荧光各向异性法研究环糊精包络物

推导了用荧光各向异性法测定环糊精包络物平衡结合常数的方程式,并用于测定芘-β-环糊精包络物的结合常数,获得了满意的结果,依据推得的方程式并结合各向异性～环糊精浓度曲线讨论了环糊精包络物存在形式及主-客体作用方式,预计了以蔡衍生物为配体的金属离子分析方法应用β-环糊精的可能性

荧光探针法研究脲素对β-环糊精内腔微环境的影响

用芘作为荧光探针,研究了脲素对β-环糊精内腔微环境的影响。结果表明脲素的加入使环糊精内腔极性增大,芘-β-环糊精包络物形成常数减小,这说明“疏水相互作用”是环糊精包络物形成动力之一.这一结论并被其它包络物体系所证实.荧光寿命及荧光量子产率估算表明,脲素的引入不仅仅是改变了溶剂的性质,而可能与β-环糊精分子间有一定的相互作用

荧光探针法研究脲素对β-环糊精内腔微环境的影响

用芘作为荧光探针,研究了脲素对β-环糊精内腔微环境的影响。结果表明脲素的加入使环糊精内腔极性增大,芘-β-环糊精包络物形成常数减小,这说明“疏水相互作用”是环糊精包络物形成动力之一.这一结论并被其它包络物体系所证实.荧光寿命及荧光量子产率估算表明,脲素的引入不仅仅是改变了溶剂的性质,而可能与β-环糊精分子间有一定的相互作用

荧光各向异性法研究环糊精包络物

推导了用荧光各向异性法测定环糊精包络物平衡结合常数的方程式,并用于测定芘-β-环糊精包络物的结合常数,获得了满意的结果,依据推得的方程式并结合各向异性～环糊精浓度曲线讨论了环糊精包络物存在形式及主-客体作用方式,预计了以蔡衍生物为配体的金属离子分析方法应用β-环糊精的可能性

Studies of Cyclodextrin Derivatives /Cellulose Acetate Blending Nanofiltration Membrane

纳滤膜是一种具有独特分离性能的现代膜分离技术，在水软化、海水淡化、食品加工、生物制药等诸多领域有着广泛的应用，如何进一步提高纳滤膜的分离性能是目前研究的热点之一。本文以β-环糊精为起始原料，合成了两种环糊精衍生物（环糊精聚合物和环糊精包合物），分别将其作为添加剂与醋酸纤维素（CA）共混，经相转化法制备共混纳滤膜，研究这两种环糊精衍生物的添加对CA纳滤膜结构和性能的影响。 本文以β-环糊精为起始原料，与2-溴-异丁酰溴反应得到全溴化的大分子引发剂（21Br-β-CD）；接着以21Br-β-CD为引发剂，通过SET-LRP聚合法制备了星型聚合物聚（甲基丙烯酸羟乙酯-甲基丙烯酸甲酯），即Poly(...Nanofiltration membrane is modern membrane separation technology with unique separation performance, which has been widely applied in water-softening, desalination, food processing, bio-pharmaceutical and many other fields. The improvement of separation performance of nanofiltration has been one of the research focus. In this study, we synthesized two cyclodextrin derivatives (cyclodextrin polymer...学位：理学硕士院系专业：化学化工学院_高分子化学与物理学号：2052014115162

Application the Cyclodextrin in Environmental Management

介绍了环糊精在富集和治理环境有机污染物方面的应用成果,以及环糊精对有机污染物生物降解过程影响方面的研究结果,提出环糊精在污染治理方面实际应用的可能性。The utilization of cyclodextrins(CDs)in enrichment and removal of environmental organic pollutants and their effects on biodegradation of environmental organic pollutants have been introduced in this paper. It claims that CDs can play a very important role in managing environmental organic pollutants

Optimization of β-Cyclodextrin Inclusion Technology of Volatile Oil from Pueraria Compound by Orthogonal Design

