Intra-Body Communications for Nervous System Applications: Current Technologies and Future Directions

The Internet of Medical Things (IoMT) paradigm will enable next generation healthcare by enhancing human abilities, supporting continuous body monitoring and restoring lost physiological functions due to serious impairments. This paper presents intra-body communication solutions that interconnect implantable devices for application to the nervous system, challenging the specific features of the complex intra-body scenario. The presented approaches include both speculative and implementative methods, ranging from neural signal transmission to testbeds, to be applied to specific neural diseases therapies. Also future directions in this research area are considered to overcome the existing technical challenges mainly associated with miniaturization, power supply, and multi-scale communications.Comment: https://www.sciencedirect.com/science/article/pii/S138912862300163

Communication channel analysis and real time compressed sensing for high density neural recording devices

Next generation neural recording and Brain- Machine Interface (BMI) devices call for high density or distributed systems with more than 1000 recording sites. As the recording site density grows, the device generates data on the scale of several hundred megabits per second (Mbps). Transmitting such large amounts of data induces significant power consumption and heat dissipation for the implanted electronics. Facing these constraints, efficient on-chip compression techniques become essential to the reduction of implanted systems power consumption. This paper analyzes the communication channel constraints for high density neural recording devices. This paper then quantifies the improvement on communication channel using efficient on-chip compression methods. Finally, This paper describes a Compressed Sensing (CS) based system that can reduce the data rate by > 10x times while using power on the order of a few hundred nW per recording channel

Developing Next-generation Brain Sensing Technologies - A Review.

Advances in sensing technology raise the possibility of creating neural interfaces that can more effectively restore or repair neural function and reveal fundamental properties of neural information processing. To realize the potential of these bioelectronic devices, it is necessary to understand the capabilities of emerging technologies and identify the best strategies to translate these technologies into products and therapies that will improve the lives of patients with neurological and other disorders. Here we discuss emerging technologies for sensing brain activity, anticipated challenges for translation, and perspectives for how to best transition these technologies from academic research labs to useful products for neuroscience researchers and human patients

Recent Advances in Neural Recording Microsystems

The accelerating pace of research in neuroscience has created a considerable demand for neural interfacing microsystems capable of monitoring the activity of large groups of neurons. These emerging tools have revealed a tremendous potential for the advancement of knowledge in brain research and for the development of useful clinical applications. They can extract the relevant control signals directly from the brain enabling individuals with severe disabilities to communicate their intentions to other devices, like computers or various prostheses. Such microsystems are self-contained devices composed of a neural probe attached with an integrated circuit for extracting neural signals from multiple channels, and transferring the data outside the body. The greatest challenge facing development of such emerging devices into viable clinical systems involves addressing their small form factor and low-power consumption constraints, while providing superior resolution. In this paper, we survey the recent progress in the design and the implementation of multi-channel neural recording Microsystems, with particular emphasis on the design of recording and telemetry electronics. An overview of the numerous neural signal modalities is given and the existing microsystem topologies are covered. We present energy-efficient sensory circuits to retrieve weak signals from neural probes and we compare them. We cover data management and smart power scheduling approaches, and we review advances in low-power telemetry. Finally, we conclude by summarizing the remaining challenges and by highlighting the emerging trends in the field

