122,147 research outputs found
Spatial and seasonal patterns of FMD primary outbreaks in cattle in Zimbabwe between 1931 and 2016
Foot and mouth disease (FMD) is an important livestock disease impacting mainly intensive production systems. In southern Africa, the FMD virus is maintained in wildlife and its control is therefore complicated. However, FMD control is an important task to allow countries access to lucrative foreign meat market and veterinary services implement drastic control measures on livestock populations living in the periphery of protected areas, negatively impacting local small-scale livestock producers. This study investigated FMD primary outbreak data in Zimbabwe from 1931 to 2016 to describe the spatio-temporal distribution of FMD outbreaks and their potential drivers. The results suggest that: (i) FMD outbreaks were not randomly distributed in space across Zimbabwe but are clustered in the Southeast Lowveld (SEL); (ii) the proximity of protected areas with African buffalos was potentially responsible for primary FMD outbreaks in cattle; (iii) rainfall per se was not associated with FMD outbreaks, but seasons impacted the temporal occurrence of FMD outbreaks across regions; (iv) the frequency of FMD outbreaks increased during periods of major socio-economic and political crisis. The differences between the spatial clusters and other areas in Zimbabwe presenting similar buffalo/cattle interfaces but with fewer FMD outbreaks can be interpreted in light of the recent better understanding of wildlife/livestock interactions in these areas. The types of wildlife/livestock interfaces are hypothesized to be the key drivers of contacts between wildlife and livestock, triggering a risk of FMD inter-species spillover. The management of wildlife/livestock interfaces is therefore crucial for the control of FMD in southern Africa
Benefits of Location-Based Access Control:A Literature Study
Location-based access control (LBAC) has been suggested as a means to improve IT security. By 'grounding' users and systems to a particular location, \ud
attackers supposedly have more difficulty in compromising a system. However, the motivation behind LBAC and its potential benefits have not been investigated thoroughly. To this end, we perform a structured literature review, and examine the goals that LBAC can potentially fulfill, \ud
the specific LBAC systems that realize these goals and the context on which LBAC depends. Our paper has four main contributions:\ud
first we propose a theoretical framework for LBAC evaluation, based on goals, systems and context. Second, we formulate and apply criteria for evaluating the usefulness of an LBAC system. Third, we identify four usage scenarios for LBAC: open areas and systems, hospitals, enterprises, and finally data centers and military facilities. Fourth, we propose directions for future research:\ud
(i) assessing the tradeoffs between location-based, physical and logical access control, (ii) improving the transparency of LBAC decision making, and \ud
(iii) formulating design criteria for facilities and working environments for optimal LBAC usage
Perceptual modalities guiding bat flight in a native habitat
Flying animals accomplish high-speed navigation through fields of obstacles using a suite of sensory modalities that blend spatial memory with input from vision, tactile sensing, and, in the case of most bats and some other animals, echolocation. Although a good deal of previous research has been focused on the role of individual modes of sensing in animal locomotion, our understanding of sensory integration and the interplay among modalities is still meager. To understand how bats integrate sensory input from echolocation, vision, and spatial memory, we conducted an experiment in which bats flying in their natural habitat were challenged over the course of several evening emergences with a novel obstacle placed in their flight path. Our analysis of reconstructed flight data suggests that vision, echolocation, and spatial memory together with the possible exercise of an ability in using predictive navigation are mutually reinforcing aspects of a composite perceptual system that guides flight. Together with the recent development in robotics, our paper points to the possible interpretation that while each stream of sensory information plays an important role in bat navigation, it is the emergent effects of combining modalities that enable bats to fly through complex spaces
Spatial and temporal hot spots of Aedes albopictus abundance inside and outside a South European metropolitan area
Aedes albopictus is a tropical invasive species which in the last decades spread worldwide,
also colonizing temperate regions of Europe and US, where it has become a public health
concern due to its ability to transmit exotic arboviruses, as well as severe nuisance problems
due to its aggressive daytime outdoor biting behaviour. While several studies have
been carried out in order to predict the potential limits of the species expansions based on
eco-climatic parameters, few studies have so far focused on the specific effects of these
variables in shaping its micro-geographic abundance and dynamics. The present study
investigated eco-climatic factors affecting Ae. albopictus abundance and dynamics in metropolitan
and sub-urban/rural sites in Rome (Italy), which was colonized in 1997 and is nowadays
one of the most infested metropolitan areas in Southern Europe. To this aim,
longitudinal adult monitoring was carried out along a 70 km-transect across and beyond the
most urbanized and densely populated metropolitan area. Two fine scale spatiotemporal
datasets (one with reference to a 20m circular buffer around sticky traps used to collect
mosquitoes and the second to a 300m circular buffer within each sampling site) were
exploited to analyze the effect of climatic and socio-environmental variables on Ae. albopictus
abundance and dynamics along the transect. Results showed an association between
highly anthropized habitats and high adult abundance both in metropolitan and sub-urban/
rural areas, with “small green islands” corresponding to hot spots of abundance in the metropolitan
areas only, and a bimodal seasonal dynamics with a second peak of abundance in
autumn, due to heavy rains occurring in the preceding weeks in association with permissive
temperatures. The results provide useful indications to prioritize public mosquito control
measures in temperate urban areas where nuisance, human-mosquito contact and risk of
local arbovirus transmission are likely higher, and highlight potential public health risks also
after the summer months typically associated with high mosquito densities
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Geometric principles of second messenger dynamics in dendritic spines.
