2,275,510 research outputs found

    Mapiranje zenskih studijev in studijev spola v akademskem polju v Sloveniji

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    The aim of the present paper is to map the development of women’s and gender studies (WGS) in the academic field in Slovenia. Slovenia is the first of the former Yugoslav state republics in which WGS have succeeded in entering the academic field and becoming part of institutionalized university study. In this paper we will ask the following questions: How, when and why did this happen? How was this connected to women’s and feminist movements and politics regarding women’s issues and demands? What were the obstacles in this process? Who were the agents and what were the factors that supported demands for the incorporation of WGS in academia? How has the field evolved in the last few decades? What were the phases of this development? Which fields were the forerunners, which were the late-comers and which are still left aside? What are the thematic scopes taught in WGS courses? In which degrees are the courses offered and what are their modules? Who teaches them? The mapping in this paper is mainly based on primary sources of university programmes and their curricula at faculties of the University of Ljubljana, as well as on interviews with important agents in the field. (DIPF/Orig.

    ESTs analysis in maize developing kernels exposed to single and combined water and heat stresses

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    Molecular and metabolic response of plants to a combination of two abiotic stresses is unique and cannot be directly extrapolated from the response of plants to each of the stresses individually. cDNA macroarray has become a useful tool to analyze expression profiles and compare the similarities and differences of various expression patterns. A macroarray of approximately 2,500 maize (Zea mays L.) cDNAs was used for transcriptome profiling in response to single and simultaneous application of water and high temperature stress of maize developing kernels at 15 days after pollination. All stress treatments (water stress-WS, heat stress-HS and their combined application-CS) induced changes in expression of 106 transcripts with 54 up-regulated and 52 down-regulated. There were 11 up-regulated and 15 down-regulated transcripts in common for all three stresses. Although these common transcripts showed existence of a mutual mechanism in stress response, the 23 transcripts induced only in CS indicate that plants responded in a different manner when exposed to simultaneous effects of both stresses. A glimpse of functions regulated under WS, HS and CS is provided, and also the common and different responses between individual and simultaneous stresses.A resposta molecular e metabólica de plantas a uma combinação de dois estresses abióticos é singular, e não pode ser diretamente extrapolada da resposta das plantas a cada um dos estresses individualmente. O macroarranjo do cDNA, tornou-se uma ferramenta útil para analisar os perfís de expressão e comparar as similaridades e diferenças de vários padrões de expressão. Um macroarranjo de 2.500 cDNAs de milho (Zea mays L.) foi usado para traçar um perfil de transcriptoma em resposta ao stress ocasionado por uma única e simultânea aplicação de água e alta temperatura em espigas em desenvolvimento, 15 dias após a polinização. Todos os tratamentos de stress (stress de água - SA, stress de calor - SC e sua aplicação combinada - AC) induziram modificações na expressão de 106 transcritos com 54 regulados acima e 52 regulados abaixo. Houve 11 transcritos regulados acima e 15 regulados abaixo em comum para os três estresses. Embora esses transcritos em comum mostrassem a existência de um mecanismo mútuo na resposta do estresse, os 23 transcritos induzidos somente em AC indicam que as plantas respondem de maneira diferente quando expostos aos efeitos simultâneos de ambos os estresses. Vislumbram-se funções reguladas por SA, SC e AC e também efeitos comuns e diferentes entre estresses individuais e simultâneos

    Respostas morfogenéticas de embriões de trigo em função do ambiente de cultivo da planta doadora de explantes