Bioelectronic Sensor Nodes for Internet of Bodies

Energy-efficient sensing with Physically-secure communication for bio-sensors on, around and within the Human Body is a major area of research today for development of low-cost healthcare, enabling continuous monitoring and/or secure, perpetual operation. These devices, when used as a network of nodes form the Internet of Bodies (IoB), which poses certain challenges including stringent resource constraints (power/area/computation/memory), simultaneous sensing and communication, and security vulnerabilities as evidenced by the DHS and FDA advisories. One other major challenge is to find an efficient on-body energy harvesting method to support the sensing, communication, and security sub-modules. Due to the limitations in the harvested amount of energy, we require reduction of energy consumed per unit information, making the use of in-sensor analytics/processing imperative. In this paper, we review the challenges and opportunities in low-power sensing, processing and communication, with possible powering modalities for future bio-sensor nodes. Specifically, we analyze, compare and contrast (a) different sensing mechanisms such as voltage/current domain vs time-domain, (b) low-power, secure communication modalities including wireless techniques and human-body communication, and (c) different powering techniques for both wearable devices and implants.Comment: 30 pages, 5 Figures. This is a pre-print version of the article which has been accepted for Publication in Volume 25 of the Annual Review of Biomedical Engineering (2023). Only Personal Use is Permitte

Are Brain-Computer Interfaces Feasible withIntegrated Photonic Chips?

The present paper examines the viability of a radically novel idea for brain-computer interface (BCI), which could lead to novel technological, experimental and clinical applications. BCIs are computer-based systems that enable either one-way or two-way communication between a living brain and an external machine. BCIs read-out brain signals and transduce them into task commands, which are performed by a machine. In closed-loop the machine can stimulate the brain with appropriate signals. In recent years, it has been shown that there is some ultraweak light emission from neurons within or close to the visible and near-infrared parts of the optical spectrum. Such ultraweak photon emission (UPE) reflects the cellular (and body) oxidative status, and compelling pieces of evidence are beginning to emerge that UPE may well play an informational role in neuronal functions. In fact, several experiments point to a direct correlation between UPE intensity and neural activity, oxidative reactions, EEG activity, cerebral blood flow, cerebral energy metabolism, and release of glutamate. Therefore, we propose a novel skull implant BCI that uses UPE. We suggest that a photonic integrated chip installed on the interior surface of the skull may enable a new form of extraction of the relevant features from the UPE signals. In the current technology landsacepe, photonic technologies are advancing rapidly and poised to overtake many electrical technologies, due to their unique advantages, such as miniaturization, high speed, low thermal effects, and large integration capacity that allow for high yield, volume manufacturing, and lower cost. For our proposed BCI, we are making some very major conjectures, which need to be experimentally verified, and therefore we discuss the controversial parts, feasibility of technology and limitations, and potential impact of this envisaged technology if successfully implemented in the future.BERC.2018-2021 Severo Ochoa.SEV-2017-071

