Design of a silicon cochlea system with biologically faithful response

This paper presents the design and simulation results of a silicon cochlea system that has closely similar behavior as the real cochlea. A cochlea filter-bank based on the improved three-stage filter cascade structure is used to model the frequency decomposition function of the basilar membrane; a filter tuning block is designed to model the adaptive response of the cochlea; besides, an asynchronous event-triggered spike codec is employed as the system interface with bank-end spiking neural networks. As shown in the simulation results, the system has biologically faithful frequency response, impulse response, and active adaptation behavior; also the system outputs multiple band-pass channels of spikes from which the original sound input can be recovered. The proposed silicon cochlea is feasible for analog VLSI implementation so that it not only emulates the way that sounds are preprocessed in human ears but also is able match the compact physical size of a real cochlea

Biomimetic cochlea filters : from modelling, design to analogue VLSI implementation

This thesis presents a novel biomimetic cochlea filter which closely resembles the biological cochlea behaviour. The filter is highly feasible for analogue very-large-scale integration (VLSI) circuits, which leads to a micro-watt-power and millimetre-sized hardware implementation. By virtue of such features, the presented filter contributes to a solid foundation for future biologically-inspired audio signal processors. Unlike existing works, the presented filter is developed by taking direct inspirations from the physiologically measured results of the biological cochlea. Since the biological cochlea has prominently different characteristics of frequency response from low to high frequencies, the biomimetic cochlea filter is built by cascading three sub-filters accordingly: a 2nd-order bandpass filter for the constant gentle low-frequency response, a 2nd-order tunable low-pass filter for the variable and selective centre frequency response and a 5th-order elliptic filter for the ultra-steep roll-off at stop-band. As a proof of concept, a biomimetic cochlea filter bank is built to process audio signals, which demonstrates the highly discriminative spectral decomposition and high-resolution time-frequency analysis capabilities similar to the biological cochlea. The filter has simple representation in the Laplace domain which leads to a convenient analogue circuit realisation. A floating-active-inductor circuit cell is developed to build the corresponding RLC ladder for each of the three sub-filters. The circuits are designed based on complementary metal-oxide-semiconductor (CMOS) transistors for VLSI implementation. Non-ideal factors of CMOS transistors including parasitics, noise and mismatches are extensively analysed and consciously considered in the circuit design. An analogue VLSI chip is successfully fabricated using 0.35μ m CMOS process. The chip measurements demonstrate that the centre frequency response of the filter has about 20 dB wide gain tuning range and a high quality factor reaching maximally over 19. The filter has a 20 dB/decade constant gentle low-frequency tail and an over 300 dB/decade sharp stop-band roll-off slope. The measured results agree with the filter model expectations and are comparable with the biological cochlea characteristics. Each filter channel consumes as low as 59.5 ~90μ Wpower and occupies only 0.9 mm2 area. Besides, the biomimetic cochlea filter chip is characterised from a wide range of angles and the experimental results cover not only the auditory filter specifications but also the integrated circuit design considerations. Furthermore, following the progressive development of the acoustic resonator based on microelectro- mechanical systems (MEMS) technology, a MEMS-CMOS implementation of the proposed filter becomes possible in the future. A key challenge for such implementation is the low sensing capacitance of the MEMS resonator which suffers significantly from sensitivity degradation due to the parasitic capacitance. A novel MEMS capacitive interface circuit chip is additionally developed to solve this issue. As shown in the chip results, the interface circuit is able to cancel the parasitic capacitance and increase the sensitivity of capacitive sensors by 35 dB without consuming any extra power. Besides, the chopper-stabilisation technique is employed which effectively reduces the circuit flicker noise and offsets. Due to these features, the interface circuit chip is capable of converting a 7.5 fF capacitance change of a 1-Volt-biased 0.5 pF capacitive sensor pair into a 0.745 V signal-conditioned output while consuming only 165.2μ W power

A Compact Digital Gamma-tone Filter Processor

Area consumption is one of the most important design constrains in the development of compact digital systems. Several authors have proposed making compact Cochlear Implant processors using Gamma-tone filter banks. These model aspects of the cochlea spectral filtering. A good area-efficient design of the Gamma-tone Filter Bank could reduce the amount of circuitry allowing patients to wear these cochlear implants more easily. In consequence, many authors have reduced the area by using the minimum number of registers when implementing this type of filter. However, critical paths limit their performance. Here a compact Gamma-tone Filter processor, formulated using the impulse invariant transformation together with a normalization method, is presented. The normalization method in the model guarantees the same precision for any filter order. In addition, area resources are kept low due to the implementation of a single Second Order Section (SOS) IIR stage for processing several SOS IIR stages and several channels at different times. Results show that the combination of the properties of the model and the implementation techniques generate a processor with high processing speed, expending less resources than reported in the literature.Collaboration with Sanchez-Rivera, related to, but not funded by, EPSRC grant EP/G062609/

