167,516 research outputs found

    Standardization and Validation of Brachytherapy Seeds'' Modelling Using GATE and GGEMS Monte Carlo Toolkits

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    Simple Summary:& nbsp;This study used GATE and GGEMS simulation toolkits, to estimate dose distribution on Brachytherapy procedures. Specific guidelines were followed as defined by the American Association of Physicists in Medicine (AAPM) as well as by the European SocieTy for Radiotherapy and Oncology (ESTRO). Several types of brachytherapy seeds were modelled and simulated, namely Low-Dose-Rate (LDR), High-Dose-Rate (HDR), and Pulsed-Dose-Rate (PDR). The basic difference between GATE and GGEMS is that GGEMS incorporates GPU capabilities, which makes the use of Monte Carlo (MC) simulations more accessible in clinical routine, by minimizing the computational time to obtain a dose map. During the validation procedure of both codes with protocol data, differences as well as uncertainties were measured within the margins defined by the guidelines. The study concluded that MC simulations may be utilized in clinical practice, to optimize dose distribution in real time, as well as to evaluate therapeutic plans.This study aims to validate GATE and GGEMS simulation toolkits for brachytherapy applications and to provide accurate models for six commercial brachytherapy seeds, which will be freely available for research purposes. The AAPM TG-43 guidelines were used for the validation of two Low Dose Rate (LDR), three High Dose Rate (HDR), and one Pulsed Dose Rate (PDR) brachytherapy seeds. Each seed was represented as a 3D model and then simulated in GATE to produce one single Phase-Space (PHSP) per seed. To test the validity of the simulations'' outcome, referenced data (provided by the TG-43) was compared with GATE results. Next, validation of the GGEMS toolkit was achieved by comparing its outcome with the GATE MC simulations, incorporating clinical data. The simulation outcomes on the radial dose function (RDF), anisotropy function (AF), and dose rate constant (DRC) for the six commercial seeds were compared with TG-43 values. The statistical uncertainty was limited to 1% for RDF, to 6% (maximum) for AF, and to 2.7% (maximum) for the DRC. GGEMS provided a good agreement with GATE when compared in different situations: (a) Homogeneous water sphere, (b) heterogeneous CT phantom, and (c) a realistic clinical case. In addition, GGEMS has the advantage of very fast simulations. For the clinical case, where TG-186 guidelines were considered, GATE required 1 h for the simulation while GGEMS needed 162 s to reach the same statistical uncertainty. This study produced accurate models and simulations of their emitted spectrum of commonly used commercial brachytherapy seeds which are freely available to the scientific community. Furthermore, GGEMS was validated as an MC GPU based tool for brachytherapy. More research is deemed necessary for the expansion of brachytherapy seed modeling

    Fault testing quantum switching circuits

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    Test pattern generation is an electronic design automation tool that attempts to find an input (or test) sequence that, when applied to a digital circuit, enables one to distinguish between the correct circuit behavior and the faulty behavior caused by particular faults. The effectiveness of this classical method is measured by the fault coverage achieved for the fault model and the number of generated vectors, which should be directly proportional to test application time. This work address the quantum process validation problem by considering the quantum mechanical adaptation of test pattern generation methods used to test classical circuits. We found that quantum mechanics allows one to execute multiple test vectors concurrently, making each gate realized in the process act on a complete set of characteristic states in space/time complexity that breaks classical testability lower bounds.Comment: (almost) Forgotten rewrite from 200

    Cross-level Validation of Topological Quantum Circuits

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    Quantum computing promises a new approach to solving difficult computational problems, and the quest of building a quantum computer has started. While the first attempts on construction were succesful, scalability has never been achieved, due to the inherent fragile nature of the quantum bits (qubits). From the multitude of approaches to achieve scalability topological quantum computing (TQC) is the most promising one, by being based on an flexible approach to error-correction and making use of the straightforward measurement-based computing technique. TQC circuits are defined within a large, uniform, 3-dimensional lattice of physical qubits produced by the hardware and the physical volume of this lattice directly relates to the resources required for computation. Circuit optimization may result in non-intuitive mismatches between circuit specification and implementation. In this paper we introduce the first method for cross-level validation of TQC circuits. The specification of the circuit is expressed based on the stabilizer formalism, and the stabilizer table is checked by mapping the topology on the physical qubit level, followed by quantum circuit simulation. Simulation results show that cross-level validation of error-corrected circuits is feasible.Comment: 12 Pages, 5 Figures. Comments Welcome. RC2014, Springer Lecture Notes on Computer Science (LNCS) 8507, pp. 189-200. Springer International Publishing, Switzerland (2014), Y. Shigeru and M.Shin-ichi (Eds.

    Validation of the GATE Monte Carlo simulation platform for modelling a CsI(Tl) scintillation camera dedicated to small animal imaging

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    Monte Carlo simulations are increasingly used in scintigraphic imaging to model imaging systems and to develop and assess tomographic reconstruction algorithms and correction methods for improved image quantitation. GATE (GEANT 4 Application for Tomographic Emission) is a new Monte Carlo simulation platform based on GEANT4 dedicated to nuclear imaging applications. This paper describes the GATE simulation of a prototype of scintillation camera dedicated to small animal imaging and consisting of a CsI(Tl) crystal array coupled to a position sensitive photomultiplier tube. The relevance of GATE to model the camera prototype was assessed by comparing simulated 99mTc point spread functions, energy spectra, sensitivities, scatter fractions and image of a capillary phantom with the corresponding experimental measurements. Results showed an excellent agreement between simulated and experimental data: experimental spatial resolutions were predicted with an error less than 100 mu m. The difference between experimental and simulated system sensitivities for different source-to-collimator distances was within 2%. Simulated and experimental scatter fractions in a [98-182 keV] energy window differed by less than 2% for sources located in water. Simulated and experimental energy spectra agreed very well between 40 and 180 keV. These results demonstrate the ability and flexibility of GATE for simulating original detector designs. The main weakness of GATE concerns the long computation time it requires: this issue is currently under investigation by the GEANT4 and the GATE collaboration

    Verifying service continuity in a satellite reconfiguration procedure: application to a satellite

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    The paper discusses the use of the TURTLE UML profile to model and verify service continuity during dynamic reconfiguration of embedded software, and space-based telecommunication software in particular. TURTLE extends UML class diagrams with composition operators, and activity diagrams with temporal operators. Translating TURTLE to the formal description technique RT-LOTOS gives the profile a formal semantics and makes it possible to reuse verification techniques implemented by the RTL, the RT-LOTOS toolkit developed at LAAS-CNRS. The paper proposes a modeling and formal validation methodology based on TURTLE and RTL, and discusses its application to a payload software application in charge of an embedded packet switch. The paper demonstrates the benefits of using TURTLE to prove service continuity for dynamic reconfiguration of embedded software
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