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    A disponibilidade de embriões imaturos para estabelecer plantas de trigo (Triticum aestivum L.) por cultura de tecido pode ser limitada por fatores climáticos, e a falta de embriões de alta qualidade frequentemente dificulta a experimentação. Avaliou-se o efeito da chuva, de variáveis baseadas em temperatura e duração do brilho solar na resposta da cultura de tecido (RCT), incluindo a formação de calos (FC), regeneração dos calos (RC) e número de plantas por embrião (NPPE), para 96 genótipos de trigo. Os objetivos foram a procura de algum fator climatico específico em alguma característica da RCT e a determinação do período do desenvolvimento do trigo no qual estes fatores são mais eficazes. Os genótipos foram obtidos num campo experimental durante três estações climáticas. As relações entre as características da RTC e os fatores de clima dentro de três períodos de desenvolvimento do trigo (2, 6 e 10 semanas) antes da amostragem dos embriões foram analisadas pela técnica "biplot". As características das culturas de tecido foram influenciadas em diferentes graus pelos fatores climáticos: de 16.8% (RC) para 69.8% (FC). Ambientes da planta doadora com alta temperatura e pouca chuva reduziram (p < 0.05) o desempenho dos genótipos de trigo. A FC foi mais sensível aos fatores baseados em temperatura. As condições ambientais entre o florescimento e o estágio médio de leite dos frutos foram os mais importantes para FC, enquanto RC e NPPE não estavam relacionados a qualquer período.Availability of immature embryos as explants to establish wheat (Triticum aestivum L.) by tissue culture can be limited by climatic factors and the lack of high quality embryos frequently hampers experimentation. This study evaluates the effects of rainfall, various temperature-based variables and sunshine duration on tissue culture response (TCR) traits including callus formation (CF), regenerating calli (RC), and number of plants per embryo (PPE) for 96 wheat genotypes of worldwide origin. The objectives of this study were to evaluate the significance of a particular climatic factor on TCR traits and to determine the period of wheat growth during which these factors were the most effective. The genotypes were grown in an experimental field during three seasons differing in meteorological conditions. The relationships between TCR traits and climatic factors within three time periods of wheat growth: 2, 6 and 10 weeks prior to embryo sampling were analysed by biplot analysis. The tissue culture traits were influenced at very different degrees by climatic factors: from 16.8% (RC) to 69.8% (CF). Donor plant environment with high temperatures and low rainfalls reduced (p < 0.05) the tissue culture performance of wheat genotypes. Callus formation was most sensitive to the temperature based factors. The environmental conditions between flowering and the medium milk stage were the most important for CF, while RC and PPE were not particularly related to any period

    Editorial. Gender and education

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    The present issue of the CEPS Journal is the first edition of a scientific journal completely dedicated to the question of gender and education, and is an important element in the mosaic of scientific production on the theme in Central- East Europe. Moreover, this issue brings six articles all dealing with specific gender-related issues in the field of education. (DIPF/Orig.

    Measurement of the Strong Coupling alpha s from Four-Jet Observables in e+e- Annihilation

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    Data from e+e- annihilation into hadrons at centre-of-mass energies between 91 GeV and 209 GeV collected with the OPAL detector at LEP, are used to study the four-jet rate as a function of the Durham algorithm resolution parameter ycut. The four-jet rate is compared to next-to-leading order calculations that include the resummation of large logarithms. The strong coupling measured from the four-jet rate is alphas(Mz0)= 0.1182+-0.0003(stat.)+-0.0015(exp.)+-0.0011(had.)+-0.0012(scale)+-0.0013(mass) in agreement with the world average. Next-to-leading order fits to the D-parameter and thrust minor event-shape observables are also performed for the first time. We find consistent results, but with significantly larger theoretical uncertainties.Comment: 25 pages, 15 figures, Submitted to Euro. Phys. J.

    Using Markov Chains for link prediction in adaptive web sites

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    The large number of Web pages on many Web sites has raised navigational problems. Markov chains have recently been used to model user navigational behavior on the World Wide Web (WWW). In this paper, we propose a method for constructing a Markov model of a Web site based on past visitor behavior. We use the Markov model to make link predictions that assist new users to navigate the Web site. An algorithm for transition probability matrix compression has been used to cluster Web pages with similar transition behaviors and compress the transition matrix to an optimal size for efficient probability calculation in link prediction. A maximal forward path method is used to further improve the efficiency of link prediction. Link prediction has been implemented in an online system called ONE (Online Navigation Explorer) to assist users' navigation in the adaptive Web site

    Purchasing Power: The Corporate-White House Alliance to Pass the China Trade Bill Over the Will of the American People