目的优选葛根复方挥发油的包合工艺,提高制剂的稳定性。方法采用饱和水溶液法制备包合物,以挥发油中藁本内酯、桂皮醛、甲基丁香酚包合率及包合物得率为综合评价指标,采用正交试验法考察挥发油与β-环糊精的比例、包合时间、包合温度对包合工艺的影响,优化得到葛根复方中挥发油的最优包合工艺。结果葛根复方中挥发油的最佳包合工艺条件为挥发油与β-环糊精比例为1∶8,包合温度为30℃,包合时间为1h,验证试验中,藁本内酯、桂皮醛及甲基丁香酚的包合率为别为86.58%±0.009%,73.34%±0.001%,68.89%±0.020%,包合物得率为67.98%±0.047%。结论所确定的包合工艺挥发油的包合率高、工艺稳定可行。Objective To obtain the optimized technology of volatile oil from Pueraria Compound with β-Cyclodextrin（ β-CD）. Methods The inclusion compound was prepared by saturated peroxide solution method. In order to optimize inclusion technology,orthogonal design was performed,with the content of multi-target ingredient,such as ligustilide,cinnamic aldehyde,methyleugenol and the yield of inclusion as comprehensive evaluation indexes. Three factor was performed,the ratio of volatile oil（ m L） to β-CD（ g）,the inclusion temperature and the inclusion time. Results The optimum conditions for inclusion process were as follow： the ratio of volatile oil（ m L） to β-CD（ g） was 1： 8,the inclusion temperature was 30℃ and the inclusion time was 1h. With the optimum inclusion condition,the content of ligustilide,cinnamic aldehyde and methyleugenol and the yield of inclusion were 86. 58% ± 0. 009%,73. 34% ± 0. 001%,68. 89% ± 0. 020%,and 67. 98% ± 0. 047%,respectively.Conclusion The optimum inclusion condition was stable and reproducible with a high inclusion yield.国家自然科学基金（No.81270901）;上海市教委基金（No.15cxy21

Study of Photoisomerization of Fluoro-substituted Azobenzene Derivatives and Its Host-Guest Interaction with Cyclodextrins

超分子主客体化学由于其潜在的应用前景，近年来受到越来越多的关注。在已知的客体分子中，偶氮苯及其衍生物对各类自然刺激具有响应性且同时伴随显著的结构变化，进一步可以控制其与环糊精的主客体相互作用，故偶氮苯/环糊精体系这一主客体配合物在众多高科技领域有着重要的应用。然而，传统偶氮苯的顺反异构化必须使用高能量的紫外光，紫外光具有对生物样品的低穿透率、引发副反应及高的背景干扰的等缺点，这些特点限制了偶氮苯在生物医药方面的广泛应用。目前为止有以下几种方法可以实现在不使用紫外光的条件下使偶氮苯发生顺反异构化。一种方法是使用掺杂镧系金属的上转换纳米粒子作为光转化器。另一种方法是使用吸电子基团或给电子基团对偶氮...Host–Guest chemistry has expanded dramatically in recent years due to its potential applications in a broad range of fields. Among all available guest molecules, azobenzene and its derivatives exhibit particular advantages for their responses to various natural stimuli, accompanied by dramatic structural changes and controlled inclusion/exclusion with cyclodextrins (CDs). Owing to this unique prop...学位：理学博士院系专业：化学化工学院_高分子化学与物理学号：2052012015349

可溶性“环糊精接枝壳聚糖”的合成及其对芳香化合物的吸附研究

利用环氧氯丙烷的双官能团,将环糊精接枝到壳聚糖分子链上.对合成条件进行探索,合成了可溶于稀酸的"环糊精接枝壳聚糖".并利用紫外光谱初步研究了该产物对几种芳香化合物的吸附

Photodynamic and antiangiogenic effect of fullerene-cyclodextrin/thalidomide inclusion compound

近年来肿瘤发病率有呈上升的趋势，由于传统治疗方法有风险大、毒副作用强等弊端，人们积极寻找更安全有效的治疗手段。光动力治疗（photodynamictherapy，PDT）具有非侵入性、可多次安全重复使用等优点。抗肿瘤血管生成治疗（antiangiogenictherapy）以肿瘤血管内皮细胞为作用靶点，系统毒性较小，不易产生耐药性，与肿瘤化学药物联用可以起到协同效应。纳米颗粒输送系统基于生物体实体瘤的高通透性和滞留效应（enhancedpermeabilityandretentioneffect，EPR）或表面修饰靶向基团后，可被动或主动靶向到达肿瘤组织，起到良好的抗肿瘤作用。 本文旨在合成...Currently tumor incidence is rising year by year. Since traditional therapies have some disadvantages, such as high risk and side effects, people are seeking for safer and more effective treatment. Photodynamic therapy is non-invasive and can be repeated multiple times safely. Antiangiogenic therapy targets the tumor vascular endothelial cells, which means low systematic toxicity and not prone to ...学位：理学硕士院系专业：材料学院_生物医学工程学号：3142013115013