Pulmonary nodule classification aided by clustering

Lung nodules can be detected through examining CT scans. An automated lung nodule classification system is presented in this paper. The system employs random forests as it base classifier. A unique architecture for classification-aided-by-clustering is presented. Four experiments are conducted to study the performance of the developed system. 5721 CT lung image slices from the LIDC database are employed in the experiments. According to the experimental results, the highest sensitivity of 97.92%, and specificty of 96.28% are achieved by the system. The results demonstrate that the system has improved the performances of its tested counterparts

Image Features for Tuberculosis Classification in Digital Chest Radiographs

Tuberculosis (TB) is a respiratory disease which affects millions of people each year, accounting for the tenth leading cause of death worldwide, and is especially prevalent in underdeveloped regions where access to adequate medical care may be limited. Analysis of digital chest radiographs (CXRs) is a common and inexpensive method for the diagnosis of TB; however, a trained radiologist is required to interpret the results, and is subject to human error. Computer-Aided Detection (CAD) systems are a promising machine-learning based solution to automate the diagnosis of TB from CXR images. As the dimensionality of a high-resolution CXR image is very large, image features are used to describe the CXR image in a lower dimension while preserving the elements in the CXR necessary for the detection of TB. In this thesis, I present a set of image features using Pyramid Histogram of Oriented Gradients, Local Binary Patterns, and Principal Component Analysis which provides high classifier performance on two publicly available CXR datasets, and compare my results to current state-of-the-art research

Artificial Intelligence Techniques for Cancer Detection and Classification: Review Study

Cancer is the general name for a group of more than 100 diseases. Although cancer includes different types of diseases, they all start because abnormal cells grow out of control. Without treatment, cancer can cause serious health problems and even loss of life. Early detection of cancer may reduce mortality and morbidity. This paper presents a review of the detection methods for lung, breast, and brain cancers. These methods used for diagnosis include artificial intelligence techniques, such as support vector machine neural network, artificial neural network, fuzzy logic, and adaptive neuro-fuzzy inference system, with medical imaging like X-ray, ultrasound, magnetic resonance imaging, and computed tomography scan images. Imaging techniques are the most important approach for precise diagnosis of human cancer. We investigated all these techniques to identify a method that can provide superior accuracy and determine the best medical images for use in each type of cancer

Application of radiomics in diagnosis and treatment of lung cancer

Radiomics has become a research field that involves the process of converting standard nursing images into quantitative image data, which can be combined with other data sources and subsequently analyzed using traditional biostatistics or artificial intelligence (Al) methods. Due to the capture of biological and pathophysiological information by radiomics features, these quantitative radiomics features have been proven to provide fast and accurate non-invasive biomarkers for lung cancer risk prediction, diagnosis, prognosis, treatment response monitoring, and tumor biology. In this review, radiomics has been emphasized and discussed in lung cancer research, including advantages, challenges, and drawbacks

Radial Basis Function Artificial Neural Network for the Investigation of Thyroid Cytological Lesions

Objective. This study investigates the potential of an artificial intelligence (AI) methodology, the radial basis function (RBF) artificial neural network (ANN), in the evaluation of thyroid lesions. Study Design. The study was performed on 447 patients who had both cytological and histological evaluation in agreement. Cytological specimens were prepared using liquid-based cytology, and the histological result was based on subsequent surgical samples. Each specimen was digitized; on these images, nuclear morphology features were measured by the use of an image analysis system. The extracted measurements (41,324 nuclei) were separated into two sets: the training set that was used to create the RBF ANN and the test set that was used to evaluate the RBF performance. The system aimed to predict the histological status as benign or malignant. Results. The RBF ANN obtained in the training set has sensitivity 82.5%, specificity 94.6%, and overall accuracy 90.3%, while in the test set, these indices were 81.4%, 90.0%, and 86.9%, respectively. Algorithm was used to classify patients on the basis of the RBF ANN, the overall sensitivity was 95.0%, the specificity was 95.5%, and no statistically significant difference was observed. Conclusion. AI techniques and especially ANNs, only in the recent years, have been studied extensively. The proposed approach is promising to avoid misdiagnoses and assists the everyday practice of the cytopathology. The major drawback in this approach is the automation of a procedure to accurately detect and measure cell nuclei from the digitized images

Using Quantitative Imaging for Personalized Medicine in Pancreatic Cancer: A Review of Radiomics and Deep Learning Applications

As the most lethal major cancer, pancreatic cancer is a global healthcare challenge. Personalized medicine utilizing cutting-edge multi-omics data holds potential for major breakthroughs in tackling this critical problem. Radiomics and deep learning, two trendy quantitative imaging methods that take advantage of data science and modern medical imaging, have shown increasing promise in advancing the precision management of pancreatic cancer via diagnosing of precursor diseases, early detection, accurate diagnosis, and treatment personalization and optimization. Radiomics employs manually-crafted features, while deep learning applies computer-generated automatic features. These two methods aim to mine hidden information in medical images that is missed by conventional radiology and gain insights by systematically comparing the quantitative image information across different patients in order to characterize unique imaging phenotypes. Both methods have been studied and applied in various pancreatic cancer clinical applications. In this review, we begin with an introduction to the clinical problems and the technology. After providing technical overviews of the two methods, this review focuses on the current progress of clinical applications in precancerous lesion diagnosis, pancreatic cancer detection and diagnosis, prognosis prediction, treatment stratification, and radiogenomics. The limitations of current studies and methods are discussed, along with future directions. With better standardization and optimization of the workflow from image acquisition to analysis and with larger and especially prospective high-quality datasets, radiomics and deep learning methods could show real hope in the battle against pancreatic cancer through big data-based high-precision personalization