Body-Area Capacitive or Electric Field Sensing for Human Activity Recognition and Human-Computer Interaction: A Comprehensive Survey

Due to the fact that roughly sixty percent of the human body is essentially composed of water, the human body is inherently a conductive object, being able to, firstly, form an inherent electric field from the body to the surroundings and secondly, deform the distribution of an existing electric field near the body. Body-area capacitive sensing, also called body-area electric field sensing, is becoming a promising alternative for wearable devices to accomplish certain tasks in human activity recognition and human-computer interaction. Over the last decade, researchers have explored plentiful novel sensing systems backed by the body-area electric field. On the other hand, despite the pervasive exploration of the body-area electric field, a comprehensive survey does not exist for an enlightening guideline. Moreover, the various hardware implementations, applied algorithms, and targeted applications result in a challenging task to achieve a systematic overview of the subject. This paper aims to fill in the gap by comprehensively summarizing the existing works on body-area capacitive sensing so that researchers can have a better view of the current exploration status. To this end, we first sorted the explorations into three domains according to the involved body forms: body-part electric field, whole-body electric field, and body-to-body electric field, and enumerated the state-of-art works in the domains with a detailed survey of the backed sensing tricks and targeted applications. We then summarized the three types of sensing frontends in circuit design, which is the most critical part in body-area capacitive sensing, and analyzed the data processing pipeline categorized into three kinds of approaches. Finally, we described the challenges and outlooks of body-area electric sensing

Crexens™: an expandable general-purpose electrochemical analyzer

2019 Fall.Includes bibliographical references.Electrochemical analysis has gained a great deal of attention of late due to its low-cost, easy-to-perform, and easy-to-miniaturize, especially in personal health care where accuracy and mobility are key factors to bring diagnostics to patients. According to data from Centers for Medicare & Medicaid Services (CMS) in the US, the share of health expenditure in the US has been kept growing in the past 3 decades and reached 17.9% of its overall Gross Domestic Product till 2016, which is equivalent to $10,348 for every person in the US per year. On the other hand, health care resources are often limited not only in rural area but also appeared in well-developed countries. The urgent need and the lack of health resource brings to front the research interest of Point-of-Care (PoC) diagnosis devices. Electrochemical methods have been largely adopted by chemist and biologist for their research purposes. However, several issues exist within current commercial benchtop instruments for electrochemical measurement. First of all, the current commercial instruments are usually bulky and do not have handheld feature for point-of-care applications and the cost are easily near$5,000 each or above. Secondly, most of the instruments do not have good integration level that can perform different types of electrochemical measurements for different applications. The last but not the least, the existing generic benchtops instruments for electrochemical measurements have complex operational procedures that require users to have a sufficient biochemistry and electrochemistry background to operate them correctly. The proposed Crexens™ analyzer platform is aimed to present an affordable electrochemical analyzerwhile achieving comparable performance to the existing commercial instruments, thus, making general electrochemical measurement applications accessible to general public. In this dissertation, the overall Crexens™ electrochemical analyzer architecture and its evolution are presented. The foundation of the Crexens™ architecture was derived from two separate but related research in electrochemical sensing. One of them is a microelectrode sensor array using CMOS for neurotransmitter sensing; the other one is a DNA affinity-based capacitive sensor for infectious disease, such as ZIKA. The CMOS microelectrode sensor array achieved a 320uM sensitivity for norepinephrine, whereas the capacitive sensor achieved a dynamic range of detection from 1 /uL to 105 /uL target molecules (20 to 2 million targets), which makes it be within the detection range in a typical clinical application environment. This dissertation also covers the design details of the CMOS microelectrode array sensor and the capacitive sensor design as a prelude to the development of the Crexens™ analyzer architecture. Finally, an expandable integrated electrochemical analyzer architecture (Crexens™) has been designed for mobile point-of-care (POC) applications. Electrochemical methods have been explored in detecting various bio-molecules such as glucose, lactate, protein, DNA, neurotransmitter, steroid hormone, which resulted in good sensitivity and selectivity. The proposed system is capable of running electrochemical experiments including cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), electrochemical capacitive spectroscopy (ECS), amperometry, potentiometry, and other derived electrochemical based tests. This system consist of a front-end interface to sensor electrodes, a back-end user interface on smart phone and PC, a base unit as master module, a low-noise add-on module, a high-speed add-on module, and a multi-channel add-on module. The architecture allows LEGO™-like capability to stack add-on modules on to the base-unit for performance enhancements in noise, speed or parallelism. The analyzer is capable of performing up to 1900 V/s CV with 10 mV step, up to 12 kHz EIS scan range and a limit of detection at 637 pA for amperometric applications with the base module. With high performance module, the EIS scan range can be extended upto 5 MHz. The limit of detection can be further improved to be at 333 fA using the low-noise module. The form factor of the electrochemical analyzer is designed for its mobile/point-of-care applications, integrating its entire functionality on to a 70 cm² area of surface space. A glutamine enzymatic sensor was used to valid the capability of the proposed electrochemical analyzer and turned out to give good linearity and reached a limit of detection at 50 uM

Low-Power, Event-Driven System on a Chip for Charge Pulse Processing Applications

This dissertation presents an electronic architecture and methodology capable of processing charge pulses generated by a range of sensors, including radiation detectors and tactile synthetic skin. These sensors output a charge signal proportional to the input stimulus, which is processed electronically in both the analog and digital domains. The presented work implements this functionality using an event-driven methodology, which greatly reduces power consumption compared to standard implementations. This enables new application areas that require a long operating time or compact physical dimensions, which would not otherwise be possible. The architecture is designed, fabricated, and tested in the aforementioned applications to demonstrate its highly flexible and low-power operation. Advisors: Sina Balkır and Michael W. Hoffma