Synergistic Visualization And Quantitative Analysis Of Volumetric Medical Images

The medical diagnosis process starts with an interview with the patient, and continues with the physical exam. In practice, the medical professional may require additional screenings to precisely diagnose. Medical imaging is one of the most frequently used non-invasive screening methods to acquire insight of human body. Medical imaging is not only essential for accurate diagnosis, but also it can enable early prevention. Medical data visualization refers to projecting the medical data into a human understandable format at mediums such as 2D or head-mounted displays without causing any interpretation which may lead to clinical intervention. In contrast to the medical visualization, quantification refers to extracting the information in the medical scan to enable the clinicians to make fast and accurate decisions. Despite the extraordinary process both in medical visualization and quantitative radiology, efforts to improve these two complementary fields are often performed independently and synergistic combination is under-studied. Existing image-based software platforms mostly fail to be used in routine clinics due to lack of a unified strategy that guides clinicians both visually and quan- titatively. Hence, there is an urgent need for a bridge connecting the medical visualization and automatic quantification algorithms in the same software platform. In this thesis, we aim to fill this research gap by visualizing medical images interactively from anywhere, and performing a fast, accurate and fully-automatic quantification of the medical imaging data. To end this, we propose several innovative and novel methods. Specifically, we solve the following sub-problems of the ul- timate goal: (1) direct web-based out-of-core volume rendering, (2) robust, accurate, and efficient learning based algorithms to segment highly pathological medical data, (3) automatic landmark- ing for aiding diagnosis and surgical planning and (4) novel artificial intelligence algorithms to determine the sufficient and necessary data to derive large-scale problems

InterFace : A software package for face image warping, averaging, and principal components analysis

We describe InterFace, a software package for research in face recognition. The package supports image warping, reshaping, averaging of multiple face images, and morphing between faces. It also supports principal components analysis (PCA) of face images, along with tools for exploring the “face space” produced by PCA. The package uses a simple graphical user interface, allowing users to perform these sophisticated image manipulations without any need for programming knowledge. The program is available for download in the form of an app, which requires that users also have access to the (freely available) MATLAB Runtime environment

Quantification of Facial Traits

Measuring facial traits by quantitative means is a prerequisite to investigate epidemiological, clinical, and forensic questions. This measurement process has received intense attention in recent years. We divided this process into the registration of the face, landmarking, morphometric quantification, and dimension reduction. Face registration is the process of standardizing pose and landmarking annotates positions in the face with anatomic description or mathematically defined properties (pseudolandmarks). Morphometric quantification computes pre-specified transformations such as distances. Landmarking: We review face registration methods which are required by some landmarking methods. Although similar, face registration and landmarking are distinct problems. The registration phase can be seen as a pre-processing step and can be combined independently with a landmarking solution. Existing approaches for landmarking differ in their data requirements, modeling approach, and training complexity. In this review, we focus on 3D surface data as captured by commercial surface scanners but also cover methods for 2D facial pictures, when methodology overlaps. We discuss the broad categories of active shape models, template based approaches, recent deep-learning algorithms, and variations thereof such as hybrid algorithms. The type of algorithm chosen depends on the availability of pre-trained models for the data at hand, availability of an appropriate landmark set, accuracy characteristics, and training complexity. Quantification: Landmarking of anatomical landmarks is usually augmented by pseudo-landmarks, i.e., indirectly defined landmarks that densely cover the scan surface. Such a rich data set is not amenable to direct analysis but is reduced in dimensionality for downstream analysis. We review classic dimension reduction techniques used for facial data and face specific measures, such as geometric measurements and manifold learning. Finally, we review symmetry registration and discuss reliability

4D (3D Dynamic) statistical models of conversational expressions and the synthesis of highly-realistic 4D facial expression sequences

In this thesis, a novel approach for modelling 4D (3D Dynamic) conversational interactions and synthesising highly-realistic expression sequences is described. To achieve these goals, a fully-automatic, fast, and robust pre-processing pipeline was developed, along with an approach for tracking and inter-subject registering 3D sequences (4D data). A method for modelling and representing sequences as single entities is also introduced. These sequences can be manipulated and used for synthesising new expression sequences. Classification experiments and perceptual studies were performed to validate the methods and models developed in this work. To achieve the goals described above, a 4D database of natural, synced, dyadic conversations was captured. This database is the first of its kind in the world. Another contribution of this thesis is the development of a novel method for modelling conversational interactions. Our approach takes into account the time-sequential nature of the interactions, and encompasses the characteristics of each expression in an interaction, as well as information about the interaction itself. Classification experiments were performed to evaluate the quality of our tracking, inter-subject registration, and modelling methods. To evaluate our ability to model, manipulate, and synthesise new expression sequences, we conducted perceptual experiments. For these perceptual studies, we manipulated modelled sequences by modifying their amplitudes, and had human observers evaluate the level of expression realism and image quality. To evaluate our coupled modelling approach for conversational facial expression interactions, we performed a classification experiment that differentiated predicted frontchannel and backchannel sequences, using the original sequences in the training set. We also used the predicted backchannel sequences in a perceptual study in which human observers rated the level of similarity of the predicted and original sequences. The results of these experiments help support our methods and our claim of our ability to produce 4D, highly-realistic expression sequences that compete with state-of-the-art methods

Automatic analysis of facial actions: a survey

As one of the most comprehensive and objective ways to describe facial expressions, the Facial Action Coding System (FACS) has recently received significant attention. Over the past 30 years, extensive research has been conducted by psychologists and neuroscientists on various aspects of facial expression analysis using FACS. Automating FACS coding would make this research faster and more widely applicable, opening up new avenues to understanding how we communicate through facial expressions. Such an automated process can also potentially increase the reliability, precision and temporal resolution of coding. This paper provides a comprehensive survey of research into machine analysis of facial actions. We systematically review all components of such systems: pre-processing, feature extraction and machine coding of facial actions. In addition, the existing FACS-coded facial expression databases are summarised. Finally, challenges that have to be addressed to make automatic facial action analysis applicable in real-life situations are extensively discussed. There are two underlying motivations for us to write this survey paper: the first is to provide an up-to-date review of the existing literature, and the second is to offer some insights into the future of machine recognition of facial actions: what are the challenges and opportunities that researchers in the field face

Modelling life cycle related and individual shape variation in biological specimens

The main purpose of this research is to develop methods for automatic identification of biological specimens in digital photographs and drawings held in a database. Incorporation of taxonomic drawings into a visual indexing system has not been attempted to date. Diatoms are a single cell microscopic algae that provide a particularly suitable case study. Identification of diatoms is a challenging task due to the huge number of the species, blurred boundaries between species, and life cycle related shape changes. A novel model based on principal curves representing the life cycle related shape variation of a number of diatom species has been developed. Our model is suitable for reconstruction purposes, allowing us to produce drawings of a variety of diatom shapes, thus providing a link between the photographs and drawings. We present the classification results of photographed and drawn specimens based on the model and compare our results to another recent system for diatom identification. Finally, given a diatom specimen, we are able not only to identify the species it belongs to but also to pinpoint the stage in the life cycle it represents