858 research outputs found
A Method for Reducing the Severity of Epidemics by Allocating Vaccines According to Centrality
One long-standing question in epidemiological research is how best to
allocate limited amounts of vaccine or similar preventative measures in order
to minimize the severity of an epidemic. Much of the literature on the problem
of vaccine allocation has focused on influenza epidemics and used mathematical
models of epidemic spread to determine the effectiveness of proposed methods.
Our work applies computational models of epidemics to the problem of
geographically allocating a limited number of vaccines within several Texas
counties. We developed a graph-based, stochastic model for epidemics that is
based on the SEIR model, and tested vaccine allocation methods based on
multiple centrality measures. This approach provides an alternative method for
addressing the vaccine allocation problem, which can be combined with more
conventional approaches to yield more effective epidemic suppression
strategies. We found that allocation methods based on in-degree and inverse
betweenness centralities tended to be the most effective at containing
epidemics.Comment: 10 pages, accepted to ACM BCB 201
Persistence, extinction and spatio-temporal synchronization of SIRS cellular automata models
Spatially explicit models have been widely used in today's mathematical
ecology and epidemiology to study persistence and extinction of populations as
well as their spatial patterns. Here we extend the earlier work--static
dispersal between neighbouring individuals to mobility of individuals as well
as multi-patches environment. As is commonly found, the basic reproductive
ratio is maximized for the evolutionary stable strategy (ESS) on diseases'
persistence in mean-field theory. This has important implications, as it
implies that for a wide range of parameters that infection rate will tend
maximum. This is opposite with present results obtained in spatial explicit
models that infection rate is limited by upper bound. We observe the emergence
of trade-offs of extinction and persistence on the parameters of the infection
period and infection rate and show the extinction time having a linear
relationship with respect to system size. We further find that the higher
mobility can pronouncedly promote the persistence of spread of epidemics, i.e.,
the phase transition occurs from extinction domain to persistence domain, and
the spirals' wavelength increases as the mobility increasing and ultimately, it
will saturate at a certain value. Furthermore, for multi-patches case, we find
that the lower coupling strength leads to anti-phase oscillation of infected
fraction, while higher coupling strength corresponds to in-phase oscillation.Comment: 12page
A Mathematical Model to Study the Meningococcal Meningitis
AbstractThe main goal of this work is to introduce a novel mathematical model to study the spreading of meningococcal meningitis. Specifically, it is a discrete mathematical model based on cellular automata where the population is divided in five classes: sus- ceptible, asymptomatic infected, infected with symptoms, carriers, recovered and died. It catches the individual characteristics of people in order to give a prediction of both the individual behavior, and whole evolution of population
A Cellular Automata Modeling for Visualizing and Predicting Spreading Patterns of Dengue Fever
A Cellular Automata (CA) model is used for visualizing and predicting spreading pattern of the disease. The main problem of this model is how to find a function that represents an update rule that changes the state of a cell in time steps affected by neighborhood. This research aims to develop visualization and prediction model of the spreading patterns of Dengue Hemorrhagic Fever. The contribution of our study is to introduce a new approach in defining a probabilistic function that represents CA transmission rule by employing Von Neumann neighborhood and the Hidden Markov Model (HMM). This study only considered an infective state which dedicated particular attention to the spatial distribution of infected areas. The infected data were devided into four categories and change the definition of a cell as an area. The evaluation was conducted by comparing the results of the proposed model to that of one yielded by a Susceptible-Infected-Recovered (SIR) model. The evaluation result showed that the CA model was capable of generating patterns that similar to the patterns generated by SIR models with a similarities value of 0.95
A Simple Cellular Automaton Model for Influenza A Viral Infections
Viral kinetics have been extensively studied in the past through the use of
spatially homogeneous ordinary differential equations describing the time
evolution of the diseased state. However, spatial characteristics such as
localized populations of dead cells might adversely affect the spread of
infection, similar to the manner in which a counter-fire can stop a forest fire
from spreading. In order to investigate the influence of spatial
heterogeneities on viral spread, a simple 2-D cellular automaton (CA) model of
a viral infection has been developed. In this initial phase of the
investigation, the CA model is validated against clinical immunological data
for uncomplicated influenza A infections. Our results will be shown and
discussed.Comment: LaTeX, 12 pages, 18 EPS figures, uses document class ReTeX4, and
packages amsmath and SIunit
Invited review: Epidemics on social networks
Since its first formulations almost a century ago, mathematical models for
disease spreading contributed to understand, evaluate and control the epidemic
processes.They promoted a dramatic change in how epidemiologists thought of the
propagation of infectious diseases.In the last decade, when the traditional
epidemiological models seemed to be exhausted, new types of models were
developed.These new models incorporated concepts from graph theory to describe
and model the underlying social structure.Many of these works merely produced a
more detailed extension of the previous results, but some others triggered a
completely new paradigm in the mathematical study of epidemic processes. In
this review, we will introduce the basic concepts of epidemiology, epidemic
modeling and networks, to finally provide a brief description of the most
relevant results in the field.Comment: 17 pages, 13 figure
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