A CMOS low pass filter for soc lock-in-based measurement devices

This paper presents a fully integrated Gm–C low pass ¿lter (LPF) based on a current ¿steering Gm reduction-tuning technique, specifically designed to operate as the output stage of a SoC lock-in amplifier. To validate this proposal, a first-order and a second-order single-ended topology were integrated into a 1.8 V to 0.18 µm CMOS (Complementary Metal-Oxide-Semiconductor) process, showing experimentally a tuneable cutoff frequency that spanned five orders of magnitude, from tens of mHz to kHz, with a constant current consumption (below 3 µA/pole), compact size (<0.0140 mm2 /pole), and a dynamic range better than 70 dB. Compared to state-of-the-art solutions, the proposed approach exhibited very competitive performances while simultaneously fully satisfying the demanding requirements of on-chip portable measurement systems in terms of highly efficient area and power. This is of special relevance, taking into account the current trend towards multichannel instruments to process sensor arrays, as the total area and power consumption will be proportional to the number of channels

CMOS Design of Reconfigurable SoC Systems for Impedance Sensor Devices

La rápida evolución en el campo de los sensores inteligentes, junto con los avances en las tecnologías de la computación y la comunicación, está revolucionando la forma en que recopilamos y analizamos datos del mundo físico para tomar decisiones, facilitando nuevas soluciones que desempeñan tareas que antes eran inconcebibles de lograr.La inclusión en un mismo dado de silicio de todos los elementos necesarios para un proceso de monitorización y actuación ha sido posible gracias a los avances en micro (y nano) electrónica. Al mismo tiempo, la evolución de las tecnologías de procesamiento y micromecanizado de superficies de silicio y otros materiales complementarios ha dado lugar al desarrollo de sensores integrados compatibles con CMOS, lo que permite la implementación de matrices de sensores de alta densidad. Así, la combinación de un sistema de adquisición basado en sensores on-Chip, junto con un microprocesador como núcleo digital donde se puede ejecutar la digitalización de señales, el procesamiento y la comunicación de datos proporciona características adicionales como reducción del coste, compacidad, portabilidad, alimentación por batería, facilidad de uso e intercambio inteligente de datos, aumentando su potencial número de aplicaciones.Esta tesis pretende profundizar en el diseño de un sistema portátil de medición de espectroscopía de impedancia de baja potencia operado por batería, basado en tecnologías microelectrónicas CMOS, que pueda integrarse con el sensor, proporcionando una implementación paralelizable sin incrementar significativamente el tamaño o el consumo, pero manteniendo las principales características de fiabilidad y sensibilidad de un instrumento de laboratorio. Esto requiere el diseño tanto de la etapa de gestión de la energía como de las diferentes celdas que conforman la interfaz, que habrán de satisfacer los requisitos de un alto rendimiento a la par que las exigentes restricciones de tamaño mínimo y bajo consumo requeridas en la monitorización portátil, características que son aún más críticas al considerar la tendencia actual hacia matrices de sensores.A nivel de celdas, se proponen diferentes circuitos en un proceso CMOS de 180 nm: un regulador de baja caída de voltaje como unidad de gestión de energía, que proporciona una alimentación de 1.8 V estable, de bajo ruido, precisa e independiente de la carga para todo el sistema; amplificadores de instrumentación con una aproximación completamente diferencial, que incluyen una etapa de entrada de voltaje/corriente configurable, ganancia programable y ancho de banda ajustable, tanto en la frecuencia de corte baja como alta; un multiplicador para conformar la demodulación dual, que está embebido en el amplificador para optimizar consumo y área; y filtros pasa baja totalmente integrados, que actúan como extractores de magnitud de DC, con frecuencias de corte ajustables desde sub-Hz hasta cientos de Hz.<br /

