A Motif-based Approach for Identifying Controversy

Among the topics discussed in Social Media, some lead to controversy. A number of recent studies have focused on the problem of identifying controversy in social media mostly based on the analysis of textual content or rely on global network structure. Such approaches have strong limitations due to the difficulty of understanding natural language, and of investigating the global network structure. In this work we show that it is possible to detect controversy in social media by exploiting network motifs, i.e., local patterns of user interaction. The proposed approach allows for a language-independent and fine- grained and efficient-to-compute analysis of user discussions and their evolution over time. The supervised model exploiting motif patterns can achieve 85% accuracy, with an improvement of 7% compared to baseline structural, propagation-based and temporal network features

Text in the Natural World: Topics of Evolutionary Theory of Literature

The study of literature has expanded to include an evolutionary perspective. Its premise is that the literary text and literature as an overarching institution came into existence as a product of the same evolutionary process that gave rise to the human species. In this view, literature is an evolutionary adaptation that functions as any other adaptation does, as a means of enhancing survivability and also promoting benefits for the individual and society. Text in the Natural World is an introduction to the theory and a survey of topics pertinent to the evolutionary view of literature. After a polemical, prefatory chapter and an overview of the pertinent aspects of evolutionary theory itself, the book examines integral building blocks of literature and literary expression as effects of evolutionary development. This includes chapters on moral sense, symbolic thought, literary aesthetics in general, literary ontology, the broad topic of form, function and device in literature, a last theoretical chapter on narrative, and a chapter on literary themes. The concluding chapter builds on the preceding one as an illustration of evolutionary thematic study in practice, in a study of the fauna in the fiction of Maupassant. This text is designed to be of interest to those who read and think about things literary, as well as to those who have interest in the extension of Darwin’s great idea across the horizon of human culture. It tries to bridge the gulf that has separated the humanities from the sciences, and would be a helpful text for courses taught in both literary theory and interdisciplinary approaches to literature and philosophy.https://cupola.gettysburg.edu/books/1125/thumbnail.jp

Quantifying and minimizing risk of conflict in social networks

Controversy, disagreement, conflict, polarization and opinion divergence in social networks have been the subject of much recent research. In particular, researchers have addressed the question of how such concepts can be quantified given people’s prior opinions, and how they can be optimized by influencing the opinion of a small number of people or by editing the network’s connectivity. Here, rather than optimizing such concepts given a specific set of prior opinions, we study whether they can be optimized in the average case and in the worst case over all sets of prior opinions. In particular, we derive the worst-case and average-case conflict risk of networks, and we propose algorithms for optimizing these. For some measures of conflict, these are non-convex optimization problems with many local minima. We provide a theoretical and empirical analysis of the nature of some of these local minima, and show how they are related to existing organizational structures. Empirical results show how a small number of edits quickly decreases its conflict risk, both average-case and worst-case. Furthermore, it shows that minimizing average-case conflict risk often does not reduce worst-case conflict risk. Minimizing worst-case conflict risk on the other hand, while computationally more challenging, is generally effective at minimizing both worst-case as well as average-case conflict risk

Library Cartoons: A Literature Review of Library-themed Cartoons, Caricatures, and Comics

To understand differing views of past events, historians, political science scholars, and sociologists have analyzed political and editorial cartoons with themes ranging from elections to fiscal policy to human rights. Yet scant research has been dedicated to cartoons with library themes. The author of this paper examines peer-reviewed literature on the subject of library cartoons, including historical background, analysis of recent themes, and arguments for promoting library-themed cartoons, caricatures, and comics. The author finds a significant gap in the literature on this topic and concludes that information professionals would benefit from a comprehensive content analysis of library-themed cartoons to enhance understanding of the significance of libraries during historic events, assess public perception of libraries, and identify trends over time

Familial hypomagnesaemia, Hypercalciuria and Nephrocalcinosis associated with a novel mutation of the highly conserved leucine residue 116 of Claudin 16 in a Chinese patient with a delayed diagnosis: A case report

Background: Sixty mutations of claudin 16 coding gene have been reported in familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) patients. Recent investigations revealed that a highly conserved glycine-leucine-tryptophan (115G-L-W117) motif in the first extracellular segment (ESC1) of claudin 16 might be essential for stabilization of the appropriately folded ECS1 structure and conservation of normal claudin 16 function. However, neither missense nor nonsense mutation has ever been described in this motif. Our study aimed at identifying mutations in a Chinese patient with FHHNC and exploring the association between genotype and phenotype. Case presentation: A 33-year-old female presented with 4 years history of recurrent acute pyelonephritis without other notable past medical history. Her healthy parents, who aged 56 and 53 respectively, were second cousins, and her only sibling died from renal failure without definite cause at age 25. Renal ultrasound imaging demonstrated atrophic kidneys and bilateral nephrocalcinosis. The laboratory workup revealed impaired renal function (Stage CKD IV), hypocalcemia and mild hypomagnesemia, accompanied with marked renal loss of magnesium and hypercalciuria. During the follow-up, treatment with calcitriol and calcium but not with magnesium was difficult to achieve normal serum calcium levels, whereas her serum magnesium concentration fluctuated within normal ranges. In the end, the patient unavoidably reached ESRD at 36 years old. The clinical features and family history suggested the diagnosis of FHHNC. To make a definite diagnosis, we use whole-exome sequencing to identify the disease-causing mutations and Sanger sequencing to confirm the mutation co-segregation in the family. As a result, a novel homozygous mutation (c.346C > G, p.Leu116Val) in115G-L-W117motif of claudin 16 was identified. Her parents, grandmother and one of her cousins carried heterozygous p.Leu116Val, whereas 200 unrelated controls did not carry this mutation. Conclusions: We described a delayed diagnosis patient with FHHNC in the Chinese population and identified a novel missense mutation in the highly conserved115G-L-W117motif of claudin 16 for the first time. According to the reported data and the information deduced from 3D modeling, we speculate that this mutation probably reserve partial residual function which might be related to the slight phenotype of the patient