Dendritic spines are small, bulbous protrusions along dendrites in neurons and play a critical role in synaptic transmission. Dendritic spines come in a variety of shapes that depend on their developmental state. Additionally, roughly 14-19% of mature spines have a specialized endoplasmic reticulum called the spine apparatus. How does the shape of a postsynaptic spine and its internal organization affect the spatio-temporal dynamics of short timescale signaling? Answers to this question are central to our understanding the initiation of synaptic transmission, learning, and memory formation. In this work, we investigated the effect of spine and spine apparatus size and shape on the spatio-temporal dynamics of second messengers using mathematical modeling using reaction-diffusion equations in idealized geometries (ellipsoids, spheres, and mushroom-shaped). Our analyses and simulations showed that in the short timescale, spine size and shape coupled with the spine apparatus geometries govern the spatiotemporal dynamics of second messengers. We show that the curvature of the geometries gives rise to pseudo-harmonic functions, which predict the locations of maximum and minimum concentrations along the spine head. Furthermore, we showed that the lifetime of the concentration gradient can be fine-tuned by localization of fluxes on the spine head and varying the relative curvatures and distances between the spine apparatus and the spine head. Thus, we have identified several key geometric determinants of how the spine head and spine apparatus may regulate the short timescale chemical dynamics of small molecules that control synaptic plasticity
Elevation and cholera: an epidemiological spatial analysis of the cholera epidemic in Harare, Zimbabwe, 2008-2009
BACKGROUND: In highly populated African urban areas where access to clean water is a challenge, water source contamination is one of the most cited risk factors in a cholera epidemic. During the rainy season, where there is either no sewage disposal or working sewer system, runoff of rains follows the slopes and gets into the lower parts of towns where shallow wells could easily become contaminated by excretes. In cholera endemic areas, spatial information about topographical elevation could help to guide preventive interventions. This study aims to analyze the association between topographic elevation and the distribution of cholera cases in Harare during the cholera epidemic in 2008 and 2009. METHODS: We developed an ecological study using secondary data. First, we described attack rates by suburb and then calculated rate ratios using whole Harare as reference. We illustrated the average elevation and cholera cases by suburbs using geographical information. Finally, we estimated a generalized linear mixed model (under the assumption of a Poisson distribution) with an Empirical Bayesian approach to model the relation between the risk of cholera and the elevation in meters in Harare. We used a random intercept to allow for spatial correlation of neighboring suburbs. RESULTS: This study identifies a spatial pattern of the distribution of cholera cases in the Harare epidemic, characterized by a lower cholera risk in the highest elevation suburbs of Harare. The generalized linear mixed model showed that for each 100 meters of increase in the topographical elevation, the cholera risk was 30% lower with a rate ratio of 0.70 (95% confidence interval=0.66-0.76). Sensitivity analysis confirmed the risk reduction with an overall estimate of the rate ratio between 20% and 40%. CONCLUSION: This study highlights the importance of considering topographical elevation as a geographical and environmental risk factor in order to plan cholera preventive activities linked with water and sanitation in endemic areas. Furthermore, elevation information, among other risk factors, could help to spatially orientate cholera control interventions during an epidemic
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EEG-Based Quantification of Cortical Current Density and Dynamic Causal Connectivity Generalized across Subjects Performing BCI-Monitored Cognitive Tasks.
Quantification of dynamic causal interactions among brain regions constitutes an important component of conducting research and developing applications in experimental and translational neuroscience. Furthermore, cortical networks with dynamic causal connectivity in brain-computer interface (BCI) applications offer a more comprehensive view of brain states implicated in behavior than do individual brain regions. However, models of cortical network dynamics are difficult to generalize across subjects because current electroencephalography (EEG) signal analysis techniques are limited in their ability to reliably localize sources across subjects. We propose an algorithmic and computational framework for identifying cortical networks across subjects in which dynamic causal connectivity is modeled among user-selected cortical regions of interest (ROIs). We demonstrate the strength of the proposed framework using a "reach/saccade to spatial target" cognitive task performed by 10 right-handed individuals. Modeling of causal cortical interactions was accomplished through measurement of cortical activity using (EEG), application of independent component clustering to identify cortical ROIs as network nodes, estimation of cortical current density using cortically constrained low resolution electromagnetic brain tomography (cLORETA), multivariate autoregressive (MVAR) modeling of representative cortical activity signals from each ROI, and quantification of the dynamic causal interaction among the identified ROIs using the Short-time direct Directed Transfer function (SdDTF). The resulting cortical network and the computed causal dynamics among its nodes exhibited physiologically plausible behavior, consistent with past results reported in the literature. This physiological plausibility of the results strengthens the framework's applicability in reliably capturing complex brain functionality, which is required by applications, such as diagnostics and BCI
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