Early-stage design strategies

Decisions made at early stages of the design are of the utmost importance for the energy-efficiency of buildings. Wrong decisions and design failures related to a building’s general layout, shape, façade transparency or orientation can increase the operational energy tremendously. These failures can be avoided in advance through simple changes in the design. Using extensive parametric energy simulations by DesignBuilder, this paper investigates the impact of geometric factors for the energy-efficiency of high-rise office buildings in three climates contexts: Amsterdam (Temperate), Sydney (Sub-tropical) and Singapore (Tropical). The investigation is carried out on 12 plan shapes, 7 plan depths, 4 building orientations and discrete values for window-to-wall ratio. Among selected options, each sub-section determines the most efficient solution for different design measures and climates. The optimal design solution is the one that minimizes, on an annual basis, the sum of the energy use for heating, cooling, electric lighting and fans. The results indicate that, the general building design is an important issue to consider for high-rise buildings: they can influence the energy use up to 32%. For most of the geometric factors, the greatest difference between the optimal and the worst solution occurs in the sub-tropical climate, while the tropical climate is the one that shows the smallest difference. In case of the plan depth, special attention should be paid in a temperate climate, as the total energy use can increase more than other climates. Regarding energy performance, the following building geometry factors have the highest to lowest influence: building orientation, plan shape, plan depth, and window-to-wall ratio

Computational support for early stage architectural design

The concepts underlying 'scenario-based' design are introduced. From the analysis of a number of struc-tured interviews with practicing designers, key design scenarios are identified. These scenarios are then generalised and outline guidelines developed for structuring early stage design

Methodological Issues in Multistage Genome-Wide Association Studies

Because of the high cost of commercial genotyping chip technologies, many investigations have used a two-stage design for genome-wide association studies, using part of the sample for an initial discovery of ``promising'' SNPs at a less stringent significance level and the remainder in a joint analysis of just these SNPs using custom genotyping. Typical cost savings of about 50% are possible with this design to obtain comparable levels of overall type I error and power by using about half the sample for stage I and carrying about 0.1% of SNPs forward to the second stage, the optimal design depending primarily upon the ratio of costs per genotype for stages I and II. However, with the rapidly declining costs of the commercial panels, the generally low observed ORs of current studies, and many studies aiming to test multiple hypotheses and multiple endpoints, many investigators are abandoning the two-stage design in favor of simply genotyping all available subjects using a standard high-density panel. Concern is sometimes raised about the absence of a ``replication'' panel in this approach, as required by some high-profile journals, but it must be appreciated that the two-stage design is not a discovery/replication design but simply a more efficient design for discovery using a joint analysis of the data from both stages. Once a subset of highly-significant associations has been discovered, a truly independent ``exact replication'' study is needed in a similar population of the same promising SNPs using similar methods.Comment: Published in at http://dx.doi.org/10.1214/09-STS288 the Statistical Science (http://www.imstat.org/sts/) by the Institute of Mathematical Statistics (http://www.imstat.org

A method and tool for ‘cradle to grave’ embodied energy and carbon impacts of UK buildings in compliance with the new TC350 standards

As operational impacts from buildings are reduced, embodied impacts are increasing. However, the latter are seldom calculated in the UK; when they are, they tend to be calculated after the building has been constructed, or are underestimated by considering only the initial materials stage. In 2010, the UK Government recommended that a standard methodology for calculating embodied impacts of buildings be developed for early stage design decisions. This was followed in 2011–12 by the publication of the European TC350 standards defining the ‘cradle to grave’ impact of buildings and products through a process Life Cycle Analysis. This paper describes a new whole life embodied carbon and energy of buildings (ECEB) tool, designed as a usable empirical-based approach for early stage design decisions for UK buildings. The tool complies where possible with the TC350 standards. Initial results for a simple masonry construction dwelling are given in terms of the percentage contribution of each life cycle stage. The main difficulty in obtaining these results is found to be the lack of data, and the paper suggests that the construction and manufacturing industries now have a responsibility to develop new data in order to support this task

Modelling and Multi-stage Design of Membrane Processes Applied to Carbon Capture in Coal-fired Power Plants

AbstractAccording to recent predictions, energy generation from coal will continue to play a key role in the next decades. The UK 2008 Climate Change Act requires a reduction of 80% of greenhouse gases emissions by 2050, and carbon capture and storage will have a key role in order to meet this target.This work focuses on post-combustion capture from coal-fired power plants based on membrane separation. Adetailed multi-stage design is presented: the developed flowsheet includes cross-flow and countercurrent-sweep stages. The cross-flow stages are based on a 2D model implemented by our research group able to predict the separation through spiral-wound permeators. Different process configurations are analysed, with the aim of reducing both energy consumption and membrane area.An economic analysis is also included: both capture and avoidance costs are evaluated. The estimated values are compared with data available in the literature for processes based on amine capture technology

An allocation scheme for estimating the reliability of a parallel-series system

We give a hybrid two stage design which can be useful to estimate the reliability of a parallel-series and/or by duality a series-parallel system, when the component reliabilities are unknown as well as the total numbers of units allowed to be tested in each subsystem. When a total sample size is fixed large, asymptotic optimality is proved systematically and validated via Monte Carlo simulation.Comment: 16 pages, 4 figure

An optimal stratified Simon two-stage design

In Phase II oncology trials, therapies are increasingly being evaluated for their effectiveness in specific populations of interest. Such targeted trials require designs that allow for stratification based on the participants’ molecular characterisation. A targeted design proposed by Jones and Holmgren (JH) Jones CL, Holmgren E: ‘An adaptive Simon two-stage design for phase 2 studies of targeted therapies’, Contemporary Clinical Trials 28 (2007) 654-661.determines whether a drug only has activity in a disease sub-population or in the wider disease population. Their adaptive design uses results from a single interim analysis to decide whether to enrich the study population with a subgroup or not; it is based on two parallel Simon two-stage designs. We study the JH design in detail and extend it by providing a few alternative ways to control the familywise error rate, in the weak sense as well as the strong sense. We also introduce a novel optimal design by minimising the expected sample size. Our extended design contributes to the much needed framework for conducting Phase II trials in stratified medicine

A Cross-Disciplinary Approach to Stage Design

When designing for theater, inspiration, and ideas can come from a wide array of resources and play analysis. This thesis includes the combined method of technical lighting and scenic design for the production of Is God Is, by Aleshea Harris. Presented are approaches to script and character analysis, the incorporation of a diverse range of research, the production process, and a post-production analysis. Also included in this paper are theater design theories, visual references, a light plot, a lighting map, ground plan, and insight behind the design choices