensional navigation

The rich diversity of avian natural history provides exciting possibilities for comparative research aimed at understanding three-dimensional navigation. We propose some hypotheses relating differences in natural history to potential behavioral and neurological adaptations possessed by contrasting bird species. This comparative approach may offer unique insights into some of the important questions raised by Jeffery et al

Making a stronger case for comparative research to investigate the behavioral and neurological bases of three-dimensional navigation

The rich diversity of avian natural history provides exciting possibilities for comparative research aimed at understanding three-dimensional navigation. We propose some hypotheses relating differences in natural history to potential behavioral and neurological adaptations possessed by contrasting bird species. This comparative approach may offer unique insights into some of the important questions raised by Jeffery et al

Single‐trial regression of spatial exploration behavior indicates posterior EEG alpha modulation to reflect egocentric coding

Learning to navigate uncharted terrain is a key cognitive ability that emerges as a deeply embodied process, with eye movements and locomotion proving most useful to sample the environment. We studied healthy human participants during active spatial learning of room‐scale virtual reality (VR) mazes. In the invisible maze task, participants wearing a wireless electroencephalography (EEG) headset were free to explore their surroundings, only given the objective to build and foster a mental spatial representation of their environment. Spatial uncertainty was resolved by touching otherwise invisible walls that were briefly rendered visible inside VR, similar to finding your way in the dark. We showcase the capabilities of mobile brain/body imaging using VR, demonstrating several analysis approaches based on general linear models (GLMs) to reveal behavior‐dependent brain dynamics. Confirming spatial learning via drawn sketch maps, we employed motion capture to image spatial exploration behavior describing a shift from initial exploration to subsequent exploitation of the mental representation. Using independent component analysis, the current work specifically targeted oscillations in response to wall touches reflecting isolated spatial learning events arising in deep posterior EEG sources located in the retrosplenial complex. Single‐trial regression identified significant modulation of alpha oscillations by the immediate, egocentric, exploration behavior. When encountering novel walls, as well as with increasing walking distance between subsequent touches when encountering novel walls, alpha power decreased. We conclude that these oscillations play a prominent role during egocentric evidencing of allocentric spatial hypotheses.BMBF, 01GQ1511, D-USA Verbund: Neuronale Grundlagen aktiver Navigatio

Spatial subgoal learning in the mouse: behavioral and computational mechanisms

Here we aim to better understand how animals navigate structured environments. The prevailing wisdom is that they can select among two distinct approaches: querying a mental map of the environment or repeating previously successful trajectories to a goal. However, this dichotomy has been built around data from rodents trained to solve mazes, and it is unclear how it applies to more naturalistic scenarios such as self-motivated navigation in open environments with obstacles. In this project, we leveraged instinctive escape behavior in mice to investigate how rodents use a period of exploration to learn about goals and obstacles in an unfamiliar environment. In our most basic assay, mice explore an environment with a shelter and an obstacle for 5-20 minutes and then we present threat stimuli to trigger escapes to shelter. After 5-10 minutes of exploration, mice took inefficient paths to the shelter, often nearly running into the obstacle and then relying on visual and tactile cues to avoid it. Within twenty minutes, however, they spontaneously developed an efficient subgoal strategy, escaping directly to the obstacle edge before heading to the shelter. Mice escaped in this manner even if the obstacle was removed, suggesting that they had memorized a mental map of subgoals. Unlike typical models of map-based planning, however, we found that investigating the obstacle was not important for updating the map. Instead, learning resembled trajectory repetition: mice had to execute `practice runs' toward an obstacle edge in order to memorize subgoals. To test this hypothesis directly, we developed a closed-loop neural manipulation, interrupting spontaneous practice runs by stimulating premotor cortex. This manipulation successfully prevented subgoal learning, whereas several control manipulations did not. We modelled these results using a panel of reinforcement learning approaches and found that mice behavior is best matched by systems that explore in a non-uniform manner and possess a high-level spatial representation of regions in the arena. We conclude that mice use practice runs to learn useful subgoals and integrate them into a hierarchical cognitive map of their surroundings. These results broaden our understanding of the cognitive toolkit that mammals use to acquire spatial knowledge

Relating spatial perspective taking to the perception of other's affordances: providing a foundation for predicting the future behavior of others

Understanding what another agent can see relates functionally to the understanding of what they can do. We propose that spatial perspective taking and perceiving other's affordances, while two separate spatial processes, together share the common social function of predicting the behavior of others. Perceiving the action capabilities of others allows for a common understanding of how agents may act together. The ability to take another's perspective focuses an understanding of action goals so that more precise understanding of intentions may result. This review presents an analysis of these complementary abilities, both in terms of the frames of reference and the proposed sensorimotor mechanisms involved. Together, we argue for the importance of reconsidering the role of basic spatial processes to explain more complex behaviors

The attentive robot companion: learning spatial information from observation and verbal interaction

Ziegler L. The attentive robot companion: learning spatial information from observation and verbal interaction. Bielefeld: Universität Bielefeld; 2015.This doctoral thesis investigates how a robot companion can gain a certain degree of situational awareness through observation and interaction with its surroundings. The focus lies on the representation of the spatial knowledge gathered constantly over time in an indoor environment. However, from the background of research on an interactive service robot, methods for deployment in inference and verbal communication tasks are presented. The design and application of the models are guided by the requirements of referential communication. The approach here involves the analysis of the dynamic properties of structures in the robot’s field of view allowing it to distinguish objects of interest from other agents and background structures. The use of multiple persistent models representing these dynamic properties enables the robot to track changes in multiple scenes over time to establish spatial and temporal references. This work includes building a coherent representation considering allocentric and egocentric aspects of spatial knowledge for these models. Spatial analysis is extended with a semantic interpretation of objects and regions. This top-down approach for generating additional context information enhances the grounding process in communication. A holistic, boosting-based classification approach using a wide range of 2D and 3D visual features anchored in the spatial representation allows the system to identify room types. The process of grounding referential descriptions from a human interlocutor in the spatial representation is evaluated through referencing furniture. This method uses a probabilistic network for handling ambiguities in the descriptions and employs a strategy for resolving conflicts. In order to approve the real-world applicability of these approaches, this system was deployed on the mobile robot BIRON in a realistic apartment scenario involving observation and verbal interaction with an interlocutor