Memory Rehabilitation Strategies in Nonsurgical Temporal Lobe Epilepsy: A Review

open8siPeople with temporal lobe epilepsy (TLE) who have not undergone epilepsy surgery often complain of memory deficits. Cognitive re- habilitation is employed as a remedial intervention in clinical settings, but research is limited and findings concerning efficacy and the criteria for choosing different approaches have been inconsistent. We aimed to appraise existing evidence on memory rehabilitation in nonsurgical individuals with temporal lobe epilepsy and to ascertain the effectiveness of specific strategies. A scoping review was preferred given the het- erogeneous nature of the interventions. A comprehensive literature search using MEDLINE, EMBASE, CINAHL, AMED, Scholars Portal/ PSYCHinfo, Proceedings First, and ProQuest Dissertations and Theses identified articles published in English before February 2016. The search retrieved 372 abstracts. Of 25 eligible studies, six were included in the final review. None included pediatric populations. Strategies included cognitive training, external memory aids, brain training, and noninvasive brain stimulation. Selection criteria tended to be general. Overall, there was insufficient evidence to make definitive conclusions regarding the efficacy of traditional memory rehabilitation strategies, brain training, and noninvasive brain stimulation. The review suggests that cognitive rehabilitation in nonsurgical TLE is underresearched and that there is a need for a systematic evaluation in this population.embargoed_20180216DEL FELICE, Alessandra; Alderighi, Marzia; Martinato, Matteo; Grisafi, Davide; Bosco, Anna; Thompson, Pamela J.; Sander, Josemir W.; Masiero, StefanoDEL FELICE, Alessandra; Alderighi, Marzia; Martinato, Matteo; Grisafi, Davide; Bosco, Anna; Thompson, Pamela J.; Sander, Josemir W.; Masiero, Stefan

The positivity effect in older adults : the role of affective interference and inhibition

Objectives: Research shows that aging often involves a decrease in the experience of negative affect and might even be associated with a stabilization or an increase in experience concerning positive affect. As it has been suggested that these changes could be related to the processing of emotional information, the aim of this study was to investigate interference and inhibition toward sad and happy faces in healthy elderly people compared to a younger population. Method: We used an affective modification of the negative priming task. If interference is related to enhanced inhibition, reduced interference from negative stimuli and a related weakened inhibition toward negative stimuli in the elderly group would be in line with the positivity hypothesis. Results: As expected, the results indicated that interference from negative stimuli was significantly lower in older adults as compared to younger adults, whereas this was not the case for positive stimuli. Moreover, at inhibitory level a significantly reduced processing of negative stimuli was observed only in the older adult group, whereas there was no such effect in the case of positive material. Conclusion: These observations are indicative for a decreased negative bias in older adults at information processing level. This provides new insights with regard to age-related differences in emotion processing

Prospective Memory in Older Adults : Where We Are Now and What Is Next

M. Kliegel acknowledges financial support from the Swiss National Science Foundation (SNSF).Peer reviewedPostprin

Neuropsychological Generation of Source Amnesia: An Episodic Memory Disorder of the Frontal Brain

Source amnesia is an explicit memory (declarative) disorder, particularly episodic, where source or contextual information concerning facts is severely distorted and/or unable to be recalled. This paper reviews the literature on source amnesia, including memory distrust syndrome, and its accepted correlation with the medial diencephalic system and the temporal lobes, and the suggested linkage between the frontal lobes, including special interest with the prefrontal cortex. Posthypnotic induction was the first presentation of source amnesia identified in the literature. The Wisconsin Cart Sorting Test (WCST), Positron Emission Topography (PET), Phonemic Verbal Fluency Test, Stroop Color Word Interference Test, and explicit and implicit memory tests are defined and linked to empirical research on amnesiacs

Reduced mind-wandering in Mild Cognitive Impairment: Testing the spontaneous retrieval deficit hypothesis

© American Psychological Association, 2018. This paper is not the copy of record and may not exactly replicate the authoritative document published in the APA journal. Please do not copy or cite without author's permission. The final article is available, upon publication, at: http://dx.doi.org/10.1037/neu0000457Objective: Research on early cognitive markers of Alzheimer's disease (AD) is primarily focused on declarative episodic memory tests that involve deliberate and effortful/strategic processes at retrieval. The present study tested the spontaneous retrieval deficit hypothesis, which predicts that people with amnestic mild cognitive impairment (aMCI), who are at increased risk of developing AD, are particularly impaired on tasks that rely on spontaneous retrieval processes. Method: Twenty-three participants with aMCI and 25 healthy controls (HC) completed an easy vigilance task and thought probes (reporting what was going through their mind), which were categorized as spontaneous thoughts about the past (i.e., involuntary memories), current situation, and future (i.e., spontaneous prospection). Results: Participants with aMCI reported significantly fewer spontaneous thoughts or mind-wandering than HC. This effect was driven by significantly fewer involuntary memories, although groups did not differ in the number of current and future thoughts. Conclusions: Findings provide strong support for the spontaneous retrieval deficit hypothesis. Implications for research on mind-wandering and the default network, early cognitive markers of the disease, and our theoretical understanding of the nature of cognitive deficits in AD are discussed.Peer reviewe