Toward Brain Area Sensor Wireless Network

RÉSUMÉ De nouvelles approches d'interfaçage neuronal de haute performance sont requises pour les interfaces cerveau-machine (BMI) actuelles. Cela nécessite des capacités d'enregistrement/stimulation performantes en termes de vitesse, qualité et quantité, c’est à dire une bande passante à fréquence plus élevée, une résolution spatiale, un signal sur bruit et une zone plus large pour l'interface avec le cortex cérébral. Dans ce mémoire, nous parlons de l'idée générale proposant une méthode d'interfaçage neuronal qui, en comparaison avec l'électroencéphalographie (EEG), l'électrocorticographie (ECoG) et les méthodes d'interfaçage intracortical conventionnelles à une seule unité, offre de meilleures caractéristiques pour implémenter des IMC plus performants. Les avantages de la nouvelle approche sont 1) une résolution spatiale plus élevée - en dessous dumillimètre, et une qualité de signal plus élevée - en termes de rapport signal sur bruit et de contenu fréquentiel - comparé aux méthodes EEG et ECoG; 2) un caractère moins invasif que l'ECoG où l'enlèvement du crâne sous une opération d'enregistrement / stimulation est nécessaire; 3) une plus grande faisabilité de la libre circulation du patient à l'étude - par rapport aux deux méthodes EEG et ECoG où de nombreux fils sont connectés au patient en cours d'opération; 4) une utilisation à long terme puisque l'interface implantable est sans fil - par rapport aux deux méthodes EEG et ECoG qui offrent des temps limités de fonctionnement. Nous présentons l'architecture d'un réseau sans fil de microsystèmes implantables, que nous appelons Brain Area Sensor NETwork (Brain-ASNET). Il y a deux défis principaux dans la réalisation du projet Brain-ASNET. 1) la conception et la mise en oeuvre d'un émetteur-récepteur RF de faible consommation compatible avec la puce de capteurs de réseau implantable, et, 2) la conception d'un protocole de réseau de capteurs sans fil (WSN) ad-hoc économe en énergie. Dans ce mémoire, nous présentons un protocole de réseau ad-hoc économe en énergie pour le réseau désiré, ainsi qu'un procédé pour surmonter le problème de la longueur de paquet variable causé par le processus de remplissage de bit dans le protocole HDLC standard. Le protocole adhoc proposé conçu pour Brain-ASNET présente une meilleure efficacité énergétique par rapport aux protocoles standards tels que ZigBee, Bluetooth et Wi-Fi ainsi que des protocoles ad-hoc de pointe. Le protocole a été conçu et testé par MATLAB et Simulink.----------ABSTRACT New high-performance neural interfacing approaches are demanded for today’s Brain-Machine Interfaces (BMI). This requires high-performance recording/stimulation capabilities in terms of speed, quality, and quantity, i.e. higher frequency bandwidth, spatial resolution, signal-to-noise, and wider area to interface with the cerebral cortex. In this thesis, we talk about the general proposed idea of a neural interfacing method which in comparison with Electroencephalography (EEG), Electrocorticography (ECoG), and, conventional Single-Unit Intracortical neural interfacing methods offers better features to implement higher-performance BMIs. The new approach advantages are 1) higher spatial resolution – down to sub-millimeter, and higher signal quality − in terms of signal-to-noise ratio and frequency content − compared to both EEG and ECoG methods. 2) being less invasive than ECoG where skull removal Under recording/stimulation surgery is required. 3) higher feasibility of freely movement of patient under study − compared to both EEG and ECoG methods where lots of wires are connected to the patient under operation. 4) long-term usage as the implantable interface is wireless − compared to both EEG and ECoG methods where it is practical for only a limited time under operation. We present the architecture of a wireless network of implantable microsystems, which we call it Brain Area Sensor NETwork (Brain-ASNET). There are two main challenges in realization of the proposed Brain-ASNET. 1) design and implementation of power-hungry RF transceiver of the implantable network sensors' chip, and, 2) design of an energy-efficient ad-hoc Wireless Sensor Network (WSN) protocol. In this thesis, we introduce an energy-efficient ad-hoc network protocol for the desired network, along with a method to overcome the issue of variable packet length caused by bit stuffing process in standard HDLC protocol. The proposed ad-hoc protocol designed for Brain-ASNET shows better energy-efficiency compared to standard protocols like ZigBee, Bluetooth, and Wi-Fi as well as state-of-the-art ad-hoc protocols. The protocol was designed and tested by MATLAB and Simulink

The rise of flexible electronics in neuroscience, from materials selection to in vitro and in vivo applications

Neuroscience deals with one of the most complicate system we can study: the brain. The huge amount of connections among the cells and the different phenomena occurring at different scale give rise to a continuous flow of data that have to be collected, analyzed and interpreted. Neuroscientists try to interrogate this complexity to find basic principles underlying brain electrochemical signalling and human/animal behaviour to disclose the mechanisms that trigger neurodegenerative diseases and to understand how restoring damaged brain circuits. The main tool to perform these tasks is a neural interface, a system able to interact with brain tissue at different levels to provide a uni/bidirectional communication path. Recently, breakthroughs coming from various disciplines have been combined to enforce features and potentialities of neural interfaces. Among the different findings, flexible electronics is playing a pivotal role in revolutionizing neural interfaces. In this work, we review the most recent advances in the fabrication of neural interfaces based on flexible electronics. We define challenges and issues to be solved for the application of such platforms and we discuss the different parts of the system regarding improvements in materials selection and breakthrough in applications both for in vitro and in vivo tests