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    The passage of China Permanent Normal Trade Relations (PNTR) by the U.S. House of Representatives in late May 2000 over the overwhelming will of the American people was the result of the most forceful and aggressive corporate legislative campaign in history. Despite four-to-one public opposition, the bill was passed by the use of unprecedented amounts of corporate money in political contributions, advertising, lobbying and rented "experts," as well as the application of the White House s full resources. To fulfill their own overlapping goals, the corporate coalition and the White House worked in such tight coordination that the General Accounting Office has reported that federal law on Executive branch lobbying practices was violated. Deaf to pleas from even pro-PNTR House Democrats, the administration launched the China PNTR crusade to build a legacy for the President knowing it would damage Democrats chances to regain a House majority. To celebrate the House PNTR vote, President Clinton went out that night to a corporate political fund-raiser boycotted by many Democratic House Leaders. The corporate interest was in eliminating the annual Congressional review of China trade and to obtain unconditional, unlimited access to the U.S. market for goods produced in China. The day after the House vote, the Wall Street Journal and other papers finally reported that the corporations were not so much interested in access to the Chinese market to sell goods there, but rather sought guaranteed U.S. access for goods they could produce in China with its remarkably high-quality, cheap, government-controlled labor and lax environmental controls. Passing China PNTR was an important priority for both players for another important and symbolic reason: the proponents of corporate globalization and corporate managed trade had been defeated for five years by a determined citizen s movement that recognized that the corporate and White House globalization agenda was benefitting narrow corporate interests at the expense of working families and the environment. The Clinton administration and the corporate lobbies had pushed the North American Free Trade Agreement (NAFTA) and the Uruguay Round of the General Agreement on Tariffs and Trade (GATT) which established the World Trade Organization (WTO) through the Congress during the administration s first term. While the NAFTA and WTO fights required concerted corporate lobbying and public relations efforts, obtaining political support for expanding existing globalization policies had become much more difficult. Polling showed that people had become aware of the all-too-real down sides of what its proponents dubbed "free trade," but was increasingly revealed to be corporate managed trade. Several years after NAFTA's passage when its negative impacts became apparent, public opinion, never supportive of the corporate-White House trade agenda, turned frosty. Significant relocation of high-wage manufacturing jobs to Mexico, increased border pollution and health problems, and the declining safety of America s increasingly imported food supply made the public increasingly skeptical of the promises and projections made by the "free trade" proponents. The complete executive summary and access to the full report available via the link below

    Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy

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    AbstractBCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anti-cancer targets. Using small cell lung cancer (SCLC) as a model, we demonstrated the presence of differential addiction of cancer cells to anti-apoptotic BCL-2, BCL-XL or MCL-1, which correlated with the respective protein expression ratio. ABT-263 (navitoclax), a BCL-2/BCL-XL inhibitor, prevented BCL-XL from sequestering activator BH3-only molecules (BH3s) and BAX but not BAK. Consequently, ABT-263 failed to kill BCL-XL-addicted cells with low activator BH3s and BCL-XL overabundance conferred resistance to ABT-263. High-throughput screening identified anthracyclines including doxorubicin and CDK9 inhibitors including dinaciclib that synergized with ABT-263 through downregulation of MCL-1. As doxorubicin and dinaciclib also reduced BCL-XL, the combinations of BCL-2 inhibitor ABT-199 (venetoclax) with doxorubicin or dinaciclib provided effective therapeutic strategies for SCLC. Altogether, our study highlights the need for mechanism-guided targeting of anti-apoptotic BCL-2 proteins to effectively activate the mitochondrial cell death programme to kill cancer cells.</jats:p

    Efficiency of a single-rate and broad-based VAT system: the case of Bosnia and Herzegovina

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    The aim of this paper is to analyze the performance and efficiency of the VAT system in B&amp;H and explore the effects of internal and external factors influencing VAT collection. The VAT system in B&amp;H is a consumption-type, single-rate and broad-based system. Ever since its implementation, VAT collection in B&amp;H has been subject to strong oscillations, from an extremely high performance in the first two years after the introduction, to a sharp drop at the beginning of the crisis. After a temporary recovery, VAT collection declined in the last quarter of 2012 and has been negative ever since, although a weak recovery of the B&amp;H economy was observed in 2013. The key hypothesis is that the high efficiency of the broadbased and single-rate structured VAT system may be neutralized by the country’s specific circumstances and VAT policy design. Applying a set of indicators for VAT efficiency analysis, developed by IMF, OECD and EU, we find a deterioration of the components of the policy gap caused by derogations of the VAT Law, and an increasing compliance gap, due to an increase of the VAT debt and tax evasion, in consequence of poor policy design in the field of excises. As a result of the influence of the country’s specific circumstances and its VAT policy design the identifiable current net losses on VAT in 2013 amount to 4% of net VAT collection or 0.4% of GDP. The analysis presented in the paper proves the main hypothesis that a VAT design, even when it is close to theoretically ideal concept, cannot on its own produce a high level of VAT efficiency and performance

    Another Foxconn Employee Died of Fatigue

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    Another_Foxconn_Employee_Died_of_Fatigue_Electronics.pdf: 263 downloads, before Oct. 1, 2020
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