Collective analog bioelectronic computation

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2009.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student submitted PDF version of thesis.Includes bibliographical references (p. 677-710).In this thesis, I present two examples of fast-and-highly-parallel analog computation inspired by architectures in biology. The first example, an RF cochlea, maps the partial differential equations that describe fluid-membrane-hair-cell wave propagation in the biological cochlea to an equivalent inductor-capacitor-transistor integrated circuit. It allows ultra-broadband spectrum analysis of RF signals to be performed in a rapid low-power fashion, thus enabling applications for universal or software radio. The second example exploits detailed similarities between the equations that describe chemical-reaction dynamics and the equations that describe subthreshold current flow in transistors to create fast-and-highly-parallel integrated-circuit models of protein-protein and gene-protein networks inside a cell. Due to a natural mapping between the Poisson statistics of molecular flows in a chemical reaction and Poisson statistics of electronic current flow in a transistor, stochastic effects are automatically incorporated into the circuit architecture, allowing highly computationally intensive stochastic simulations of large-scale biochemical reaction networks to be performed rapidly. I show that the exponentially tapered transmission-line architecture of the mammalian cochlea performs constant-fractional-bandwidth spectrum analysis with O(N) expenditure of both analysis time and hardware, where N is the number of analyzed frequency bins. This is the best known performance of any spectrum-analysis architecture, including the constant-resolution Fast Fourier Transform (FFT), which scales as O(N logN), or a constant-fractional-bandwidth filterbank, which scales as O (N2).(cont.) The RF cochlea uses this bio-inspired architecture to perform real-time, on-chip spectrum analysis at radio frequencies. I demonstrate two cochlea chips, implemented in standard 0.13m CMOS technology, that decompose the RF spectrum from 600MHz to 8GHz into 50 log-spaced channels, consume < 300mW of power, and possess 70dB of dynamic range. The real-time spectrum analysis capabilities of my chips make them uniquely suitable for ultra-broadband universal or software radio receivers of the future. I show that the protein-protein and gene-protein chips that I have built are particularly suitable for simulation, parameter discovery and sensitivity analysis of interaction networks in cell biology, such as signaling, metabolic, and gene regulation pathways. Importantly, the chips carry out massively parallel computations, resulting in simulation times that are independent of model complexity, i.e., O(1). They also automatically model stochastic effects, which are of importance in many biological systems, but are numerically stiff and simulate slowly on digital computers. Currently, non-fundamental data-acquisition limitations show that my proof-of-concept chips simulate small-scale biochemical reaction networks at least 100 times faster than modern desktop machines. It should be possible to get 103 to 106 simulation speedups of genome-scale and organ-scale intracellular and extracellular biochemical reaction networks with improved versions of my chips. Such chips could be important both as analysis tools in systems biology and design tools in synthetic biology.by Soumyajit Mandal.Ph.D

Biomimetic Based Applications

The interaction between cells, tissues and biomaterial surfaces are the highlights of the book "Biomimetic Based Applications". In this regard the effect of nanostructures and nanotopographies and their effect on the development of a new generation of biomaterials including advanced multifunctional scaffolds for tissue engineering are discussed. The 2 volumes contain articles that cover a wide spectrum of subject matter such as different aspects of the development of scaffolds and coatings with enhanced performance and bioactivity, including investigations of material surface-cell interactions

Análisis y diseño de filtros paso banda basados en VCO para aplicaciones de extracción de características vocales

El objetivo del presente trabajo es el estudio, diseño e implementación de una novedosa arquitectura de filtros paso banda basados en VCO, con aplicación directa en tareas de extracción de características vocales. Partiendo del modelo a nivel de sistema del filtro analógico clásico (filtro de variables de estado), se plantean las ventajas de un modelo basado en VCO, conduciéndolo así hasta el modelo final diseñado, mostrando los resultados obtenidos en simulación. Además, se propone una posible implementación hardware del modelo, realizando así una primera aproximación al diseño a nivel de circuito. Se muestran también simulaciones de las distintas partes que forman el circuito, además de una estimación del consumo de cada una de ellas. Posteriormente, se realiza un análisis de los resultados obtenidos, tanto a nivel de sistema como a nivel de circuito. Además, se exponen los resultados de simulación de las medidas de energía en un banco de filtros ante distintas señales de entrada. De esta manera, se obtienen patrones de la señal de entrada que posteriormente pueden ser introducidas en redes neuronales o árboles de decisión, con el objetivo de detectar la existencia de eventos.Máster Universitario en Ingeniería de Sistemas Electrónicos y Aplicaciones. Curso 2018/201