Psychological principles of successful aging technologies: A mini-review

Based on resource-oriented conceptions of successful life-span development, we propose three principles for evaluating assistive technology: (a) net resource release; (b) person specificity, and (c) proximal versus distal frames of evaluation. We discuss how these general principles can aid the design and evaluation of assistive technology in adulthood and old age, and propose two technological strategies, one targeting sensorimotor and the other cognitive functioning. The sensorimotor strategy aims at releasing cognitive resources such as attention and working memory by reducing the cognitive demands of sensory or sensorimotor aspects of performance. The cognitive strategy attempts to provide adaptive and individualized cuing structures orienting the individual in time and space by providing prompts that connect properties of the environment to the individual's action goals. We argue that intelligent assistive technology continuously adjusts the balance between `environmental support' and `self-initiated processing' in person-specific and aging-sensitive ways, leading to enhanced allocation of cognitive resources. Furthermore, intelligent assistive technology may foster the generation of formerly latent cognitive resources by activating developmental reserves (plasticity). We conclude that `lifespan technology', if co-constructed by behavioral scientists, engineers, and aging individuals, offers great promise for improving both the transition from middle adulthood to old age and the degree of autonomy in old age in present and future generations. Copyright (C) 2008 S. Karger AG, Basel

Short-term prospective memory deficits in chronic back pain patients

Objective: Chronic pain, particularly low back pain, is widespread. Although a great deal is known about the impact that this has on quality of life and physical activity, relatively little has been established regarding the more cognitive effects of pain. This study aims to find out whether individuals with chronic pain experience memory deficits in prospective memory (PM), the process of remembering to do things at some future point in time. Examples of PM include remembering to keep an appointment, such as a visit to a clinic, or to perform a particular task, such as paying a bill on time. Methods: The PM of 50 participants with chronic pain was compared with 50 pain-free participants. Each participant completed the Prospective Memory Questionnaire, which assesses three aspects of prospective memory (short-term habitual, long-term episodic, and internally cued), and records the use of strategies to aid remembering. Results: In comparison to those not in pain, participants with chronic pain had significantly impaired short-term prospective memory, an effect which was evident even after co-varying use of analgesics and other drugs. Conclusions: These findings provide new insights into prospective memory dysfunction in people with chronic pain. Possible mechanisms for this dysfunction are discussed and suggestions for future research given

Medial temporal lobe contributions to intra-item associative recognition memory in the aging brain

Aging is associated with a decline in episodic memory function. This is accompanied by degradation of and functional changes in the medial temporal lobe (MTL) which subserves mnemonic processing. To date no study has investigated age-related functional change in MTL substructures during specific episodic memory processes such as intra-item associative memory. The aim of this study was to characterize age-related change in the neural correlates of intra-item associative memory processing. Sixteen young and 10 older subjects participated in a compound word intra-item associative memory task comprising a measure of associative recognition memory and a measure of recognition memory. There was no difference in performance between groups on the associative memory measure but each group recruited different MTL regions while performing the task.The young group recruited the left anterior hippocampus and posterior parahippocampal gyrus whereas the older participants recruited the hippocampus bilaterally. In contrast, recognition memory was significantlyworse in the older subjects.The left anterior hippocampuswas recruited in the young group during successful recognition memory whereas the older group recruited a more posterior region of the left hippocampus and showed a more bilateral activation of frontal brain regions than was observed in the young group. Our results suggest a reorganization of the neural correlates of intra-item associative memory in the aging brain

Absence of age effects on spontaneous past and future thinking in daily life

© Springer-Verlag GmbH Germany, part of Springer Nature 2018.Previous research on voluntary mental time travel (i.e., deliberately thinking about the past or future) has resulted in negative age effects. In contrast, studies on spontaneous past thoughts (i.e., involuntary autobiographical memories) have reported small or no age effects. The aim of the present research was to investigate the effects of age on the nature and frequency of spontaneous future thoughts in everyday life. In two studies, we examined whether older adults reported spontaneous future thoughts as often as younger adults, and whether these thoughts were predominantly goal-oriented and less dependent on incidental cues than thoughts about the past. In Study 1, young and old participants kept a diary of spontaneous thoughts of upcoming prospective memory tasks and involuntary autobiographical memories for 2 weeks. In Study 2, a 1-day experience sampling method was used to investigate spontaneous and deliberate task-unrelated future and past thoughts, by having young and old participants complete a questionnaire in response to 30 random signals. In both studies, no age effects were found in the frequency of spontaneous future thoughts, which were reported as frequently as thoughts about the past (Study 2) and referred predominantly to upcoming tasks and goals rather than future events or hypothetical events (Study 2). Results concerning the triggers of reported thoughts provide initial support for the idea that representations of future thoughts may be more activated than memories of past events. Taken together, these results have important implications for research on cognitive ageing, mind-wandering, prospective memory and involuntary autobiographical memories.Peer reviewedFinal Accepted Versio

Acceptability of novel lifelogging technology to determine context of sedentary behaviour in older adults

<strong>Objective:</strong> Lifelogging, using body worn sensors (activity monitors and time lapse photography) has the potential to shed light on the context of sedentary behaviour. The objectives of this study were to examine the acceptability, to older adults, of using lifelogging technology and indicate its usefulness for understanding behaviour.<strong> </strong><strong>Method:</strong> 6 older adults (4 males, mean age: 68yrs) wore the equipment (ActivPAL^TM and Vicon Revue^TM/SenseCam^TM) for 7 consecutive days during free-living activity. The older adults’ perception of the lifelogging technology was assessed through semi-structured interviews, including a brief questionnaire (Likert scale), and reference to the researcher&#39;s diary. <strong>Results:</strong> Older adults in this study found the equipment acceptable to wear and it did not interfere with privacy, safety or create reactivity, but they reported problems with the actual technical functioning of the camera. <strong>Conclusion:</strong> This combination of sensors has good potential to provide lifelogging information on the context of sedentary behaviour