Peptide vocabulary analysis reveals ultra-conservation and homonymity in protein sequences

A new algorithm is presented for vocabulary analysis (word detection) in texts of human origin. It performs at 60%–70% overall accuracy and greater than 80% accuracy for longer words, and approximately 85% sensitivity on Alice in Wonderland, a considerable improvement on previous methods. When applied to protein sequences, it detects short sequences analogous to words in human texts, i.e. intolerant to changes in spelling (mutation), and relatively contextindependent in their meaning (function). Some of these are homonyms of up to 7 amino acids, which can assume different structures in different proteins. Others are ultra-conserved stretches of up to 18 amino acids within proteins of less than 40% overall identity, reflecting extreme constraint or convergent evolution. Different species are found to have qualitatively different major peptide vocabularies, e.g. some are dominated by large gene families, while others are rich in simple repeats or dominated by internally repetitive proteins. This suggests the possibility of a peptide vocabulary signature, analogous to genome signatures in DNA. Homonyms may be useful in detecting convergent evolution and positive selection in protein evolution. Ultra-conserved words may be useful in identifying structures intolerant to substitution over long periods of evolutionary time

Peder Borgen’s Bread from Heaven—Midrashic Developments in John 6 as a Case Study in John’s Unity and Disunity (A Foreword to Bread from Heaven)

Among the weighty treatments of the Gospel of John over the last half-century, one of the most incisive has been Bread from Heaven, by Peder Borgen. As the unity and disunity of the Fourth Gospel had been debated extensively among Johannine scholars for the previous half-century, approaching this issue from a text-based comparative standpoint posed a new window through which one could assess key issues and contribute to the larger discussions. Whereas Rudolf Bultmann and Wilhelm Bousset had envisioned the context of John’s composition as Hellenistic Christianity leading into Gnostic trajectories, Borgen focused on particularly Jewish writings as John’s primary backdrop—albeit within a diaspora Hellenistic setting. More specifically, the writings of Philo and the Palestinian midrashim offer a text-based way forward in discerning the origin and development of John’s presentation of the feeding and sea-crossing in the ministry of Jesus in John 6, followed by ensuing discussions and the confession of Peter. Given the numerous explicit and implicit cases of John’s citing of Jewish biblical motifs, if the case could be made for the Johannine narrator’s following Jewish patterns of thinking and writing, then implications would extend to understandings of the Johannine tradition’s origin and contextual development, elucidating also its character and meaning

EZH2 RIP-seq Identifies Tissue-specific Long Non-coding RNAs.

BackgroundPolycomb Repressive Complex 2 (PRC2) catalyzes histone methylation at H3 Lys27, and plays crucial roles during development and diseases in numerous systems. Its catalytic subunit EZH2 represents a key nuclear target for long non-coding RNAs (lncRNAs) that emerging to be a novel class of epigenetic regulator and participate in diverse cellular processes. LncRNAs are characterized by high tissue-specificity; however, little is known about the tissue profile of the EZH2- interacting lncRNAs.ObjectiveHere we performed a global screening for EZH2-binding lncRNAs in tissues including brain, lung, heart, liver, kidney, intestine, spleen, testis, muscle and blood by combining RNA immuno- precipitation and RNA sequencing. We identified 1328 EZH2-binding lncRNAs, among which 470 were shared in at least two tissues while 858 were only detected in single tissue. An RNA motif with specific secondary structure was identified in a number of lncRNAs, albeit not in all EZH2-binding lncRNAs. The EZH2-binding lncRNAs fell into four categories including intergenic lncRNA, antisense lncRNA, intron-related lncRNA and promoter-related lncRNA, suggesting diverse regulations of both cis and trans-mechanisms. A promoter-related lncRNA Hnf1aos1 bound to EZH2 specifically in the liver, a feature same as its paired coding gene Hnf1a, further confirming the validity of our study. In addition to the well known EZH2-binding lncRNAs like Kcnq1ot1, Gas5, Meg3, Hotair and Malat1, majority of the lncRNAs were firstly reported to be associated with EZH2.ConclusionOur findings provide a profiling view of the EZH2-interacting lncRNAs across different tissues, and suggest critical roles of lncRNAs during cell differentiation and maturation