Imaging of the Breast

Early detection of breast cancer combined with targeted therapy offers the best outcome for breast cancer patients. This volume deal with a wide range of new technical innovations for improving breast cancer detection, diagnosis and therapy. There is a special focus on improvements in mammographic image quality, image analysis, magnetic resonance imaging of the breast and molecular imaging. A chapter on targeted therapy explores the option of less radical postoperative therapy for women with early, screen-detected breast cancers

Gynaecological Cancers Risk

The International Agency for Research on Cancer suggests that the burden of women’s cancers including breast, ovarian, and womb will rise by 50% over the next 20 years. It is essential for us to improve early diagnosis and prevention of these cancers in our health systems. The last decade has seen significant strides in our ability to understand and predict a woman’s risk of these cancers and offer personalized medicine approaches for risk management. There have been improvements in identifying individuals at increased risk, as well as implementing and evaluating strategies for screening and prevention. In this special collection, we bring together 16 articles from leading scientists and researchers. These capture some of the important advances observed in estimating cancer risk, providing genetic testing, offering risk management to those at increased risk, as well as screening and prevention of breast, ovarian, and womb cancers in women. This makes an important contribution to the rapidly advancing knowledge base across the area of personalized medicine and precision prevention of ovarian, endometrial, and breast cancers

Transactional and analytical data management on persistent memory

Die zunehmende Anzahl von Smart-Geräten und Sensoren, aber auch die sozialen Medien lassen das Datenvolumen und damit die geforderte Verarbeitungsgeschwindigkeit stetig wachsen. Gleichzeitig müssen viele Anwendungen Daten persistent speichern oder sogar strenge Transaktionsgarantien einhalten. Die neuartige Speichertechnologie Persistent Memory (PMem) mit ihren einzigartigen Eigenschaften scheint ein natürlicher Anwärter zu sein, um diesen Anforderungen effizient nachzukommen. Sie ist im Vergleich zu DRAM skalierbarer, günstiger und dauerhaft. Im Gegensatz zu Disks ist sie deutlich schneller und direkt adressierbar. Daher wird in dieser Dissertation der gezielte Einsatz von PMem untersucht, um den Anforderungen moderner Anwendung gerecht zu werden. Nach der Darlegung der grundlegenden Arbeitsweise von und mit PMem, konzentrieren wir uns primär auf drei Aspekte der Datenverwaltung. Zunächst zerlegen wir mehrere persistente Daten- und Indexstrukturen in ihre zugrundeliegenden Entwurfsprimitive, um Abwägungen für verschiedene Zugriffsmuster aufzuzeigen. So können wir ihre besten Anwendungsfälle und Schwachstellen, aber auch allgemeine Erkenntnisse über das Entwerfen von PMem-basierten Datenstrukturen ermitteln. Zweitens schlagen wir zwei Speicherlayouts vor, die auf analytische Arbeitslasten abzielen und eine effiziente Abfrageausführung auf beliebigen Attributen ermöglichen. Während der erste Ansatz eine verknüpfte Liste von mehrdimensionalen gruppierten Blöcken verwendet, handelt es sich beim zweiten Ansatz um einen mehrdimensionalen Index, der Knoten im DRAM zwischenspeichert. Drittens zeigen wir unter Verwendung der bisherigen Datenstrukturen und Erkenntnisse, wie Datenstrom- und Ereignisverarbeitungssysteme mit transaktionaler Zustandsverwaltung verbessert werden können. Dabei schlagen wir ein neuartiges Transactional Stream Processing (TSP) Modell mit geeigneten Konsistenz- und Nebenläufigkeitsprotokollen vor, die an PMem angepasst sind. Zusammen sollen die diskutierten Aspekte eine Grundlage für die Entwicklung noch ausgereifterer PMem-fähiger Systeme bilden. Gleichzeitig zeigen sie, wie Datenverwaltungsaufgaben PMem ausnutzen können, indem sie neue Anwendungsgebiete erschließen, die Leistung, Skalierbarkeit und Wiederherstellungsgarantien verbessern, die Codekomplexität vereinfachen sowie die ökonomischen und ökologischen Kosten reduzieren.The increasing number of smart devices and sensors, but also social media are causing the volume of data and thus the demanded processing speed to grow steadily. At the same time, many applications need to store data persistently or even comply with strict transactional guarantees. The novel storage technology Persistent Memory (PMem), with its unique properties, seems to be a natural candidate to meet these requirements efficiently. Compared to DRAM, it is more scalable, less expensive, and durable. In contrast to disks, it is significantly faster and directly addressable. Therefore, this dissertation investigates the deliberate employment of PMem to fit the needs of modern applications. After presenting the fundamental work of and with PMem, we focus primarily on three aspects of data management. First, we disassemble several persistent data and index structures into their underlying design primitives to reveal the trade-offs for various access patterns. It allows us to identify their best use cases and vulnerabilities but also to gain general insights into the design of PMem-based data structures. Second, we propose two storage layouts that target analytical workloads and enable an efficient query execution on arbitrary attributes. While the first approach employs a linked list of multi-dimensional clustered blocks that potentially span several storage layers, the second approach is a multi-dimensional index that caches nodes in DRAM. Third, we show how to improve stream and event processing systems involving transactional state management using the preceding data structures and insights. In this context, we propose a novel Transactional Stream Processing (TSP) model with appropriate consistency and concurrency protocols adapted to PMem. Together, the discussed aspects are intended to provide a foundation for developing even more sophisticated PMemenabled systems. At the same time, they show how data management tasks can take advantage of PMem by opening up new application domains, improving performance, scalability, and recovery guarantees, simplifying code complexity, plus reducing economic and environmental costs

Gaze-Based Human-Robot Interaction by the Brunswick Model

We present a new paradigm for human-robot interaction based on social signal processing, and in particular on the Brunswick model. Originally, the Brunswick model copes with face-to-face dyadic interaction, assuming that the interactants are communicating through a continuous exchange of non verbal social signals, in addition to the spoken messages. Social signals have to be interpreted, thanks to a proper recognition phase that considers visual and audio information. The Brunswick model allows to quantitatively evaluate the quality of the interaction using statistical tools which measure how effective is the recognition phase. In this paper we cast this theory when one of the interactants is a robot; in this case, the recognition phase performed by the robot and the human have to be revised w.r.t. the original model. The model is applied to Berrick, a recent open-source low-cost robotic head platform, where the gazing is the social signal to be considered